LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AWF9_LEIMU
TriTrypDb:
LmxM.23.1390
Length:
165

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

E9AWF9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWF9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 140 142 PF00675 0.385
CLV_NRD_NRD_1 151 153 PF00675 0.403
CLV_PCSK_KEX2_1 139 141 PF00082 0.379
CLV_PCSK_KEX2_1 151 153 PF00082 0.403
CLV_PCSK_KEX2_1 163 165 PF00082 0.417
CLV_PCSK_PC1ET2_1 163 165 PF00082 0.531
CLV_PCSK_SKI1_1 133 137 PF00082 0.355
DEG_APCC_DBOX_1 140 148 PF00400 0.654
DEG_APCC_KENBOX_2 78 82 PF00400 0.356
DEG_Nend_Nbox_1 1 3 PF02207 0.456
DOC_CYCLIN_yCln2_LP_2 85 91 PF00134 0.456
DOC_MAPK_gen_1 136 144 PF00069 0.615
DOC_PP2B_LxvP_1 142 145 PF13499 0.650
LIG_Actin_WH2_2 121 138 PF00022 0.429
LIG_deltaCOP1_diTrp_1 107 116 PF00928 0.399
LIG_FHA_1 130 136 PF00498 0.594
LIG_FHA_1 24 30 PF00498 0.369
LIG_LIR_Gen_1 122 131 PF02991 0.464
LIG_LIR_Gen_1 66 74 PF02991 0.381
LIG_LIR_Nem_3 122 128 PF02991 0.434
LIG_LIR_Nem_3 66 70 PF02991 0.381
LIG_NRP_CendR_1 163 165 PF00754 0.504
LIG_SH2_CRK 67 71 PF00017 0.371
LIG_SH2_SRC 91 94 PF00017 0.407
LIG_SH2_STAT5 91 94 PF00017 0.481
LIG_SUMO_SIM_par_1 127 132 PF11976 0.553
LIG_UBA3_1 128 136 PF00899 0.597
LIG_WRC_WIRS_1 74 79 PF05994 0.410
MOD_CK1_1 3 9 PF00069 0.477
MOD_GlcNHglycan 119 122 PF01048 0.198
MOD_GlcNHglycan 12 15 PF01048 0.338
MOD_GlcNHglycan 3 6 PF01048 0.652
MOD_NEK2_1 1 6 PF00069 0.439
MOD_NEK2_1 114 119 PF00069 0.350
MOD_NEK2_1 135 140 PF00069 0.602
MOD_NEK2_1 29 34 PF00069 0.501
MOD_NEK2_1 63 68 PF00069 0.435
MOD_NEK2_1 70 75 PF00069 0.399
MOD_Plk_1 129 135 PF00069 0.552
TRG_DiLeu_BaLyEn_6 130 135 PF01217 0.598
TRG_ENDOCYTIC_2 67 70 PF00928 0.377
TRG_ER_diArg_1 139 141 PF00400 0.598
TRG_ER_diArg_1 150 152 PF00400 0.616
TRG_Pf-PMV_PEXEL_1 148 153 PF00026 0.357
TRG_Pf-PMV_PEXEL_1 97 102 PF00026 0.635

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJY8 Leptomonas seymouri 48% 97%
A0A3S5H7C4 Leishmania donovani 91% 100%
A0A422NXW8 Trypanosoma rangeli 36% 100%
A4HD12 Leishmania braziliensis 72% 100%
A4I0J8 Leishmania infantum 91% 100%
Q4QB13 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS