Mitochondrial carrier protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein-like protein

Species:

Leishmania mexicana

UniProt:

E9AWF7_LEIMU

TriTrypDb:

LmxM.23.1370

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 15
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17
GO:0005743	mitochondrial inner membrane	5	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1

Expansion

Sequence features

E9AWF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWF7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0009987	cellular process	1	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0055085	transmembrane transport	2	3

Molecular functions
Term	Name	Level	Count
GO:0000095	S-adenosyl-L-methionine transmembrane transporter activity	4	1
GO:0005215	transporter activity	1	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015101	organic cation transmembrane transporter activity	5	1
GO:0022857	transmembrane transporter activity	2	1
GO:1901682	sulfur compound transmembrane transporter activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	387	389	PF00675	0.504
CLV_PCSK_KEX2_1	387	389	PF00082	0.504
CLV_PCSK_SKI1_1	104	108	PF00082	0.153
CLV_PCSK_SKI1_1	144	148	PF00082	0.287
CLV_PCSK_SKI1_1	302	306	PF00082	0.327
CLV_PCSK_SKI1_1	382	386	PF00082	0.347
CLV_PCSK_SKI1_1	76	80	PF00082	0.268
DEG_APCC_DBOX_1	117	125	PF00400	0.288
DEG_Nend_Nbox_1	1	3	PF02207	0.714
DOC_ANK_TNKS_1	92	99	PF00023	0.153
DOC_CYCLIN_RxL_1	73	83	PF00134	0.288
DOC_CYCLIN_yClb1_LxF_4	142	147	PF00134	0.258
DOC_PP1_RVXF_1	102	109	PF00149	0.228
DOC_PP1_RVXF_1	142	148	PF00149	0.258
DOC_PP1_RVXF_1	361	367	PF00149	0.325
DOC_PP2B_LxvP_1	202	205	PF13499	0.347
DOC_PP2B_LxvP_1	239	242	PF13499	0.347
DOC_PP2B_LxvP_1	317	320	PF13499	0.409
DOC_PP4_FxxP_1	147	150	PF00568	0.258
DOC_USP7_MATH_1	216	220	PF00917	0.284
DOC_USP7_MATH_1	284	288	PF00917	0.608
DOC_USP7_MATH_1	65	69	PF00917	0.247
DOC_USP7_UBL2_3	107	111	PF12436	0.180
DOC_WW_Pin1_4	110	115	PF00397	0.212
DOC_WW_Pin1_4	130	135	PF00397	0.374
DOC_WW_Pin1_4	22	27	PF00397	0.705
DOC_WW_Pin1_4	282	287	PF00397	0.412
DOC_WW_Pin1_4	36	41	PF00397	0.535
DOC_WW_Pin1_4	6	11	PF00397	0.727
LIG_BIR_III_4	175	179	PF00653	0.485
LIG_BRCT_BRCA1_1	157	161	PF00533	0.252
LIG_BRCT_BRCA1_1	190	194	PF00533	0.434
LIG_BRCT_BRCA1_1	305	309	PF00533	0.374
LIG_FHA_1	283	289	PF00498	0.376
LIG_FHA_1	316	322	PF00498	0.326
LIG_FHA_1	324	330	PF00498	0.337
LIG_FHA_2	10	16	PF00498	0.581
LIG_Integrin_RGD_1	388	390	PF01839	0.331
LIG_LIR_Apic_2	55	61	PF02991	0.486
LIG_LIR_Gen_1	248	259	PF02991	0.363
LIG_LIR_Nem_3	248	254	PF02991	0.324
LIG_LIR_Nem_3	291	296	PF02991	0.483
LIG_LIR_Nem_3	306	312	PF02991	0.287
LIG_Pex14_1	229	233	PF04695	0.234
LIG_SH2_CRK	138	142	PF00017	0.325
LIG_SH2_CRK	251	255	PF00017	0.312
LIG_SH2_NCK_1	251	255	PF00017	0.312
LIG_SH2_NCK_1	58	62	PF00017	0.575
LIG_SH2_SRC	126	129	PF00017	0.290
LIG_SH2_SRC	13	16	PF00017	0.549
LIG_SH2_SRC	58	61	PF00017	0.574
LIG_SH2_STAT5	105	108	PF00017	0.153
LIG_SH2_STAT5	13	16	PF00017	0.549
LIG_SH2_STAT5	148	151	PF00017	0.414
LIG_SH2_STAT5	155	158	PF00017	0.269
LIG_SH2_STAT5	184	187	PF00017	0.406
LIG_SH2_STAT5	342	345	PF00017	0.371
LIG_SH2_STAT5	374	377	PF00017	0.287
LIG_SH3_3	283	289	PF00018	0.394
LIG_SH3_3	93	99	PF00018	0.346
LIG_TYR_ITIM	249	254	PF00017	0.287
LIG_TYR_ITIM	257	262	PF00017	0.241
LIG_UBA3_1	78	86	PF00899	0.264
MOD_CDK_SPK_2	36	41	PF00069	0.461
MOD_CK1_1	110	116	PF00069	0.462
MOD_CK1_1	20	26	PF00069	0.695
MOD_CK1_1	291	297	PF00069	0.477
MOD_CK1_1	315	321	PF00069	0.255
MOD_CK1_1	39	45	PF00069	0.736
MOD_CK1_1	69	75	PF00069	0.329
MOD_CK1_1	9	15	PF00069	0.665
MOD_CK2_1	9	15	PF00069	0.581
MOD_GlcNHglycan	190	193	PF01048	0.278
MOD_GlcNHglycan	198	201	PF01048	0.286
MOD_GlcNHglycan	214	217	PF01048	0.247
MOD_GlcNHglycan	218	221	PF01048	0.135
MOD_GlcNHglycan	305	308	PF01048	0.273
MOD_GlcNHglycan	309	312	PF01048	0.329
MOD_GSK3_1	106	113	PF00069	0.414
MOD_GSK3_1	151	158	PF00069	0.318
MOD_GSK3_1	16	23	PF00069	0.645
MOD_GSK3_1	2	9	PF00069	0.595
MOD_GSK3_1	212	219	PF00069	0.414
MOD_GSK3_1	284	291	PF00069	0.551
MOD_GSK3_1	303	310	PF00069	0.286
MOD_GSK3_1	391	398	PF00069	0.670
MOD_GSK3_1	61	68	PF00069	0.432
MOD_GSK3_1	70	77	PF00069	0.281
MOD_N-GLC_1	392	397	PF02516	0.515
MOD_NEK2_1	106	111	PF00069	0.326
MOD_NEK2_1	116	121	PF00069	0.412
MOD_NEK2_1	2	7	PF00069	0.552
MOD_NEK2_1	300	305	PF00069	0.277
MOD_NEK2_1	312	317	PF00069	0.277
MOD_NEK2_1	365	370	PF00069	0.339
MOD_NEK2_1	66	71	PF00069	0.308
MOD_NEK2_2	205	210	PF00069	0.312
MOD_NEK2_2	218	223	PF00069	0.312
MOD_NEK2_2	81	86	PF00069	0.318
MOD_PIKK_1	263	269	PF00454	0.313
MOD_Plk_1	61	67	PF00069	0.546
MOD_Plk_4	151	157	PF00069	0.309
MOD_Plk_4	241	247	PF00069	0.269
MOD_Plk_4	249	255	PF00069	0.310
MOD_Plk_4	288	294	PF00069	0.473
MOD_Plk_4	312	318	PF00069	0.339
MOD_Plk_4	53	59	PF00069	0.608
MOD_Plk_4	74	80	PF00069	0.342
MOD_Plk_4	9	15	PF00069	0.697
MOD_ProDKin_1	110	116	PF00069	0.212
MOD_ProDKin_1	130	136	PF00069	0.374
MOD_ProDKin_1	22	28	PF00069	0.710
MOD_ProDKin_1	282	288	PF00069	0.407
MOD_ProDKin_1	36	42	PF00069	0.538
MOD_ProDKin_1	6	12	PF00069	0.729
TRG_DiLeu_BaEn_1	379	384	PF01217	0.153
TRG_DiLeu_LyEn_5	379	384	PF01217	0.153
TRG_ENDOCYTIC_2	138	141	PF00928	0.309
TRG_ENDOCYTIC_2	251	254	PF00928	0.296
TRG_ENDOCYTIC_2	259	262	PF00928	0.295
TRG_ENDOCYTIC_2	374	377	PF00928	0.317
TRG_ER_diArg_1	117	120	PF00400	0.288
TRG_ER_diArg_1	324	327	PF00400	0.295
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX21	Leptomonas seymouri	60%	100%
A0A0N1I0W9	Leptomonas seymouri	23%	100%
A0A0S4KJX8	Bodo saltans	26%	100%
A0A1X0NWP7	Trypanosomatidae	46%	79%
A0A3Q8IFM5	Leishmania donovani	24%	100%
A0A3R7M746	Trypanosoma rangeli	47%	100%
A0A3S7WXX9	Leishmania donovani	90%	100%
A4HD10	Leishmania braziliensis	74%	100%
A4HJZ1	Leishmania braziliensis	25%	100%
A4I0J6	Leishmania infantum	90%	100%
A4I7H4	Leishmania infantum	24%	100%
A6QR09	Bos taurus	22%	100%
C9ZKK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZVC3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B2D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
F4HT41	Arabidopsis thaliana	23%	100%
P33303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q03829	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
Q17QI7	Bos taurus	22%	100%
Q4Q5S5	Leishmania major	24%	88%
Q4QB15	Leishmania major	87%	100%
Q55E45	Dictyostelium discoideum	22%	100%
Q66H23	Rattus norvegicus	24%	100%
Q86AV5	Dictyostelium discoideum	23%	100%
Q920G8	Mus musculus	24%	100%
Q94AG6	Arabidopsis thaliana	24%	100%
Q9BZJ4	Homo sapiens	20%	100%
Q9NYZ2	Homo sapiens	23%	100%
V5C243	Trypanosoma cruzi	23%	100%
V5DFJ2	Trypanosoma cruzi	46%	100%