Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWF6_LEIMU

TriTrypDb:

LmxM.23.1360

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AWF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.347
CLV_NRD_NRD_1	148	150	PF00675	0.628
CLV_NRD_NRD_1	186	188	PF00675	0.607
CLV_NRD_NRD_1	233	235	PF00675	0.394
CLV_NRD_NRD_1	99	101	PF00675	0.654
CLV_PCSK_KEX2_1	148	150	PF00082	0.546
CLV_PCSK_KEX2_1	99	101	PF00082	0.680
CLV_PCSK_SKI1_1	187	191	PF00082	0.656
CLV_PCSK_SKI1_1	235	239	PF00082	0.417
CLV_PCSK_SKI1_1	291	295	PF00082	0.508
CLV_PCSK_SKI1_1	364	368	PF00082	0.547
CLV_PCSK_SKI1_1	70	74	PF00082	0.654
CLV_Separin_Metazoa	315	319	PF03568	0.496
DEG_SPOP_SBC_1	10	14	PF00917	0.435
DOC_CKS1_1	274	279	PF01111	0.664
DOC_MAPK_gen_1	335	343	PF00069	0.650
DOC_MAPK_MEF2A_6	337	345	PF00069	0.696
DOC_PP1_RVXF_1	367	373	PF00149	0.711
DOC_PP2B_LxvP_1	7	10	PF13499	0.300
DOC_PP4_FxxP_1	257	260	PF00568	0.646
DOC_PP4_FxxP_1	274	277	PF00568	0.632
DOC_PP4_FxxP_1	33	36	PF00568	0.518
DOC_USP7_MATH_1	10	14	PF00917	0.440
DOC_USP7_MATH_1	16	20	PF00917	0.368
DOC_USP7_MATH_1	247	251	PF00917	0.576
DOC_USP7_MATH_1	302	306	PF00917	0.699
DOC_USP7_MATH_1	336	340	PF00917	0.689
DOC_USP7_MATH_1	355	359	PF00917	0.773
DOC_USP7_UBL2_3	122	126	PF12436	0.393
DOC_WW_Pin1_4	102	107	PF00397	0.474
DOC_WW_Pin1_4	273	278	PF00397	0.608
LIG_14-3-3_CanoR_1	340	344	PF00244	0.750
LIG_14-3-3_CanoR_1	369	373	PF00244	0.663
LIG_14-3-3_CanoR_1	4	8	PF00244	0.697
LIG_14-3-3_CanoR_1	42	47	PF00244	0.495
LIG_14-3-3_CanoR_1	57	63	PF00244	0.475
LIG_APCC_ABBA_1	317	322	PF00400	0.671
LIG_BRCT_BRCA1_1	249	253	PF00533	0.652
LIG_FHA_1	12	18	PF00498	0.390
LIG_FHA_1	164	170	PF00498	0.425
LIG_FHA_1	294	300	PF00498	0.605
LIG_FHA_1	3	9	PF00498	0.702
LIG_FHA_1	398	404	PF00498	0.705
LIG_FHA_2	140	146	PF00498	0.426
LIG_FHA_2	200	206	PF00498	0.395
LIG_FHA_2	236	242	PF00498	0.584
LIG_FHA_2	363	369	PF00498	0.708
LIG_FHA_2	47	53	PF00498	0.454
LIG_Integrin_isoDGR_2	286	288	PF01839	0.449
LIG_LIR_Apic_2	256	260	PF02991	0.703
LIG_LIR_Apic_2	271	277	PF02991	0.704
LIG_LIR_Gen_1	365	375	PF02991	0.653
LIG_LIR_Gen_1	387	395	PF02991	0.631
LIG_LIR_Gen_1	83	94	PF02991	0.455
LIG_LIR_Nem_3	107	112	PF02991	0.493
LIG_LIR_Nem_3	365	370	PF02991	0.662
LIG_LIR_Nem_3	371	375	PF02991	0.599
LIG_LIR_Nem_3	387	392	PF02991	0.614
LIG_LIR_Nem_3	83	89	PF02991	0.400
LIG_MLH1_MIPbox_1	249	253	PF16413	0.652
LIG_NBox_RRM_1	216	226	PF00076	0.449
LIG_Pex14_2	253	257	PF04695	0.679
LIG_Pex14_2	86	90	PF04695	0.291
LIG_REV1ctd_RIR_1	87	96	PF16727	0.304
LIG_SH2_GRB2like	273	276	PF00017	0.707
LIG_SH2_SRC	172	175	PF00017	0.348
LIG_SH2_STAP1	232	236	PF00017	0.671
LIG_SH2_STAT3	289	292	PF00017	0.709
LIG_SH2_STAT3	308	311	PF00017	0.629
LIG_SH2_STAT5	172	175	PF00017	0.342
LIG_SH2_STAT5	236	239	PF00017	0.632
LIG_SH2_STAT5	252	255	PF00017	0.596
LIG_SH2_STAT5	273	276	PF00017	0.648
LIG_SH2_STAT5	344	347	PF00017	0.721
LIG_SH3_3	24	30	PF00018	0.536
LIG_SH3_5	265	269	PF00018	0.630
LIG_TRAF2_1	157	160	PF00917	0.460
LIG_TRAF2_1	307	310	PF00917	0.599
LIG_TRAF2_1	371	374	PF00917	0.662
LIG_UBA3_1	55	63	PF00899	0.501
LIG_WRC_WIRS_1	254	259	PF05994	0.671
LIG_WRC_WIRS_1	86	91	PF05994	0.446
MOD_CK1_1	339	345	PF00069	0.751
MOD_CK1_1	358	364	PF00069	0.733
MOD_CK1_1	397	403	PF00069	0.695
MOD_CK1_1	45	51	PF00069	0.419
MOD_CK2_1	199	205	PF00069	0.341
MOD_CK2_1	275	281	PF00069	0.654
MOD_CK2_1	292	298	PF00069	0.576
MOD_CK2_1	362	368	PF00069	0.741
MOD_CK2_1	395	401	PF00069	0.721
MOD_GlcNHglycan	303	307	PF01048	0.456
MOD_GlcNHglycan	33	36	PF01048	0.745
MOD_GlcNHglycan	374	378	PF01048	0.455
MOD_GlcNHglycan	411	414	PF01048	0.528
MOD_GlcNHglycan	73	76	PF01048	0.745
MOD_GSK3_1	214	221	PF00069	0.419
MOD_GSK3_1	237	244	PF00069	0.677
MOD_GSK3_1	339	346	PF00069	0.671
MOD_GSK3_1	355	362	PF00069	0.758
MOD_GSK3_1	390	397	PF00069	0.680
MOD_GSK3_1	42	49	PF00069	0.467
MOD_GSK3_1	66	73	PF00069	0.551
MOD_N-GLC_1	208	213	PF02516	0.654
MOD_NEK2_1	11	16	PF00069	0.382
MOD_NEK2_1	17	22	PF00069	0.350
MOD_NEK2_1	173	178	PF00069	0.459
MOD_NEK2_1	179	184	PF00069	0.475
MOD_NEK2_1	253	258	PF00069	0.631
MOD_NEK2_1	46	51	PF00069	0.446
MOD_NEK2_1	58	63	PF00069	0.458
MOD_PK_1	324	330	PF00069	0.616
MOD_PKA_1	100	106	PF00069	0.502
MOD_PKA_2	3	9	PF00069	0.726
MOD_PKA_2	336	342	PF00069	0.624
MOD_PKA_2	358	364	PF00069	0.776
MOD_PKA_2	368	374	PF00069	0.663
MOD_PKA_2	390	396	PF00069	0.639
MOD_PKB_1	206	214	PF00069	0.456
MOD_PKB_1	407	415	PF00069	0.688
MOD_Plk_1	173	179	PF00069	0.381
MOD_Plk_1	208	214	PF00069	0.359
MOD_Plk_1	324	330	PF00069	0.699
MOD_Plk_1	362	368	PF00069	0.696
MOD_Plk_1	51	57	PF00069	0.486
MOD_Plk_2-3	368	374	PF00069	0.705
MOD_Plk_4	173	179	PF00069	0.428
MOD_Plk_4	208	214	PF00069	0.337
MOD_Plk_4	253	259	PF00069	0.647
MOD_Plk_4	3	9	PF00069	0.767
MOD_Plk_4	339	345	PF00069	0.736
MOD_Plk_4	51	57	PF00069	0.468
MOD_Plk_4	85	91	PF00069	0.449
MOD_ProDKin_1	102	108	PF00069	0.473
MOD_ProDKin_1	273	279	PF00069	0.609
MOD_SUMO_for_1	130	133	PF00179	0.459
MOD_SUMO_rev_2	114	124	PF00179	0.422
MOD_SUMO_rev_2	327	336	PF00179	0.668
TRG_DiLeu_BaEn_4	312	318	PF01217	0.598
TRG_ENDOCYTIC_2	186	189	PF00928	0.447
TRG_ENDOCYTIC_2	252	255	PF00928	0.596
TRG_ER_diArg_1	147	149	PF00400	0.336
TRG_ER_diArg_1	98	100	PF00400	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S8	Leptomonas seymouri	66%	98%
A0A0S4IRC9	Bodo saltans	35%	100%
A0A1X0NWQ4	Trypanosomatidae	44%	97%
A0A3Q8IMB7	Leishmania donovani	90%	100%
A0A422NXY7	Trypanosoma rangeli	43%	100%
A4HD09	Leishmania braziliensis	76%	100%
A4I0J5	Leishmania infantum	90%	100%
C9ZVC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4QB16	Leishmania major	88%	100%
V5BJ93	Trypanosoma cruzi	44%	99%