Elongator complex protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acetyltransferase-like protein

Species:

Leishmania mexicana

UniProt:

E9AWF5_LEIMU

TriTrypDb:

LmxM.23.1350

Length:

702

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005635	nuclear envelope	4	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	2
GO:0005819	spindle	5	1
GO:0016020	membrane	2	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	2
GO:0033588	elongator holoenzyme complex	3	2

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Expansion

Sequence features

E9AWF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWF5

Function

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Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	2
GO:0002098	tRNA wobble uridine modification	8	2
GO:0002926	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	1
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006473	protein acetylation	6	1
GO:0006475	internal protein amino acid acetylation	7	1

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Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	23
GO:0003676	nucleic acid binding	3	23
GO:0003723	RNA binding	4	23
GO:0003824	catalytic activity	1	23
GO:0005488	binding	1	23
GO:0016407	acetyltransferase activity	5	23
GO:0016740	transferase activity	2	23
GO:0016746	acyltransferase activity	3	23
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	23
GO:0043167	ion binding	2	23

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.492
CLV_NRD_NRD_1	117	119	PF00675	0.434
CLV_NRD_NRD_1	158	160	PF00675	0.444
CLV_NRD_NRD_1	187	189	PF00675	0.416
CLV_NRD_NRD_1	341	343	PF00675	0.223
CLV_NRD_NRD_1	380	382	PF00675	0.124
CLV_NRD_NRD_1	641	643	PF00675	0.281
CLV_PCSK_KEX2_1	117	119	PF00082	0.431
CLV_PCSK_KEX2_1	13	15	PF00082	0.688
CLV_PCSK_KEX2_1	341	343	PF00082	0.223

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P567	Leptomonas seymouri	83%	100%
A0A0N1PFU7	Leptomonas seymouri	45%	94%
A0A0S4IQT9	Bodo saltans	69%	100%
A0A0S4KPU1	Bodo saltans	45%	100%
A0A1X0NG94	Trypanosomatidae	41%	95%
A0A1X0NX69	Trypanosomatidae	76%	100%
A0A3Q8ICG0	Leishmania donovani	46%	92%
A0A3R7KUY9	Trypanosoma rangeli	77%	100%
A0A3S7WXV4	Leishmania donovani	95%	99%
A0A422NDG5	Trypanosoma rangeli	42%	94%

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