Elongator complex protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acetyltransferase-like protein

Species:

Leishmania mexicana

UniProt:

E9AWF5_LEIMU

TriTrypDb:

LmxM.23.1350

Length:

702

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005634	nucleus	5	2
GO:0005635	nuclear envelope	4	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	2
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0032991	protein-containing complex	1	2
GO:0033588	elongator holoenzyme complex	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:0005819	spindle	5	1

Expansion

Sequence features

E9AWF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWF5

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	2
GO:0002098	tRNA wobble uridine modification	8	2
GO:0002926	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	1
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006400	tRNA modification	6	2
GO:0006473	protein acetylation	6	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006996	organelle organization	4	1
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	2
GO:0016570	histone modification	5	1
GO:0016573	histone acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0018393	internal peptidyl-lysine acetylation	8	1
GO:0018394	peptidyl-lysine acetylation	7	1
GO:0019538	protein metabolic process	3	1
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0036211	protein modification process	4	1
GO:0043007	maintenance of rDNA	6	1
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	1
GO:0043570	maintenance of DNA repeat elements	5	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	2
GO:0051276	chromosome organization	5	1
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	23
GO:0003676	nucleic acid binding	3	23
GO:0003723	RNA binding	4	23
GO:0003824	catalytic activity	1	23
GO:0005488	binding	1	23
GO:0016407	acetyltransferase activity	5	23
GO:0016740	transferase activity	2	23
GO:0016746	acyltransferase activity	3	23
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	23
GO:0043167	ion binding	2	23
GO:0043169	cation binding	3	23
GO:0046872	metal ion binding	4	23
GO:0051536	iron-sulfur cluster binding	3	23
GO:0051539	4 iron, 4 sulfur cluster binding	4	23
GO:0051540	metal cluster binding	2	23
GO:0097159	organic cyclic compound binding	2	23
GO:0106261	tRNA uridine(34) acetyltransferase activity	6	12
GO:1901363	heterocyclic compound binding	2	23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.492
CLV_NRD_NRD_1	117	119	PF00675	0.434
CLV_NRD_NRD_1	158	160	PF00675	0.444
CLV_NRD_NRD_1	187	189	PF00675	0.416
CLV_NRD_NRD_1	341	343	PF00675	0.223
CLV_NRD_NRD_1	380	382	PF00675	0.124
CLV_NRD_NRD_1	641	643	PF00675	0.281
CLV_PCSK_KEX2_1	117	119	PF00082	0.431
CLV_PCSK_KEX2_1	13	15	PF00082	0.688
CLV_PCSK_KEX2_1	341	343	PF00082	0.223
CLV_PCSK_KEX2_1	380	382	PF00082	0.136
CLV_PCSK_KEX2_1	493	495	PF00082	0.218
CLV_PCSK_KEX2_1	641	643	PF00082	0.289
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.686
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.284
CLV_PCSK_SKI1_1	118	122	PF00082	0.425
CLV_PCSK_SKI1_1	380	384	PF00082	0.200
CLV_PCSK_SKI1_1	622	626	PF00082	0.391
CLV_PCSK_SKI1_1	691	695	PF00082	0.605
DEG_APCC_DBOX_1	472	480	PF00400	0.418
DEG_APCC_DBOX_1	493	501	PF00400	0.418
DOC_ANK_TNKS_1	171	178	PF00023	0.265
DOC_CYCLIN_RxL_1	374	384	PF00134	0.337
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.444
DOC_MAPK_gen_1	188	199	PF00069	0.404
DOC_MAPK_gen_1	320	328	PF00069	0.381
DOC_MAPK_gen_1	338	348	PF00069	0.503
DOC_MAPK_gen_1	625	634	PF00069	0.401
DOC_MAPK_HePTP_8	186	202	PF00069	0.373
DOC_MAPK_MEF2A_6	320	328	PF00069	0.376
DOC_PIKK_1	95	103	PF02985	0.457
DOC_PP2B_LxvP_1	50	53	PF13499	0.446
DOC_PP4_FxxP_1	203	206	PF00568	0.278
DOC_PP4_FxxP_1	209	212	PF00568	0.309
DOC_PP4_FxxP_1	21	24	PF00568	0.474
DOC_USP7_MATH_1	133	137	PF00917	0.515
DOC_USP7_MATH_1	158	162	PF00917	0.381
DOC_USP7_MATH_1	27	31	PF00917	0.711
DOC_USP7_MATH_1	305	309	PF00917	0.459
DOC_USP7_MATH_1	398	402	PF00917	0.431
DOC_USP7_MATH_1	682	686	PF00917	0.614
DOC_WW_Pin1_4	20	25	PF00397	0.524
LIG_14-3-3_CanoR_1	159	167	PF00244	0.428
LIG_14-3-3_CanoR_1	304	310	PF00244	0.443
LIG_14-3-3_CanoR_1	341	347	PF00244	0.450
LIG_14-3-3_CanoR_1	538	546	PF00244	0.243
LIG_AP2alpha_1	533	537	PF02296	0.276
LIG_BIR_II_1	1	5	PF00653	0.533
LIG_Clathr_ClatBox_1	419	423	PF01394	0.307
LIG_EH1_1	457	465	PF00400	0.484
LIG_eIF4E_1	458	464	PF01652	0.452
LIG_FHA_1	428	434	PF00498	0.418
LIG_FHA_1	483	489	PF00498	0.443
LIG_FHA_1	605	611	PF00498	0.349
LIG_FHA_1	63	69	PF00498	0.579
LIG_FHA_1	652	658	PF00498	0.326
LIG_FHA_2	294	300	PF00498	0.428
LIG_FHA_2	312	318	PF00498	0.415
LIG_FHA_2	328	334	PF00498	0.410
LIG_FHA_2	435	441	PF00498	0.331
LIG_FHA_2	601	607	PF00498	0.299
LIG_FHA_2	664	670	PF00498	0.349
LIG_LIR_Apic_2	18	24	PF02991	0.477
LIG_LIR_Apic_2	201	206	PF02991	0.265
LIG_LIR_Apic_2	208	212	PF02991	0.328
LIG_LIR_Apic_2	90	94	PF02991	0.511
LIG_LIR_Gen_1	108	116	PF02991	0.532
LIG_LIR_Gen_1	407	415	PF02991	0.293
LIG_LIR_Gen_1	432	443	PF02991	0.418
LIG_LIR_Gen_1	543	553	PF02991	0.281
LIG_LIR_Gen_1	626	636	PF02991	0.306
LIG_LIR_Gen_1	681	690	PF02991	0.461
LIG_LIR_Gen_1	83	91	PF02991	0.489
LIG_LIR_LC3C_4	195	200	PF02991	0.376
LIG_LIR_Nem_3	108	113	PF02991	0.463
LIG_LIR_Nem_3	164	170	PF02991	0.380
LIG_LIR_Nem_3	274	278	PF02991	0.418
LIG_LIR_Nem_3	407	412	PF02991	0.298
LIG_LIR_Nem_3	423	428	PF02991	0.431
LIG_LIR_Nem_3	432	438	PF02991	0.418
LIG_LIR_Nem_3	543	549	PF02991	0.266
LIG_LIR_Nem_3	555	561	PF02991	0.248
LIG_LIR_Nem_3	591	595	PF02991	0.320
LIG_LIR_Nem_3	681	686	PF02991	0.639
LIG_LIR_Nem_3	692	696	PF02991	0.657
LIG_LIR_Nem_3	83	87	PF02991	0.474
LIG_PCNA_yPIPBox_3	172	186	PF02747	0.420
LIG_Pex14_2	239	243	PF04695	0.516
LIG_Pex14_2	409	413	PF04695	0.315
LIG_Pex14_2	533	537	PF04695	0.260
LIG_PTB_Apo_2	452	459	PF02174	0.540
LIG_PTB_Phospho_1	452	458	PF10480	0.540
LIG_Rb_pABgroove_1	244	252	PF01858	0.324
LIG_SH2_CRK	167	171	PF00017	0.381
LIG_SH2_CRK	592	596	PF00017	0.276
LIG_SH2_CRK	644	648	PF00017	0.286
LIG_SH2_NCK_1	250	254	PF00017	0.429
LIG_SH2_NCK_1	298	302	PF00017	0.431
LIG_SH2_NCK_1	91	95	PF00017	0.432
LIG_SH2_STAP1	282	286	PF00017	0.433
LIG_SH2_STAP1	683	687	PF00017	0.443
LIG_SH2_STAT5	217	220	PF00017	0.418
LIG_SH2_STAT5	228	231	PF00017	0.418
LIG_SH2_STAT5	334	337	PF00017	0.458
LIG_SH2_STAT5	465	468	PF00017	0.415
LIG_SH2_STAT5	487	490	PF00017	0.418
LIG_SH2_STAT5	546	549	PF00017	0.246
LIG_SH3_2	302	307	PF14604	0.484
LIG_SH3_2	53	58	PF14604	0.442
LIG_SH3_3	21	27	PF00018	0.519
LIG_SH3_3	216	222	PF00018	0.418
LIG_SH3_3	299	305	PF00018	0.442
LIG_SH3_3	392	398	PF00018	0.421
LIG_SH3_3	50	56	PF00018	0.615
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.368
LIG_SUMO_SIM_anti_2	264	270	PF11976	0.418
LIG_SUMO_SIM_par_1	195	201	PF11976	0.368
LIG_SUMO_SIM_par_1	594	599	PF11976	0.260
LIG_TRAF2_1	570	573	PF00917	0.349
LIG_UBA3_1	585	594	PF00899	0.325
LIG_WRC_WIRS_1	683	688	PF05994	0.607
LIG_WRC_WIRS_1	690	695	PF05994	0.560
LIG_WRPW_2	447	450	PF00400	0.260
MOD_CK1_1	124	130	PF00069	0.476
MOD_CK1_1	161	167	PF00069	0.392
MOD_CK1_1	540	546	PF00069	0.263
MOD_CK1_1	61	67	PF00069	0.733
MOD_CK1_1	665	671	PF00069	0.564
MOD_CK1_1	681	687	PF00069	0.533
MOD_CK1_1	83	89	PF00069	0.509
MOD_CK2_1	133	139	PF00069	0.551
MOD_CK2_1	251	257	PF00069	0.276
MOD_CK2_1	305	311	PF00069	0.254
MOD_CK2_1	333	339	PF00069	0.314
MOD_CK2_1	397	403	PF00069	0.290
MOD_CK2_1	434	440	PF00069	0.236
MOD_CK2_1	567	573	PF00069	0.284
MOD_CK2_1	600	606	PF00069	0.284
MOD_CK2_1	66	72	PF00069	0.520
MOD_CK2_1	663	669	PF00069	0.365
MOD_GlcNHglycan	136	139	PF01048	0.540
MOD_GlcNHglycan	194	197	PF01048	0.394
MOD_GlcNHglycan	253	256	PF01048	0.276
MOD_GlcNHglycan	299	302	PF01048	0.306
MOD_GlcNHglycan	335	338	PF01048	0.240
MOD_GlcNHglycan	41	44	PF01048	0.548
MOD_GlcNHglycan	413	416	PF01048	0.496
MOD_GlcNHglycan	679	683	PF01048	0.543
MOD_GSK3_1	154	161	PF00069	0.449
MOD_GSK3_1	293	300	PF00069	0.272
MOD_GSK3_1	342	349	PF00069	0.291
MOD_GSK3_1	429	436	PF00069	0.266
MOD_GSK3_1	527	534	PF00069	0.210
MOD_GSK3_1	567	574	PF00069	0.347
MOD_GSK3_1	58	65	PF00069	0.666
MOD_GSK3_1	596	603	PF00069	0.276
MOD_GSK3_1	678	685	PF00069	0.556
MOD_NEK2_1	121	126	PF00069	0.417
MOD_NEK2_1	154	159	PF00069	0.482
MOD_NEK2_1	198	203	PF00069	0.313
MOD_NEK2_1	271	276	PF00069	0.260
MOD_NEK2_1	287	292	PF00069	0.260
MOD_NEK2_1	346	351	PF00069	0.269
MOD_NEK2_1	408	413	PF00069	0.448
MOD_NEK2_1	651	656	PF00069	0.337
MOD_NEK2_1	66	71	PF00069	0.434
MOD_NEK2_1	686	691	PF00069	0.579
MOD_NEK2_1	696	701	PF00069	0.648
MOD_NEK2_2	273	278	PF00069	0.260
MOD_PIKK_1	244	250	PF00454	0.282
MOD_PIKK_1	552	558	PF00454	0.409
MOD_PIKK_1	596	602	PF00454	0.380
MOD_PIKK_1	604	610	PF00454	0.210
MOD_PIKK_1	611	617	PF00454	0.135
MOD_PK_1	58	64	PF00069	0.530
MOD_PKA_2	158	164	PF00069	0.407
MOD_PKA_2	251	257	PF00069	0.294
MOD_PKA_2	537	543	PF00069	0.248
MOD_PKA_2	604	610	PF00069	0.448
MOD_Plk_1	311	317	PF00069	0.296
MOD_Plk_1	552	558	PF00069	0.329
MOD_Plk_1	651	657	PF00069	0.346
MOD_Plk_1	678	684	PF00069	0.648
MOD_Plk_2-3	311	317	PF00069	0.295
MOD_Plk_4	198	204	PF00069	0.348
MOD_Plk_4	27	33	PF00069	0.450
MOD_Plk_4	287	293	PF00069	0.270
MOD_Plk_4	372	378	PF00069	0.334
MOD_Plk_4	408	414	PF00069	0.427
MOD_Plk_4	483	489	PF00069	0.278
MOD_Plk_4	651	657	PF00069	0.356
MOD_Plk_4	682	688	PF00069	0.564
MOD_Plk_4	689	695	PF00069	0.541
MOD_Plk_4	83	89	PF00069	0.532
MOD_ProDKin_1	20	26	PF00069	0.522
MOD_SUMO_rev_2	90	100	PF00179	0.494
TRG_DiLeu_BaEn_4	572	578	PF01217	0.240
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.253
TRG_ENDOCYTIC_2	167	170	PF00928	0.365
TRG_ENDOCYTIC_2	450	453	PF00928	0.369
TRG_ENDOCYTIC_2	546	549	PF00928	0.239
TRG_ENDOCYTIC_2	558	561	PF00928	0.228
TRG_ENDOCYTIC_2	592	595	PF00928	0.261
TRG_ENDOCYTIC_2	629	632	PF00928	0.315
TRG_ENDOCYTIC_2	644	647	PF00928	0.261
TRG_ENDOCYTIC_2	683	686	PF00928	0.632
TRG_ER_diArg_1	12	15	PF00400	0.694
TRG_ER_diArg_1	320	323	PF00400	0.263
TRG_ER_diArg_1	340	342	PF00400	0.266
TRG_ER_diArg_1	379	381	PF00400	0.128
TRG_ER_diArg_1	472	475	PF00400	0.253
TRG_ER_diArg_1	505	508	PF00400	0.441
TRG_ER_diArg_1	561	564	PF00400	0.260
TRG_ER_diArg_1	640	642	PF00400	0.268
TRG_ER_FFAT_2	329	339	PF00635	0.240
TRG_NES_CRM1_1	339	352	PF08389	0.276
TRG_NLS_MonoExtC_3	11	16	PF00514	0.510
TRG_NLS_MonoExtC_3	187	192	PF00514	0.416
TRG_NLS_MonoExtN_4	12	17	PF00514	0.512
TRG_NLS_MonoExtN_4	188	193	PF00514	0.416
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.232
TRG_Pf-PMV_PEXEL_1	478	482	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	658	662	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P567	Leptomonas seymouri	83%	100%
A0A0N1PFU7	Leptomonas seymouri	45%	94%
A0A0S4IQT9	Bodo saltans	69%	100%
A0A0S4KPU1	Bodo saltans	45%	100%
A0A1X0NG94	Trypanosomatidae	41%	95%
A0A1X0NX69	Trypanosomatidae	76%	100%
A0A3Q8ICG0	Leishmania donovani	46%	92%
A0A3R7KUY9	Trypanosoma rangeli	77%	100%
A0A3S7WXV4	Leishmania donovani	95%	99%
A0A422NDG5	Trypanosoma rangeli	42%	94%
A4H8F0	Leishmania braziliensis	45%	92%
A4HD08	Leishmania braziliensis	94%	100%
A4HWS3	Leishmania infantum	46%	92%
A4I0J4	Leishmania infantum	95%	99%
C9ZVC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
C9ZW50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D5VRB9	Methanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)	36%	100%
E9AQI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	91%
O14023	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
Q02908	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
Q1ZXC6	Dictyostelium discoideum	33%	100%
Q23651	Caenorhabditis elegans	34%	100%
Q2KJ61	Bos taurus	33%	100%
Q4QB17	Leishmania major	95%	100%
Q4QEZ6	Leishmania major	45%	92%
Q58536	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	36%	100%
Q5HZM6	Xenopus laevis	33%	100%
Q5RIC0	Danio rerio	33%	100%
Q5ZHS1	Gallus gallus	33%	100%
Q60LW7	Caenorhabditis briggsae	34%	100%
Q6NVL5	Xenopus tropicalis	32%	100%
Q7X7L3	Oryza sativa subsp. japonica	35%	100%
Q93ZR1	Arabidopsis thaliana	33%	100%
Q9CZX0	Mus musculus	32%	100%
Q9H9T3	Homo sapiens	33%	100%
Q9VQZ6	Drosophila melanogaster	33%	100%
V5B5L2	Trypanosoma cruzi	42%	100%
V5BNQ5	Trypanosoma cruzi	76%	100%