Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWF4_LEIMU

TriTrypDb:

LmxM.23.1340

Length:

682

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.559
CLV_C14_Caspase3-7	74	78	PF00656	0.498
CLV_MEL_PAP_1	467	473	PF00089	0.310
CLV_NRD_NRD_1	487	489	PF00675	0.353
CLV_NRD_NRD_1	613	615	PF00675	0.497
CLV_NRD_NRD_1	634	636	PF00675	0.467
CLV_PCSK_KEX2_1	141	143	PF00082	0.664
CLV_PCSK_KEX2_1	326	328	PF00082	0.522
CLV_PCSK_KEX2_1	487	489	PF00082	0.353
CLV_PCSK_KEX2_1	613	615	PF00082	0.509
CLV_PCSK_KEX2_1	634	636	PF00082	0.449
CLV_PCSK_KEX2_1	661	663	PF00082	0.547
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.584
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.522
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.449
CLV_PCSK_PC1ET2_1	661	663	PF00082	0.547
CLV_PCSK_PC7_1	609	615	PF00082	0.501
CLV_PCSK_SKI1_1	24	28	PF00082	0.315
CLV_PCSK_SKI1_1	297	301	PF00082	0.397
CLV_PCSK_SKI1_1	397	401	PF00082	0.473
CLV_PCSK_SKI1_1	422	426	PF00082	0.341
CLV_PCSK_SKI1_1	601	605	PF00082	0.372
CLV_PCSK_SKI1_1	609	613	PF00082	0.404
DEG_SCF_FBW7_2	407	412	PF00400	0.456
DEG_SPOP_SBC_1	171	175	PF00917	0.525
DOC_CYCLIN_yCln2_LP_2	541	547	PF00134	0.454
DOC_MAPK_gen_1	180	190	PF00069	0.636
DOC_MAPK_gen_1	232	239	PF00069	0.325
DOC_MAPK_HePTP_8	424	436	PF00069	0.313
DOC_MAPK_MEF2A_6	427	436	PF00069	0.313
DOC_PP1_RVXF_1	126	133	PF00149	0.517
DOC_PP1_RVXF_1	468	474	PF00149	0.346
DOC_PP2B_LxvP_1	356	359	PF13499	0.552
DOC_PP4_FxxP_1	654	657	PF00568	0.429
DOC_USP7_MATH_1	151	155	PF00917	0.488
DOC_USP7_MATH_1	172	176	PF00917	0.606
DOC_USP7_MATH_1	184	188	PF00917	0.565
DOC_USP7_MATH_1	469	473	PF00917	0.312
DOC_USP7_MATH_1	9	13	PF00917	0.692
DOC_USP7_UBL2_3	630	634	PF12436	0.432
DOC_WW_Pin1_4	267	272	PF00397	0.436
DOC_WW_Pin1_4	350	355	PF00397	0.496
DOC_WW_Pin1_4	405	410	PF00397	0.477
DOC_WW_Pin1_4	498	503	PF00397	0.477
DOC_WW_Pin1_4	54	59	PF00397	0.688
LIG_14-3-3_CanoR_1	33	39	PF00244	0.394
LIG_14-3-3_CanoR_1	470	474	PF00244	0.442
LIG_14-3-3_CanoR_1	613	621	PF00244	0.446
LIG_14-3-3_CanoR_1	668	672	PF00244	0.681
LIG_BRCT_BRCA1_1	11	15	PF00533	0.519
LIG_BRCT_BRCA1_1	174	178	PF00533	0.480
LIG_BRCT_BRCA1_1	277	281	PF00533	0.404
LIG_BRCT_BRCA1_1	493	497	PF00533	0.341
LIG_CSL_BTD_1	194	197	PF09270	0.391
LIG_CSL_BTD_1	285	288	PF09270	0.328
LIG_EH1_1	625	633	PF00400	0.539
LIG_EVH1_2	119	123	PF00568	0.396
LIG_FHA_1	216	222	PF00498	0.369
LIG_FHA_1	23	29	PF00498	0.462
LIG_FHA_1	268	274	PF00498	0.470
LIG_FHA_1	35	41	PF00498	0.403
LIG_FHA_1	351	357	PF00498	0.445
LIG_FHA_1	406	412	PF00498	0.424
LIG_FHA_1	549	555	PF00498	0.454
LIG_FHA_1	627	633	PF00498	0.458
LIG_FHA_1	635	641	PF00498	0.468
LIG_FHA_2	16	22	PF00498	0.623
LIG_FHA_2	334	340	PF00498	0.525
LIG_FHA_2	396	402	PF00498	0.326
LIG_FHA_2	499	505	PF00498	0.466
LIG_FHA_2	558	564	PF00498	0.397
LIG_FHA_2	59	65	PF00498	0.790
LIG_FHA_2	662	668	PF00498	0.590
LIG_LIR_Apic_2	242	246	PF02991	0.377
LIG_LIR_Apic_2	247	252	PF02991	0.410
LIG_LIR_Apic_2	373	377	PF02991	0.446
LIG_LIR_Apic_2	653	657	PF02991	0.427
LIG_LIR_Gen_1	145	153	PF02991	0.488
LIG_LIR_Gen_1	191	201	PF02991	0.370
LIG_LIR_Gen_1	235	243	PF02991	0.357
LIG_LIR_Gen_1	32	41	PF02991	0.417
LIG_LIR_Gen_1	448	456	PF02991	0.462
LIG_LIR_LC3C_4	629	633	PF02991	0.548
LIG_LIR_Nem_3	145	150	PF02991	0.488
LIG_LIR_Nem_3	191	196	PF02991	0.379
LIG_LIR_Nem_3	235	239	PF02991	0.354
LIG_LIR_Nem_3	419	424	PF02991	0.319
LIG_LIR_Nem_3	610	615	PF02991	0.410
LIG_NRBOX	15	21	PF00104	0.436
LIG_NRP_CendR_1	679	682	PF00754	0.669
LIG_PALB2_WD40_1	118	126	PF16756	0.398
LIG_PCNA_PIPBox_1	93	102	PF02747	0.452
LIG_Pex14_2	245	249	PF04695	0.491
LIG_Pex14_2	421	425	PF04695	0.329
LIG_Pex14_2	450	454	PF04695	0.396
LIG_Pex14_2	489	493	PF04695	0.377
LIG_PTAP_UEV_1	588	593	PF05743	0.329
LIG_PTB_Apo_2	553	560	PF02174	0.409
LIG_PTB_Phospho_1	553	559	PF10480	0.409
LIG_RPA_C_Fungi	316	328	PF08784	0.248
LIG_SH2_NCK_1	374	378	PF00017	0.446
LIG_SH2_PTP2	193	196	PF00017	0.493
LIG_SH2_SRC	355	358	PF00017	0.558
LIG_SH2_SRC	374	377	PF00017	0.269
LIG_SH2_STAP1	652	656	PF00017	0.428
LIG_SH2_STAT3	363	366	PF00017	0.523
LIG_SH2_STAT3	511	514	PF00017	0.352
LIG_SH2_STAT3	559	562	PF00017	0.470
LIG_SH2_STAT5	131	134	PF00017	0.554
LIG_SH2_STAT5	193	196	PF00017	0.370
LIG_SH2_STAT5	219	222	PF00017	0.436
LIG_SH2_STAT5	236	239	PF00017	0.356
LIG_SH2_STAT5	243	246	PF00017	0.367
LIG_SH2_STAT5	355	358	PF00017	0.561
LIG_SH2_STAT5	511	514	PF00017	0.376
LIG_SH2_STAT5	559	562	PF00017	0.428
LIG_SH2_STAT5	571	574	PF00017	0.404
LIG_SH3_1	441	447	PF00018	0.383
LIG_SH3_2	83	88	PF14604	0.466
LIG_SH3_3	165	171	PF00018	0.602
LIG_SH3_3	191	197	PF00018	0.500
LIG_SH3_3	263	269	PF00018	0.480
LIG_SH3_3	285	291	PF00018	0.442
LIG_SH3_3	43	49	PF00018	0.497
LIG_SH3_3	437	443	PF00018	0.358
LIG_SH3_3	468	474	PF00018	0.349
LIG_SH3_3	586	592	PF00018	0.562
LIG_SH3_3	80	86	PF00018	0.542
LIG_SUMO_SIM_par_1	199	205	PF11976	0.476
LIG_SUMO_SIM_par_1	23	32	PF11976	0.538
LIG_TRAF2_1	336	339	PF00917	0.569
LIG_TRAF2_1	560	563	PF00917	0.456
LIG_TRFH_1	384	388	PF08558	0.475
LIG_UBA3_1	420	427	PF00899	0.329
LIG_WRC_WIRS_1	300	305	PF05994	0.487
LIG_WW_2	168	171	PF00397	0.519
MOD_CDK_SPK_2	54	59	PF00069	0.552
MOD_CK1_1	14	20	PF00069	0.539
MOD_CK1_1	173	179	PF00069	0.622
MOD_CK1_1	254	260	PF00069	0.399
MOD_CK1_1	267	273	PF00069	0.382
MOD_CK1_1	302	308	PF00069	0.427
MOD_CK2_1	15	21	PF00069	0.497
MOD_CK2_1	333	339	PF00069	0.521
MOD_CK2_1	469	475	PF00069	0.218
MOD_CK2_1	557	563	PF00069	0.403
MOD_GlcNHglycan	11	14	PF01048	0.605
MOD_GlcNHglycan	135	138	PF01048	0.482
MOD_GlcNHglycan	175	178	PF01048	0.690
MOD_GlcNHglycan	436	439	PF01048	0.383
MOD_GlcNHglycan	64	67	PF01048	0.734
MOD_GlcNHglycan	72	77	PF01048	0.737
MOD_GSK3_1	11	18	PF00069	0.565
MOD_GSK3_1	172	179	PF00069	0.751
MOD_GSK3_1	250	257	PF00069	0.377
MOD_GSK3_1	298	305	PF00069	0.517
MOD_GSK3_1	391	398	PF00069	0.294
MOD_GSK3_1	430	437	PF00069	0.461
MOD_GSK3_1	492	499	PF00069	0.397
MOD_GSK3_1	54	61	PF00069	0.694
MOD_GSK3_1	657	664	PF00069	0.526
MOD_LATS_1	395	401	PF00433	0.485
MOD_N-GLC_1	52	57	PF02516	0.497
MOD_N-GLC_2	478	480	PF02516	0.369
MOD_NEK2_1	1	6	PF00069	0.653
MOD_NEK2_1	15	20	PF00069	0.407
MOD_NEK2_1	239	244	PF00069	0.377
MOD_NEK2_1	28	33	PF00069	0.586
MOD_NEK2_1	391	396	PF00069	0.398
MOD_NEK2_2	505	510	PF00069	0.451
MOD_PIKK_1	254	260	PF00454	0.476
MOD_PIKK_1	302	308	PF00454	0.262
MOD_PIKK_1	334	340	PF00454	0.559
MOD_PIKK_1	454	460	PF00454	0.427
MOD_PKA_1	634	640	PF00069	0.419
MOD_PKA_1	661	667	PF00069	0.585
MOD_PKA_2	469	475	PF00069	0.413
MOD_PKA_2	58	64	PF00069	0.561
MOD_PKA_2	634	640	PF00069	0.419
MOD_PKA_2	661	667	PF00069	0.585
MOD_Plk_1	184	190	PF00069	0.535
MOD_Plk_1	22	28	PF00069	0.558
MOD_Plk_2-3	667	673	PF00069	0.563
MOD_Plk_4	11	17	PF00069	0.505
MOD_Plk_4	416	422	PF00069	0.341
MOD_Plk_4	505	511	PF00069	0.445
MOD_ProDKin_1	267	273	PF00069	0.427
MOD_ProDKin_1	350	356	PF00069	0.507
MOD_ProDKin_1	405	411	PF00069	0.468
MOD_ProDKin_1	498	504	PF00069	0.473
MOD_ProDKin_1	54	60	PF00069	0.696
MOD_SUMO_rev_2	433	443	PF00179	0.362
TRG_DiLeu_BaEn_2	447	453	PF01217	0.420
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.472
TRG_DiLeu_BaLyEn_6	376	381	PF01217	0.409
TRG_DiLeu_BaLyEn_6	643	648	PF01217	0.449
TRG_DiLeu_BaLyEn_6	676	681	PF01217	0.641
TRG_ENDOCYTIC_2	193	196	PF00928	0.386
TRG_ENDOCYTIC_2	236	239	PF00928	0.356
TRG_ENDOCYTIC_2	322	325	PF00928	0.520
TRG_ENDOCYTIC_2	35	38	PF00928	0.391
TRG_ENDOCYTIC_2	510	513	PF00928	0.480
TRG_ER_diArg_1	487	489	PF00400	0.357
TRG_ER_diArg_1	528	531	PF00400	0.410
TRG_ER_diArg_1	612	614	PF00400	0.504
TRG_NES_CRM1_1	431	446	PF08389	0.369
TRG_NLS_MonoExtC_3	633	638	PF00514	0.443
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	638	642	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	646	650	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA50	Leptomonas seymouri	26%	100%
A0A0N1PBN6	Leptomonas seymouri	75%	98%
A0A0S4ISW7	Bodo saltans	50%	92%
A0A1X0NY35	Trypanosomatidae	60%	97%
A0A3Q8IBV8	Leishmania donovani	94%	81%
A0A3Q8IE69	Leishmania donovani	27%	100%
A0A3R7MZ34	Trypanosoma rangeli	61%	100%
A4HAI4	Leishmania braziliensis	27%	100%
A4HD07	Leishmania braziliensis	88%	100%
A4I0J3	Leishmania infantum	94%	81%
C9ZN08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZVC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	99%
E9AHS5	Leishmania infantum	27%	100%
E9B4P5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4Q3D1	Leishmania major	28%	100%
Q4QB18	Leishmania major	92%	100%
V5BEM5	Trypanosoma cruzi	53%	100%