Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AWE9_LEIMU

TriTrypDb:

LmxM.23.1290

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AWE9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWE9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.673
CLV_C14_Caspase3-7	24	28	PF00656	0.626
CLV_C14_Caspase3-7	295	299	PF00656	0.739
CLV_C14_Caspase3-7	536	540	PF00656	0.731
CLV_MEL_PAP_1	46	52	PF00089	0.453
CLV_NRD_NRD_1	130	132	PF00675	0.608
CLV_NRD_NRD_1	173	175	PF00675	0.443
CLV_NRD_NRD_1	20	22	PF00675	0.575
CLV_NRD_NRD_1	31	33	PF00675	0.497
CLV_NRD_NRD_1	345	347	PF00675	0.549
CLV_NRD_NRD_1	48	50	PF00675	0.564
CLV_NRD_NRD_1	584	586	PF00675	0.499
CLV_NRD_NRD_1	639	641	PF00675	0.448
CLV_PCSK_FUR_1	637	641	PF00082	0.458
CLV_PCSK_KEX2_1	132	134	PF00082	0.614
CLV_PCSK_KEX2_1	173	175	PF00082	0.443
CLV_PCSK_KEX2_1	20	22	PF00082	0.575
CLV_PCSK_KEX2_1	31	33	PF00082	0.497
CLV_PCSK_KEX2_1	345	347	PF00082	0.549
CLV_PCSK_KEX2_1	452	454	PF00082	0.474
CLV_PCSK_KEX2_1	48	50	PF00082	0.599
CLV_PCSK_KEX2_1	584	586	PF00082	0.499
CLV_PCSK_KEX2_1	639	641	PF00082	0.448
CLV_PCSK_KEX2_1	90	92	PF00082	0.440
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.568
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.474
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.440
CLV_PCSK_SKI1_1	340	344	PF00082	0.505
CLV_PCSK_SKI1_1	399	403	PF00082	0.498
CLV_PCSK_SKI1_1	522	526	PF00082	0.568
CLV_PCSK_SKI1_1	584	588	PF00082	0.521
CLV_PCSK_SKI1_1	648	652	PF00082	0.223
DEG_SCF_FBW7_1	389	396	PF00400	0.645
DEG_SCF_FBW7_2	236	242	PF00400	0.729
DEG_SPOP_SBC_1	404	408	PF00917	0.755
DOC_CKS1_1	101	106	PF01111	0.764
DOC_CKS1_1	236	241	PF01111	0.678
DOC_CKS1_1	269	274	PF01111	0.710
DOC_CKS1_1	390	395	PF01111	0.654
DOC_MAPK_gen_1	637	647	PF00069	0.629
DOC_MAPK_JIP1_4	228	234	PF00069	0.728
DOC_MAPK_MEF2A_6	639	647	PF00069	0.650
DOC_PP1_RVXF_1	343	350	PF00149	0.747
DOC_PP1_RVXF_1	646	653	PF00149	0.417
DOC_PP2B_LxvP_1	120	123	PF13499	0.644
DOC_PP2B_LxvP_1	38	41	PF13499	0.730
DOC_PP4_FxxP_1	338	341	PF00568	0.699
DOC_USP7_MATH_1	202	206	PF00917	0.756
DOC_USP7_MATH_1	244	248	PF00917	0.697
DOC_USP7_MATH_1	252	256	PF00917	0.718
DOC_USP7_MATH_1	317	321	PF00917	0.810
DOC_USP7_MATH_1	326	330	PF00917	0.691
DOC_USP7_MATH_1	365	369	PF00917	0.653
DOC_USP7_MATH_1	384	388	PF00917	0.686
DOC_USP7_MATH_1	404	408	PF00917	0.715
DOC_USP7_MATH_1	469	473	PF00917	0.774
DOC_USP7_MATH_1	537	541	PF00917	0.792
DOC_USP7_MATH_1	614	618	PF00917	0.650
DOC_USP7_MATH_1	63	67	PF00917	0.778
DOC_USP7_UBL2_3	522	526	PF12436	0.755
DOC_WW_Pin1_4	100	105	PF00397	0.764
DOC_WW_Pin1_4	194	199	PF00397	0.708
DOC_WW_Pin1_4	232	237	PF00397	0.824
DOC_WW_Pin1_4	257	262	PF00397	0.663
DOC_WW_Pin1_4	268	273	PF00397	0.742
DOC_WW_Pin1_4	280	285	PF00397	0.679
DOC_WW_Pin1_4	31	36	PF00397	0.764
DOC_WW_Pin1_4	389	394	PF00397	0.682
DOC_WW_Pin1_4	414	419	PF00397	0.674
DOC_WW_Pin1_4	457	462	PF00397	0.701
DOC_WW_Pin1_4	465	470	PF00397	0.684
DOC_WW_Pin1_4	49	54	PF00397	0.812
DOC_WW_Pin1_4	569	574	PF00397	0.793
DOC_WW_Pin1_4	621	626	PF00397	0.833
DOC_WW_Pin1_4	8	13	PF00397	0.713
LIG_14-3-3_CanoR_1	173	177	PF00244	0.703
LIG_14-3-3_CanoR_1	20	30	PF00244	0.732
LIG_14-3-3_CanoR_1	231	235	PF00244	0.732
LIG_14-3-3_CanoR_1	291	297	PF00244	0.643
LIG_14-3-3_CanoR_1	31	35	PF00244	0.696
LIG_14-3-3_CanoR_1	48	53	PF00244	0.750
LIG_14-3-3_CanoR_1	502	508	PF00244	0.630
LIG_14-3-3_CanoR_1	553	557	PF00244	0.739
LIG_14-3-3_CanoR_1	584	590	PF00244	0.724
LIG_Clathr_ClatBox_1	189	193	PF01394	0.628
LIG_CtBP_PxDLS_1	575	579	PF00389	0.660
LIG_deltaCOP1_diTrp_1	552	557	PF00928	0.721
LIG_DLG_GKlike_1	585	593	PF00625	0.614
LIG_FHA_1	184	190	PF00498	0.632
LIG_FHA_1	198	204	PF00498	0.757
LIG_FHA_1	306	312	PF00498	0.748
LIG_FHA_1	32	38	PF00498	0.648
LIG_FHA_1	364	370	PF00498	0.739
LIG_FHA_1	577	583	PF00498	0.686
LIG_FHA_1	585	591	PF00498	0.724
LIG_FHA_1	96	102	PF00498	0.735
LIG_FHA_2	152	158	PF00498	0.659
LIG_FHA_2	390	396	PF00498	0.689
LIG_LIR_Apic_2	336	341	PF02991	0.700
LIG_LIR_Gen_1	81	88	PF02991	0.733
LIG_LIR_Nem_3	661	667	PF02991	0.338
LIG_LIR_Nem_3	81	85	PF02991	0.775
LIG_PTAP_UEV_1	624	629	PF05743	0.674
LIG_SH2_SRC	514	517	PF00017	0.754
LIG_SH2_STAT5	589	592	PF00017	0.732
LIG_SH3_1	74	80	PF00018	0.678
LIG_SH3_2	314	319	PF14604	0.682
LIG_SH3_2	40	45	PF14604	0.754
LIG_SH3_3	233	239	PF00018	0.677
LIG_SH3_3	260	266	PF00018	0.738
LIG_SH3_3	308	314	PF00018	0.824
LIG_SH3_3	34	40	PF00018	0.754
LIG_SH3_3	387	393	PF00018	0.696
LIG_SH3_3	47	53	PF00018	0.682
LIG_SH3_3	513	519	PF00018	0.752
LIG_SH3_3	570	576	PF00018	0.714
LIG_SH3_3	619	625	PF00018	0.726
LIG_SH3_3	74	80	PF00018	0.678
LIG_SH3_4	522	529	PF00018	0.756
LIG_SUMO_SIM_anti_2	271	277	PF11976	0.677
LIG_SUMO_SIM_par_1	188	193	PF11976	0.737
LIG_SUMO_SIM_par_1	199	205	PF11976	0.698
LIG_SUMO_SIM_par_1	307	313	PF11976	0.722
LIG_SUMO_SIM_par_1	656	661	PF11976	0.344
LIG_UBA3_1	447	452	PF00899	0.639
LIG_UBA3_1	643	651	PF00899	0.512
MOD_CDK_SPxxK_3	100	107	PF00069	0.765
MOD_CK1_1	106	112	PF00069	0.710
MOD_CK1_1	11	17	PF00069	0.721
MOD_CK1_1	141	147	PF00069	0.807
MOD_CK1_1	183	189	PF00069	0.733
MOD_CK1_1	197	203	PF00069	0.740
MOD_CK1_1	247	253	PF00069	0.758
MOD_CK1_1	255	261	PF00069	0.710
MOD_CK1_1	285	291	PF00069	0.722
MOD_CK1_1	292	298	PF00069	0.706
MOD_CK1_1	299	305	PF00069	0.654
MOD_CK1_1	307	313	PF00069	0.790
MOD_CK1_1	325	331	PF00069	0.699
MOD_CK1_1	391	397	PF00069	0.736
MOD_CK1_1	403	409	PF00069	0.632
MOD_CK1_1	410	416	PF00069	0.713
MOD_CK1_1	417	423	PF00069	0.700
MOD_CK1_1	468	474	PF00069	0.847
MOD_CK1_1	500	506	PF00069	0.662
MOD_CK1_1	529	535	PF00069	0.758
MOD_CK1_1	57	63	PF00069	0.800
MOD_CK1_1	630	636	PF00069	0.804
MOD_CK1_1	67	73	PF00069	0.703
MOD_CK1_1	81	87	PF00069	0.669
MOD_CK2_1	151	157	PF00069	0.661
MOD_CK2_1	317	323	PF00069	0.733
MOD_CK2_1	65	71	PF00069	0.652
MOD_CMANNOS	554	557	PF00535	0.554
MOD_Cter_Amidation	582	585	PF01082	0.447
MOD_Cter_Amidation	637	640	PF01082	0.466
MOD_DYRK1A_RPxSP_1	49	53	PF00069	0.651
MOD_GlcNHglycan	133	136	PF01048	0.529
MOD_GlcNHglycan	16	19	PF01048	0.549
MOD_GlcNHglycan	176	179	PF01048	0.637
MOD_GlcNHglycan	193	197	PF01048	0.481
MOD_GlcNHglycan	204	207	PF01048	0.555
MOD_GlcNHglycan	216	219	PF01048	0.479
MOD_GlcNHglycan	244	247	PF01048	0.562
MOD_GlcNHglycan	284	287	PF01048	0.497
MOD_GlcNHglycan	291	294	PF01048	0.472
MOD_GlcNHglycan	323	327	PF01048	0.534
MOD_GlcNHglycan	402	405	PF01048	0.546
MOD_GlcNHglycan	414	417	PF01048	0.508
MOD_GlcNHglycan	440	443	PF01048	0.603
MOD_GlcNHglycan	471	474	PF01048	0.525
MOD_GlcNHglycan	485	488	PF01048	0.524
MOD_GlcNHglycan	493	496	PF01048	0.541
MOD_GlcNHglycan	505	508	PF01048	0.464
MOD_GlcNHglycan	535	538	PF01048	0.592
MOD_GlcNHglycan	606	610	PF01048	0.623
MOD_GlcNHglycan	616	619	PF01048	0.507
MOD_GlcNHglycan	629	632	PF01048	0.423
MOD_GlcNHglycan	67	70	PF01048	0.525
MOD_GSK3_1	108	115	PF00069	0.684
MOD_GSK3_1	138	145	PF00069	0.687
MOD_GSK3_1	172	179	PF00069	0.735
MOD_GSK3_1	188	195	PF00069	0.796
MOD_GSK3_1	21	28	PF00069	0.615
MOD_GSK3_1	220	227	PF00069	0.689
MOD_GSK3_1	230	237	PF00069	0.651
MOD_GSK3_1	252	259	PF00069	0.762
MOD_GSK3_1	285	292	PF00069	0.694
MOD_GSK3_1	301	308	PF00069	0.788
MOD_GSK3_1	317	324	PF00069	0.776
MOD_GSK3_1	326	333	PF00069	0.706
MOD_GSK3_1	365	372	PF00069	0.780
MOD_GSK3_1	384	391	PF00069	0.665
MOD_GSK3_1	4	11	PF00069	0.808
MOD_GSK3_1	400	407	PF00069	0.717
MOD_GSK3_1	410	417	PF00069	0.703
MOD_GSK3_1	438	445	PF00069	0.712
MOD_GSK3_1	465	472	PF00069	0.839
MOD_GSK3_1	489	496	PF00069	0.737
MOD_GSK3_1	49	56	PF00069	0.784
MOD_GSK3_1	497	504	PF00069	0.689
MOD_GSK3_1	529	536	PF00069	0.749
MOD_GSK3_1	537	544	PF00069	0.724
MOD_GSK3_1	548	555	PF00069	0.721
MOD_GSK3_1	565	572	PF00069	0.713
MOD_GSK3_1	623	630	PF00069	0.746
MOD_GSK3_1	63	70	PF00069	0.756
MOD_GSK3_1	96	103	PF00069	0.736
MOD_N-GLC_1	250	255	PF02516	0.523
MOD_N-GLC_1	404	409	PF02516	0.555
MOD_NEK2_1	112	117	PF00069	0.656
MOD_NEK2_1	26	31	PF00069	0.630
MOD_NEK2_1	322	327	PF00069	0.638
MOD_NEK2_1	488	493	PF00069	0.675
MOD_NEK2_1	498	503	PF00069	0.668
MOD_NEK2_1	96	101	PF00069	0.778
MOD_NEK2_2	365	370	PF00069	0.616
MOD_NEK2_2	4	9	PF00069	0.719
MOD_PIKK_1	112	118	PF00454	0.740
MOD_PIKK_1	250	256	PF00454	0.723
MOD_PIKK_1	89	95	PF00454	0.731
MOD_PKA_1	131	137	PF00069	0.767
MOD_PKA_1	213	219	PF00069	0.639
MOD_PKA_1	48	54	PF00069	0.748
MOD_PKA_1	584	590	PF00069	0.690
MOD_PKA_2	106	112	PF00069	0.772
MOD_PKA_2	172	178	PF00069	0.766
MOD_PKA_2	230	236	PF00069	0.729
MOD_PKA_2	30	36	PF00069	0.777
MOD_PKA_2	369	375	PF00069	0.744
MOD_PKA_2	432	438	PF00069	0.638
MOD_PKA_2	474	480	PF00069	0.723
MOD_PKA_2	48	54	PF00069	0.799
MOD_PKA_2	501	507	PF00069	0.671
MOD_PKA_2	529	535	PF00069	0.755
MOD_PKA_2	552	558	PF00069	0.693
MOD_PKA_2	584	590	PF00069	0.694
MOD_PKA_2	63	69	PF00069	0.753
MOD_PKB_1	319	327	PF00069	0.678
MOD_Plk_1	107	113	PF00069	0.799
MOD_Plk_1	26	32	PF00069	0.728
MOD_Plk_2-3	108	114	PF00069	0.774
MOD_Plk_4	11	17	PF00069	0.712
MOD_Plk_4	185	191	PF00069	0.632
MOD_Plk_4	271	277	PF00069	0.702
MOD_Plk_4	384	390	PF00069	0.738
MOD_Plk_4	442	448	PF00069	0.777
MOD_Plk_4	585	591	PF00069	0.724
MOD_Plk_4	658	664	PF00069	0.328
MOD_ProDKin_1	100	106	PF00069	0.765
MOD_ProDKin_1	194	200	PF00069	0.709
MOD_ProDKin_1	232	238	PF00069	0.824
MOD_ProDKin_1	257	263	PF00069	0.663
MOD_ProDKin_1	268	274	PF00069	0.744
MOD_ProDKin_1	280	286	PF00069	0.680
MOD_ProDKin_1	31	37	PF00069	0.765
MOD_ProDKin_1	389	395	PF00069	0.684
MOD_ProDKin_1	414	420	PF00069	0.673
MOD_ProDKin_1	457	463	PF00069	0.704
MOD_ProDKin_1	465	471	PF00069	0.684
MOD_ProDKin_1	49	55	PF00069	0.811
MOD_ProDKin_1	569	575	PF00069	0.792
MOD_ProDKin_1	621	627	PF00069	0.832
MOD_ProDKin_1	8	14	PF00069	0.714
TRG_ER_diArg_1	130	133	PF00400	0.754
TRG_ER_diArg_1	20	22	PF00400	0.762
TRG_ER_diArg_1	30	32	PF00400	0.664
TRG_ER_diArg_1	319	322	PF00400	0.684
TRG_ER_diArg_1	345	347	PF00400	0.749
TRG_ER_diArg_1	376	379	PF00400	0.694
TRG_ER_diArg_1	47	49	PF00400	0.753
TRG_ER_diArg_1	584	586	PF00400	0.699
TRG_ER_diArg_1	599	602	PF00400	0.642
TRG_ER_diArg_1	637	640	PF00400	0.752
TRG_ER_diArg_1	645	648	PF00400	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFX5	Leishmania donovani	76%	98%
A4HD02	Leishmania braziliensis	49%	99%
A4I0I7	Leishmania infantum	76%	98%
Q4QB23	Leishmania major	76%	100%