Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AWE6_LEIMU

TriTrypDb:

LmxM.23.1267

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AWE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.717
CLV_NRD_NRD_1	224	226	PF00675	0.533
CLV_NRD_NRD_1	380	382	PF00675	0.426
CLV_PCSK_KEX2_1	224	226	PF00082	0.533
CLV_PCSK_KEX2_1	380	382	PF00082	0.426
CLV_PCSK_PC7_1	220	226	PF00082	0.510
CLV_PCSK_SKI1_1	307	311	PF00082	0.427
DEG_SCF_FBW7_1	209	214	PF00400	0.727
DEG_SCF_FBW7_1	285	292	PF00400	0.722
DEG_SPOP_SBC_1	264	268	PF00917	0.737
DOC_CKS1_1	279	284	PF01111	0.693
DOC_CYCLIN_RxL_1	120	131	PF00134	0.601
DOC_MAPK_MEF2A_6	13	21	PF00069	0.417
DOC_PP2B_LxvP_1	335	338	PF13499	0.718
DOC_PP2B_PxIxI_1	353	359	PF00149	0.721
DOC_USP7_MATH_1	102	106	PF00917	0.680
DOC_USP7_MATH_1	129	133	PF00917	0.740
DOC_USP7_MATH_1	152	156	PF00917	0.802
DOC_USP7_MATH_1	162	166	PF00917	0.643
DOC_USP7_MATH_1	178	182	PF00917	0.715
DOC_USP7_MATH_1	211	215	PF00917	0.773
DOC_USP7_MATH_1	223	227	PF00917	0.692
DOC_USP7_MATH_1	229	233	PF00917	0.657
DOC_USP7_MATH_1	257	261	PF00917	0.756
DOC_USP7_MATH_1	264	268	PF00917	0.741
DOC_USP7_MATH_1	289	293	PF00917	0.748
DOC_USP7_MATH_1	347	351	PF00917	0.629
DOC_USP7_MATH_2	211	217	PF00917	0.638
DOC_WW_Pin1_4	131	136	PF00397	0.719
DOC_WW_Pin1_4	207	212	PF00397	0.760
DOC_WW_Pin1_4	255	260	PF00397	0.719
DOC_WW_Pin1_4	278	283	PF00397	0.736
DOC_WW_Pin1_4	285	290	PF00397	0.729
DOC_WW_Pin1_4	333	338	PF00397	0.719
DOC_WW_Pin1_4	343	348	PF00397	0.676
DOC_WW_Pin1_4	350	355	PF00397	0.625
DOC_WW_Pin1_4	366	371	PF00397	0.632
DOC_WW_Pin1_4	383	388	PF00397	0.652
LIG_14-3-3_CanoR_1	224	230	PF00244	0.810
LIG_AP2alpha_2	171	173	PF02296	0.607
LIG_APCC_ABBA_1	91	96	PF00400	0.660
LIG_BRCT_BRCA1_1	181	185	PF00533	0.777
LIG_Clathr_ClatBox_1	127	131	PF01394	0.615
LIG_FHA_1	120	126	PF00498	0.597
LIG_FHA_1	174	180	PF00498	0.714
LIG_FHA_1	187	193	PF00498	0.610
LIG_FHA_1	274	280	PF00498	0.682
LIG_FHA_1	286	292	PF00498	0.699
LIG_FHA_1	360	366	PF00498	0.671
LIG_FHA_1	95	101	PF00498	0.574
LIG_FHA_2	114	120	PF00498	0.603
LIG_FHA_2	208	214	PF00498	0.637
LIG_FHA_2	241	247	PF00498	0.727
LIG_FHA_2	306	312	PF00498	0.721
LIG_FHA_2	337	343	PF00498	0.728
LIG_LIR_Gen_1	182	192	PF02991	0.718
LIG_LIR_Gen_1	228	238	PF02991	0.711
LIG_LIR_Gen_1	239	246	PF02991	0.651
LIG_LIR_Nem_3	182	188	PF02991	0.715
LIG_LIR_Nem_3	239	244	PF02991	0.685
LIG_PCNA_yPIPBox_3	81	91	PF02747	0.681
LIG_Pex14_1	51	55	PF04695	0.405
LIG_SH2_SRC	340	343	PF00017	0.735
LIG_SH2_STAP1	340	344	PF00017	0.735
LIG_SH2_STAT5	94	97	PF00017	0.701
LIG_SH3_3	253	259	PF00018	0.744
LIG_SH3_3	27	33	PF00018	0.405
LIG_SH3_3	276	282	PF00018	0.711
LIG_SH3_3	292	298	PF00018	0.694
LIG_SH3_3	87	93	PF00018	0.702
LIG_SUMO_SIM_par_1	126	132	PF11976	0.605
LIG_SUMO_SIM_par_1	34	41	PF11976	0.453
LIG_TRAF2_1	193	196	PF00917	0.736
LIG_TRAF2_1	339	342	PF00917	0.733
LIG_WW_1	337	340	PF00397	0.722
MOD_CDK_SPK_2	350	355	PF00069	0.720
MOD_CK1_1	165	171	PF00069	0.661
MOD_CK1_1	258	264	PF00069	0.838
MOD_CK1_1	267	273	PF00069	0.768
MOD_CK1_1	317	323	PF00069	0.792
MOD_CK1_1	336	342	PF00069	0.619
MOD_CK1_1	348	354	PF00069	0.655
MOD_CK1_1	383	389	PF00069	0.648
MOD_CK2_1	113	119	PF00069	0.746
MOD_CK2_1	174	180	PF00069	0.710
MOD_CK2_1	190	196	PF00069	0.809
MOD_CK2_1	207	213	PF00069	0.641
MOD_CK2_1	240	246	PF00069	0.726
MOD_CK2_1	336	342	PF00069	0.725
MOD_DYRK1A_RPxSP_1	133	137	PF00069	0.737
MOD_GlcNHglycan	154	157	PF01048	0.550
MOD_GlcNHglycan	158	161	PF01048	0.520
MOD_GlcNHglycan	164	167	PF01048	0.401
MOD_GlcNHglycan	176	179	PF01048	0.517
MOD_GlcNHglycan	180	184	PF01048	0.472
MOD_GlcNHglycan	215	218	PF01048	0.627
MOD_GlcNHglycan	269	272	PF01048	0.508
MOD_GlcNHglycan	291	294	PF01048	0.549
MOD_GlcNHglycan	316	319	PF01048	0.444
MOD_GlcNHglycan	8	11	PF01048	0.331
MOD_GSK3_1	115	122	PF00069	0.712
MOD_GSK3_1	129	136	PF00069	0.647
MOD_GSK3_1	152	159	PF00069	0.778
MOD_GSK3_1	162	169	PF00069	0.764
MOD_GSK3_1	174	181	PF00069	0.732
MOD_GSK3_1	186	193	PF00069	0.635
MOD_GSK3_1	205	212	PF00069	0.755
MOD_GSK3_1	236	243	PF00069	0.746
MOD_GSK3_1	246	253	PF00069	0.766
MOD_GSK3_1	258	265	PF00069	0.776
MOD_GSK3_1	269	276	PF00069	0.719
MOD_GSK3_1	281	288	PF00069	0.648
MOD_GSK3_1	305	312	PF00069	0.741
MOD_GSK3_1	327	334	PF00069	0.719
MOD_GSK3_1	343	350	PF00069	0.679
MOD_N-GLC_1	152	157	PF02516	0.554
MOD_NEK2_1	173	178	PF00069	0.727
MOD_NEK2_1	179	184	PF00069	0.661
MOD_NEK2_1	186	191	PF00069	0.620
MOD_NEK2_1	305	310	PF00069	0.715
MOD_NEK2_1	77	82	PF00069	0.551
MOD_PIKK_1	311	317	PF00454	0.683
MOD_PIKK_1	327	333	PF00454	0.664
MOD_PKA_1	380	386	PF00069	0.625
MOD_PKA_2	223	229	PF00069	0.730
MOD_PKA_2	380	386	PF00069	0.625
MOD_Plk_1	95	101	PF00069	0.661
MOD_Plk_2-3	250	256	PF00069	0.712
MOD_Plk_4	275	281	PF00069	0.628
MOD_Plk_4	44	50	PF00069	0.405
MOD_ProDKin_1	131	137	PF00069	0.720
MOD_ProDKin_1	207	213	PF00069	0.762
MOD_ProDKin_1	255	261	PF00069	0.719
MOD_ProDKin_1	278	284	PF00069	0.736
MOD_ProDKin_1	285	291	PF00069	0.730
MOD_ProDKin_1	333	339	PF00069	0.721
MOD_ProDKin_1	343	349	PF00069	0.676
MOD_ProDKin_1	350	356	PF00069	0.626
MOD_ProDKin_1	366	372	PF00069	0.632
MOD_ProDKin_1	383	389	PF00069	0.653
TRG_DiLeu_BaEn_1	96	101	PF01217	0.662
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.405
TRG_ER_diArg_1	223	225	PF00400	0.712
TRG_ER_diArg_1	379	381	PF00400	0.630
TRG_ER_diArg_1	82	85	PF00400	0.622
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WXU4	Leishmania donovani	82%	100%
A4HCZ9	Leishmania braziliensis	62%	100%
A4I0I4	Leishmania infantum	82%	100%
Q4QB26	Leishmania major	81%	100%