Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWE2_LEIMU

TriTrypDb:

LmxM.23.1240

Length:

707

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.723
CLV_C14_Caspase3-7	582	586	PF00656	0.516
CLV_NRD_NRD_1	244	246	PF00675	0.428
CLV_NRD_NRD_1	3	5	PF00675	0.283
CLV_NRD_NRD_1	311	313	PF00675	0.486
CLV_NRD_NRD_1	316	318	PF00675	0.540
CLV_NRD_NRD_1	361	363	PF00675	0.375
CLV_NRD_NRD_1	373	375	PF00675	0.436
CLV_NRD_NRD_1	468	470	PF00675	0.446
CLV_NRD_NRD_1	478	480	PF00675	0.444
CLV_NRD_NRD_1	625	627	PF00675	0.538
CLV_NRD_NRD_1	635	637	PF00675	0.453
CLV_NRD_NRD_1	642	644	PF00675	0.411
CLV_NRD_NRD_1	657	659	PF00675	0.521
CLV_NRD_NRD_1	680	682	PF00675	0.498
CLV_NRD_NRD_1	686	688	PF00675	0.515
CLV_NRD_NRD_1	94	96	PF00675	0.524
CLV_PCSK_FUR_1	370	374	PF00082	0.544
CLV_PCSK_KEX2_1	244	246	PF00082	0.454
CLV_PCSK_KEX2_1	3	5	PF00082	0.265
CLV_PCSK_KEX2_1	316	318	PF00082	0.612
CLV_PCSK_KEX2_1	361	363	PF00082	0.375
CLV_PCSK_KEX2_1	372	374	PF00082	0.428
CLV_PCSK_KEX2_1	468	470	PF00082	0.448
CLV_PCSK_KEX2_1	478	480	PF00082	0.437
CLV_PCSK_KEX2_1	624	626	PF00082	0.557
CLV_PCSK_KEX2_1	635	637	PF00082	0.459
CLV_PCSK_KEX2_1	655	657	PF00082	0.389
CLV_PCSK_KEX2_1	679	681	PF00082	0.523
CLV_PCSK_KEX2_1	94	96	PF00082	0.524
CLV_PCSK_PC1ET2_1	655	657	PF00082	0.543
CLV_PCSK_PC1ET2_1	679	681	PF00082	0.523
CLV_PCSK_PC7_1	312	318	PF00082	0.559
CLV_PCSK_PC7_1	90	96	PF00082	0.600
CLV_PCSK_SKI1_1	105	109	PF00082	0.527
CLV_PCSK_SKI1_1	228	232	PF00082	0.526
CLV_PCSK_SKI1_1	239	243	PF00082	0.335
CLV_PCSK_SKI1_1	494	498	PF00082	0.531
CLV_PCSK_SKI1_1	52	56	PF00082	0.468
CLV_PCSK_SKI1_1	59	63	PF00082	0.502
CLV_PCSK_SKI1_1	604	608	PF00082	0.457
DEG_APCC_DBOX_1	195	203	PF00400	0.537
DEG_Nend_Nbox_1	1	3	PF02207	0.491
DEG_SPOP_SBC_1	109	113	PF00917	0.641
DEG_SPOP_SBC_1	151	155	PF00917	0.673
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.476
DOC_MAPK_MEF2A_6	3	12	PF00069	0.359
DOC_MAPK_MEF2A_6	334	342	PF00069	0.441
DOC_PP1_SILK_1	308	313	PF00149	0.481
DOC_PP2B_LxvP_1	304	307	PF13499	0.607
DOC_PP4_FxxP_1	496	499	PF00568	0.438
DOC_PP4_FxxP_1	572	575	PF00568	0.460
DOC_USP7_MATH_1	110	114	PF00917	0.695
DOC_USP7_MATH_1	133	137	PF00917	0.611
DOC_USP7_MATH_1	144	148	PF00917	0.767
DOC_USP7_MATH_1	151	155	PF00917	0.799
DOC_USP7_MATH_1	520	524	PF00917	0.584
DOC_USP7_MATH_1	548	552	PF00917	0.700
DOC_USP7_UBL2_3	65	69	PF12436	0.294
DOC_USP7_UBL2_3	651	655	PF12436	0.486
DOC_WW_Pin1_4	111	116	PF00397	0.555
DOC_WW_Pin1_4	131	136	PF00397	0.778
DOC_WW_Pin1_4	269	274	PF00397	0.603
DOC_WW_Pin1_4	297	302	PF00397	0.532
DOC_WW_Pin1_4	408	413	PF00397	0.570
DOC_WW_Pin1_4	494	499	PF00397	0.493
LIG_14-3-3_CanoR_1	196	200	PF00244	0.538
LIG_14-3-3_CanoR_1	228	234	PF00244	0.460
LIG_14-3-3_CanoR_1	332	338	PF00244	0.435
LIG_14-3-3_CanoR_1	692	700	PF00244	0.681
LIG_Actin_WH2_2	204	220	PF00022	0.381
LIG_Actin_WH2_2	599	614	PF00022	0.565
LIG_APCC_ABBA_1	74	79	PF00400	0.595
LIG_BRCT_BRCA1_1	568	572	PF00533	0.483
LIG_CtBP_PxDLS_1	78	82	PF00389	0.561
LIG_deltaCOP1_diTrp_1	26	33	PF00928	0.281
LIG_FHA_1	12	18	PF00498	0.281
LIG_FHA_1	158	164	PF00498	0.556
LIG_FHA_1	221	227	PF00498	0.452
LIG_FHA_1	298	304	PF00498	0.553
LIG_FHA_1	387	393	PF00498	0.405
LIG_FHA_1	413	419	PF00498	0.460
LIG_FHA_1	442	448	PF00498	0.431
LIG_FHA_1	511	517	PF00498	0.474
LIG_FHA_2	189	195	PF00498	0.514
LIG_FHA_2	547	553	PF00498	0.699
LIG_FHA_2	66	72	PF00498	0.509
LIG_LIR_Apic_2	495	499	PF02991	0.434
LIG_LIR_Apic_2	569	575	PF02991	0.448
LIG_LIR_Gen_1	328	338	PF02991	0.350
LIG_LIR_Gen_1	432	441	PF02991	0.405
LIG_LIR_Gen_1	46	54	PF02991	0.392
LIG_LIR_Nem_3	26	30	PF02991	0.281
LIG_LIR_Nem_3	328	333	PF02991	0.383
LIG_LIR_Nem_3	432	437	PF02991	0.411
LIG_LIR_Nem_3	46	51	PF02991	0.256
LIG_NRBOX	681	687	PF00104	0.503
LIG_Pex14_2	367	371	PF04695	0.388
LIG_SH2_CRK	13	17	PF00017	0.281
LIG_SH2_PTP2	48	51	PF00017	0.381
LIG_SH2_STAP1	13	17	PF00017	0.281
LIG_SH2_STAP1	363	367	PF00017	0.362
LIG_SH2_STAP1	633	637	PF00017	0.557
LIG_SH2_STAT3	363	366	PF00017	0.436
LIG_SH2_STAT5	13	16	PF00017	0.281
LIG_SH2_STAT5	210	213	PF00017	0.471
LIG_SH2_STAT5	248	251	PF00017	0.384
LIG_SH2_STAT5	391	394	PF00017	0.567
LIG_SH2_STAT5	48	51	PF00017	0.381
LIG_SH2_STAT5	639	642	PF00017	0.604
LIG_SH3_2	414	419	PF14604	0.536
LIG_SH3_3	112	118	PF00018	0.586
LIG_SH3_3	318	324	PF00018	0.616
LIG_SH3_3	411	417	PF00018	0.599
LIG_SH3_3	514	520	PF00018	0.721
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.466
LIG_SUMO_SIM_par_1	339	345	PF11976	0.537
LIG_TYR_ITIM	11	16	PF00017	0.281
LIG_UBA3_1	340	346	PF00899	0.498
MOD_CDK_SPxxK_3	412	419	PF00069	0.469
MOD_CK1_1	15	21	PF00069	0.237
MOD_CK1_1	154	160	PF00069	0.759
MOD_CK1_1	234	240	PF00069	0.450
MOD_CK1_1	266	272	PF00069	0.754
MOD_CK1_1	492	498	PF00069	0.481
MOD_CK1_1	522	528	PF00069	0.668
MOD_CK1_1	647	653	PF00069	0.594
MOD_CK2_1	188	194	PF00069	0.588
MOD_CK2_1	333	339	PF00069	0.455
MOD_CK2_1	546	552	PF00069	0.651
MOD_CK2_1	65	71	PF00069	0.529
MOD_GlcNHglycan	135	138	PF01048	0.522
MOD_GlcNHglycan	154	157	PF01048	0.739
MOD_GlcNHglycan	233	236	PF01048	0.448
MOD_GlcNHglycan	393	396	PF01048	0.587
MOD_GlcNHglycan	404	407	PF01048	0.727
MOD_GlcNHglycan	474	477	PF01048	0.475
MOD_GlcNHglycan	491	494	PF01048	0.458
MOD_GlcNHglycan	525	528	PF01048	0.681
MOD_GlcNHglycan	568	571	PF01048	0.559
MOD_GlcNHglycan	695	698	PF01048	0.571
MOD_GSK3_1	11	18	PF00069	0.305
MOD_GSK3_1	150	157	PF00069	0.660
MOD_GSK3_1	178	185	PF00069	0.585
MOD_GSK3_1	229	236	PF00069	0.408
MOD_GSK3_1	342	349	PF00069	0.464
MOD_GSK3_1	387	394	PF00069	0.528
MOD_GSK3_1	408	415	PF00069	0.711
MOD_GSK3_1	494	501	PF00069	0.557
MOD_GSK3_1	518	525	PF00069	0.621
MOD_LATS_1	162	168	PF00433	0.503
MOD_LATS_1	344	350	PF00433	0.423
MOD_N-GLC_1	170	175	PF02516	0.555
MOD_N-GLC_1	263	268	PF02516	0.633
MOD_N-GLC_1	565	570	PF02516	0.514
MOD_NEK2_1	11	16	PF00069	0.281
MOD_NEK2_1	342	347	PF00069	0.458
MOD_NEK2_1	489	494	PF00069	0.402
MOD_NEK2_1	528	533	PF00069	0.726
MOD_NEK2_1	565	570	PF00069	0.435
MOD_NEK2_1	583	588	PF00069	0.521
MOD_NEK2_1	637	642	PF00069	0.605
MOD_PIKK_1	170	176	PF00454	0.579
MOD_PIKK_1	220	226	PF00454	0.426
MOD_PIKK_1	528	534	PF00454	0.728
MOD_PKA_2	195	201	PF00069	0.613
MOD_PKA_2	333	339	PF00069	0.441
MOD_PKA_2	427	433	PF00069	0.471
MOD_Plk_1	170	176	PF00069	0.555
MOD_Plk_1	287	293	PF00069	0.542
MOD_Plk_4	12	18	PF00069	0.298
MOD_Plk_4	355	361	PF00069	0.378
MOD_Plk_4	376	382	PF00069	0.379
MOD_Plk_4	387	393	PF00069	0.393
MOD_Plk_4	44	50	PF00069	0.391
MOD_Plk_4	644	650	PF00069	0.469
MOD_ProDKin_1	111	117	PF00069	0.559
MOD_ProDKin_1	131	137	PF00069	0.780
MOD_ProDKin_1	269	275	PF00069	0.603
MOD_ProDKin_1	297	303	PF00069	0.526
MOD_ProDKin_1	408	414	PF00069	0.565
MOD_ProDKin_1	494	500	PF00069	0.501
MOD_SUMO_rev_2	465	473	PF00179	0.513
TRG_DiLeu_BaEn_1	337	342	PF01217	0.538
TRG_DiLeu_BaEn_1	7	12	PF01217	0.281
TRG_ENDOCYTIC_2	13	16	PF00928	0.281
TRG_ENDOCYTIC_2	30	33	PF00928	0.281
TRG_ENDOCYTIC_2	434	437	PF00928	0.429
TRG_ENDOCYTIC_2	48	51	PF00928	0.381
TRG_ER_diArg_1	2	4	PF00400	0.428
TRG_ER_diArg_1	332	335	PF00400	0.551
TRG_ER_diArg_1	360	362	PF00400	0.375
TRG_ER_diArg_1	371	374	PF00400	0.409
TRG_ER_diArg_1	467	469	PF00400	0.470
TRG_ER_diArg_1	477	479	PF00400	0.412
TRG_ER_diArg_1	57	60	PF00400	0.481
TRG_ER_diArg_1	624	626	PF00400	0.567
TRG_ER_diArg_1	635	637	PF00400	0.477
TRG_ER_diArg_1	656	658	PF00400	0.596
TRG_ER_diArg_1	680	682	PF00400	0.512
TRG_NES_CRM1_1	254	267	PF08389	0.474
TRG_NES_CRM1_1	64	80	PF08389	0.563
TRG_NLS_Bipartite_1	643	659	PF00514	0.699
TRG_NLS_MonoCore_2	654	659	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	680	684	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJP3	Leptomonas seymouri	66%	91%
A0A1X0NWS4	Trypanosomatidae	47%	77%
A0A3S5IS90	Trypanosoma rangeli	52%	94%
A0A3S7WXT9	Leishmania donovani	93%	99%
A4HCZ5	Leishmania braziliensis	82%	100%
A4I0I0	Leishmania infantum	93%	99%
C9ZVA6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	90%
Q4QB30	Leishmania major	93%	100%
V5BJA5	Trypanosoma cruzi	51%	100%