Membrane-bound acid phosphatase 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane-bound acid phosphatase 2

Species:

Leishmania mexicana

UniProt:

E9AWD7_LEIMU

TriTrypDb:

LmxM.23.1170

Length:

531

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 65

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 31, no: 4
NetGPI	no	yes: 0, no: 35

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	27
GO:0110165	cellular anatomical entity	1	27

Expansion

Sequence features

E9AWD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWD7

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016311	dephosphorylation	5	5
GO:0044237	cellular metabolic process	2	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0003993	acid phosphatase activity	6	1
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	200	202	PF00675	0.552
CLV_NRD_NRD_1	430	432	PF00675	0.534
CLV_NRD_NRD_1	522	524	PF00675	0.451
CLV_PCSK_KEX2_1	200	202	PF00082	0.517
CLV_PCSK_KEX2_1	432	434	PF00082	0.608
CLV_PCSK_KEX2_1	524	526	PF00082	0.438
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.462
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.486
CLV_PCSK_SKI1_1	121	125	PF00082	0.517
CLV_PCSK_SKI1_1	2	6	PF00082	0.721
CLV_PCSK_SKI1_1	525	529	PF00082	0.421
DEG_APCC_DBOX_1	1	9	PF00400	0.681
DEG_APCC_DBOX_1	230	238	PF00400	0.305
DEG_Nend_UBRbox_1	1	4	PF02207	0.680
DEG_SPOP_SBC_1	278	282	PF00917	0.198
DOC_ANK_TNKS_1	406	413	PF00023	0.299
DOC_CDC14_PxL_1	221	229	PF14671	0.402
DOC_CDC14_PxL_1	9	17	PF14671	0.399
DOC_CYCLIN_yCln2_LP_2	15	21	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	310	313	PF00134	0.233
DOC_MAPK_gen_1	226	234	PF00069	0.280
DOC_MAPK_MEF2A_6	2	9	PF00069	0.643
DOC_MAPK_NFAT4_5	2	10	PF00069	0.444
DOC_PP1_RVXF_1	380	387	PF00149	0.410
DOC_PP2B_LxvP_1	10	13	PF13499	0.632
DOC_PP2B_LxvP_1	15	18	PF13499	0.653
DOC_PP2B_LxvP_1	310	313	PF13499	0.233
DOC_USP7_MATH_1	278	282	PF00917	0.379
DOC_USP7_MATH_1	390	394	PF00917	0.427
DOC_USP7_MATH_1	43	47	PF00917	0.381
DOC_USP7_MATH_1	484	488	PF00917	0.587
DOC_WW_Pin1_4	471	476	PF00397	0.589
DOC_WW_Pin1_4	53	58	PF00397	0.437
LIG_14-3-3_CanoR_1	105	113	PF00244	0.311
LIG_14-3-3_CanoR_1	200	208	PF00244	0.328
LIG_14-3-3_CanoR_1	297	303	PF00244	0.233
LIG_14-3-3_CanoR_1	374	378	PF00244	0.354
LIG_14-3-3_CanoR_1	79	87	PF00244	0.373
LIG_deltaCOP1_diTrp_1	349	356	PF00928	0.327
LIG_EH1_1	501	509	PF00400	0.374
LIG_FHA_1	145	151	PF00498	0.306
LIG_FHA_1	227	233	PF00498	0.350
LIG_FHA_1	315	321	PF00498	0.339
LIG_FHA_1	379	385	PF00498	0.366
LIG_FHA_1	484	490	PF00498	0.496
LIG_FHA_1	492	498	PF00498	0.288
LIG_FHA_1	499	505	PF00498	0.355
LIG_FHA_1	511	517	PF00498	0.474
LIG_FHA_2	134	140	PF00498	0.363
LIG_FHA_2	205	211	PF00498	0.294
LIG_FHA_2	303	309	PF00498	0.323
LIG_GBD_Chelix_1	318	326	PF00786	0.433
LIG_LIR_Gen_1	178	186	PF02991	0.354
LIG_LIR_Gen_1	203	213	PF02991	0.306
LIG_LIR_Gen_1	379	388	PF02991	0.319
LIG_LIR_Gen_1	393	403	PF02991	0.351
LIG_LIR_Nem_3	129	134	PF02991	0.305
LIG_LIR_Nem_3	141	146	PF02991	0.336
LIG_LIR_Nem_3	173	179	PF02991	0.351
LIG_LIR_Nem_3	203	209	PF02991	0.274
LIG_LIR_Nem_3	222	227	PF02991	0.312
LIG_LIR_Nem_3	280	286	PF02991	0.328
LIG_LIR_Nem_3	379	383	PF02991	0.331
LIG_LIR_Nem_3	393	399	PF02991	0.385
LIG_LIR_Nem_3	400	406	PF02991	0.327
LIG_LIR_Nem_3	418	423	PF02991	0.418
LIG_LIR_Nem_3	62	66	PF02991	0.319
LIG_LYPXL_S_1	130	134	PF13949	0.538
LIG_LYPXL_yS_3	131	134	PF13949	0.338
LIG_LYPXL_yS_3	224	227	PF13949	0.299
LIG_NRBOX	4	10	PF00104	0.489
LIG_NRBOX	456	462	PF00104	0.277
LIG_PCNA_yPIPBox_3	263	271	PF02747	0.291
LIG_Pex14_2	119	123	PF04695	0.389
LIG_Pex14_2	153	157	PF04695	0.349
LIG_Pex14_2	348	352	PF04695	0.449
LIG_SH2_CRK	403	407	PF00017	0.344
LIG_SH2_GRB2like	146	149	PF00017	0.379
LIG_SH2_STAP1	146	150	PF00017	0.347
LIG_SH2_STAP1	437	441	PF00017	0.448
LIG_SH2_STAP1	97	101	PF00017	0.343
LIG_SH2_STAT3	149	152	PF00017	0.408
LIG_SH2_STAT5	143	146	PF00017	0.336
LIG_SH2_STAT5	149	152	PF00017	0.318
LIG_SH2_STAT5	194	197	PF00017	0.329
LIG_SH2_STAT5	246	249	PF00017	0.365
LIG_SH2_STAT5	396	399	PF00017	0.345
LIG_SH2_STAT5	60	63	PF00017	0.356
LIG_SH3_3	164	170	PF00018	0.305
LIG_SH3_3	465	471	PF00018	0.577
LIG_SH3_3	84	90	PF00018	0.336
LIG_SH3_5	93	97	PF00018	0.270
LIG_SUMO_SIM_par_1	316	321	PF11976	0.344
LIG_UBA3_1	208	215	PF00899	0.395
LIG_WRC_WIRS_1	499	504	PF05994	0.374
MOD_CK1_1	104	110	PF00069	0.372
MOD_CK1_1	115	121	PF00069	0.382
MOD_CK1_1	180	186	PF00069	0.273
MOD_CK1_1	196	202	PF00069	0.337
MOD_CK1_1	327	333	PF00069	0.308
MOD_CK1_1	343	349	PF00069	0.421
MOD_CK1_1	487	493	PF00069	0.558
MOD_CK1_1	85	91	PF00069	0.376
MOD_CK2_1	133	139	PF00069	0.415
MOD_CK2_1	343	349	PF00069	0.420
MOD_GlcNHglycan	114	117	PF01048	0.513
MOD_GlcNHglycan	260	263	PF01048	0.566
MOD_GlcNHglycan	288	291	PF01048	0.542
MOD_GlcNHglycan	345	348	PF01048	0.647
MOD_GlcNHglycan	361	364	PF01048	0.513
MOD_GlcNHglycan	370	373	PF01048	0.581
MOD_GlcNHglycan	386	389	PF01048	0.490
MOD_GlcNHglycan	486	489	PF01048	0.768
MOD_GSK3_1	177	184	PF00069	0.367
MOD_GSK3_1	286	293	PF00069	0.313
MOD_GSK3_1	298	305	PF00069	0.288
MOD_GSK3_1	39	46	PF00069	0.404
MOD_GSK3_1	455	462	PF00069	0.418
MOD_GSK3_1	479	486	PF00069	0.613
MOD_GSK3_1	487	494	PF00069	0.540
MOD_GSK3_1	75	82	PF00069	0.390
MOD_N-GLC_1	248	253	PF02516	0.507
MOD_N-GLC_1	324	329	PF02516	0.530
MOD_N-GLC_1	368	373	PF02516	0.578
MOD_N-GLC_1	47	52	PF02516	0.593
MOD_N-GLC_1	479	484	PF02516	0.654
MOD_N-GLC_2	373	375	PF02516	0.544
MOD_NEK2_1	277	282	PF00069	0.337
MOD_NEK2_1	314	319	PF00069	0.334
MOD_NEK2_1	326	331	PF00069	0.336
MOD_NEK2_1	361	366	PF00069	0.460
MOD_NEK2_1	444	449	PF00069	0.383
MOD_NEK2_1	460	465	PF00069	0.384
MOD_NEK2_1	69	74	PF00069	0.327
MOD_NEK2_1	75	80	PF00069	0.354
MOD_NEK2_2	204	209	PF00069	0.350
MOD_OFUCOSY	434	439	PF10250	0.549
MOD_OFUCOSY	452	459	PF10250	0.664
MOD_PIKK_1	232	238	PF00454	0.317
MOD_PIKK_1	47	53	PF00454	0.358
MOD_PKA_2	104	110	PF00069	0.311
MOD_PKA_2	199	205	PF00069	0.361
MOD_PKA_2	232	238	PF00069	0.326
MOD_PKA_2	343	349	PF00069	0.339
MOD_PKA_2	373	379	PF00069	0.375
MOD_PKB_1	77	85	PF00069	0.402
MOD_Plk_1	177	183	PF00069	0.219
MOD_Plk_1	291	297	PF00069	0.316
MOD_Plk_1	327	333	PF00069	0.233
MOD_Plk_1	378	384	PF00069	0.381
MOD_Plk_1	445	451	PF00069	0.305
MOD_Plk_1	47	53	PF00069	0.375
MOD_Plk_1	82	88	PF00069	0.339
MOD_Plk_4	115	121	PF00069	0.408
MOD_Plk_4	126	132	PF00069	0.361
MOD_Plk_4	314	320	PF00069	0.330
MOD_Plk_4	82	88	PF00069	0.348
MOD_ProDKin_1	471	477	PF00069	0.590
MOD_ProDKin_1	53	59	PF00069	0.430
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.456
TRG_ENDOCYTIC_2	131	134	PF00928	0.357
TRG_ENDOCYTIC_2	156	159	PF00928	0.278
TRG_ENDOCYTIC_2	224	227	PF00928	0.414
TRG_ENDOCYTIC_2	396	399	PF00928	0.417
TRG_ENDOCYTIC_2	403	406	PF00928	0.331
TRG_ER_diArg_1	231	234	PF00400	0.198
TRG_ER_diArg_1	430	433	PF00400	0.360
TRG_ER_diArg_1	76	79	PF00400	0.348
TRG_NES_CRM1_1	308	321	PF08389	0.320
TRG_NLS_MonoExtC_3	430	435	PF00514	0.257
TRG_NLS_MonoExtN_4	521	527	PF00514	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y5	Leptomonas seymouri	45%	93%
A0A0N1I756	Leptomonas seymouri	41%	100%
A0A0N1PEH4	Leptomonas seymouri	37%	100%
A0A0S4IRF5	Bodo saltans	24%	79%
A0A0S4IUV8	Bodo saltans	23%	100%
A0A0S4IV77	Bodo saltans	34%	100%
A0A0S4IXN9	Bodo saltans	24%	100%
A0A0S4JEA9	Bodo saltans	27%	100%
A0A0S4JJK3	Bodo saltans	27%	100%
A0A0S4JW09	Bodo saltans	27%	100%
A0A1X0NNY4	Trypanosomatidae	36%	96%
A0A1X0NQL4	Trypanosomatidae	28%	97%
A0A1X0NY34	Trypanosomatidae	25%	100%
A0A1X0P7V5	Trypanosomatidae	46%	100%
A0A3Q8IR23	Leishmania donovani	50%	93%
A0A3R7KSH4	Trypanosoma rangeli	25%	100%
A0A3R7MEN7	Trypanosoma rangeli	43%	100%
A0A3R7MHJ7	Trypanosoma rangeli	28%	100%
A0A3S5H827	Leishmania donovani	38%	100%
A0A3S7WXU0	Leishmania donovani	93%	100%
A0A3S7X1W4	Leishmania donovani	44%	97%
A4HCZ0	Leishmania braziliensis	85%	100%
A4HGW8	Leishmania braziliensis	43%	100%
A4HPC1	Leishmania braziliensis	38%	100%
A4HPC5	Leishmania braziliensis	51%	100%
A4HQG6	Leishmania braziliensis	35%	100%
A4HQG9	Leishmania braziliensis	34%	100%
A4I0H5	Leishmania infantum	94%	100%
A4I3Z8	Leishmania infantum	43%	97%
A4ICA5	Leishmania infantum	36%	80%
A4ICG3	Leishmania infantum	39%	100%
A4ICG5	Leishmania infantum	50%	93%
B1H1P9	Xenopus laevis	26%	100%
D0A3E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D0A947	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A948	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A9J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AT34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AT36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9B088	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	97%
P11117	Homo sapiens	28%	100%
Q4Q0A9	Leishmania major	31%	99%
Q4Q1G2	Leishmania major	51%	100%
Q4Q1G4	Leishmania major	38%	100%
Q4Q7Z7	Leishmania major	42%	100%
Q4QB35	Leishmania major	92%	100%
Q4R5N9	Macaca fascicularis	28%	100%
Q5NVF6	Pongo abelii	28%	100%
V5BCI2	Trypanosoma cruzi	26%	100%
V5BK91	Trypanosoma cruzi	42%	100%
V5BL75	Trypanosoma cruzi	27%	100%