Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

coronin, putative

Species:

Leishmania mexicana

UniProt:

E9AWD4_LEIMU

TriTrypDb:

LmxM.23.1165

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005815	microtubule organizing center	2	1
GO:0020016	ciliary pocket	2	1
GO:0036064	ciliary basal body	3	1
GO:0000139	Golgi membrane	5	1
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9AWD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWD4

PDB structure(s): 6icr_A , 6icr_B , 6icr_C , 6icr_D

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007015	actin filament organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0019894	kinesin binding	4	1
GO:0044877	protein-containing complex binding	2	1
GO:0051015	actin filament binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	221	223	PF00675	0.417
CLV_NRD_NRD_1	244	246	PF00675	0.485
CLV_NRD_NRD_1	343	345	PF00675	0.359
CLV_NRD_NRD_1	470	472	PF00675	0.645
CLV_NRD_NRD_1	489	491	PF00675	0.516
CLV_PCSK_KEX2_1	221	223	PF00082	0.423
CLV_PCSK_KEX2_1	470	472	PF00082	0.667
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.466
CLV_PCSK_SKI1_1	18	22	PF00082	0.422
CLV_PCSK_SKI1_1	237	241	PF00082	0.482
CLV_PCSK_SKI1_1	414	418	PF00082	0.842
CLV_PCSK_SKI1_1	490	494	PF00082	0.622
DEG_APCC_DBOX_1	178	186	PF00400	0.453
DEG_SPOP_SBC_1	23	27	PF00917	0.469
DOC_CYCLIN_RxL_1	12	25	PF00134	0.463
DOC_MAPK_gen_1	126	133	PF00069	0.399
DOC_MAPK_gen_1	15	23	PF00069	0.463
DOC_MAPK_gen_1	221	229	PF00069	0.419
DOC_MAPK_MEF2A_6	452	460	PF00069	0.485
DOC_MAPK_MEF2A_6	63	72	PF00069	0.495
DOC_MAPK_MEF2A_6	75	83	PF00069	0.453
DOC_USP7_MATH_1	361	365	PF00917	0.499
DOC_USP7_MATH_1	407	411	PF00917	0.629
DOC_USP7_MATH_1	436	440	PF00917	0.745
DOC_USP7_UBL2_3	122	126	PF12436	0.559
DOC_USP7_UBL2_3	417	421	PF12436	0.726
DOC_WW_Pin1_4	113	118	PF00397	0.610
DOC_WW_Pin1_4	246	251	PF00397	0.450
DOC_WW_Pin1_4	389	394	PF00397	0.605
DOC_WW_Pin1_4	399	404	PF00397	0.667
LIG_14-3-3_CanoR_1	344	351	PF00244	0.430
LIG_14-3-3_CanoR_1	5	13	PF00244	0.403
LIG_Actin_WH2_2	178	195	PF00022	0.459
LIG_AP2alpha_2	455	457	PF02296	0.508
LIG_AP2alpha_2	84	86	PF02296	0.527
LIG_APCC_ABBA_1	264	269	PF00400	0.423
LIG_BIR_II_1	1	5	PF00653	0.402
LIG_BRCT_BRCA1_1	259	263	PF00533	0.495
LIG_BRCT_BRCA1_1	384	388	PF00533	0.605
LIG_Clathr_ClatBox_1	335	339	PF01394	0.487
LIG_deltaCOP1_diTrp_1	175	183	PF00928	0.502
LIG_EH1_1	335	343	PF00400	0.456
LIG_eIF4E_1	382	388	PF01652	0.537
LIG_FHA_1	105	111	PF00498	0.510
LIG_FHA_1	189	195	PF00498	0.519
LIG_FHA_1	8	14	PF00498	0.382
LIG_FHA_2	170	176	PF00498	0.452
LIG_FHA_2	252	258	PF00498	0.582
LIG_FHA_2	357	363	PF00498	0.391
LIG_FHA_2	459	465	PF00498	0.669
LIG_FHA_2	91	97	PF00498	0.402
LIG_LIR_Gen_1	323	332	PF02991	0.500
LIG_LIR_Gen_1	40	50	PF02991	0.359
LIG_LIR_Gen_1	455	465	PF02991	0.590
LIG_LIR_Nem_3	260	266	PF02991	0.525
LIG_LIR_Nem_3	323	327	PF02991	0.498
LIG_LIR_Nem_3	331	335	PF02991	0.485
LIG_LIR_Nem_3	40	45	PF02991	0.359
LIG_LIR_Nem_3	59	64	PF02991	0.400
LIG_LIR_Nem_3	80	86	PF02991	0.404
LIG_Pex14_2	356	360	PF04695	0.430
LIG_Rb_LxCxE_1	281	299	PF01857	0.261
LIG_Rb_pABgroove_1	382	390	PF01858	0.511
LIG_SH2_CRK	332	336	PF00017	0.513
LIG_SH2_STAP1	267	271	PF00017	0.453
LIG_SH3_1	63	69	PF00018	0.543
LIG_SH3_3	10	16	PF00018	0.469
LIG_SH3_3	191	197	PF00018	0.459
LIG_SH3_3	40	46	PF00018	0.446
LIG_SH3_3	430	436	PF00018	0.815
LIG_SH3_3	63	69	PF00018	0.544
LIG_SUMO_SIM_par_1	272	278	PF11976	0.444
LIG_TRAF2_1	461	464	PF00917	0.522
LIG_TRAF2_1	492	495	PF00917	0.633
LIG_TYR_ITIM	330	335	PF00017	0.506
LIG_UBA3_1	226	233	PF00899	0.512
LIG_UBA3_1	273	279	PF00899	0.491
LIG_UBA3_1	337	345	PF00899	0.211
LIG_WRC_WIRS_1	130	135	PF05994	0.411
MOD_CDC14_SPxK_1	402	405	PF00782	0.731
MOD_CDK_SPK_2	389	394	PF00069	0.586
MOD_CDK_SPxK_1	399	405	PF00069	0.712
MOD_CK1_1	112	118	PF00069	0.513
MOD_CK1_1	132	138	PF00069	0.207
MOD_CK1_1	165	171	PF00069	0.582
MOD_CK1_1	205	211	PF00069	0.486
MOD_CK1_1	249	255	PF00069	0.559
MOD_CK1_1	364	370	PF00069	0.502
MOD_CK1_1	399	405	PF00069	0.776
MOD_CK1_1	431	437	PF00069	0.801
MOD_CK1_1	439	445	PF00069	0.774
MOD_CK2_1	169	175	PF00069	0.506
MOD_CK2_1	201	207	PF00069	0.566
MOD_CK2_1	249	255	PF00069	0.508
MOD_CK2_1	275	281	PF00069	0.434
MOD_CK2_1	344	350	PF00069	0.432
MOD_CK2_1	364	370	PF00069	0.430
MOD_CK2_1	431	437	PF00069	0.729
MOD_CK2_1	458	464	PF00069	0.648
MOD_CK2_1	90	96	PF00069	0.398
MOD_GlcNHglycan	135	138	PF01048	0.401
MOD_GlcNHglycan	142	145	PF01048	0.371
MOD_GlcNHglycan	210	213	PF01048	0.458
MOD_GlcNHglycan	259	262	PF01048	0.564
MOD_GlcNHglycan	362	366	PF01048	0.493
MOD_GlcNHglycan	372	375	PF01048	0.259
MOD_GlcNHglycan	383	387	PF01048	0.558
MOD_GlcNHglycan	442	445	PF01048	0.746
MOD_GlcNHglycan	485	489	PF01048	0.646
MOD_GSK3_1	109	116	PF00069	0.345
MOD_GSK3_1	129	136	PF00069	0.204
MOD_GSK3_1	156	163	PF00069	0.522
MOD_GSK3_1	165	172	PF00069	0.455
MOD_GSK3_1	184	191	PF00069	0.234
MOD_GSK3_1	198	205	PF00069	0.483
MOD_GSK3_1	225	232	PF00069	0.473
MOD_GSK3_1	288	295	PF00069	0.382
MOD_GSK3_1	30	37	PF00069	0.469
MOD_GSK3_1	431	438	PF00069	0.745
MOD_GSK3_1	46	53	PF00069	0.469
MOD_GSK3_1	92	99	PF00069	0.427
MOD_N-GLC_1	112	117	PF02516	0.478
MOD_N-GLC_1	165	170	PF02516	0.517
MOD_N-GLC_1	21	26	PF02516	0.400
MOD_N-GLC_1	300	305	PF02516	0.411
MOD_N-GLC_1	429	434	PF02516	0.695
MOD_NEK2_1	1	6	PF00069	0.358
MOD_NEK2_1	133	138	PF00069	0.245
MOD_NEK2_1	178	183	PF00069	0.380
MOD_NEK2_1	21	26	PF00069	0.172
MOD_NEK2_1	229	234	PF00069	0.434
MOD_NEK2_1	256	261	PF00069	0.489
MOD_NEK2_1	396	401	PF00069	0.689
MOD_NEK2_1	50	55	PF00069	0.400
MOD_NEK2_2	129	134	PF00069	0.408
MOD_PIKK_1	211	217	PF00454	0.519
MOD_PIKK_1	231	237	PF00454	0.242
MOD_PIKK_1	407	413	PF00454	0.521
MOD_PIKK_1	458	464	PF00454	0.635
MOD_PKA_1	222	228	PF00069	0.546
MOD_PKA_1	344	350	PF00069	0.469
MOD_PKA_2	156	162	PF00069	0.514
MOD_PKA_2	178	184	PF00069	0.479
MOD_PKA_2	445	451	PF00069	0.666
MOD_PKA_2	6	12	PF00069	0.358
MOD_PKB_1	5	13	PF00069	0.469
MOD_Plk_1	188	194	PF00069	0.509
MOD_Plk_1	198	204	PF00069	0.468
MOD_Plk_1	361	367	PF00069	0.501
MOD_Plk_1	428	434	PF00069	0.848
MOD_Plk_1	484	490	PF00069	0.576
MOD_Plk_4	178	184	PF00069	0.390
MOD_Plk_4	198	204	PF00069	0.264
MOD_Plk_4	222	228	PF00069	0.551
MOD_Plk_4	331	337	PF00069	0.393
MOD_Plk_4	96	102	PF00069	0.418
MOD_ProDKin_1	113	119	PF00069	0.604
MOD_ProDKin_1	246	252	PF00069	0.445
MOD_ProDKin_1	389	395	PF00069	0.597
MOD_ProDKin_1	399	405	PF00069	0.671
MOD_SUMO_for_1	420	423	PF00179	0.838
TRG_DiLeu_BaEn_1	269	274	PF01217	0.490
TRG_ENDOCYTIC_2	332	335	PF00928	0.521
TRG_ER_diArg_1	470	472	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	414	418	PF00026	0.751
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGC0	Leptomonas seymouri	60%	99%
A0A0S4IT51	Bodo saltans	50%	100%
A0A1X0NWV5	Trypanosomatidae	47%	96%
A0A3Q8IEM1	Leishmania donovani	93%	100%
A0A3R7K7Y6	Trypanosoma rangeli	45%	100%
A4HCY7	Leishmania braziliensis	79%	100%
A4I0H2	Leishmania infantum	93%	100%
A8WGE3	Xenopus tropicalis	33%	100%
B0R0D7	Danio rerio	35%	100%
C9ZV95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	98%
O13923	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	85%
O89046	Rattus norvegicus	36%	100%
O89053	Mus musculus	36%	100%
P27133	Dictyostelium discoideum	35%	100%
P31146	Homo sapiens	36%	100%
Q06440	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	78%
Q21624	Caenorhabditis elegans	31%	84%
Q32LP9	Bos taurus	30%	97%
Q4QB38	Leishmania major	92%	100%
Q4R4J2	Macaca fascicularis	36%	100%
Q5NVK4	Pongo abelii	36%	100%
Q6DJD8	Xenopus laevis	33%	100%
Q6QEF8	Homo sapiens	35%	100%
Q8BH44	Mus musculus	33%	100%
Q8C0P5	Mus musculus	29%	97%
Q91ZN1	Rattus norvegicus	37%	100%
Q920J3	Rattus norvegicus	35%	100%
Q920M5	Mus musculus	35%	100%
Q92176	Bos taurus	36%	100%
Q92828	Homo sapiens	32%	97%
Q9BR76	Homo sapiens	36%	100%
Q9ULV4	Homo sapiens	36%	100%
Q9UQ03	Homo sapiens	33%	100%
Q9WUM3	Mus musculus	36%	100%
Q9WUM4	Mus musculus	36%	100%
Q9XS70	Oryctolagus cuniculus	36%	100%