LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AWD3_LEIMU
TriTrypDb:
LmxM.23.1160
Length:
123

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

E9AWD3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWD3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 100 102 PF00675 0.613
DOC_PP4_FxxP_1 75 78 PF00568 0.465
LIG_deltaCOP1_diTrp_1 10 18 PF00928 0.670
LIG_LIR_Nem_3 10 16 PF02991 0.692
LIG_LIR_Nem_3 88 94 PF02991 0.429
LIG_PTB_Apo_2 19 26 PF02174 0.623
LIG_SH2_GRB2like 94 97 PF00017 0.411
LIG_SH2_STAP1 104 108 PF00017 0.491
LIG_SH2_STAP1 43 47 PF00017 0.574
LIG_SH2_STAT3 5 8 PF00017 0.665
LIG_SH2_STAT3 94 97 PF00017 0.439
LIG_SH2_STAT5 114 117 PF00017 0.431
LIG_SH2_STAT5 29 32 PF00017 0.573
LIG_UBA3_1 16 23 PF00899 0.625
MOD_CK1_1 64 70 PF00069 0.591
MOD_GSK3_1 61 68 PF00069 0.485
MOD_NEK2_1 109 114 PF00069 0.404
MOD_NEK2_1 85 90 PF00069 0.486
MOD_PIKK_1 85 91 PF00454 0.457
TRG_ENDOCYTIC_2 14 17 PF00928 0.588
TRG_ENDOCYTIC_2 34 37 PF00928 0.612
TRG_NLS_MonoExtC_3 30 35 PF00514 0.610

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IXF2 Bodo saltans 40% 98%
A0A1X0NXG0 Trypanosomatidae 52% 99%
A0A3Q8IBL8 Leishmania donovani 96% 100%
A0A3R7RF65 Trypanosoma rangeli 52% 75%
A4HCY6 Leishmania braziliensis 85% 100%
A4I0H1 Leishmania infantum 96% 100%
C9ZV94 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 91%
Q4QB39 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS