Coiled-coil protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Coiled-coil protein

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AWD2_LEIMU

TriTrypDb:

LmxM.23.1155

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	207	209	PF00675	0.578
CLV_NRD_NRD_1	263	265	PF00675	0.533
CLV_NRD_NRD_1	324	326	PF00675	0.495
CLV_NRD_NRD_1	379	381	PF00675	0.392
CLV_PCSK_FUR_1	204	208	PF00082	0.385
CLV_PCSK_KEX2_1	162	164	PF00082	0.604
CLV_PCSK_KEX2_1	204	206	PF00082	0.629
CLV_PCSK_KEX2_1	207	209	PF00082	0.634
CLV_PCSK_KEX2_1	30	32	PF00082	0.672
CLV_PCSK_KEX2_1	90	92	PF00082	0.504
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.604
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.672
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.524
CLV_PCSK_SKI1_1	198	202	PF00082	0.593
CLV_PCSK_SKI1_1	208	212	PF00082	0.504
CLV_PCSK_SKI1_1	428	432	PF00082	0.577
CLV_PCSK_SKI1_1	442	446	PF00082	0.562
DOC_CYCLIN_yClb1_LxF_4	448	454	PF00134	0.531
DOC_MAPK_MEF2A_6	385	393	PF00069	0.523
DOC_PP4_FxxP_1	165	168	PF00568	0.534
DOC_USP7_MATH_1	118	122	PF00917	0.467
DOC_USP7_MATH_1	184	188	PF00917	0.573
DOC_USP7_MATH_1	29	33	PF00917	0.547
DOC_USP7_MATH_1	371	375	PF00917	0.487
DOC_USP7_MATH_1	65	69	PF00917	0.547
DOC_USP7_UBL2_3	381	385	PF12436	0.358
DOC_WW_Pin1_4	1	6	PF00397	0.576
DOC_WW_Pin1_4	164	169	PF00397	0.501
DOC_WW_Pin1_4	222	227	PF00397	0.683
LIG_14-3-3_CanoR_1	144	150	PF00244	0.538
LIG_14-3-3_CanoR_1	190	194	PF00244	0.544
LIG_14-3-3_CanoR_1	218	226	PF00244	0.566
LIG_14-3-3_CanoR_1	31	39	PF00244	0.571
LIG_14-3-3_CanoR_1	91	101	PF00244	0.477
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_BRCT_BRCA1_1	108	112	PF00533	0.373
LIG_CaM_IQ_9	77	93	PF13499	0.417
LIG_FHA_1	1	7	PF00498	0.572
LIG_FHA_1	212	218	PF00498	0.524
LIG_FHA_1	232	238	PF00498	0.641
LIG_FHA_2	120	126	PF00498	0.660
LIG_FHA_2	190	196	PF00498	0.583
LIG_FHA_2	431	437	PF00498	0.424
LIG_FHA_2	56	62	PF00498	0.548
LIG_FHA_2	93	99	PF00498	0.521
LIG_GBD_Chelix_1	245	253	PF00786	0.572
LIG_LIR_Gen_1	12	21	PF02991	0.443
LIG_LIR_Gen_1	369	376	PF02991	0.538
LIG_LIR_Nem_3	12	17	PF02991	0.447
LIG_LIR_Nem_3	369	375	PF02991	0.542
LIG_NRBOX	346	352	PF00104	0.538
LIG_PCNA_yPIPBox_3	154	163	PF02747	0.401
LIG_SH2_CRK	344	348	PF00017	0.499
LIG_SH2_CRK	372	376	PF00017	0.537
LIG_SH2_NCK_1	14	18	PF00017	0.366
LIG_SH2_STAT5	126	129	PF00017	0.489
LIG_SH2_STAT5	416	419	PF00017	0.470
LIG_SH2_STAT5	450	453	PF00017	0.626
LIG_SUMO_SIM_par_1	230	240	PF11976	0.544
LIG_TRAF2_1	177	180	PF00917	0.541
LIG_TRAF2_1	319	322	PF00917	0.544
LIG_TRAF2_1	32	35	PF00917	0.512
LIG_TRAF2_1	331	334	PF00917	0.482
LIG_TRAF2_1	69	72	PF00917	0.562
MOD_CDK_SPxK_1	1	7	PF00069	0.516
MOD_CK1_1	273	279	PF00069	0.455
MOD_CK1_1	285	291	PF00069	0.580
MOD_CK1_1	299	305	PF00069	0.498
MOD_CK1_1	374	380	PF00069	0.578
MOD_CK1_1	41	47	PF00069	0.630
MOD_CK1_1	422	428	PF00069	0.563
MOD_CK2_1	173	179	PF00069	0.559
MOD_CK2_1	273	279	PF00069	0.433
MOD_CK2_1	29	35	PF00069	0.514
MOD_CK2_1	357	363	PF00069	0.530
MOD_CK2_1	430	436	PF00069	0.404
MOD_CK2_1	460	466	PF00069	0.545
MOD_CK2_1	55	61	PF00069	0.564
MOD_CK2_1	65	71	PF00069	0.461
MOD_CK2_1	9	15	PF00069	0.607
MOD_CK2_1	92	98	PF00069	0.524
MOD_GlcNHglycan	108	111	PF01048	0.501
MOD_GlcNHglycan	122	125	PF01048	0.507
MOD_GlcNHglycan	175	178	PF01048	0.586
MOD_GlcNHglycan	186	189	PF01048	0.575
MOD_GlcNHglycan	26	30	PF01048	0.603
MOD_GlcNHglycan	271	275	PF01048	0.364
MOD_GlcNHglycan	397	400	PF01048	0.350
MOD_GlcNHglycan	402	406	PF01048	0.407
MOD_GlcNHglycan	43	46	PF01048	0.458
MOD_GlcNHglycan	67	70	PF01048	0.569
MOD_GSK3_1	189	196	PF00069	0.536
MOD_GSK3_1	227	234	PF00069	0.655
MOD_GSK3_1	25	32	PF00069	0.586
MOD_GSK3_1	37	44	PF00069	0.441
MOD_GSK3_1	385	392	PF00069	0.373
MOD_GSK3_1	415	422	PF00069	0.552
MOD_GSK3_1	51	58	PF00069	0.468
MOD_GSK3_1	9	16	PF00069	0.596
MOD_N-GLC_2	133	135	PF02516	0.600
MOD_NEK2_1	145	150	PF00069	0.611
MOD_NEK2_1	189	194	PF00069	0.527
MOD_NEK2_1	245	250	PF00069	0.634
MOD_NEK2_1	38	43	PF00069	0.556
MOD_NEK2_1	389	394	PF00069	0.402
MOD_PIKK_1	247	253	PF00454	0.608
MOD_PIKK_1	283	289	PF00454	0.623
MOD_PIKK_1	296	302	PF00454	0.527
MOD_PIKK_1	30	36	PF00454	0.514
MOD_PIKK_1	374	380	PF00454	0.425
MOD_PKA_1	30	36	PF00069	0.633
MOD_PKA_2	173	179	PF00069	0.576
MOD_PKA_2	184	190	PF00069	0.535
MOD_PKA_2	217	223	PF00069	0.552
MOD_PKA_2	282	288	PF00069	0.457
MOD_PKA_2	30	36	PF00069	0.554
MOD_PKA_2	389	395	PF00069	0.512
MOD_PKA_2	460	466	PF00069	0.557
MOD_PKB_1	206	214	PF00069	0.547
MOD_Plk_1	179	185	PF00069	0.574
MOD_Plk_1	231	237	PF00069	0.599
MOD_Plk_2-3	329	335	PF00069	0.369
MOD_Plk_2-3	9	15	PF00069	0.522
MOD_Plk_4	145	151	PF00069	0.520
MOD_Plk_4	156	162	PF00069	0.633
MOD_Plk_4	231	237	PF00069	0.586
MOD_Plk_4	273	279	PF00069	0.403
MOD_Plk_4	308	314	PF00069	0.562
MOD_Plk_4	371	377	PF00069	0.535
MOD_Plk_4	422	428	PF00069	0.563
MOD_Plk_4	9	15	PF00069	0.468
MOD_ProDKin_1	1	7	PF00069	0.573
MOD_ProDKin_1	164	170	PF00069	0.499
MOD_ProDKin_1	222	228	PF00069	0.686
MOD_SUMO_for_1	6	9	PF00179	0.568
TRG_DiLeu_BaEn_1	232	237	PF01217	0.597
TRG_ENDOCYTIC_2	14	17	PF00928	0.445
TRG_ENDOCYTIC_2	344	347	PF00928	0.469
TRG_ENDOCYTIC_2	372	375	PF00928	0.543
TRG_ENDOCYTIC_2	450	453	PF00928	0.571
TRG_ENDOCYTIC_2	83	86	PF00928	0.486
TRG_ER_diArg_1	203	206	PF00400	0.511
TRG_NLS_MonoCore_2	263	268	PF00514	0.519
TRG_NLS_MonoExtN_4	262	269	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	208	213	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	318	322	PF00026	0.644
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9S1	Leptomonas seymouri	25%	100%
A0A3Q8IFW4	Leishmania donovani	85%	100%
A4HCY5	Leishmania braziliensis	68%	100%
A4I0H0	Leishmania infantum	85%	100%
Q4QB40	Leishmania major	83%	100%