Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWD1_LEIMU

TriTrypDb:

LmxM.23.1150

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005814	centriole	5	1
GO:0005874	microtubule	6	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AWD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWD1

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.571
CLV_C14_Caspase3-7	254	258	PF00656	0.527
CLV_C14_Caspase3-7	31	35	PF00656	0.615
CLV_C14_Caspase3-7	475	479	PF00656	0.437
CLV_C14_Caspase3-7	531	535	PF00656	0.530
CLV_NRD_NRD_1	104	106	PF00675	0.552
CLV_NRD_NRD_1	194	196	PF00675	0.587
CLV_NRD_NRD_1	269	271	PF00675	0.634
CLV_NRD_NRD_1	322	324	PF00675	0.427
CLV_NRD_NRD_1	383	385	PF00675	0.521
CLV_NRD_NRD_1	396	398	PF00675	0.565
CLV_NRD_NRD_1	54	56	PF00675	0.637
CLV_NRD_NRD_1	588	590	PF00675	0.366
CLV_NRD_NRD_1	6	8	PF00675	0.576
CLV_NRD_NRD_1	79	81	PF00675	0.527
CLV_PCSK_KEX2_1	193	195	PF00082	0.585
CLV_PCSK_KEX2_1	344	346	PF00082	0.583
CLV_PCSK_KEX2_1	382	384	PF00082	0.522
CLV_PCSK_KEX2_1	396	398	PF00082	0.526
CLV_PCSK_KEX2_1	56	58	PF00082	0.743
CLV_PCSK_KEX2_1	565	567	PF00082	0.431
CLV_PCSK_KEX2_1	582	584	PF00082	0.583
CLV_PCSK_KEX2_1	6	8	PF00082	0.555
CLV_PCSK_KEX2_1	608	610	PF00082	0.551
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.585
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.583
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.677
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.583
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.428
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.551
CLV_PCSK_SKI1_1	130	134	PF00082	0.475
CLV_PCSK_SKI1_1	195	199	PF00082	0.536
CLV_PCSK_SKI1_1	270	274	PF00082	0.462
CLV_PCSK_SKI1_1	334	338	PF00082	0.541
CLV_PCSK_SKI1_1	396	400	PF00082	0.496
DEG_SPOP_SBC_1	40	44	PF00917	0.564
DEG_SPOP_SBC_1	72	76	PF00917	0.521
DOC_CYCLIN_RxL_1	328	341	PF00134	0.485
DOC_MAPK_gen_1	193	200	PF00069	0.588
DOC_MAPK_gen_1	321	331	PF00069	0.481
DOC_MAPK_gen_1	4	11	PF00069	0.492
DOC_MAPK_gen_1	589	600	PF00069	0.499
DOC_MAPK_gen_1	608	614	PF00069	0.542
DOC_MAPK_MEF2A_6	4	13	PF00069	0.593
DOC_PP1_RVXF_1	557	563	PF00149	0.490
DOC_PP2B_LxvP_1	372	375	PF13499	0.645
DOC_PP2B_LxvP_1	439	442	PF13499	0.565
DOC_SPAK_OSR1_1	609	613	PF12202	0.540
DOC_USP7_MATH_1	148	152	PF00917	0.658
DOC_USP7_MATH_1	16	20	PF00917	0.672
DOC_USP7_MATH_1	161	165	PF00917	0.514
DOC_USP7_MATH_1	169	173	PF00917	0.378
DOC_USP7_MATH_1	22	26	PF00917	0.630
DOC_USP7_MATH_1	258	262	PF00917	0.595
DOC_USP7_MATH_1	40	44	PF00917	0.669
DOC_USP7_MATH_1	402	406	PF00917	0.739
DOC_USP7_MATH_1	407	411	PF00917	0.672
DOC_USP7_UBL2_3	4	8	PF12436	0.521
DOC_USP7_UBL2_3	570	574	PF12436	0.586
DOC_WW_Pin1_4	14	19	PF00397	0.605
DOC_WW_Pin1_4	210	215	PF00397	0.656
LIG_14-3-3_CanoR_1	10	16	PF00244	0.609
LIG_14-3-3_CanoR_1	208	217	PF00244	0.481
LIG_14-3-3_CanoR_1	383	389	PF00244	0.555
LIG_14-3-3_CanoR_1	55	65	PF00244	0.670
LIG_14-3-3_CanoR_1	80	86	PF00244	0.511
LIG_Actin_WH2_2	381	398	PF00022	0.545
LIG_FAT_LD_1	614	622	PF03623	0.418
LIG_FHA_1	18	24	PF00498	0.599
LIG_FHA_1	211	217	PF00498	0.662
LIG_FHA_1	352	358	PF00498	0.453
LIG_FHA_1	40	46	PF00498	0.560
LIG_FHA_1	494	500	PF00498	0.361
LIG_FHA_1	573	579	PF00498	0.546
LIG_FHA_1	594	600	PF00498	0.468
LIG_FHA_2	166	172	PF00498	0.641
LIG_FHA_2	185	191	PF00498	0.527
LIG_FHA_2	262	268	PF00498	0.526
LIG_FHA_2	362	368	PF00498	0.575
LIG_Integrin_RGD_1	532	534	PF01839	0.490
LIG_LIR_Gen_1	140	148	PF02991	0.511
LIG_LIR_Nem_3	140	146	PF02991	0.500
LIG_MAD2	10	18	PF02301	0.572
LIG_NRBOX	613	619	PF00104	0.419
LIG_PCNA_yPIPBox_3	608	618	PF02747	0.538
LIG_PTB_Apo_2	86	93	PF02174	0.598
LIG_SH2_STAP1	549	553	PF00017	0.581
LIG_SH2_STAT5	567	570	PF00017	0.478
LIG_SH2_STAT5	91	94	PF00017	0.648
LIG_SH3_4	433	440	PF00018	0.739
LIG_SUMO_SIM_anti_2	223	230	PF11976	0.629
LIG_SUMO_SIM_anti_2	28	35	PF11976	0.593
LIG_SUMO_SIM_par_1	28	35	PF11976	0.658
LIG_SUMO_SIM_par_1	519	525	PF11976	0.483
LIG_SUMO_SIM_par_1	552	558	PF11976	0.555
LIG_TRAF2_1	346	349	PF00917	0.646
LIG_UBA3_1	29	38	PF00899	0.660
LIG_UBA3_1	521	529	PF00899	0.496
LIG_UBA3_1	578	582	PF00899	0.554
MOD_CK1_1	17	23	PF00069	0.734
MOD_CK1_1	261	267	PF00069	0.537
MOD_CK1_1	286	292	PF00069	0.525
MOD_CK1_1	41	47	PF00069	0.599
MOD_CK1_1	525	531	PF00069	0.510
MOD_CK1_1	535	541	PF00069	0.431
MOD_CK1_1	73	79	PF00069	0.630
MOD_CK1_1	90	96	PF00069	0.647
MOD_CK2_1	184	190	PF00069	0.530
MOD_CK2_1	22	28	PF00069	0.608
MOD_CK2_1	230	236	PF00069	0.422
MOD_CK2_1	261	267	PF00069	0.537
MOD_CK2_1	301	307	PF00069	0.509
MOD_CK2_1	361	367	PF00069	0.575
MOD_CK2_1	383	389	PF00069	0.558
MOD_CK2_1	451	457	PF00069	0.558
MOD_CK2_1	508	514	PF00069	0.623
MOD_CK2_1	71	77	PF00069	0.692
MOD_Cter_Amidation	4	7	PF01082	0.482
MOD_Cter_Amidation	53	56	PF01082	0.642
MOD_Cter_Amidation	78	81	PF01082	0.528
MOD_GlcNHglycan	154	157	PF01048	0.598
MOD_GlcNHglycan	171	174	PF01048	0.547
MOD_GlcNHglycan	218	221	PF01048	0.714
MOD_GlcNHglycan	24	27	PF01048	0.550
MOD_GlcNHglycan	315	318	PF01048	0.654
MOD_GlcNHglycan	409	412	PF01048	0.692
MOD_GlcNHglycan	50	53	PF01048	0.601
MOD_GlcNHglycan	503	506	PF01048	0.592
MOD_GSK3_1	148	155	PF00069	0.477
MOD_GSK3_1	161	168	PF00069	0.527
MOD_GSK3_1	184	191	PF00069	0.560
MOD_GSK3_1	204	211	PF00069	0.597
MOD_GSK3_1	212	219	PF00069	0.666
MOD_GSK3_1	247	254	PF00069	0.531
MOD_GSK3_1	261	268	PF00069	0.590
MOD_GSK3_1	40	47	PF00069	0.594
MOD_GSK3_1	447	454	PF00069	0.607
MOD_GSK3_1	472	479	PF00069	0.512
MOD_GSK3_1	87	94	PF00069	0.641
MOD_N-GLC_1	121	126	PF02516	0.539
MOD_N-GLC_1	169	174	PF02516	0.616
MOD_N-GLC_1	38	43	PF02516	0.721
MOD_N-GLC_1	493	498	PF02516	0.355
MOD_NEK2_1	152	157	PF00069	0.490
MOD_NEK2_1	206	211	PF00069	0.660
MOD_NEK2_1	242	247	PF00069	0.600
MOD_NEK2_1	294	299	PF00069	0.508
MOD_NEK2_1	308	313	PF00069	0.488
MOD_NEK2_1	447	452	PF00069	0.538
MOD_NEK2_1	472	477	PF00069	0.405
MOD_NEK2_1	50	55	PF00069	0.575
MOD_NEK2_1	513	518	PF00069	0.618
MOD_NEK2_1	522	527	PF00069	0.473
MOD_NEK2_1	87	92	PF00069	0.601
MOD_PIKK_1	107	113	PF00454	0.536
MOD_PIKK_1	242	248	PF00454	0.597
MOD_PIKK_1	286	292	PF00454	0.532
MOD_PIKK_1	516	522	PF00454	0.577
MOD_PIKK_1	602	608	PF00454	0.551
MOD_PK_1	247	253	PF00069	0.585
MOD_PK_1	301	307	PF00069	0.509
MOD_PK_1	476	482	PF00069	0.565
MOD_PKA_1	301	307	PF00069	0.509
MOD_PKA_1	383	389	PF00069	0.558
MOD_PKA_1	55	61	PF00069	0.748
MOD_PKA_1	80	86	PF00069	0.511
MOD_PKA_2	242	248	PF00069	0.597
MOD_PKA_2	383	389	PF00069	0.558
MOD_PKA_2	538	544	PF00069	0.535
MOD_PKA_2	56	62	PF00069	0.748
MOD_PKB_1	382	390	PF00069	0.506
MOD_Plk_1	121	127	PF00069	0.540
MOD_Plk_1	261	267	PF00069	0.590
MOD_Plk_1	294	300	PF00069	0.394
MOD_Plk_1	447	453	PF00069	0.587
MOD_Plk_1	493	499	PF00069	0.359
MOD_Plk_1	508	514	PF00069	0.592
MOD_Plk_1	549	555	PF00069	0.573
MOD_Plk_1	87	93	PF00069	0.597
MOD_Plk_4	121	127	PF00069	0.540
MOD_Plk_4	148	154	PF00069	0.497
MOD_Plk_4	212	218	PF00069	0.676
MOD_Plk_4	451	457	PF00069	0.579
MOD_Plk_4	549	555	PF00069	0.573
MOD_Plk_4	619	625	PF00069	0.536
MOD_Plk_4	87	93	PF00069	0.668
MOD_ProDKin_1	14	20	PF00069	0.604
MOD_ProDKin_1	210	216	PF00069	0.656
MOD_SUMO_rev_2	123	132	PF00179	0.595
MOD_SUMO_rev_2	142	151	PF00179	0.339
MOD_SUMO_rev_2	233	242	PF00179	0.396
MOD_SUMO_rev_2	267	273	PF00179	0.538
MOD_SUMO_rev_2	348	357	PF00179	0.583
MOD_SUMO_rev_2	485	493	PF00179	0.576
MOD_SUMO_rev_2	571	575	PF00179	0.505
MOD_SUMO_rev_2	577	584	PF00179	0.455
MOD_SUMO_rev_2	586	591	PF00179	0.442
MOD_SUMO_rev_2	597	605	PF00179	0.568
TRG_DiLeu_BaEn_1	594	599	PF01217	0.581
TRG_DiLeu_BaEn_2	557	563	PF01217	0.490
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.524
TRG_ER_diArg_1	328	331	PF00400	0.546
TRG_ER_diArg_1	368	371	PF00400	0.588
TRG_ER_diArg_1	381	384	PF00400	0.470
TRG_ER_diArg_1	395	397	PF00400	0.535
TRG_NLS_MonoExtC_3	54	60	PF00514	0.574
TRG_NLS_MonoExtN_4	4	11	PF00514	0.590
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IB33	Leishmania donovani	90%	100%
A0A422NPG5	Trypanosoma rangeli	25%	84%
A4HCY4	Leishmania braziliensis	81%	100%
A4I0G9	Leishmania infantum	90%	100%
Q4QB41	Leishmania major	91%	100%