Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWC9_LEIMU

TriTrypDb:

LmxM.23.1130

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0005874	microtubule	6	1
GO:0005881	cytoplasmic microtubule	7	1
GO:0035371	microtubule plus-end	3	1
GO:0051233	spindle midzone	2	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1
GO:1990752	microtubule end	2	1

Expansion

Sequence features

E9AWC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWC9

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0007051	spindle organization	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022607	cellular component assembly	4	1
GO:0031110	regulation of microtubule polymerization or depolymerization	6	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0033036	macromolecule localization	2	1
GO:0033043	regulation of organelle organization	5	1
GO:0033365	protein localization to organelle	5	1
GO:0035372	protein localization to microtubule	8	1
GO:0044380	protein localization to cytoskeleton	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051179	localization	1	1
GO:0051225	spindle assembly	4	1
GO:0051493	regulation of cytoskeleton organization	6	1
GO:0051641	cellular localization	2	1
GO:0065007	biological regulation	1	1
GO:0070507	regulation of microtubule cytoskeleton organization	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072698	protein localization to microtubule cytoskeleton	7	1
GO:0140694	non-membrane-bounded organelle assembly	6	1
GO:1904825	protein localization to microtubule plus-end	10	1
GO:1905725	protein localization to microtubule end	9	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0005515	protein binding	2	9
GO:0008017	microtubule binding	5	9
GO:0008092	cytoskeletal protein binding	3	9
GO:0015631	tubulin binding	4	9
GO:0051010	microtubule plus-end binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	244	248	PF00656	0.628
CLV_C14_Caspase3-7	31	35	PF00656	0.323
CLV_NRD_NRD_1	10	12	PF00675	0.544
CLV_NRD_NRD_1	423	425	PF00675	0.479
CLV_PCSK_KEX2_1	423	425	PF00082	0.404
CLV_PCSK_SKI1_1	12	16	PF00082	0.496
CLV_PCSK_SKI1_1	130	134	PF00082	0.481
CLV_PCSK_SKI1_1	159	163	PF00082	0.512
CLV_PCSK_SKI1_1	342	346	PF00082	0.621
DEG_APCC_DBOX_1	326	334	PF00400	0.557
DEG_SCF_FBW7_1	251	258	PF00400	0.595
DEG_SPOP_SBC_1	265	269	PF00917	0.669
DOC_CKS1_1	252	257	PF01111	0.749
DOC_CYCLIN_RxL_1	139	151	PF00134	0.504
DOC_PP1_RVXF_1	75	81	PF00149	0.377
DOC_PP1_RVXF_1	98	105	PF00149	0.442
DOC_PP4_FxxP_1	252	255	PF00568	0.715
DOC_USP7_MATH_1	189	193	PF00917	0.516
DOC_USP7_MATH_1	224	228	PF00917	0.683
DOC_USP7_MATH_1	245	249	PF00917	0.692
DOC_USP7_MATH_1	255	259	PF00917	0.761
DOC_USP7_MATH_1	265	269	PF00917	0.604
DOC_USP7_MATH_1	28	32	PF00917	0.425
DOC_USP7_MATH_1	418	422	PF00917	0.537
DOC_USP7_MATH_1	55	59	PF00917	0.563
DOC_USP7_MATH_1	90	94	PF00917	0.590
DOC_USP7_UBL2_3	160	164	PF12436	0.578
DOC_WW_Pin1_4	215	220	PF00397	0.764
DOC_WW_Pin1_4	247	252	PF00397	0.750
DOC_WW_Pin1_4	285	290	PF00397	0.798
LIG_14-3-3_CanoR_1	123	127	PF00244	0.537
LIG_14-3-3_CanoR_1	257	262	PF00244	0.710
LIG_14-3-3_CanoR_1	327	331	PF00244	0.672
LIG_14-3-3_CanoR_1	366	371	PF00244	0.668
LIG_BIR_II_1	1	5	PF00653	0.686
LIG_FHA_1	131	137	PF00498	0.452
LIG_FHA_1	179	185	PF00498	0.650
LIG_FHA_1	317	323	PF00498	0.662
LIG_FHA_1	362	368	PF00498	0.517
LIG_FHA_1	386	392	PF00498	0.597
LIG_FHA_1	414	420	PF00498	0.457
LIG_FHA_1	81	87	PF00498	0.493
LIG_FHA_2	235	241	PF00498	0.810
LIG_FHA_2	38	44	PF00498	0.366
LIG_LIR_Apic_2	250	255	PF02991	0.707
LIG_LIR_Gen_1	101	110	PF02991	0.371
LIG_LIR_Nem_3	23	29	PF02991	0.405
LIG_LYPXL_yS_3	26	29	PF13949	0.355
LIG_NRBOX	393	399	PF00104	0.490
LIG_NRBOX	435	441	PF00104	0.552
LIG_Pex14_1	145	149	PF04695	0.370
LIG_SH2_CRK	38	42	PF00017	0.335
LIG_SH2_NCK_1	408	412	PF00017	0.514
LIG_SH2_STAP1	157	161	PF00017	0.450
LIG_SH2_STAP1	375	379	PF00017	0.469
LIG_SH2_STAT5	147	150	PF00017	0.471
LIG_SH2_STAT5	297	300	PF00017	0.794
LIG_SH2_STAT5	315	318	PF00017	0.544
LIG_SH2_STAT5	38	41	PF00017	0.337
LIG_SH2_STAT5	74	77	PF00017	0.487
LIG_SH3_3	425	431	PF00018	0.550
LIG_SUMO_SIM_anti_2	138	144	PF11976	0.404
LIG_SUMO_SIM_anti_2	435	441	PF11976	0.527
LIG_SUMO_SIM_par_1	387	393	PF11976	0.535
LIG_TRAF2_1	390	393	PF00917	0.608
LIG_UBA3_1	14	20	PF00899	0.456
MOD_CDC14_SPxK_1	250	253	PF00782	0.827
MOD_CDK_SPK_2	215	220	PF00069	0.645
MOD_CDK_SPxK_1	247	253	PF00069	0.740
MOD_CK1_1	2	8	PF00069	0.649
MOD_CK1_1	229	235	PF00069	0.770
MOD_CK1_1	260	266	PF00069	0.544
MOD_CK1_1	281	287	PF00069	0.744
MOD_CK1_1	93	99	PF00069	0.413
MOD_CK2_1	229	235	PF00069	0.784
MOD_CK2_1	37	43	PF00069	0.449
MOD_CK2_1	387	393	PF00069	0.610
MOD_CK2_1	95	101	PF00069	0.425
MOD_Cter_Amidation	9	12	PF01082	0.543
MOD_GlcNHglycan	1	4	PF01048	0.649
MOD_GlcNHglycan	228	231	PF01048	0.655
MOD_GlcNHglycan	243	246	PF01048	0.716
MOD_GlcNHglycan	263	266	PF01048	0.551
MOD_GlcNHglycan	283	286	PF01048	0.730
MOD_GlcNHglycan	300	303	PF01048	0.779
MOD_GlcNHglycan	420	423	PF01048	0.544
MOD_GlcNHglycan	79	83	PF01048	0.485
MOD_GlcNHglycan	8	11	PF01048	0.429
MOD_GSK3_1	183	190	PF00069	0.623
MOD_GSK3_1	2	9	PF00069	0.597
MOD_GSK3_1	224	231	PF00069	0.650
MOD_GSK3_1	241	248	PF00069	0.607
MOD_GSK3_1	251	258	PF00069	0.715
MOD_GSK3_1	260	267	PF00069	0.685
MOD_GSK3_1	277	284	PF00069	0.704
MOD_N-GLC_1	178	183	PF02516	0.638
MOD_N-GLC_1	214	219	PF02516	0.630
MOD_NEK2_1	148	153	PF00069	0.452
MOD_NEK2_1	178	183	PF00069	0.610
MOD_NEK2_1	326	331	PF00069	0.555
MOD_NEK2_1	78	83	PF00069	0.453
MOD_NEK2_2	28	33	PF00069	0.422
MOD_PIKK_1	379	385	PF00454	0.434
MOD_PIKK_1	53	59	PF00454	0.627
MOD_PK_1	366	372	PF00069	0.730
MOD_PKA_2	122	128	PF00069	0.527
MOD_PKA_2	245	251	PF00069	0.820
MOD_PKA_2	278	284	PF00069	0.797
MOD_PKA_2	316	322	PF00069	0.646
MOD_PKA_2	326	332	PF00069	0.583
MOD_PKA_2	385	391	PF00069	0.628
MOD_PKA_2	93	99	PF00069	0.585
MOD_PKB_1	185	193	PF00069	0.634
MOD_PKB_1	239	247	PF00069	0.732
MOD_Plk_1	178	184	PF00069	0.637
MOD_Plk_1	307	313	PF00069	0.669
MOD_Plk_1	377	383	PF00069	0.611
MOD_Plk_2-3	387	393	PF00069	0.617
MOD_Plk_2-3	95	101	PF00069	0.482
MOD_Plk_4	326	332	PF00069	0.509
MOD_Plk_4	37	43	PF00069	0.336
MOD_Plk_4	410	416	PF00069	0.374
MOD_ProDKin_1	215	221	PF00069	0.765
MOD_ProDKin_1	247	253	PF00069	0.754
MOD_ProDKin_1	285	291	PF00069	0.799
MOD_SUMO_rev_2	158	166	PF00179	0.558
TRG_DiLeu_BaEn_1	393	398	PF01217	0.529
TRG_DiLeu_BaEn_4	399	405	PF01217	0.469
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.428
TRG_DiLeu_BaLyEn_6	428	433	PF01217	0.565
TRG_ENDOCYTIC_2	147	150	PF00928	0.441
TRG_ENDOCYTIC_2	26	29	PF00928	0.355
TRG_ENDOCYTIC_2	38	41	PF00928	0.337
TRG_ENDOCYTIC_2	408	411	PF00928	0.545
TRG_ER_diArg_1	182	185	PF00400	0.688
TRG_ER_diArg_1	331	334	PF00400	0.412
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.648
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ6	Leptomonas seymouri	55%	100%
A0A1X0NWV1	Trypanosomatidae	34%	100%
A0A3R7KIS5	Trypanosoma rangeli	35%	100%
A0A3S7WXV0	Leishmania donovani	93%	100%
A4HCY2	Leishmania braziliensis	81%	100%
A4I0G7	Leishmania infantum	93%	100%
C9ZV68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QB43	Leishmania major	91%	100%