Stealth_CR2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AWC8_LEIMU

TriTrypDb:

LmxM.23.1120

Length:

656

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AWC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWC8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.413
CLV_C14_Caspase3-7	593	597	PF00656	0.357
CLV_NRD_NRD_1	101	103	PF00675	0.454
CLV_NRD_NRD_1	138	140	PF00675	0.501
CLV_NRD_NRD_1	163	165	PF00675	0.509
CLV_NRD_NRD_1	405	407	PF00675	0.425
CLV_NRD_NRD_1	488	490	PF00675	0.531
CLV_NRD_NRD_1	88	90	PF00675	0.496
CLV_PCSK_KEX2_1	101	103	PF00082	0.454
CLV_PCSK_KEX2_1	138	140	PF00082	0.501
CLV_PCSK_KEX2_1	163	165	PF00082	0.509
CLV_PCSK_KEX2_1	405	407	PF00082	0.421
CLV_PCSK_KEX2_1	488	490	PF00082	0.545
CLV_PCSK_KEX2_1	88	90	PF00082	0.496
CLV_PCSK_PC7_1	97	103	PF00082	0.577
CLV_PCSK_SKI1_1	188	192	PF00082	0.489
CLV_PCSK_SKI1_1	225	229	PF00082	0.509
CLV_PCSK_SKI1_1	26	30	PF00082	0.534
CLV_PCSK_SKI1_1	280	284	PF00082	0.586
CLV_PCSK_SKI1_1	600	604	PF00082	0.408
CLV_PCSK_SKI1_1	635	639	PF00082	0.380
CLV_PCSK_SKI1_1	66	70	PF00082	0.573
DEG_APCC_DBOX_1	109	117	PF00400	0.376
DEG_Nend_Nbox_1	1	3	PF02207	0.659
DOC_CKS1_1	67	72	PF01111	0.558
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.429
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	480	486	PF00134	0.509
DOC_CYCLIN_yCln2_LP_2	613	619	PF00134	0.425
DOC_MAPK_gen_1	163	169	PF00069	0.309
DOC_MAPK_gen_1	405	412	PF00069	0.415
DOC_MAPK_MEF2A_6	382	390	PF00069	0.537
DOC_MAPK_MEF2A_6	518	525	PF00069	0.416
DOC_MAPK_MEF2A_6	635	644	PF00069	0.284
DOC_MAPK_MEF2A_6	66	75	PF00069	0.423
DOC_PP1_RVXF_1	236	243	PF00149	0.309
DOC_PP1_RVXF_1	486	493	PF00149	0.557
DOC_PP1_RVXF_1	633	639	PF00149	0.512
DOC_PP1_RVXF_1	92	99	PF00149	0.575
DOC_PP2B_LxvP_1	343	346	PF13499	0.477
DOC_PP4_FxxP_1	354	357	PF00568	0.598
DOC_PP4_FxxP_1	79	82	PF00568	0.531
DOC_USP7_MATH_1	19	23	PF00917	0.545
DOC_USP7_MATH_1	499	503	PF00917	0.509
DOC_WW_Pin1_4	1	6	PF00397	0.650
DOC_WW_Pin1_4	247	252	PF00397	0.554
DOC_WW_Pin1_4	35	40	PF00397	0.558
DOC_WW_Pin1_4	361	366	PF00397	0.574
DOC_WW_Pin1_4	392	397	PF00397	0.493
DOC_WW_Pin1_4	428	433	PF00397	0.580
DOC_WW_Pin1_4	559	564	PF00397	0.544
DOC_WW_Pin1_4	66	71	PF00397	0.568
LIG_14-3-3_CanoR_1	110	114	PF00244	0.376
LIG_14-3-3_CanoR_1	188	196	PF00244	0.289
LIG_14-3-3_CanoR_1	238	243	PF00244	0.309
LIG_14-3-3_CanoR_1	30	36	PF00244	0.510
LIG_14-3-3_CanoR_1	334	342	PF00244	0.490
LIG_14-3-3_CanoR_1	488	493	PF00244	0.623
LIG_Actin_WH2_2	172	190	PF00022	0.274
LIG_AP2alpha_1	242	246	PF02296	0.309
LIG_BRCT_BRCA1_1	223	227	PF00533	0.309
LIG_Clathr_ClatBox_1	398	402	PF01394	0.461
LIG_deltaCOP1_diTrp_1	611	618	PF00928	0.408
LIG_DLG_GKlike_1	238	245	PF00625	0.309
LIG_FHA_1	509	515	PF00498	0.606
LIG_FHA_2	189	195	PF00498	0.289
LIG_FHA_2	301	307	PF00498	0.618
LIG_FHA_2	582	588	PF00498	0.495
LIG_HCF-1_HBM_1	571	574	PF13415	0.530
LIG_LIR_Apic_2	200	206	PF02991	0.300
LIG_LIR_Apic_2	351	357	PF02991	0.536
LIG_LIR_Apic_2	545	550	PF02991	0.443
LIG_LIR_Apic_2	78	82	PF02991	0.404
LIG_LIR_Gen_1	105	113	PF02991	0.385
LIG_LIR_Gen_1	224	235	PF02991	0.389
LIG_LIR_Gen_1	241	251	PF02991	0.268
LIG_LIR_Gen_1	25	36	PF02991	0.546
LIG_LIR_Gen_1	434	444	PF02991	0.504
LIG_LIR_Gen_1	45	56	PF02991	0.350
LIG_LIR_Gen_1	462	471	PF02991	0.540
LIG_LIR_Gen_1	571	581	PF02991	0.488
LIG_LIR_Gen_1	589	599	PF02991	0.431
LIG_LIR_Gen_1	74	85	PF02991	0.405
LIG_LIR_Nem_3	105	109	PF02991	0.313
LIG_LIR_Nem_3	181	187	PF02991	0.312
LIG_LIR_Nem_3	224	230	PF02991	0.309
LIG_LIR_Nem_3	241	246	PF02991	0.309
LIG_LIR_Nem_3	25	31	PF02991	0.616
LIG_LIR_Nem_3	371	377	PF02991	0.511
LIG_LIR_Nem_3	402	407	PF02991	0.435
LIG_LIR_Nem_3	409	415	PF02991	0.458
LIG_LIR_Nem_3	434	439	PF02991	0.524
LIG_LIR_Nem_3	45	51	PF02991	0.355
LIG_LIR_Nem_3	462	467	PF02991	0.548
LIG_LIR_Nem_3	502	507	PF02991	0.506
LIG_LIR_Nem_3	524	530	PF02991	0.537
LIG_LIR_Nem_3	570	576	PF02991	0.486
LIG_LIR_Nem_3	589	595	PF02991	0.456
LIG_LIR_Nem_3	74	80	PF02991	0.391
LIG_MLH1_MIPbox_1	223	227	PF16413	0.309
LIG_PCNA_PIPBox_1	444	453	PF02747	0.534
LIG_Pex14_2	242	246	PF04695	0.269
LIG_SH2_CRK	404	408	PF00017	0.423
LIG_SH2_CRK	574	578	PF00017	0.531
LIG_SH2_CRK	77	81	PF00017	0.396
LIG_SH2_NCK_1	14	18	PF00017	0.691
LIG_SH2_NCK_1	430	434	PF00017	0.520
LIG_SH2_NCK_1	547	551	PF00017	0.538
LIG_SH2_SRC	392	395	PF00017	0.457
LIG_SH2_SRC	547	550	PF00017	0.548
LIG_SH2_STAP1	423	427	PF00017	0.496
LIG_SH2_STAP1	48	52	PF00017	0.574
LIG_SH2_STAP1	508	512	PF00017	0.588
LIG_SH2_STAP1	574	578	PF00017	0.531
LIG_SH2_STAP1	610	614	PF00017	0.380
LIG_SH2_STAT5	166	169	PF00017	0.309
LIG_SH2_STAT5	229	232	PF00017	0.286
LIG_SH2_STAT5	35	38	PF00017	0.550
LIG_SH2_STAT5	377	380	PF00017	0.490
LIG_SH2_STAT5	77	80	PF00017	0.398
LIG_SH3_2	248	253	PF14604	0.556
LIG_SH3_3	245	251	PF00018	0.429
LIG_SH3_3	33	39	PF00018	0.559
LIG_SH3_3	383	389	PF00018	0.390
LIG_SH3_3	426	432	PF00018	0.534
LIG_SH3_3	64	70	PF00018	0.466
LIG_SH3_3	647	653	PF00018	0.547
LIG_SH3_3	79	85	PF00018	0.418
LIG_SUMO_SIM_anti_2	339	347	PF11976	0.453
LIG_SUMO_SIM_par_1	339	347	PF11976	0.472
LIG_SUMO_SIM_par_1	397	402	PF11976	0.461
LIG_TRAF2_1	197	200	PF00917	0.274
LIG_TRAF2_1	313	316	PF00917	0.502
LIG_TYR_ITIM	525	530	PF00017	0.570
LIG_TYR_ITIM	608	613	PF00017	0.429
LIG_TYR_ITIM	75	80	PF00017	0.393
LIG_UBA3_1	591	600	PF00899	0.522
LIG_WRC_WIRS_1	76	81	PF05994	0.522
MOD_CDC14_SPxK_1	250	253	PF00782	0.557
MOD_CDK_SPK_2	361	366	PF00069	0.562
MOD_CDK_SPxK_1	247	253	PF00069	0.553
MOD_CK1_1	112	118	PF00069	0.381
MOD_CK1_1	15	21	PF00069	0.636
MOD_CK1_1	262	268	PF00069	0.585
MOD_CK1_1	272	278	PF00069	0.623
MOD_CK1_1	336	342	PF00069	0.505
MOD_CK1_1	347	353	PF00069	0.577
MOD_CK1_1	495	501	PF00069	0.525
MOD_CK2_1	112	118	PF00069	0.465
MOD_CK2_1	19	25	PF00069	0.615
MOD_CK2_1	194	200	PF00069	0.309
MOD_CK2_1	288	294	PF00069	0.483
MOD_CK2_1	300	306	PF00069	0.650
MOD_CK2_1	35	41	PF00069	0.524
MOD_DYRK1A_RPxSP_1	247	251	PF00069	0.553
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.573
MOD_GlcNHglycan	122	125	PF01048	0.483
MOD_GlcNHglycan	196	199	PF01048	0.615
MOD_GlcNHglycan	21	24	PF01048	0.553
MOD_GlcNHglycan	214	217	PF01048	0.411
MOD_GlcNHglycan	326	329	PF01048	0.516
MOD_GlcNHglycan	44	47	PF01048	0.604
MOD_GlcNHglycan	494	497	PF01048	0.547
MOD_GlcNHglycan	62	65	PF01048	0.405
MOD_GSK3_1	15	22	PF00069	0.631
MOD_GSK3_1	262	269	PF00069	0.590
MOD_GSK3_1	31	38	PF00069	0.546
MOD_GSK3_1	332	339	PF00069	0.515
MOD_GSK3_1	344	351	PF00069	0.669
MOD_GSK3_1	488	495	PF00069	0.563
MOD_GSK3_1	62	69	PF00069	0.610
MOD_N-GLC_1	147	152	PF02516	0.490
MOD_N-GLC_1	259	264	PF02516	0.581
MOD_N-GLC_1	275	280	PF02516	0.544
MOD_N-GLC_1	416	421	PF02516	0.417
MOD_N-GLC_1	54	59	PF02516	0.445
MOD_N-GLC_1	629	634	PF02516	0.551
MOD_NEK2_1	109	114	PF00069	0.375
MOD_NEK2_1	413	418	PF00069	0.489
MOD_NEK2_1	451	456	PF00069	0.525
MOD_NEK2_1	581	586	PF00069	0.576
MOD_NEK2_1	640	645	PF00069	0.274
MOD_NEK2_2	377	382	PF00069	0.406
MOD_NEK2_2	499	504	PF00069	0.524
MOD_PKA_1	488	494	PF00069	0.548
MOD_PKA_2	109	115	PF00069	0.374
MOD_PKA_2	262	268	PF00069	0.639
MOD_PKA_2	333	339	PF00069	0.484
MOD_PKA_2	467	473	PF00069	0.614
MOD_PKA_2	488	494	PF00069	0.555
MOD_Plk_1	499	505	PF00069	0.508
MOD_Plk_1	508	514	PF00069	0.546
MOD_Plk_1	54	60	PF00069	0.446
MOD_Plk_1	586	592	PF00069	0.517
MOD_Plk_4	157	163	PF00069	0.508
MOD_Plk_4	238	244	PF00069	0.309
MOD_Plk_4	31	37	PF00069	0.679
MOD_Plk_4	451	457	PF00069	0.498
MOD_Plk_4	470	476	PF00069	0.457
MOD_Plk_4	499	505	PF00069	0.661
MOD_Plk_4	54	60	PF00069	0.460
MOD_Plk_4	572	578	PF00069	0.532
MOD_Plk_4	586	592	PF00069	0.519
MOD_Plk_4	75	81	PF00069	0.392
MOD_ProDKin_1	1	7	PF00069	0.651
MOD_ProDKin_1	247	253	PF00069	0.553
MOD_ProDKin_1	35	41	PF00069	0.564
MOD_ProDKin_1	361	367	PF00069	0.568
MOD_ProDKin_1	392	398	PF00069	0.485
MOD_ProDKin_1	428	434	PF00069	0.580
MOD_ProDKin_1	559	565	PF00069	0.539
MOD_ProDKin_1	66	72	PF00069	0.565
MOD_SUMO_for_1	298	301	PF00179	0.645
MOD_SUMO_for_1	608	611	PF00179	0.355
MOD_SUMO_rev_2	593	602	PF00179	0.387
TRG_DiLeu_BaEn_1	340	345	PF01217	0.554
TRG_DiLeu_BaEn_1	598	603	PF01217	0.364
TRG_ENDOCYTIC_2	166	169	PF00928	0.309
TRG_ENDOCYTIC_2	375	378	PF00928	0.512
TRG_ENDOCYTIC_2	404	407	PF00928	0.533
TRG_ENDOCYTIC_2	430	433	PF00928	0.561
TRG_ENDOCYTIC_2	436	439	PF00928	0.565
TRG_ENDOCYTIC_2	47	50	PF00928	0.499
TRG_ENDOCYTIC_2	527	530	PF00928	0.543
TRG_ENDOCYTIC_2	573	576	PF00928	0.473
TRG_ENDOCYTIC_2	578	581	PF00928	0.489
TRG_ENDOCYTIC_2	610	613	PF00928	0.446
TRG_ENDOCYTIC_2	77	80	PF00928	0.398
TRG_ER_diArg_1	101	103	PF00400	0.457
TRG_ER_diArg_1	137	139	PF00400	0.470
TRG_ER_diArg_1	162	164	PF00400	0.309
TRG_ER_diArg_1	252	255	PF00400	0.601
TRG_ER_diArg_1	311	314	PF00400	0.559
TRG_ER_diArg_1	404	406	PF00400	0.418
TRG_ER_diArg_1	488	490	PF00400	0.540
TRG_ER_diArg_1	87	89	PF00400	0.481
TRG_ER_FFAT_1	291	301	PF00635	0.483
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYV0	Leptomonas seymouri	64%	87%
A0A3Q8ICL5	Leishmania donovani	92%	100%
A0A3Q8ICR3	Leishmania donovani	63%	83%
A0A3S7WXU9	Leishmania donovani	92%	100%
A4HCY1	Leishmania braziliensis	44%	95%
A4I0G4	Leishmania infantum	47%	94%
A4I0G5	Leishmania infantum	92%	100%
E9AWC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	98%
Q4QB44	Leishmania major	87%	100%
Q4QB45	Leishmania major	62%	94%