Stealth_CR2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AWC7_LEIMU

TriTrypDb:

LmxM.23.1110

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AWC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWC7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.419
CLV_C14_Caspase3-7	645	649	PF00656	0.555
CLV_NRD_NRD_1	101	103	PF00675	0.511
CLV_NRD_NRD_1	138	140	PF00675	0.543
CLV_NRD_NRD_1	163	165	PF00675	0.551
CLV_NRD_NRD_1	323	325	PF00675	0.394
CLV_NRD_NRD_1	406	408	PF00675	0.616
CLV_NRD_NRD_1	430	432	PF00675	0.516
CLV_NRD_NRD_1	457	459	PF00675	0.596
CLV_NRD_NRD_1	463	465	PF00675	0.764
CLV_NRD_NRD_1	569	571	PF00675	0.511
CLV_NRD_NRD_1	632	634	PF00675	0.550
CLV_NRD_NRD_1	88	90	PF00675	0.553
CLV_PCSK_FUR_1	461	465	PF00082	0.634
CLV_PCSK_KEX2_1	101	103	PF00082	0.515
CLV_PCSK_KEX2_1	138	140	PF00082	0.543
CLV_PCSK_KEX2_1	163	165	PF00082	0.551
CLV_PCSK_KEX2_1	280	282	PF00082	0.448
CLV_PCSK_KEX2_1	323	325	PF00082	0.394
CLV_PCSK_KEX2_1	406	408	PF00082	0.549
CLV_PCSK_KEX2_1	430	432	PF00082	0.516
CLV_PCSK_KEX2_1	461	463	PF00082	0.779
CLV_PCSK_KEX2_1	571	573	PF00082	0.502
CLV_PCSK_KEX2_1	632	634	PF00082	0.550
CLV_PCSK_KEX2_1	88	90	PF00082	0.553
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.481
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.502
CLV_PCSK_PC7_1	458	464	PF00082	0.563
CLV_PCSK_PC7_1	97	103	PF00082	0.571
CLV_PCSK_SKI1_1	188	192	PF00082	0.532
CLV_PCSK_SKI1_1	225	229	PF00082	0.551
CLV_PCSK_SKI1_1	253	257	PF00082	0.554
CLV_PCSK_SKI1_1	26	30	PF00082	0.573
CLV_PCSK_SKI1_1	384	388	PF00082	0.500
CLV_PCSK_SKI1_1	453	457	PF00082	0.503
CLV_PCSK_SKI1_1	547	551	PF00082	0.639
CLV_PCSK_SKI1_1	66	70	PF00082	0.564
CLV_Separin_Metazoa	385	389	PF03568	0.237
DEG_APCC_DBOX_1	109	117	PF00400	0.471
DEG_APCC_DBOX_1	300	308	PF00400	0.536
DEG_APCC_DBOX_1	383	391	PF00400	0.268
DEG_APCC_DBOX_1	406	414	PF00400	0.268
DEG_Kelch_Keap1_1	621	626	PF01344	0.489
DEG_Nend_Nbox_1	1	3	PF02207	0.561
DOC_CKS1_1	67	72	PF01111	0.550
DOC_CYCLIN_RxL_1	541	554	PF00134	0.629
DOC_CYCLIN_RxL_1	673	682	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.446
DOC_MAPK_gen_1	163	169	PF00069	0.351
DOC_MAPK_gen_1	280	286	PF00069	0.562
DOC_MAPK_MEF2A_6	579	587	PF00069	0.626
DOC_MAPK_MEF2A_6	632	641	PF00069	0.524
DOC_MAPK_MEF2A_6	66	75	PF00069	0.478
DOC_MAPK_RevD_3	309	324	PF00069	0.384
DOC_PP1_RVXF_1	236	243	PF00149	0.351
DOC_PP1_RVXF_1	674	680	PF00149	0.618
DOC_PP1_RVXF_1	92	99	PF00149	0.568
DOC_PP2B_LxvP_1	249	252	PF13499	0.587
DOC_PP4_FxxP_1	343	346	PF00568	0.622
DOC_PP4_FxxP_1	79	82	PF00568	0.535
DOC_SPAK_OSR1_1	599	603	PF12202	0.509
DOC_USP7_MATH_1	19	23	PF00917	0.607
DOC_USP7_MATH_1	513	517	PF00917	0.579
DOC_USP7_MATH_1	520	524	PF00917	0.543
DOC_USP7_MATH_2	472	478	PF00917	0.639
DOC_WW_Pin1_4	1	6	PF00397	0.629
DOC_WW_Pin1_4	247	252	PF00397	0.577
DOC_WW_Pin1_4	35	40	PF00397	0.626
DOC_WW_Pin1_4	414	419	PF00397	0.351
DOC_WW_Pin1_4	505	510	PF00397	0.726
DOC_WW_Pin1_4	66	71	PF00397	0.560
LIG_14-3-3_CanoR_1	110	114	PF00244	0.443
LIG_14-3-3_CanoR_1	188	196	PF00244	0.332
LIG_14-3-3_CanoR_1	238	243	PF00244	0.351
LIG_14-3-3_CanoR_1	30	36	PF00244	0.550
LIG_14-3-3_CanoR_1	430	438	PF00244	0.546
LIG_14-3-3_CanoR_1	444	450	PF00244	0.422
LIG_14-3-3_CanoR_1	453	460	PF00244	0.488
LIG_14-3-3_CanoR_1	462	472	PF00244	0.575
LIG_14-3-3_CanoR_1	481	491	PF00244	0.547
LIG_14-3-3_CanoR_1	579	584	PF00244	0.583
LIG_14-3-3_CanoR_1	632	637	PF00244	0.619
LIG_Actin_WH2_2	172	190	PF00022	0.315
LIG_AP2alpha_1	242	246	PF02296	0.351
LIG_BIR_III_2	265	269	PF00653	0.477
LIG_BRCT_BRCA1_1	223	227	PF00533	0.351
LIG_CaM_IQ_9	436	452	PF13499	0.504
LIG_Clathr_ClatBox_2	688	693	PF01394	0.546
LIG_DLG_GKlike_1	238	245	PF00625	0.351
LIG_FHA_1	432	438	PF00498	0.557
LIG_FHA_1	477	483	PF00498	0.556
LIG_FHA_1	502	508	PF00498	0.630
LIG_FHA_1	656	662	PF00498	0.563
LIG_FHA_2	189	195	PF00498	0.332
LIG_FHA_2	387	393	PF00498	0.268
LIG_FHA_2	399	405	PF00498	0.221
LIG_FHA_2	640	646	PF00498	0.610
LIG_LIR_Apic_2	200	206	PF02991	0.343
LIG_LIR_Apic_2	292	298	PF02991	0.529
LIG_LIR_Apic_2	682	686	PF02991	0.496
LIG_LIR_Apic_2	691	696	PF02991	0.536
LIG_LIR_Apic_2	78	82	PF02991	0.467
LIG_LIR_Gen_1	105	113	PF02991	0.482
LIG_LIR_Gen_1	224	235	PF02991	0.319
LIG_LIR_Gen_1	241	251	PF02991	0.298
LIG_LIR_Gen_1	25	36	PF02991	0.588
LIG_LIR_Gen_1	372	382	PF02991	0.343
LIG_LIR_Gen_1	45	56	PF02991	0.337
LIG_LIR_Gen_1	604	613	PF02991	0.590
LIG_LIR_Gen_1	74	85	PF02991	0.468
LIG_LIR_Nem_3	105	109	PF02991	0.403
LIG_LIR_Nem_3	181	187	PF02991	0.312
LIG_LIR_Nem_3	224	230	PF02991	0.311
LIG_LIR_Nem_3	241	246	PF02991	0.300
LIG_LIR_Nem_3	25	31	PF02991	0.640
LIG_LIR_Nem_3	45	51	PF02991	0.348
LIG_LIR_Nem_3	562	566	PF02991	0.792
LIG_LIR_Nem_3	595	601	PF02991	0.732
LIG_LIR_Nem_3	604	609	PF02991	0.567
LIG_LIR_Nem_3	74	80	PF02991	0.454
LIG_MLH1_MIPbox_1	223	227	PF16413	0.351
LIG_PDZ_Class_2	692	697	PF00595	0.572
LIG_Pex14_1	679	683	PF04695	0.456
LIG_Pex14_2	226	230	PF04695	0.318
LIG_Pex14_2	242	246	PF04695	0.298
LIG_Pex14_2	286	290	PF04695	0.484
LIG_SH2_CRK	77	81	PF00017	0.461
LIG_SH2_GRB2like	229	232	PF00017	0.331
LIG_SH2_NCK_1	14	18	PF00017	0.697
LIG_SH2_NCK_1	563	567	PF00017	0.501
LIG_SH2_PTP2	295	298	PF00017	0.545
LIG_SH2_SRC	295	298	PF00017	0.502
LIG_SH2_STAP1	422	426	PF00017	0.286
LIG_SH2_STAP1	48	52	PF00017	0.560
LIG_SH2_STAT3	360	363	PF00017	0.511
LIG_SH2_STAT5	166	169	PF00017	0.351
LIG_SH2_STAT5	229	232	PF00017	0.320
LIG_SH2_STAT5	295	298	PF00017	0.589
LIG_SH2_STAT5	35	38	PF00017	0.620
LIG_SH2_STAT5	361	364	PF00017	0.537
LIG_SH2_STAT5	409	412	PF00017	0.300
LIG_SH2_STAT5	683	686	PF00017	0.433
LIG_SH2_STAT5	77	80	PF00017	0.462
LIG_SH3_1	683	689	PF00018	0.482
LIG_SH3_2	248	253	PF14604	0.585
LIG_SH3_3	245	251	PF00018	0.446
LIG_SH3_3	293	299	PF00018	0.579
LIG_SH3_3	33	39	PF00018	0.595
LIG_SH3_3	466	472	PF00018	0.614
LIG_SH3_3	503	509	PF00018	0.561
LIG_SH3_3	64	70	PF00018	0.520
LIG_SH3_3	683	689	PF00018	0.690
LIG_SH3_3	79	85	PF00018	0.481
LIG_TRAF2_1	197	200	PF00917	0.315
LIG_TYR_ITIM	561	566	PF00017	0.544
LIG_TYR_ITIM	75	80	PF00017	0.456
LIG_WRC_WIRS_1	422	427	PF05994	0.268
LIG_WRC_WIRS_1	76	81	PF05994	0.525
LIG_WW_3	250	254	PF00397	0.575
MOD_CDC14_SPxK_1	250	253	PF00782	0.603
MOD_CDK_SPxK_1	247	253	PF00069	0.580
MOD_CK1_1	112	118	PF00069	0.426
MOD_CK1_1	15	21	PF00069	0.711
MOD_CK1_1	300	306	PF00069	0.704
MOD_CK1_1	500	506	PF00069	0.556
MOD_CK1_1	523	529	PF00069	0.581
MOD_CK1_1	551	557	PF00069	0.627
MOD_CK1_1	621	627	PF00069	0.556
MOD_CK2_1	112	118	PF00069	0.503
MOD_CK2_1	19	25	PF00069	0.618
MOD_CK2_1	194	200	PF00069	0.343
MOD_CK2_1	35	41	PF00069	0.530
MOD_CK2_1	398	404	PF00069	0.268
MOD_CK2_1	505	511	PF00069	0.530
MOD_CK2_1	611	617	PF00069	0.525
MOD_CMANNOS	690	693	PF00535	0.556
MOD_DYRK1A_RPxSP_1	247	251	PF00069	0.565
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.564
MOD_GlcNHglycan	122	125	PF01048	0.487
MOD_GlcNHglycan	196	199	PF01048	0.617
MOD_GlcNHglycan	21	24	PF01048	0.617
MOD_GlcNHglycan	214	217	PF01048	0.551
MOD_GlcNHglycan	44	47	PF01048	0.649
MOD_GlcNHglycan	531	534	PF01048	0.695
MOD_GlcNHglycan	555	558	PF01048	0.667
MOD_GlcNHglycan	566	569	PF01048	0.573
MOD_GlcNHglycan	617	621	PF01048	0.567
MOD_GlcNHglycan	62	65	PF01048	0.442
MOD_GSK3_1	15	22	PF00069	0.715
MOD_GSK3_1	270	277	PF00069	0.650
MOD_GSK3_1	285	292	PF00069	0.481
MOD_GSK3_1	31	38	PF00069	0.535
MOD_GSK3_1	497	504	PF00069	0.569
MOD_GSK3_1	505	512	PF00069	0.583
MOD_GSK3_1	520	527	PF00069	0.590
MOD_GSK3_1	571	578	PF00069	0.632
MOD_GSK3_1	62	69	PF00069	0.606
MOD_GSK3_1	621	628	PF00069	0.497
MOD_LATS_1	451	457	PF00433	0.499
MOD_N-GLC_1	147	152	PF02516	0.551
MOD_N-GLC_1	414	419	PF02516	0.581
MOD_N-GLC_1	54	59	PF02516	0.482
MOD_N-GLC_1	621	626	PF02516	0.526
MOD_N-GLC_1	664	669	PF02516	0.600
MOD_NEK2_1	109	114	PF00069	0.415
MOD_NEK2_1	285	290	PF00069	0.543
MOD_NEK2_1	398	403	PF00069	0.345
MOD_NEK2_1	616	621	PF00069	0.511
MOD_NEK2_1	639	644	PF00069	0.604
MOD_NEK2_1	656	661	PF00069	0.478
MOD_NEK2_2	445	450	PF00069	0.521
MOD_NEK2_2	476	481	PF00069	0.693
MOD_PIKK_1	270	276	PF00454	0.490
MOD_PIKK_1	474	480	PF00454	0.636
MOD_PIKK_1	540	546	PF00454	0.636
MOD_PK_1	571	577	PF00069	0.494
MOD_PKA_1	463	469	PF00069	0.776
MOD_PKA_1	571	577	PF00069	0.494
MOD_PKA_1	632	638	PF00069	0.534
MOD_PKA_2	109	115	PF00069	0.470
MOD_PKA_2	300	306	PF00069	0.543
MOD_PKA_2	463	469	PF00069	0.788
MOD_PKA_2	520	526	PF00069	0.673
MOD_PKA_2	571	577	PF00069	0.582
MOD_PKA_2	632	638	PF00069	0.622
MOD_PKB_1	461	469	PF00069	0.600
MOD_Plk_1	330	336	PF00069	0.472
MOD_Plk_1	54	60	PF00069	0.482
MOD_Plk_1	575	581	PF00069	0.622
MOD_Plk_1	594	600	PF00069	0.642
MOD_Plk_1	664	670	PF00069	0.551
MOD_Plk_4	157	163	PF00069	0.508
MOD_Plk_4	238	244	PF00069	0.351
MOD_Plk_4	285	291	PF00069	0.620
MOD_Plk_4	31	37	PF00069	0.663
MOD_Plk_4	54	60	PF00069	0.496
MOD_Plk_4	579	585	PF00069	0.699
MOD_Plk_4	679	685	PF00069	0.459
MOD_Plk_4	75	81	PF00069	0.456
MOD_ProDKin_1	1	7	PF00069	0.638
MOD_ProDKin_1	247	253	PF00069	0.580
MOD_ProDKin_1	35	41	PF00069	0.630
MOD_ProDKin_1	414	420	PF00069	0.351
MOD_ProDKin_1	505	511	PF00069	0.729
MOD_ProDKin_1	66	72	PF00069	0.558
MOD_SUMO_rev_2	277	282	PF00179	0.536
MOD_SUMO_rev_2	493	499	PF00179	0.557
TRG_DiLeu_BaEn_3	364	370	PF01217	0.495
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.482
TRG_DiLeu_BaLyEn_6	673	678	PF01217	0.619
TRG_ENDOCYTIC_2	166	169	PF00928	0.351
TRG_ENDOCYTIC_2	375	378	PF00928	0.354
TRG_ENDOCYTIC_2	422	425	PF00928	0.362
TRG_ENDOCYTIC_2	47	50	PF00928	0.552
TRG_ENDOCYTIC_2	563	566	PF00928	0.548
TRG_ENDOCYTIC_2	77	80	PF00928	0.462
TRG_ER_diArg_1	101	103	PF00400	0.518
TRG_ER_diArg_1	137	139	PF00400	0.516
TRG_ER_diArg_1	162	164	PF00400	0.351
TRG_ER_diArg_1	323	325	PF00400	0.578
TRG_ER_diArg_1	405	407	PF00400	0.409
TRG_ER_diArg_1	429	431	PF00400	0.496
TRG_ER_diArg_1	460	463	PF00400	0.775
TRG_ER_diArg_1	87	89	PF00400	0.539
TRG_NES_CRM1_1	581	595	PF08389	0.560
TRG_NLS_MonoExtC_3	457	462	PF00514	0.544
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	547	552	PF00026	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYV0	Leptomonas seymouri	39%	92%
A0A3Q8ICL5	Leishmania donovani	48%	100%
A0A3Q8ICR3	Leishmania donovani	91%	88%
A0A3S7WXU9	Leishmania donovani	48%	100%
A4HCY1	Leishmania braziliensis	77%	99%
A4I0G4	Leishmania infantum	91%	100%
A4I0G5	Leishmania infantum	48%	100%
E9AWC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
Q4QB44	Leishmania major	63%	100%
Q4QB45	Leishmania major	87%	100%