LeishMANIAdb
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Probable methyltransferase BMT2 homolog

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Probable methyltransferase BMT2 homolog
Gene product:
Probable methyltransferase BTM2 homolog
Species:
Leishmania mexicana
UniProt:
E9AWC5_LEIMU
TriTrypDb:
LmxM.23.1090
Length:
672

Annotations

LeishMANIAdb annotations

Homologous to S-adenosylmethionine sensor upstream of mTORC1. Does not appear to be membrane-associated.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWC5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWC5

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 10
GO:0032259 methylation 2 10
GO:0009966 regulation of signal transduction 4 1
GO:0009968 negative regulation of signal transduction 5 1
GO:0010646 regulation of cell communication 4 1
GO:0010648 negative regulation of cell communication 5 1
GO:0023051 regulation of signaling 3 1
GO:0023057 negative regulation of signaling 4 1
GO:0032006 regulation of TOR signaling 6 1
GO:0032007 negative regulation of TOR signaling 7 1
GO:0048519 negative regulation of biological process 3 1
GO:0048523 negative regulation of cellular process 4 1
GO:0048583 regulation of response to stimulus 3 1
GO:0048585 negative regulation of response to stimulus 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:1902531 regulation of intracellular signal transduction 5 1
GO:1902532 negative regulation of intracellular signal transduction 6 1
GO:1903432 regulation of TORC1 signaling 7 1
GO:1904262 negative regulation of TORC1 signaling 8 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0008168 methyltransferase activity 4 10
GO:0016740 transferase activity 2 11
GO:0016741 transferase activity, transferring one-carbon groups 3 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 180 184 PF00656 0.565
CLV_C14_Caspase3-7 338 342 PF00656 0.538
CLV_C14_Caspase3-7 506 510 PF00656 0.569
CLV_C14_Caspase3-7 520 524 PF00656 0.539
CLV_NRD_NRD_1 103 105 PF00675 0.532
CLV_NRD_NRD_1 290 292 PF00675 0.533
CLV_NRD_NRD_1 373 375 PF00675 0.691
CLV_NRD_NRD_1 591 593 PF00675 0.406
CLV_NRD_NRD_1 633 635 PF00675 0.456
CLV_PCSK_KEX2_1 103 105 PF00082 0.532
CLV_PCSK_KEX2_1 174 176 PF00082 0.826
CLV_PCSK_KEX2_1 290 292 PF00082 0.535
CLV_PCSK_KEX2_1 373 375 PF00082 0.691
CLV_PCSK_KEX2_1 590 592 PF00082 0.425
CLV_PCSK_KEX2_1 633 635 PF00082 0.459
CLV_PCSK_PC1ET2_1 174 176 PF00082 0.826
CLV_PCSK_PC7_1 170 176 PF00082 0.770
CLV_PCSK_SKI1_1 104 108 PF00082 0.617
CLV_PCSK_SKI1_1 135 139 PF00082 0.561
CLV_PCSK_SKI1_1 284 288 PF00082 0.545
CLV_PCSK_SKI1_1 290 294 PF00082 0.535
CLV_PCSK_SKI1_1 299 303 PF00082 0.410
DEG_ODPH_VHL_1 323 336 PF01847 0.348
DEG_ODPH_VHL_1 425 437 PF01847 0.451
DEG_SPOP_SBC_1 258 262 PF00917 0.404
DOC_CKS1_1 312 317 PF01111 0.434
DOC_CKS1_1 556 561 PF01111 0.376
DOC_MAPK_DCC_7 421 430 PF00069 0.444
DOC_MAPK_gen_1 284 294 PF00069 0.419
DOC_MAPK_MEF2A_6 574 582 PF00069 0.335
DOC_PP1_RVXF_1 288 295 PF00149 0.435
DOC_PP1_RVXF_1 558 564 PF00149 0.396
DOC_USP7_MATH_1 161 165 PF00917 0.502
DOC_USP7_MATH_1 188 192 PF00917 0.397
DOC_USP7_MATH_1 257 261 PF00917 0.482
DOC_USP7_MATH_1 317 321 PF00917 0.464
DOC_USP7_MATH_1 325 329 PF00917 0.507
DOC_USP7_MATH_1 34 38 PF00917 0.600
DOC_USP7_MATH_1 479 483 PF00917 0.418
DOC_USP7_MATH_1 485 489 PF00917 0.509
DOC_USP7_MATH_1 503 507 PF00917 0.492
DOC_USP7_MATH_1 518 522 PF00917 0.537
DOC_USP7_MATH_1 530 534 PF00917 0.457
DOC_USP7_MATH_1 86 90 PF00917 0.357
DOC_WW_Pin1_4 25 30 PF00397 0.608
DOC_WW_Pin1_4 259 264 PF00397 0.493
DOC_WW_Pin1_4 311 316 PF00397 0.420
DOC_WW_Pin1_4 391 396 PF00397 0.540
DOC_WW_Pin1_4 452 457 PF00397 0.478
DOC_WW_Pin1_4 499 504 PF00397 0.401
DOC_WW_Pin1_4 555 560 PF00397 0.380
DOC_WW_Pin1_4 624 629 PF00397 0.616
LIG_14-3-3_CanoR_1 103 107 PF00244 0.462
LIG_14-3-3_CanoR_1 114 122 PF00244 0.440
LIG_14-3-3_CanoR_1 175 185 PF00244 0.557
LIG_14-3-3_CanoR_1 212 220 PF00244 0.411
LIG_14-3-3_CanoR_1 299 306 PF00244 0.348
LIG_14-3-3_CanoR_1 592 602 PF00244 0.583
LIG_14-3-3_CanoR_1 633 637 PF00244 0.649
LIG_APCC_ABBA_1 266 271 PF00400 0.311
LIG_BIR_II_1 1 5 PF00653 0.563
LIG_BRCT_BRCA1_1 603 607 PF00533 0.622
LIG_deltaCOP1_diTrp_1 462 469 PF00928 0.327
LIG_FHA_1 201 207 PF00498 0.605
LIG_FHA_1 345 351 PF00498 0.417
LIG_FHA_1 402 408 PF00498 0.385
LIG_FHA_1 44 50 PF00498 0.502
LIG_FHA_1 556 562 PF00498 0.375
LIG_FHA_1 597 603 PF00498 0.624
LIG_FHA_2 13 19 PF00498 0.409
LIG_FHA_2 136 142 PF00498 0.488
LIG_FHA_2 300 306 PF00498 0.359
LIG_FHA_2 380 386 PF00498 0.324
LIG_FHA_2 431 437 PF00498 0.342
LIG_FHA_2 488 494 PF00498 0.414
LIG_FHA_2 660 666 PF00498 0.603
LIG_Integrin_RGD_1 460 462 PF01839 0.433
LIG_Integrin_RGDW_4 460 463 PF00362 0.426
LIG_LIR_Apic_2 127 132 PF02991 0.424
LIG_LIR_Gen_1 462 470 PF02991 0.329
LIG_LIR_Gen_1 542 552 PF02991 0.375
LIG_LIR_Gen_1 604 614 PF02991 0.608
LIG_LIR_Gen_1 622 630 PF02991 0.543
LIG_LIR_Gen_1 635 644 PF02991 0.554
LIG_LIR_Nem_3 273 278 PF02991 0.355
LIG_LIR_Nem_3 332 336 PF02991 0.360
LIG_LIR_Nem_3 409 414 PF02991 0.358
LIG_LIR_Nem_3 542 547 PF02991 0.296
LIG_LIR_Nem_3 604 610 PF02991 0.604
LIG_LIR_Nem_3 622 626 PF02991 0.523
LIG_LIR_Nem_3 635 639 PF02991 0.559
LIG_LYPXL_SIV_4 117 125 PF13949 0.458
LIG_REV1ctd_RIR_1 291 300 PF16727 0.427
LIG_REV1ctd_RIR_1 412 421 PF16727 0.396
LIG_SH2_CRK 544 548 PF00017 0.340
LIG_SH2_GRB2like 129 132 PF00017 0.506
LIG_SH2_NCK_1 544 548 PF00017 0.340
LIG_SH2_SRC 118 121 PF00017 0.455
LIG_SH2_STAP1 118 122 PF00017 0.364
LIG_SH2_STAP1 214 218 PF00017 0.426
LIG_SH2_STAP1 386 390 PF00017 0.344
LIG_SH2_STAP1 544 548 PF00017 0.340
LIG_SH2_STAT3 220 223 PF00017 0.405
LIG_SH2_STAT3 269 272 PF00017 0.264
LIG_SH2_STAT3 498 501 PF00017 0.495
LIG_SH2_STAT5 220 223 PF00017 0.371
LIG_SH2_STAT5 229 232 PF00017 0.309
LIG_SH2_STAT5 269 272 PF00017 0.343
LIG_SH2_STAT5 386 389 PF00017 0.493
LIG_SH2_STAT5 555 558 PF00017 0.334
LIG_SH3_1 421 427 PF00018 0.460
LIG_SH3_3 182 188 PF00018 0.560
LIG_SH3_3 23 29 PF00018 0.591
LIG_SH3_3 282 288 PF00018 0.408
LIG_SH3_3 309 315 PF00018 0.462
LIG_SH3_3 421 427 PF00018 0.460
LIG_SUMO_SIM_par_1 403 409 PF11976 0.303
LIG_SUMO_SIM_par_1 577 584 PF11976 0.335
LIG_SxIP_EBH_1 549 562 PF03271 0.346
LIG_TRAF2_1 490 493 PF00917 0.422
LIG_TRAF2_1 613 616 PF00917 0.625
LIG_TRAF2_1 94 97 PF00917 0.428
LIG_WW_1 92 95 PF00397 0.438
MOD_CDK_SPK_2 555 560 PF00069 0.380
MOD_CDK_SPxxK_3 555 562 PF00069 0.377
MOD_CK1_1 12 18 PF00069 0.443
MOD_CK1_1 164 170 PF00069 0.629
MOD_CK1_1 178 184 PF00069 0.540
MOD_CK1_1 224 230 PF00069 0.409
MOD_CK1_1 3 9 PF00069 0.493
MOD_CK1_1 30 36 PF00069 0.406
MOD_CK1_1 337 343 PF00069 0.508
MOD_CK1_1 502 508 PF00069 0.500
MOD_CK1_1 583 589 PF00069 0.571
MOD_CK1_1 596 602 PF00069 0.524
MOD_CK1_1 635 641 PF00069 0.577
MOD_CK1_1 648 654 PF00069 0.591
MOD_CK1_1 84 90 PF00069 0.547
MOD_CK2_1 12 18 PF00069 0.491
MOD_CK2_1 299 305 PF00069 0.350
MOD_CK2_1 343 349 PF00069 0.524
MOD_CK2_1 36 42 PF00069 0.581
MOD_CK2_1 487 493 PF00069 0.440
MOD_CK2_1 610 616 PF00069 0.588
MOD_CK2_1 91 97 PF00069 0.481
MOD_GlcNHglycan 11 14 PF01048 0.673
MOD_GlcNHglycan 115 118 PF01048 0.672
MOD_GlcNHglycan 2 5 PF01048 0.747
MOD_GlcNHglycan 32 35 PF01048 0.664
MOD_GlcNHglycan 341 345 PF01048 0.715
MOD_GlcNHglycan 36 39 PF01048 0.636
MOD_GlcNHglycan 396 399 PF01048 0.700
MOD_GlcNHglycan 447 450 PF01048 0.631
MOD_GlcNHglycan 487 490 PF01048 0.640
MOD_GlcNHglycan 513 516 PF01048 0.769
MOD_GlcNHglycan 523 527 PF01048 0.717
MOD_GlcNHglycan 628 631 PF01048 0.419
MOD_GlcNHglycan 652 655 PF01048 0.425
MOD_GlcNHglycan 70 73 PF01048 0.676
MOD_GlcNHglycan 88 91 PF01048 0.748
MOD_GSK3_1 12 19 PF00069 0.415
MOD_GSK3_1 135 142 PF00069 0.505
MOD_GSK3_1 194 201 PF00069 0.568
MOD_GSK3_1 212 219 PF00069 0.467
MOD_GSK3_1 30 37 PF00069 0.490
MOD_GSK3_1 313 320 PF00069 0.434
MOD_GSK3_1 335 342 PF00069 0.467
MOD_GSK3_1 375 382 PF00069 0.462
MOD_GSK3_1 38 45 PF00069 0.553
MOD_GSK3_1 481 488 PF00069 0.454
MOD_GSK3_1 499 506 PF00069 0.332
MOD_GSK3_1 518 525 PF00069 0.537
MOD_GSK3_1 530 537 PF00069 0.278
MOD_GSK3_1 551 558 PF00069 0.371
MOD_GSK3_1 645 652 PF00069 0.627
MOD_GSK3_1 68 75 PF00069 0.512
MOD_GSK3_1 76 83 PF00069 0.568
MOD_N-GLC_2 311 313 PF02516 0.457
MOD_NEK2_1 194 199 PF00069 0.551
MOD_NEK2_1 334 339 PF00069 0.472
MOD_NEK2_1 430 435 PF00069 0.298
MOD_NEK2_1 534 539 PF00069 0.419
MOD_NEK2_1 551 556 PF00069 0.207
MOD_NEK2_1 649 654 PF00069 0.627
MOD_NEK2_1 80 85 PF00069 0.511
MOD_PIKK_1 3 9 PF00454 0.493
MOD_PIKK_1 36 42 PF00454 0.527
MOD_PIKK_1 583 589 PF00454 0.571
MOD_PKA_2 102 108 PF00069 0.482
MOD_PKA_2 113 119 PF00069 0.347
MOD_PKA_2 176 182 PF00069 0.620
MOD_PKA_2 216 222 PF00069 0.412
MOD_PKA_2 632 638 PF00069 0.625
MOD_PKA_2 659 665 PF00069 0.644
MOD_Plk_1 194 200 PF00069 0.393
MOD_Plk_1 270 276 PF00069 0.398
MOD_Plk_1 367 373 PF00069 0.468
MOD_Plk_1 375 381 PF00069 0.447
MOD_Plk_4 124 130 PF00069 0.472
MOD_Plk_4 188 194 PF00069 0.600
MOD_Plk_4 224 230 PF00069 0.415
MOD_Plk_4 50 56 PF00069 0.488
MOD_Plk_4 551 557 PF00069 0.330
MOD_Plk_4 645 651 PF00069 0.604
MOD_ProDKin_1 25 31 PF00069 0.608
MOD_ProDKin_1 259 265 PF00069 0.489
MOD_ProDKin_1 311 317 PF00069 0.426
MOD_ProDKin_1 391 397 PF00069 0.536
MOD_ProDKin_1 452 458 PF00069 0.466
MOD_ProDKin_1 499 505 PF00069 0.405
MOD_ProDKin_1 555 561 PF00069 0.379
MOD_ProDKin_1 624 630 PF00069 0.620
MOD_SUMO_rev_2 94 101 PF00179 0.478
TRG_DiLeu_BaEn_1 305 310 PF01217 0.416
TRG_DiLeu_BaEn_1 575 580 PF01217 0.408
TRG_ENDOCYTIC_2 297 300 PF00928 0.387
TRG_ENDOCYTIC_2 411 414 PF00928 0.356
TRG_ENDOCYTIC_2 544 547 PF00928 0.340
TRG_ER_diArg_1 102 104 PF00400 0.329
TRG_ER_diArg_1 289 291 PF00400 0.329
TRG_ER_diArg_1 372 374 PF00400 0.504
TRG_ER_diArg_1 495 498 PF00400 0.459
TRG_ER_diArg_1 559 562 PF00400 0.282
TRG_ER_diArg_1 590 592 PF00400 0.703
TRG_ER_diArg_1 632 634 PF00400 0.657
TRG_NLS_MonoExtN_4 325 330 PF00514 0.410
TRG_Pf-PMV_PEXEL_1 104 109 PF00026 0.500
TRG_Pf-PMV_PEXEL_1 290 295 PF00026 0.640
TRG_Pf-PMV_PEXEL_1 354 358 PF00026 0.648
TRG_Pf-PMV_PEXEL_1 364 368 PF00026 0.614

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHP2 Leptomonas seymouri 49% 100%
A0A1X0NWU4 Trypanosomatidae 29% 100%
A0A3Q8IM81 Leishmania donovani 87% 100%
A0A3R7NJ73 Trypanosoma rangeli 29% 100%
A4HCX9 Leishmania braziliensis 73% 98%
A4I0G2 Leishmania infantum 87% 100%
C9ZV78 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
Q4QB47 Leishmania major 85% 100%
V5BEP9 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS