Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWC4_LEIMU

TriTrypDb:

LmxM.23.1065

Length:

539

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AWC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	189	191	PF00675	0.545
CLV_NRD_NRD_1	393	395	PF00675	0.561
CLV_PCSK_KEX2_1	128	130	PF00082	0.444
CLV_PCSK_KEX2_1	189	191	PF00082	0.545
CLV_PCSK_KEX2_1	393	395	PF00082	0.561
CLV_PCSK_KEX2_1	530	532	PF00082	0.439
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.444
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.439
CLV_PCSK_SKI1_1	14	18	PF00082	0.459
CLV_PCSK_SKI1_1	213	217	PF00082	0.413
CLV_PCSK_SKI1_1	278	282	PF00082	0.468
CLV_PCSK_SKI1_1	393	397	PF00082	0.551
DEG_APCC_DBOX_1	277	285	PF00400	0.460
DEG_APCC_DBOX_1	9	17	PF00400	0.444
DEG_SCF_FBW7_1	341	347	PF00400	0.539
DEG_SPOP_SBC_1	330	334	PF00917	0.583
DEG_SPOP_SBC_1	462	466	PF00917	0.636
DOC_CKS1_1	1	6	PF01111	0.432
DOC_CKS1_1	341	346	PF01111	0.762
DOC_CYCLIN_RxL_1	273	282	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	15	21	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	152	158	PF00134	0.458
DOC_CYCLIN_yCln2_LP_2	501	504	PF00134	0.442
DOC_MAPK_FxFP_2	71	74	PF00069	0.413
DOC_MAPK_gen_1	311	320	PF00069	0.499
DOC_MAPK_gen_1	8	17	PF00069	0.455
DOC_MAPK_MEF2A_6	197	204	PF00069	0.383
DOC_MAPK_MEF2A_6	8	17	PF00069	0.455
DOC_MAPK_NFAT4_5	10	18	PF00069	0.441
DOC_PP1_RVXF_1	391	398	PF00149	0.478
DOC_PP1_RVXF_1	426	433	PF00149	0.515
DOC_PP1_RVXF_1	66	72	PF00149	0.446
DOC_PP2B_LxvP_1	15	18	PF13499	0.436
DOC_PP2B_LxvP_1	152	155	PF13499	0.469
DOC_PP2B_LxvP_1	501	504	PF13499	0.442
DOC_PP2B_PxIxI_1	204	210	PF00149	0.422
DOC_PP4_FxxP_1	167	170	PF00568	0.364
DOC_PP4_FxxP_1	489	492	PF00568	0.516
DOC_PP4_FxxP_1	71	74	PF00568	0.470
DOC_PP4_FxxP_1	98	101	PF00568	0.365
DOC_USP7_MATH_1	137	141	PF00917	0.458
DOC_USP7_MATH_1	409	413	PF00917	0.619
DOC_USP7_MATH_1	485	489	PF00917	0.425
DOC_USP7_MATH_1	74	78	PF00917	0.464
DOC_WW_Pin1_4	133	138	PF00397	0.399
DOC_WW_Pin1_4	150	155	PF00397	0.549
DOC_WW_Pin1_4	331	336	PF00397	0.641
DOC_WW_Pin1_4	340	345	PF00397	0.702
DOC_WW_Pin1_4	376	381	PF00397	0.677
DOC_WW_Pin1_4	398	403	PF00397	0.573
DOC_WW_Pin1_4	72	77	PF00397	0.481
DOC_WW_Pin1_4	97	102	PF00397	0.369
LIG_14-3-3_CanoR_1	135	145	PF00244	0.459
LIG_14-3-3_CanoR_1	182	191	PF00244	0.541
LIG_14-3-3_CanoR_1	220	225	PF00244	0.356
LIG_14-3-3_CanoR_1	254	259	PF00244	0.387
LIG_14-3-3_CanoR_1	68	74	PF00244	0.460
LIG_Actin_WH2_2	227	242	PF00022	0.461
LIG_Actin_WH2_2	369	387	PF00022	0.520
LIG_BRCT_BRCA1_1	74	78	PF00533	0.469
LIG_Clathr_ClatBox_1	28	32	PF01394	0.439
LIG_EVH1_2	493	497	PF00568	0.382
LIG_FHA_1	163	169	PF00498	0.448
LIG_FHA_1	31	37	PF00498	0.471
LIG_FHA_1	317	323	PF00498	0.435
LIG_FHA_1	401	407	PF00498	0.587
LIG_FHA_2	209	215	PF00498	0.353
LIG_FHA_2	403	409	PF00498	0.585
LIG_FHA_2	523	529	PF00498	0.474
LIG_FXI_DFP_1	90	94	PF00024	0.316
LIG_LIR_Apic_2	165	170	PF02991	0.438
LIG_LIR_Apic_2	488	492	PF02991	0.534
LIG_LIR_Apic_2	72	76	PF02991	0.462
LIG_LIR_Apic_2	96	101	PF02991	0.359
LIG_LIR_Gen_1	219	230	PF02991	0.437
LIG_LIR_Gen_1	289	297	PF02991	0.482
LIG_LIR_Gen_1	378	389	PF02991	0.486
LIG_LIR_Gen_1	75	86	PF02991	0.385
LIG_LIR_Nem_3	219	225	PF02991	0.433
LIG_LIR_Nem_3	289	295	PF02991	0.560
LIG_LIR_Nem_3	378	384	PF02991	0.498
LIG_LIR_Nem_3	75	81	PF02991	0.423
LIG_LIR_Nem_3	96	102	PF02991	0.403
LIG_MAD2	394	402	PF02301	0.490
LIG_SH2_CRK	146	150	PF00017	0.458
LIG_SH2_CRK	261	265	PF00017	0.450
LIG_SH2_CRK	381	385	PF00017	0.482
LIG_SH2_STAP1	270	274	PF00017	0.384
LIG_SH2_STAT5	208	211	PF00017	0.338
LIG_SH2_STAT5	27	30	PF00017	0.444
LIG_SH3_2	155	160	PF14604	0.408
LIG_SH3_3	152	158	PF00018	0.394
LIG_SH3_3	199	205	PF00018	0.503
LIG_SH3_3	332	338	PF00018	0.693
LIG_SH3_3	488	494	PF00018	0.489
LIG_SH3_3	497	503	PF00018	0.301
LIG_SH3_3	99	105	PF00018	0.412
LIG_Sin3_3	78	85	PF02671	0.373
LIG_SUMO_SIM_par_1	82	87	PF11976	0.306
LIG_TRAF2_1	326	329	PF00917	0.496
LIG_TRAF2_1	525	528	PF00917	0.469
LIG_TYR_ITIM	290	295	PF00017	0.530
LIG_WRC_WIRS_1	317	322	PF05994	0.423
MOD_CK1_1	136	142	PF00069	0.355
MOD_CK1_1	148	154	PF00069	0.386
MOD_CK1_1	331	337	PF00069	0.650
MOD_CK1_1	375	381	PF00069	0.541
MOD_CK1_1	400	406	PF00069	0.644
MOD_CK1_1	512	518	PF00069	0.425
MOD_CK1_1	72	78	PF00069	0.482
MOD_CK2_1	182	188	PF00069	0.412
MOD_CK2_1	402	408	PF00069	0.581
MOD_CK2_1	522	528	PF00069	0.467
MOD_GlcNHglycan	10	13	PF01048	0.462
MOD_GlcNHglycan	114	117	PF01048	0.474
MOD_GlcNHglycan	139	142	PF01048	0.406
MOD_GlcNHglycan	184	187	PF01048	0.350
MOD_GlcNHglycan	303	306	PF01048	0.616
MOD_GlcNHglycan	411	414	PF01048	0.533
MOD_GlcNHglycan	436	439	PF01048	0.577
MOD_GlcNHglycan	63	66	PF01048	0.367
MOD_GSK3_1	133	140	PF00069	0.352
MOD_GSK3_1	178	185	PF00069	0.367
MOD_GSK3_1	336	343	PF00069	0.697
MOD_GSK3_1	35	42	PF00069	0.441
MOD_GSK3_1	367	374	PF00069	0.517
MOD_GSK3_1	375	382	PF00069	0.412
MOD_GSK3_1	396	403	PF00069	0.595
MOD_GSK3_1	457	464	PF00069	0.646
MOD_GSK3_1	46	53	PF00069	0.383
MOD_GSK3_1	508	515	PF00069	0.471
MOD_GSK3_1	93	100	PF00069	0.361
MOD_LATS_1	218	224	PF00433	0.268
MOD_N-GLC_1	182	187	PF02516	0.339
MOD_N-GLC_1	299	304	PF02516	0.532
MOD_N-GLC_2	307	309	PF02516	0.454
MOD_NEK2_1	19	24	PF00069	0.449
MOD_NEK2_1	396	401	PF00069	0.584
MOD_NEK2_1	432	437	PF00069	0.583
MOD_NEK2_1	50	55	PF00069	0.359
MOD_NEK2_1	69	74	PF00069	0.442
MOD_NEK2_1	93	98	PF00069	0.356
MOD_PIKK_1	192	198	PF00454	0.553
MOD_PK_1	457	463	PF00069	0.478
MOD_PK_1	509	515	PF00069	0.422
MOD_PKA_1	530	536	PF00069	0.395
MOD_PKA_2	181	187	PF00069	0.506
MOD_PKA_2	19	25	PF00069	0.447
MOD_PKA_2	262	268	PF00069	0.266
MOD_PKA_2	508	514	PF00069	0.469
MOD_PKA_2	530	536	PF00069	0.395
MOD_PKB_1	37	45	PF00069	0.414
MOD_Plk_1	162	168	PF00069	0.545
MOD_Plk_1	426	432	PF00069	0.517
MOD_Plk_4	162	168	PF00069	0.516
MOD_Plk_4	19	25	PF00069	0.447
MOD_Plk_4	344	350	PF00069	0.538
MOD_Plk_4	379	385	PF00069	0.475
MOD_Plk_4	39	45	PF00069	0.389
MOD_Plk_4	402	408	PF00069	0.444
MOD_Plk_4	46	52	PF00069	0.363
MOD_Plk_4	509	515	PF00069	0.422
MOD_Plk_4	54	60	PF00069	0.325
MOD_Plk_4	93	99	PF00069	0.322
MOD_ProDKin_1	133	139	PF00069	0.405
MOD_ProDKin_1	150	156	PF00069	0.545
MOD_ProDKin_1	331	337	PF00069	0.642
MOD_ProDKin_1	340	346	PF00069	0.692
MOD_ProDKin_1	376	382	PF00069	0.669
MOD_ProDKin_1	398	404	PF00069	0.569
MOD_ProDKin_1	72	78	PF00069	0.482
MOD_ProDKin_1	97	103	PF00069	0.369
MOD_SUMO_rev_2	404	412	PF00179	0.577
MOD_SUMO_rev_2	527	532	PF00179	0.489
TRG_DiLeu_BaEn_2	162	168	PF01217	0.451
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.445
TRG_DiLeu_BaLyEn_6	202	207	PF01217	0.454
TRG_ENDOCYTIC_2	146	149	PF00928	0.426
TRG_ENDOCYTIC_2	292	295	PF00928	0.548
TRG_ENDOCYTIC_2	381	384	PF00928	0.487
TRG_ER_diArg_1	189	191	PF00400	0.541
TRG_ER_diArg_1	36	39	PF00400	0.430
TRG_ER_diArg_1	393	395	PF00400	0.493
TRG_ER_diArg_1	7	10	PF00400	0.442
TRG_NES_CRM1_1	282	297	PF08389	0.378
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	524	528	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R2	Leptomonas seymouri	44%	100%
A0A3Q8IBT7	Leishmania donovani	87%	100%
A4HCX8	Leishmania braziliensis	71%	100%
A4I0G1	Leishmania infantum	87%	100%
Q4QB48	Leishmania major	87%	99%