HIT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HIT domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AWC3_LEIMU

TriTrypDb:

LmxM.23.1055

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWC3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0047710	bis(5'-adenosyl)-triphosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.614
CLV_C14_Caspase3-7	172	176	PF00656	0.518
CLV_NRD_NRD_1	250	252	PF00675	0.379
CLV_NRD_NRD_1	3	5	PF00675	0.574
CLV_NRD_NRD_1	316	318	PF00675	0.569
CLV_PCSK_KEX2_1	250	252	PF00082	0.328
CLV_PCSK_KEX2_1	3	5	PF00082	0.574
CLV_PCSK_KEX2_1	315	317	PF00082	0.577
CLV_PCSK_SKI1_1	178	182	PF00082	0.430
CLV_PCSK_SKI1_1	3	7	PF00082	0.522
CLV_PCSK_SKI1_1	333	337	PF00082	0.550
DEG_SPOP_SBC_1	161	165	PF00917	0.504
DEG_SPOP_SBC_1	74	78	PF00917	0.699
DOC_CKS1_1	319	324	PF01111	0.627
DOC_CYCLIN_RxL_1	330	340	PF00134	0.525
DOC_MAPK_FxFP_2	14	17	PF00069	0.341
DOC_PP4_FxxP_1	14	17	PF00568	0.597
DOC_USP7_MATH_1	135	139	PF00917	0.530
DOC_USP7_MATH_1	157	161	PF00917	0.564
DOC_USP7_MATH_1	188	192	PF00917	0.389
DOC_USP7_MATH_1	193	197	PF00917	0.369
DOC_USP7_MATH_1	342	346	PF00917	0.628
DOC_USP7_MATH_1	37	41	PF00917	0.706
DOC_USP7_MATH_1	73	77	PF00917	0.759
DOC_USP7_MATH_1	8	12	PF00917	0.480
DOC_WW_Pin1_4	103	108	PF00397	0.672
DOC_WW_Pin1_4	162	167	PF00397	0.703
DOC_WW_Pin1_4	261	266	PF00397	0.562
DOC_WW_Pin1_4	318	323	PF00397	0.637
DOC_WW_Pin1_4	33	38	PF00397	0.497
DOC_WW_Pin1_4	343	348	PF00397	0.403
DOC_WW_Pin1_4	54	59	PF00397	0.588
LIG_14-3-3_CanoR_1	3	8	PF00244	0.530
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_BRCT_BRCA1_1	10	14	PF00533	0.564
LIG_BRCT_BRCA1_1	195	199	PF00533	0.354
LIG_FHA_1	18	24	PF00498	0.691
LIG_FHA_1	240	246	PF00498	0.480
LIG_FHA_1	262	268	PF00498	0.585
LIG_FHA_1	327	333	PF00498	0.458
LIG_FHA_1	91	97	PF00498	0.596
LIG_FHA_2	114	120	PF00498	0.625
LIG_FHA_2	124	130	PF00498	0.565
LIG_FHA_2	226	232	PF00498	0.513
LIG_FHA_2	24	30	PF00498	0.745
LIG_FHA_2	76	82	PF00498	0.738
LIG_LIR_Apic_2	11	17	PF02991	0.474
LIG_LIR_Gen_1	196	207	PF02991	0.482
LIG_LIR_Gen_1	90	99	PF02991	0.565
LIG_LIR_Nem_3	175	180	PF02991	0.400
LIG_LIR_Nem_3	196	202	PF02991	0.431
LIG_LIR_Nem_3	233	238	PF02991	0.509
LIG_LIR_Nem_3	90	95	PF02991	0.567
LIG_MLH1_MIPbox_1	195	199	PF16413	0.294
LIG_PDZ_Class_2	346	351	PF00595	0.460
LIG_Pex14_2	12	16	PF04695	0.326
LIG_SH2_CRK	177	181	PF00017	0.232
LIG_SH2_CRK	63	67	PF00017	0.550
LIG_SH2_NCK_1	156	160	PF00017	0.582
LIG_SH2_NCK_1	339	343	PF00017	0.582
LIG_SH2_SRC	45	48	PF00017	0.556
LIG_SH2_STAP1	273	277	PF00017	0.562
LIG_SH2_STAP1	339	343	PF00017	0.610
LIG_SH2_STAT3	194	197	PF00017	0.518
LIG_SH2_STAT5	194	197	PF00017	0.431
LIG_SH2_STAT5	198	201	PF00017	0.501
LIG_SH2_STAT5	339	342	PF00017	0.549
LIG_SH2_STAT5	45	48	PF00017	0.600
LIG_SH3_1	316	322	PF00018	0.642
LIG_SH3_3	187	193	PF00018	0.491
LIG_SH3_3	204	210	PF00018	0.366
LIG_SH3_3	262	268	PF00018	0.541
LIG_SH3_3	293	299	PF00018	0.496
LIG_SH3_3	316	322	PF00018	0.642
LIG_SH3_4	139	146	PF00018	0.599
LIG_TRAF2_1	106	109	PF00917	0.702
LIG_TRAF2_1	228	231	PF00917	0.534
LIG_TRFH_1	69	73	PF08558	0.701
LIG_UBA3_1	169	174	PF00899	0.683
LIG_WW_3	317	321	PF00397	0.597
MOD_CK1_1	160	166	PF00069	0.542
MOD_CK1_1	261	267	PF00069	0.567
MOD_CK1_1	33	39	PF00069	0.677
MOD_CK1_1	345	351	PF00069	0.754
MOD_CK1_1	76	82	PF00069	0.590
MOD_CK2_1	103	109	PF00069	0.690
MOD_CK2_1	123	129	PF00069	0.561
MOD_CK2_1	225	231	PF00069	0.482
MOD_CK2_1	75	81	PF00069	0.748
MOD_GlcNHglycan	108	113	PF01048	0.652
MOD_GlcNHglycan	186	189	PF01048	0.494
MOD_GlcNHglycan	261	264	PF01048	0.349
MOD_GlcNHglycan	32	35	PF01048	0.807
MOD_GSK3_1	113	120	PF00069	0.624
MOD_GSK3_1	157	164	PF00069	0.539
MOD_GSK3_1	184	191	PF00069	0.506
MOD_GSK3_1	23	30	PF00069	0.728
MOD_GSK3_1	33	40	PF00069	0.620
MOD_GSK3_1	8	15	PF00069	0.485
MOD_GSK3_1	90	97	PF00069	0.562
MOD_N-GLC_1	12	17	PF02516	0.540
MOD_N-GLC_1	271	276	PF02516	0.362
MOD_NEK2_1	12	17	PF00069	0.480
MOD_NEK2_1	122	127	PF00069	0.332
MOD_NEK2_1	23	28	PF00069	0.610
MOD_NEK2_1	239	244	PF00069	0.497
MOD_NEK2_2	220	225	PF00069	0.508
MOD_PIKK_1	193	199	PF00454	0.479
MOD_PIKK_1	252	258	PF00454	0.456
MOD_PKA_1	3	9	PF00069	0.586
MOD_PKA_2	239	245	PF00069	0.502
MOD_PKA_2	252	258	PF00069	0.549
MOD_PKA_2	3	9	PF00069	0.583
MOD_Plk_1	117	123	PF00069	0.604
MOD_Plk_1	12	18	PF00069	0.440
MOD_Plk_1	271	277	PF00069	0.562
MOD_Plk_2-3	306	312	PF00069	0.525
MOD_Plk_4	165	171	PF00069	0.642
MOD_ProDKin_1	103	109	PF00069	0.673
MOD_ProDKin_1	162	168	PF00069	0.706
MOD_ProDKin_1	261	267	PF00069	0.562
MOD_ProDKin_1	318	324	PF00069	0.633
MOD_ProDKin_1	33	39	PF00069	0.494
MOD_ProDKin_1	343	349	PF00069	0.411
MOD_ProDKin_1	54	60	PF00069	0.582
TRG_ENDOCYTIC_2	177	180	PF00928	0.350
TRG_ENDOCYTIC_2	198	201	PF00928	0.415
TRG_ENDOCYTIC_2	45	48	PF00928	0.651
TRG_ENDOCYTIC_2	63	66	PF00928	0.326
TRG_ER_diArg_1	249	251	PF00400	0.579
TRG_ER_diArg_1	3	5	PF00400	0.575
TRG_ER_diArg_1	315	317	PF00400	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P352	Leptomonas seymouri	58%	81%
A0A0S4JIU0	Bodo saltans	32%	92%
A0A1X0NWV2	Trypanosomatidae	39%	77%
A0A3S7WXW4	Leishmania donovani	90%	100%
A4HCX7	Leishmania braziliensis	81%	100%
A4I0G0	Leishmania infantum	90%	100%
C9ZV80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	84%
Q4QB49	Leishmania major	89%	100%
V5BJC2	Trypanosoma cruzi	44%	86%