Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AWC1_LEIMU

TriTrypDb:

LmxM.23.1035

Length:

696

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWC1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.680
CLV_NRD_NRD_1	10	12	PF00675	0.665
CLV_NRD_NRD_1	128	130	PF00675	0.690
CLV_NRD_NRD_1	465	467	PF00675	0.759
CLV_NRD_NRD_1	637	639	PF00675	0.582
CLV_PCSK_KEX2_1	10	12	PF00082	0.665
CLV_PCSK_KEX2_1	127	129	PF00082	0.693
CLV_PCSK_KEX2_1	465	467	PF00082	0.702
CLV_PCSK_KEX2_1	56	58	PF00082	0.564
CLV_PCSK_KEX2_1	637	639	PF00082	0.582
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.564
CLV_PCSK_SKI1_1	180	184	PF00082	0.598
CLV_PCSK_SKI1_1	394	398	PF00082	0.536
CLV_PCSK_SKI1_1	439	443	PF00082	0.716
CLV_PCSK_SKI1_1	487	491	PF00082	0.596
CLV_PCSK_SKI1_1	522	526	PF00082	0.595
CLV_PCSK_SKI1_1	638	642	PF00082	0.630
CLV_Separin_Metazoa	181	185	PF03568	0.438
CLV_Separin_Metazoa	301	305	PF03568	0.539
DEG_APCC_DBOX_1	636	644	PF00400	0.571
DEG_Nend_UBRbox_3	1	3	PF02207	0.639
DEG_SCF_FBW7_2	151	156	PF00400	0.478
DEG_SPOP_SBC_1	36	40	PF00917	0.609
DEG_SPOP_SBC_1	421	425	PF00917	0.682
DEG_SPOP_SBC_1	48	52	PF00917	0.665
DEG_SPOP_SBC_1	657	661	PF00917	0.688
DOC_CKS1_1	663	668	PF01111	0.667
DOC_CYCLIN_RxL_1	519	527	PF00134	0.590
DOC_CYCLIN_RxL_1	632	645	PF00134	0.618
DOC_MAPK_gen_1	10	16	PF00069	0.661
DOC_MAPK_gen_1	637	643	PF00069	0.576
DOC_PP2B_LxvP_1	199	202	PF13499	0.653
DOC_PP2B_LxvP_1	211	214	PF13499	0.542
DOC_PP2B_LxvP_1	303	306	PF13499	0.537
DOC_PP4_MxPP_1	553	556	PF00568	0.515
DOC_SPAK_OSR1_1	625	629	PF12202	0.404
DOC_USP7_MATH_1	114	118	PF00917	0.718
DOC_USP7_MATH_1	140	144	PF00917	0.675
DOC_USP7_MATH_1	313	317	PF00917	0.780
DOC_USP7_MATH_1	318	322	PF00917	0.788
DOC_USP7_MATH_1	325	329	PF00917	0.576
DOC_USP7_MATH_1	365	369	PF00917	0.672
DOC_USP7_MATH_1	388	392	PF00917	0.734
DOC_USP7_MATH_1	421	425	PF00917	0.682
DOC_USP7_MATH_1	444	448	PF00917	0.688
DOC_USP7_MATH_1	570	574	PF00917	0.689
DOC_USP7_MATH_1	575	579	PF00917	0.595
DOC_USP7_MATH_1	614	618	PF00917	0.688
DOC_USP7_MATH_1	68	72	PF00917	0.678
DOC_USP7_MATH_1	84	88	PF00917	0.610
DOC_WW_Pin1_4	133	138	PF00397	0.812
DOC_WW_Pin1_4	149	154	PF00397	0.530
DOC_WW_Pin1_4	204	209	PF00397	0.728
DOC_WW_Pin1_4	292	297	PF00397	0.776
DOC_WW_Pin1_4	327	332	PF00397	0.523
DOC_WW_Pin1_4	428	433	PF00397	0.682
DOC_WW_Pin1_4	451	456	PF00397	0.752
DOC_WW_Pin1_4	547	552	PF00397	0.737
DOC_WW_Pin1_4	605	610	PF00397	0.647
DOC_WW_Pin1_4	648	653	PF00397	0.683
DOC_WW_Pin1_4	658	663	PF00397	0.645
DOC_WW_Pin1_4	66	71	PF00397	0.687
DOC_WW_Pin1_4	93	98	PF00397	0.651
LIG_14-3-3_CanoR_1	135	144	PF00244	0.566
LIG_14-3-3_CanoR_1	163	169	PF00244	0.637
LIG_14-3-3_CanoR_1	210	214	PF00244	0.701
LIG_14-3-3_CanoR_1	221	229	PF00244	0.651
LIG_14-3-3_CanoR_1	46	55	PF00244	0.738
LIG_14-3-3_CanoR_1	57	61	PF00244	0.628
LIG_14-3-3_CanoR_1	637	641	PF00244	0.586
LIG_Actin_WH2_2	621	639	PF00022	0.554
LIG_BIR_III_4	376	380	PF00653	0.661
LIG_FHA_1	152	158	PF00498	0.575
LIG_FHA_1	226	232	PF00498	0.640
LIG_FHA_1	328	334	PF00498	0.533
LIG_FHA_1	361	367	PF00498	0.676
LIG_FHA_1	382	388	PF00498	0.706
LIG_FHA_1	469	475	PF00498	0.520
LIG_FHA_1	50	56	PF00498	0.711
LIG_FHA_1	578	584	PF00498	0.624
LIG_FHA_1	619	625	PF00498	0.614
LIG_FHA_1	658	664	PF00498	0.698
LIG_FHA_2	268	274	PF00498	0.680
LIG_FHA_2	380	386	PF00498	0.606
LIG_FHA_2	413	419	PF00498	0.645
LIG_FHA_2	606	612	PF00498	0.723
LIG_FHA_2	637	643	PF00498	0.626
LIG_GSK3_LRP6_1	66	72	PF00069	0.535
LIG_IRF3_LxIS_1	416	423	PF10401	0.678
LIG_LIR_Apic_2	79	84	PF02991	0.611
LIG_LIR_Gen_1	218	227	PF02991	0.574
LIG_LIR_Gen_1	415	422	PF02991	0.678
LIG_LIR_Gen_1	504	514	PF02991	0.674
LIG_LIR_Nem_3	218	222	PF02991	0.572
LIG_LIR_Nem_3	415	420	PF02991	0.675
LIG_LIR_Nem_3	504	510	PF02991	0.684
LIG_LIR_Nem_3	519	524	PF02991	0.479
LIG_LIR_Nem_3	559	564	PF02991	0.672
LIG_Pex14_1	622	626	PF04695	0.600
LIG_SH2_CRK	81	85	PF00017	0.611
LIG_SH2_NCK_1	587	591	PF00017	0.625
LIG_SH2_NCK_1	81	85	PF00017	0.611
LIG_SH2_PTP2	13	16	PF00017	0.658
LIG_SH2_SRC	419	422	PF00017	0.731
LIG_SH2_SRC	81	84	PF00017	0.613
LIG_SH2_STAP1	227	231	PF00017	0.665
LIG_SH2_STAT3	395	398	PF00017	0.673
LIG_SH2_STAT5	13	16	PF00017	0.658
LIG_SH2_STAT5	227	230	PF00017	0.483
LIG_SH2_STAT5	395	398	PF00017	0.720
LIG_SH2_STAT5	419	422	PF00017	0.681
LIG_SH2_STAT5	587	590	PF00017	0.621
LIG_SH3_2	83	88	PF14604	0.739
LIG_SH3_3	211	217	PF00018	0.601
LIG_SH3_3	299	305	PF00018	0.673
LIG_SH3_3	31	37	PF00018	0.642
LIG_SH3_3	351	357	PF00018	0.712
LIG_SH3_3	438	444	PF00018	0.756
LIG_SH3_3	464	470	PF00018	0.494
LIG_SH3_3	64	70	PF00018	0.665
LIG_SH3_3	80	86	PF00018	0.627
LIG_SUMO_SIM_par_1	227	232	PF11976	0.555
LIG_SUMO_SIM_par_1	357	363	PF11976	0.509
LIG_SUMO_SIM_par_1	497	504	PF11976	0.697
LIG_SUMO_SIM_par_1	639	645	PF11976	0.632
LIG_WRC_WIRS_1	216	221	PF05994	0.572
MOD_CDK_SPxK_1	204	210	PF00069	0.731
MOD_CDK_SPxxK_3	451	458	PF00069	0.687
MOD_CK1_1	109	115	PF00069	0.670
MOD_CK1_1	116	122	PF00069	0.627
MOD_CK1_1	136	142	PF00069	0.713
MOD_CK1_1	143	149	PF00069	0.650
MOD_CK1_1	197	203	PF00069	0.700
MOD_CK1_1	212	218	PF00069	0.517
MOD_CK1_1	447	453	PF00069	0.603
MOD_CK1_1	50	56	PF00069	0.700
MOD_CK1_1	532	538	PF00069	0.616
MOD_CK1_1	645	651	PF00069	0.646
MOD_CK1_1	688	694	PF00069	0.603
MOD_CK1_1	69	75	PF00069	0.591
MOD_CK2_1	143	149	PF00069	0.626
MOD_CK2_1	234	240	PF00069	0.817
MOD_CK2_1	284	290	PF00069	0.744
MOD_CK2_1	412	418	PF00069	0.650
MOD_CK2_1	56	62	PF00069	0.690
MOD_CK2_1	570	576	PF00069	0.719
MOD_CK2_1	605	611	PF00069	0.674
MOD_CK2_1	636	642	PF00069	0.617
MOD_CK2_1	647	653	PF00069	0.583
MOD_GlcNHglycan	108	111	PF01048	0.714
MOD_GlcNHglycan	118	121	PF01048	0.596
MOD_GlcNHglycan	145	148	PF01048	0.656
MOD_GlcNHglycan	196	199	PF01048	0.714
MOD_GlcNHglycan	211	214	PF01048	0.528
MOD_GlcNHglycan	236	239	PF01048	0.691
MOD_GlcNHglycan	257	260	PF01048	0.683
MOD_GlcNHglycan	285	289	PF01048	0.731
MOD_GlcNHglycan	315	318	PF01048	0.657
MOD_GlcNHglycan	320	323	PF01048	0.656
MOD_GlcNHglycan	349	352	PF01048	0.818
MOD_GlcNHglycan	391	394	PF01048	0.663
MOD_GlcNHglycan	558	561	PF01048	0.740
MOD_GlcNHglycan	576	580	PF01048	0.519
MOD_GlcNHglycan	58	61	PF01048	0.581
MOD_GlcNHglycan	599	602	PF01048	0.608
MOD_GSK3_1	102	109	PF00069	0.622
MOD_GSK3_1	131	138	PF00069	0.797
MOD_GSK3_1	139	146	PF00069	0.722
MOD_GSK3_1	200	207	PF00069	0.661
MOD_GSK3_1	221	228	PF00069	0.592
MOD_GSK3_1	313	320	PF00069	0.759
MOD_GSK3_1	325	332	PF00069	0.601
MOD_GSK3_1	379	386	PF00069	0.653
MOD_GSK3_1	444	451	PF00069	0.740
MOD_GSK3_1	47	54	PF00069	0.632
MOD_GSK3_1	605	612	PF00069	0.696
MOD_GSK3_1	614	621	PF00069	0.609
MOD_GSK3_1	642	649	PF00069	0.615
MOD_GSK3_1	658	665	PF00069	0.582
MOD_GSK3_1	93	100	PF00069	0.655
MOD_N-GLC_1	234	239	PF02516	0.711
MOD_N-GLC_1	388	393	PF02516	0.671
MOD_N-GLC_1	402	407	PF02516	0.565
MOD_N-GLC_1	428	433	PF02516	0.654
MOD_NEK2_1	164	169	PF00069	0.653
MOD_NEK2_1	255	260	PF00069	0.620
MOD_NEK2_1	360	365	PF00069	0.509
MOD_NEK2_1	49	54	PF00069	0.724
MOD_NEK2_1	55	60	PF00069	0.703
MOD_NEK2_1	564	569	PF00069	0.491
MOD_NEK2_1	636	641	PF00069	0.638
MOD_NEK2_1	671	676	PF00069	0.697
MOD_PIKK_1	342	348	PF00454	0.708
MOD_PIKK_1	394	400	PF00454	0.716
MOD_PIKK_1	444	450	PF00454	0.642
MOD_PIKK_1	529	535	PF00454	0.585
MOD_PKA_1	56	62	PF00069	0.558
MOD_PKA_2	114	120	PF00069	0.710
MOD_PKA_2	131	137	PF00069	0.506
MOD_PKA_2	209	215	PF00069	0.704
MOD_PKA_2	56	62	PF00069	0.558
MOD_PKA_2	636	642	PF00069	0.601
MOD_PKA_2	645	651	PF00069	0.615
MOD_Plk_1	402	408	PF00069	0.540
MOD_Plk_1	671	677	PF00069	0.642
MOD_Plk_4	215	221	PF00069	0.605
MOD_Plk_4	412	418	PF00069	0.684
MOD_Plk_4	564	570	PF00069	0.517
MOD_Plk_4	618	624	PF00069	0.573
MOD_Plk_4	651	657	PF00069	0.534
MOD_ProDKin_1	133	139	PF00069	0.815
MOD_ProDKin_1	149	155	PF00069	0.528
MOD_ProDKin_1	204	210	PF00069	0.731
MOD_ProDKin_1	292	298	PF00069	0.777
MOD_ProDKin_1	327	333	PF00069	0.521
MOD_ProDKin_1	428	434	PF00069	0.684
MOD_ProDKin_1	451	457	PF00069	0.746
MOD_ProDKin_1	547	553	PF00069	0.736
MOD_ProDKin_1	605	611	PF00069	0.649
MOD_ProDKin_1	648	654	PF00069	0.686
MOD_ProDKin_1	658	664	PF00069	0.644
MOD_ProDKin_1	66	72	PF00069	0.690
MOD_ProDKin_1	93	99	PF00069	0.649
MOD_SUMO_rev_2	431	441	PF00179	0.723
TRG_DiLeu_BaEn_4	30	36	PF01217	0.693
TRG_ENDOCYTIC_2	13	16	PF00928	0.640
TRG_ENDOCYTIC_2	419	422	PF00928	0.731
TRG_ENDOCYTIC_2	561	564	PF00928	0.671
TRG_ER_diArg_1	126	129	PF00400	0.693
TRG_ER_diArg_1	168	171	PF00400	0.662
TRG_ER_diArg_1	465	467	PF00400	0.610
TRG_ER_diArg_1	636	638	PF00400	0.574
TRG_ER_diArg_1	9	11	PF00400	0.663
TRG_Pf-PMV_PEXEL_1	10	15	PF00026	0.661
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.667
TRG_Pf-PMV_PEXEL_1	472	476	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	522	526	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	638	642	PF00026	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBK4	Leishmania donovani	83%	100%
A4HCX5	Leishmania braziliensis	61%	99%
A4I0F8	Leishmania infantum	82%	100%
Q4QB51	Leishmania major	83%	100%