Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWC0_LEIMU

TriTrypDb:

LmxM.23.1025

Length:

557

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWC0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.570
CLV_C14_Caspase3-7	529	533	PF00656	0.531
CLV_NRD_NRD_1	107	109	PF00675	0.516
CLV_NRD_NRD_1	204	206	PF00675	0.675
CLV_NRD_NRD_1	332	334	PF00675	0.734
CLV_NRD_NRD_1	356	358	PF00675	0.716
CLV_NRD_NRD_1	406	408	PF00675	0.640
CLV_NRD_NRD_1	481	483	PF00675	0.704
CLV_NRD_NRD_1	499	501	PF00675	0.750
CLV_NRD_NRD_1	545	547	PF00675	0.595
CLV_PCSK_FUR_1	497	501	PF00082	0.748
CLV_PCSK_KEX2_1	180	182	PF00082	0.583
CLV_PCSK_KEX2_1	206	208	PF00082	0.734
CLV_PCSK_KEX2_1	302	304	PF00082	0.711
CLV_PCSK_KEX2_1	332	334	PF00082	0.734
CLV_PCSK_KEX2_1	356	358	PF00082	0.716
CLV_PCSK_KEX2_1	406	408	PF00082	0.639
CLV_PCSK_KEX2_1	481	483	PF00082	0.704
CLV_PCSK_KEX2_1	497	499	PF00082	0.636
CLV_PCSK_KEX2_1	545	547	PF00082	0.595
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.583
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.726
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.759
CLV_PCSK_SKI1_1	152	156	PF00082	0.541
CLV_PCSK_SKI1_1	165	169	PF00082	0.596
CLV_PCSK_SKI1_1	198	202	PF00082	0.589
CLV_PCSK_SKI1_1	206	210	PF00082	0.552
CLV_PCSK_SKI1_1	401	405	PF00082	0.621
CLV_PCSK_SKI1_1	430	434	PF00082	0.679
DEG_APCC_DBOX_1	151	159	PF00400	0.553
DEG_SCF_FBW7_2	386	393	PF00400	0.651
DEG_SPOP_SBC_1	259	263	PF00917	0.719
DOC_CDC14_PxL_1	221	229	PF14671	0.648
DOC_MAPK_gen_1	108	115	PF00069	0.577
DOC_MAPK_MEF2A_6	235	244	PF00069	0.718
DOC_PP2B_LxvP_1	468	471	PF13499	0.686
DOC_PP4_FxxP_1	501	504	PF00568	0.691
DOC_PP4_FxxP_1	58	61	PF00568	0.612
DOC_USP7_MATH_1	245	249	PF00917	0.677
DOC_USP7_MATH_1	343	347	PF00917	0.721
DOC_USP7_MATH_1	486	490	PF00917	0.728
DOC_USP7_MATH_1	491	495	PF00917	0.649
DOC_USP7_MATH_1	6	10	PF00917	0.703
DOC_WW_Pin1_4	158	163	PF00397	0.636
DOC_WW_Pin1_4	297	302	PF00397	0.678
DOC_WW_Pin1_4	379	384	PF00397	0.668
DOC_WW_Pin1_4	386	391	PF00397	0.617
DOC_WW_Pin1_4	42	47	PF00397	0.683
DOC_WW_Pin1_4	500	505	PF00397	0.682
LIG_14-3-3_CanoR_1	260	265	PF00244	0.717
LIG_14-3-3_CanoR_1	551	555	PF00244	0.481
LIG_Actin_WH2_2	150	167	PF00022	0.554
LIG_BIR_II_1	1	5	PF00653	0.584
LIG_deltaCOP1_diTrp_1	442	452	PF00928	0.666
LIG_eIF4E_1	264	270	PF01652	0.726
LIG_FHA_1	520	526	PF00498	0.627
LIG_FHA_2	164	170	PF00498	0.551
LIG_FHA_2	364	370	PF00498	0.698
LIG_FHA_2	387	393	PF00498	0.644
LIG_FHA_2	47	53	PF00498	0.634
LIG_IBAR_NPY_1	419	421	PF08397	0.682
LIG_LIR_Apic_2	55	61	PF02991	0.612
LIG_LIR_Gen_1	172	182	PF02991	0.531
LIG_LIR_Nem_3	172	177	PF02991	0.514
LIG_LIR_Nem_3	261	267	PF02991	0.623
LIG_LIR_Nem_3	311	315	PF02991	0.596
LIG_LIR_Nem_3	553	557	PF02991	0.499
LIG_LIR_Nem_3	67	72	PF02991	0.586
LIG_LYPXL_yS_3	239	242	PF13949	0.716
LIG_MYND_1	431	435	PF01753	0.534
LIG_NRBOX	95	101	PF00104	0.500
LIG_SH2_CRK	174	178	PF00017	0.511
LIG_SH2_CRK	264	268	PF00017	0.724
LIG_SH2_CRK	298	302	PF00017	0.497
LIG_SH2_SRC	554	557	PF00017	0.645
LIG_SH2_STAP1	293	297	PF00017	0.736
LIG_SH2_STAP1	325	329	PF00017	0.604
LIG_SH2_STAP1	73	77	PF00017	0.590
LIG_SH2_STAP1	89	93	PF00017	0.451
LIG_SH2_STAT3	421	424	PF00017	0.606
LIG_SH2_STAT3	77	80	PF00017	0.540
LIG_SH2_STAT5	174	177	PF00017	0.559
LIG_SH3_1	235	241	PF00018	0.647
LIG_SH3_1	482	488	PF00018	0.776
LIG_SH3_2	425	430	PF14604	0.532
LIG_SH3_3	219	225	PF00018	0.720
LIG_SH3_3	235	241	PF00018	0.638
LIG_SH3_3	422	428	PF00018	0.705
LIG_SH3_3	463	469	PF00018	0.607
LIG_SH3_3	482	488	PF00018	0.724
LIG_SH3_3	58	64	PF00018	0.655
LIG_SH3_4	189	196	PF00018	0.601
LIG_SUMO_SIM_par_1	156	161	PF11976	0.631
LIG_SUMO_SIM_par_1	240	246	PF11976	0.698
LIG_SUMO_SIM_par_1	267	274	PF11976	0.731
LIG_TRAF2_1	24	27	PF00917	0.645
LIG_TRAF2_1	390	393	PF00917	0.639
LIG_TYR_ITIM	552	557	PF00017	0.475
LIG_TYR_ITSM	170	177	PF00017	0.540
LIG_TYR_ITSM	260	267	PF00017	0.720
LIG_WW_2	466	469	PF00397	0.624
MOD_CDC14_SPxK_1	300	303	PF00782	0.684
MOD_CDK_SPK_2	297	302	PF00069	0.678
MOD_CDK_SPxK_1	297	303	PF00069	0.680
MOD_CDK_SPxxK_3	158	165	PF00069	0.635
MOD_CK1_1	103	109	PF00069	0.460
MOD_CK1_1	274	280	PF00069	0.747
MOD_CK1_1	370	376	PF00069	0.563
MOD_CK1_1	503	509	PF00069	0.644
MOD_CK1_1	519	525	PF00069	0.606
MOD_CK1_1	550	556	PF00069	0.477
MOD_CK2_1	163	169	PF00069	0.533
MOD_CK2_1	21	27	PF00069	0.616
MOD_CK2_1	240	246	PF00069	0.591
MOD_CK2_1	363	369	PF00069	0.700
MOD_CK2_1	386	392	PF00069	0.661
MOD_CK2_1	6	12	PF00069	0.596
MOD_Cter_Amidation	479	482	PF01082	0.717
MOD_GlcNHglycan	118	121	PF01048	0.574
MOD_GlcNHglycan	214	217	PF01048	0.626
MOD_GlcNHglycan	282	287	PF01048	0.672
MOD_GlcNHglycan	315	318	PF01048	0.617
MOD_GlcNHglycan	345	348	PF01048	0.793
MOD_GlcNHglycan	350	353	PF01048	0.828
MOD_GlcNHglycan	372	375	PF01048	0.791
MOD_GlcNHglycan	439	442	PF01048	0.716
MOD_GlcNHglycan	493	496	PF01048	0.713
MOD_GlcNHglycan	505	508	PF01048	0.699
MOD_GlcNHglycan	8	11	PF01048	0.700
MOD_GSK3_1	169	176	PF00069	0.420
MOD_GSK3_1	247	254	PF00069	0.582
MOD_GSK3_1	282	289	PF00069	0.717
MOD_GSK3_1	359	366	PF00069	0.689
MOD_GSK3_1	42	49	PF00069	0.665
MOD_GSK3_1	519	526	PF00069	0.707
MOD_GSK3_1	532	539	PF00069	0.546
MOD_GSK3_1	546	553	PF00069	0.538
MOD_N-GLC_1	129	134	PF02516	0.370
MOD_N-GLC_1	370	375	PF02516	0.800
MOD_N-GLC_1	516	521	PF02516	0.530
MOD_NEK2_1	271	276	PF00069	0.741
MOD_NEK2_1	350	355	PF00069	0.786
MOD_NEK2_1	359	364	PF00069	0.645
MOD_NEK2_1	452	457	PF00069	0.535
MOD_NEK2_2	173	178	PF00069	0.606
MOD_OFUCOSY	451	456	PF10250	0.501
MOD_PIKK_1	350	356	PF00454	0.793
MOD_PIKK_1	394	400	PF00454	0.641
MOD_PIKK_1	526	532	PF00454	0.733
MOD_PKA_1	206	212	PF00069	0.721
MOD_PKA_2	183	189	PF00069	0.405
MOD_PKA_2	206	212	PF00069	0.731
MOD_PKA_2	259	265	PF00069	0.718
MOD_PKA_2	304	310	PF00069	0.578
MOD_PKA_2	343	349	PF00069	0.800
MOD_PKA_2	367	373	PF00069	0.632
MOD_PKA_2	523	529	PF00069	0.710
MOD_PKA_2	550	556	PF00069	0.495
MOD_PKB_1	303	311	PF00069	0.583
MOD_Plk_1	271	277	PF00069	0.695
MOD_Plk_1	547	553	PF00069	0.486
MOD_Plk_4	169	175	PF00069	0.539
MOD_Plk_4	251	257	PF00069	0.697
MOD_Plk_4	381	387	PF00069	0.603
MOD_ProDKin_1	158	164	PF00069	0.632
MOD_ProDKin_1	297	303	PF00069	0.680
MOD_ProDKin_1	379	385	PF00069	0.668
MOD_ProDKin_1	386	392	PF00069	0.616
MOD_ProDKin_1	42	48	PF00069	0.688
MOD_ProDKin_1	500	506	PF00069	0.681
TRG_DiLeu_BaEn_1	149	154	PF01217	0.524
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.373
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.654
TRG_DiLeu_BaLyEn_6	318	323	PF01217	0.577
TRG_DiLeu_LyEn_5	149	154	PF01217	0.549
TRG_ENDOCYTIC_2	174	177	PF00928	0.516
TRG_ENDOCYTIC_2	239	242	PF00928	0.716
TRG_ENDOCYTIC_2	264	267	PF00928	0.723
TRG_ENDOCYTIC_2	554	557	PF00928	0.656
TRG_ENDOCYTIC_2	69	72	PF00928	0.616
TRG_ER_diArg_1	141	144	PF00400	0.509
TRG_ER_diArg_1	205	208	PF00400	0.700
TRG_ER_diArg_1	331	333	PF00400	0.723
TRG_ER_diArg_1	481	483	PF00400	0.709
TRG_ER_diArg_1	496	499	PF00400	0.697
TRG_ER_diArg_1	544	546	PF00400	0.591
TRG_ER_FFAT_2	373	382	PF00635	0.525
TRG_NLS_MonoExtN_4	301	306	PF00514	0.684
TRG_Pf-PMV_PEXEL_1	135	140	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	70	75	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I063	Leptomonas seymouri	48%	100%
A0A3S7WXT8	Leishmania donovani	87%	100%
A0A422NP96	Trypanosoma rangeli	30%	100%
A4HCX4	Leishmania braziliensis	67%	99%
A4I0F7	Leishmania infantum	87%	100%
Q4QB52	Leishmania major	85%	100%