LeishMANIAdb
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Hydrophilic acylated surface protein a

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hydrophilic acylated surface protein a
Gene product:
hydrophilic acylated surface protein a
Species:
Leishmania mexicana
UniProt:
E9AWB5_LEIMU
TriTrypDb:
LmxM.23.1040
Length:
69

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 3
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWB5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWB5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 49 53 PF00656 0.646
CLV_PCSK_KEX2_1 15 17 PF00082 0.573
CLV_PCSK_PC1ET2_1 15 17 PF00082 0.573
DOC_USP7_UBL2_3 29 33 PF12436 0.517
DOC_USP7_UBL2_3 7 11 PF12436 0.739
LIG_FHA_2 22 28 PF00498 0.749
MOD_CK1_1 3 9 PF00069 0.721
MOD_CK2_1 6 12 PF00069 0.737
MOD_GSK3_1 19 26 PF00069 0.699
MOD_GSK3_1 3 10 PF00069 0.533
MOD_LATS_1 61 67 PF00433 0.530
MOD_NEK2_1 1 6 PF00069 0.729
MOD_NMyristoyl 1 7 PF02799 0.780
MOD_SUMO_rev_2 26 34 PF00179 0.514

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WXQ9 Leishmania donovani 56% 86%
A4I0F2 Leishmania infantum 55% 86%
P90552 Leishmania major 62% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS