F-BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AWB2_LEIMU

TriTrypDb:

LmxM.23.1000

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.346
CLV_C14_Caspase3-7	97	101	PF00656	0.470
CLV_NRD_NRD_1	203	205	PF00675	0.446
CLV_PCSK_KEX2_1	148	150	PF00082	0.553
CLV_PCSK_KEX2_1	203	205	PF00082	0.445
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.553
CLV_PCSK_SKI1_1	125	129	PF00082	0.479
CLV_PCSK_SKI1_1	15	19	PF00082	0.562
CLV_PCSK_SKI1_1	158	162	PF00082	0.595
CLV_PCSK_SKI1_1	179	183	PF00082	0.521
DOC_MAPK_gen_1	191	200	PF00069	0.591
DOC_MAPK_gen_1	203	211	PF00069	0.373
DOC_MAPK_MEF2A_6	179	186	PF00069	0.525
DOC_MAPK_MEF2A_6	203	211	PF00069	0.395
DOC_USP7_MATH_1	2	6	PF00917	0.594
DOC_USP7_MATH_1	20	24	PF00917	0.487
DOC_USP7_MATH_1	37	41	PF00917	0.323
DOC_USP7_MATH_1	61	65	PF00917	0.560
DOC_USP7_UBL2_3	11	15	PF12436	0.475
DOC_USP7_UBL2_3	125	129	PF12436	0.443
DOC_USP7_UBL2_3	144	148	PF12436	0.589
DOC_USP7_UBL2_3	158	162	PF12436	0.427
DOC_USP7_UBL2_3	171	175	PF12436	0.474
LIG_14-3-3_CanoR_1	203	211	PF00244	0.551
LIG_14-3-3_CanoR_1	216	223	PF00244	0.465
LIG_14-3-3_CanoR_1	67	73	PF00244	0.495
LIG_14-3-3_CanoR_1	92	99	PF00244	0.715
LIG_Actin_WH2_2	110	127	PF00022	0.544
LIG_APCC_Cbox_2	73	79	PF00515	0.563
LIG_FHA_1	112	118	PF00498	0.436
LIG_FHA_1	203	209	PF00498	0.524
LIG_FHA_2	68	74	PF00498	0.560
LIG_FHA_2	95	101	PF00498	0.513
LIG_LIR_Gen_1	195	201	PF02991	0.617
LIG_LIR_Gen_1	220	230	PF02991	0.564
LIG_LIR_Nem_3	103	109	PF02991	0.550
LIG_LIR_Nem_3	195	200	PF02991	0.562
LIG_LIR_Nem_3	220	226	PF02991	0.483
LIG_SH2_CRK	197	201	PF00017	0.434
LIG_SH2_NCK_1	24	28	PF00017	0.481
LIG_SH2_STAP1	24	28	PF00017	0.443
LIG_SH2_STAT5	31	34	PF00017	0.452
LIG_TRAF2_1	136	139	PF00917	0.338
MOD_CK1_1	111	117	PF00069	0.564
MOD_CK1_1	165	171	PF00069	0.430
MOD_CK1_1	224	230	PF00069	0.509
MOD_CK1_1	23	29	PF00069	0.617
MOD_CK1_1	94	100	PF00069	0.542
MOD_CK2_1	133	139	PF00069	0.404
MOD_CK2_1	164	170	PF00069	0.676
MOD_CK2_1	37	43	PF00069	0.528
MOD_CK2_1	45	51	PF00069	0.539
MOD_GlcNHglycan	118	121	PF01048	0.493
MOD_GlcNHglycan	25	28	PF01048	0.462
MOD_GlcNHglycan	4	7	PF01048	0.463
MOD_GlcNHglycan	63	66	PF01048	0.581
MOD_GlcNHglycan	84	87	PF01048	0.749
MOD_GSK3_1	111	118	PF00069	0.549
MOD_GSK3_1	192	199	PF00069	0.507
MOD_GSK3_1	217	224	PF00069	0.548
MOD_GSK3_1	87	94	PF00069	0.523
MOD_N-GLC_1	162	167	PF02516	0.438
MOD_N-GLC_1	87	92	PF02516	0.670
MOD_NEK2_1	226	231	PF00069	0.519
MOD_NEK2_1	45	50	PF00069	0.446
MOD_NEK2_1	76	81	PF00069	0.626
MOD_NEK2_1	93	98	PF00069	0.645
MOD_PIKK_1	202	208	PF00454	0.506
MOD_PIKK_1	50	56	PF00454	0.546
MOD_PIKK_1	87	93	PF00454	0.522
MOD_PK_1	162	168	PF00069	0.399
MOD_PKA_1	147	153	PF00069	0.562
MOD_PKA_1	15	21	PF00069	0.460
MOD_PKA_2	202	208	PF00069	0.467
MOD_PKA_2	91	97	PF00069	0.665
MOD_Plk_1	162	168	PF00069	0.399
MOD_Plk_1	38	44	PF00069	0.513
MOD_Plk_1	94	100	PF00069	0.527
MOD_Plk_4	196	202	PF00069	0.538
MOD_SUMO_rev_2	118	127	PF00179	0.526
MOD_SUMO_rev_2	150	160	PF00179	0.577
MOD_SUMO_rev_2	4	13	PF00179	0.576
TRG_DiLeu_BaEn_1	196	201	PF01217	0.577
TRG_DiLeu_BaEn_1	9	14	PF01217	0.569
TRG_ENDOCYTIC_2	197	200	PF00928	0.520
TRG_ENDOCYTIC_2	223	226	PF00928	0.550
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCG3	Leptomonas seymouri	51%	99%
A0A1X0NYD1	Trypanosomatidae	30%	90%
A0A3Q8ICK8	Leishmania donovani	78%	100%
A0A3R7KGK2	Trypanosoma rangeli	28%	100%
A4HCW9	Leishmania braziliensis	61%	100%
A4I0E9	Leishmania infantum	78%	100%
Q4QB63	Leishmania major	78%	100%