Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWB1_LEIMU

TriTrypDb:

LmxM.23.0990

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWB1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	433	437	PF00656	0.851
CLV_C14_Caspase3-7	462	466	PF00656	0.645
CLV_C14_Caspase3-7	476	480	PF00656	0.565
CLV_NRD_NRD_1	156	158	PF00675	0.549
CLV_NRD_NRD_1	161	163	PF00675	0.556
CLV_NRD_NRD_1	168	170	PF00675	0.599
CLV_NRD_NRD_1	187	189	PF00675	0.424
CLV_NRD_NRD_1	323	325	PF00675	0.788
CLV_NRD_NRD_1	407	409	PF00675	0.702
CLV_NRD_NRD_1	459	461	PF00675	0.781
CLV_NRD_NRD_1	539	541	PF00675	0.772
CLV_NRD_NRD_1	562	564	PF00675	0.797
CLV_NRD_NRD_1	588	590	PF00675	0.766
CLV_NRD_NRD_1	591	593	PF00675	0.743
CLV_PCSK_FUR_1	589	593	PF00082	0.728
CLV_PCSK_KEX2_1	292	294	PF00082	0.881
CLV_PCSK_KEX2_1	323	325	PF00082	0.694
CLV_PCSK_KEX2_1	407	409	PF00082	0.702
CLV_PCSK_KEX2_1	459	461	PF00082	0.781
CLV_PCSK_KEX2_1	539	541	PF00082	0.772
CLV_PCSK_KEX2_1	591	593	PF00082	0.745
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.804
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.643
CLV_PCSK_SKI1_1	163	167	PF00082	0.448
CLV_PCSK_SKI1_1	172	176	PF00082	0.499
CLV_PCSK_SKI1_1	28	32	PF00082	0.508
CLV_PCSK_SKI1_1	464	468	PF00082	0.686
CLV_PCSK_SKI1_1	563	567	PF00082	0.587
DEG_Nend_Nbox_1	1	3	PF02207	0.776
DEG_SCF_FBW7_1	565	570	PF00400	0.588
DEG_SCF_TRCP1_1	254	260	PF00400	0.639
DEG_SCF_TRCP1_1	343	348	PF00400	0.704
DOC_CKS1_1	610	615	PF01111	0.591
DOC_MAPK_DCC_7	547	556	PF00069	0.752
DOC_MAPK_gen_1	323	330	PF00069	0.731
DOC_MAPK_gen_1	539	546	PF00069	0.763
DOC_MAPK_MEF2A_6	323	332	PF00069	0.526
DOC_PP1_RVXF_1	150	157	PF00149	0.354
DOC_USP7_MATH_1	304	308	PF00917	0.716
DOC_USP7_MATH_1	372	376	PF00917	0.741
DOC_USP7_MATH_1	382	386	PF00917	0.628
DOC_USP7_MATH_1	567	571	PF00917	0.842
DOC_USP7_MATH_1	577	581	PF00917	0.676
DOC_USP7_MATH_1	9	13	PF00917	0.636
DOC_USP7_UBL2_3	147	151	PF12436	0.584
DOC_USP7_UBL2_3	166	170	PF12436	0.396
DOC_USP7_UBL2_3	178	182	PF12436	0.460
DOC_WW_Pin1_4	286	291	PF00397	0.740
DOC_WW_Pin1_4	295	300	PF00397	0.696
DOC_WW_Pin1_4	3	8	PF00397	0.724
DOC_WW_Pin1_4	354	359	PF00397	0.795
DOC_WW_Pin1_4	364	369	PF00397	0.770
DOC_WW_Pin1_4	392	397	PF00397	0.738
DOC_WW_Pin1_4	563	568	PF00397	0.589
DOC_WW_Pin1_4	609	614	PF00397	0.789
DOC_WW_Pin1_4	622	627	PF00397	0.582
DOC_WW_Pin1_4	712	717	PF00397	0.777
DOC_WW_Pin1_4	736	741	PF00397	0.706
LIG_14-3-3_CanoR_1	169	175	PF00244	0.637
LIG_14-3-3_CanoR_1	274	283	PF00244	0.631
LIG_14-3-3_CanoR_1	384	392	PF00244	0.614
LIG_14-3-3_CanoR_1	39	47	PF00244	0.650
LIG_14-3-3_CanoR_1	522	529	PF00244	0.638
LIG_14-3-3_CanoR_1	539	544	PF00244	0.822
LIG_14-3-3_CanoR_1	624	634	PF00244	0.808
LIG_Actin_WH2_2	118	136	PF00022	0.638
LIG_BIR_III_2	410	414	PF00653	0.749
LIG_BRCT_BRCA1_1	312	316	PF00533	0.708
LIG_Clathr_ClatBox_1	551	555	PF01394	0.841
LIG_CtBP_PxDLS_1	553	557	PF00389	0.548
LIG_FHA_1	137	143	PF00498	0.510
LIG_FHA_1	470	476	PF00498	0.741
LIG_FHA_1	539	545	PF00498	0.766
LIG_FHA_2	201	207	PF00498	0.558
LIG_FHA_2	217	223	PF00498	0.353
LIG_FHA_2	431	437	PF00498	0.851
LIG_FHA_2	469	475	PF00498	0.753
LIG_Integrin_RGD_1	477	479	PF01839	0.577
LIG_LIR_Gen_1	202	213	PF02991	0.537
LIG_LIR_Gen_1	221	231	PF02991	0.326
LIG_LIR_Gen_1	348	358	PF02991	0.705
LIG_LIR_Gen_1	57	65	PF02991	0.573
LIG_LIR_Gen_1	77	87	PF02991	0.404
LIG_LIR_Nem_3	112	117	PF02991	0.497
LIG_LIR_Nem_3	153	159	PF02991	0.465
LIG_LIR_Nem_3	202	208	PF02991	0.533
LIG_LIR_Nem_3	313	319	PF02991	0.693
LIG_LIR_Nem_3	348	354	PF02991	0.706
LIG_LIR_Nem_3	57	61	PF02991	0.564
LIG_LIR_Nem_3	77	82	PF02991	0.432
LIG_NRBOX	258	264	PF00104	0.656
LIG_PDZ_Class_1	736	741	PF00595	0.734
LIG_PTAP_UEV_1	612	617	PF05743	0.582
LIG_SH2_CRK	351	355	PF00017	0.716
LIG_SH2_GRB2like	320	323	PF00017	0.777
LIG_SH2_NCK_1	386	390	PF00017	0.765
LIG_SH2_STAP1	14	18	PF00017	0.580
LIG_SH2_STAP1	194	198	PF00017	0.514
LIG_SH2_STAP1	205	209	PF00017	0.422
LIG_SH2_STAT3	180	183	PF00017	0.571
LIG_SH2_STAT3	416	419	PF00017	0.658
LIG_SH2_STAT5	167	170	PF00017	0.597
LIG_SH2_STAT5	180	183	PF00017	0.513
LIG_SH2_STAT5	214	217	PF00017	0.548
LIG_SH2_STAT5	416	419	PF00017	0.756
LIG_SH2_STAT5	496	499	PF00017	0.585
LIG_SH2_STAT5	79	82	PF00017	0.754
LIG_SH3_3	329	335	PF00018	0.554
LIG_SH3_3	388	394	PF00018	0.742
LIG_SH3_3	397	403	PF00018	0.722
LIG_SH3_3	604	610	PF00018	0.851
LIG_SH3_3	734	740	PF00018	0.619
LIG_SUMO_SIM_anti_2	49	55	PF11976	0.535
LIG_SUMO_SIM_par_1	516	521	PF11976	0.573
LIG_UBA3_1	105	109	PF00899	0.548
LIG_WRC_WIRS_1	79	84	PF05994	0.736
MOD_CDK_SPK_2	563	568	PF00069	0.589
MOD_CDK_SPxK_1	286	292	PF00069	0.804
MOD_CDK_SPxK_1	295	301	PF00069	0.713
MOD_CDK_SPxK_1	354	360	PF00069	0.885
MOD_CDK_SPxK_1	364	370	PF00069	0.679
MOD_CDK_SPxxK_3	286	293	PF00069	0.867
MOD_CK1_1	286	292	PF00069	0.785
MOD_CK1_1	3	9	PF00069	0.629
MOD_CK1_1	344	350	PF00069	0.803
MOD_CK1_1	364	370	PF00069	0.844
MOD_CK1_1	431	437	PF00069	0.731
MOD_CK1_1	49	55	PF00069	0.589
MOD_CK1_1	542	548	PF00069	0.745
MOD_CK1_1	570	576	PF00069	0.785
MOD_CK1_1	625	631	PF00069	0.785
MOD_CK1_1	701	707	PF00069	0.874
MOD_CK2_1	158	164	PF00069	0.604
MOD_CK2_1	170	176	PF00069	0.485
MOD_CK2_1	200	206	PF00069	0.513
MOD_CK2_1	384	390	PF00069	0.844
MOD_CK2_1	468	474	PF00069	0.752
MOD_CK2_1	54	60	PF00069	0.526
MOD_Cter_Amidation	457	460	PF01082	0.780
MOD_GlcNHglycan	101	104	PF01048	0.561
MOD_GlcNHglycan	254	257	PF01048	0.714
MOD_GlcNHglycan	343	346	PF01048	0.841
MOD_GlcNHglycan	374	377	PF01048	0.689
MOD_GlcNHglycan	386	389	PF01048	0.635
MOD_GlcNHglycan	429	433	PF01048	0.557
MOD_GlcNHglycan	498	501	PF01048	0.747
MOD_GlcNHglycan	524	527	PF01048	0.763
MOD_GlcNHglycan	613	616	PF01048	0.876
MOD_GlcNHglycan	680	683	PF01048	0.762
MOD_GlcNHglycan	700	703	PF01048	0.539
MOD_GSK3_1	1	8	PF00069	0.746
MOD_GSK3_1	113	120	PF00069	0.568
MOD_GSK3_1	170	177	PF00069	0.382
MOD_GSK3_1	200	207	PF00069	0.549
MOD_GSK3_1	225	232	PF00069	0.569
MOD_GSK3_1	282	289	PF00069	0.741
MOD_GSK3_1	300	307	PF00069	0.634
MOD_GSK3_1	310	317	PF00069	0.768
MOD_GSK3_1	341	348	PF00069	0.831
MOD_GSK3_1	350	357	PF00069	0.759
MOD_GSK3_1	364	371	PF00069	0.796
MOD_GSK3_1	380	387	PF00069	0.728
MOD_GSK3_1	424	431	PF00069	0.800
MOD_GSK3_1	464	471	PF00069	0.847
MOD_GSK3_1	534	541	PF00069	0.736
MOD_GSK3_1	559	566	PF00069	0.707
MOD_GSK3_1	567	574	PF00069	0.826
MOD_GSK3_1	618	625	PF00069	0.798
MOD_GSK3_1	65	72	PF00069	0.594
MOD_GSK3_1	662	669	PF00069	0.876
MOD_GSK3_1	701	708	PF00069	0.797
MOD_GSK3_1	712	719	PF00069	0.845
MOD_GSK3_1	86	93	PF00069	0.609
MOD_N-GLC_1	117	122	PF02516	0.638
MOD_N-GLC_1	283	288	PF02516	0.756
MOD_N-GLC_1	314	319	PF02516	0.791
MOD_N-GLC_1	364	369	PF02516	0.845
MOD_N-GLC_1	65	70	PF02516	0.566
MOD_NEK2_1	1	6	PF00069	0.733
MOD_NEK2_1	150	155	PF00069	0.378
MOD_NEK2_1	174	179	PF00069	0.577
MOD_NEK2_1	282	287	PF00069	0.753
MOD_NEK2_1	634	639	PF00069	0.770
MOD_NEK2_1	654	659	PF00069	0.572
MOD_NEK2_1	675	680	PF00069	0.779
MOD_NEK2_1	707	712	PF00069	0.787
MOD_NEK2_1	86	91	PF00069	0.600
MOD_NEK2_2	117	122	PF00069	0.638
MOD_PIKK_1	274	280	PF00454	0.593
MOD_PIKK_1	38	44	PF00454	0.649
MOD_PIKK_1	627	633	PF00454	0.860
MOD_PIKK_1	730	736	PF00454	0.846
MOD_PK_1	459	465	PF00069	0.666
MOD_PK_1	539	545	PF00069	0.720
MOD_PKA_1	459	465	PF00069	0.783
MOD_PKA_1	539	545	PF00069	0.763
MOD_PKA_1	591	597	PF00069	0.670
MOD_PKA_2	38	44	PF00069	0.649
MOD_PKA_2	459	465	PF00069	0.818
MOD_PKA_2	469	475	PF00069	0.724
MOD_PKA_2	538	544	PF00069	0.739
MOD_PKA_2	567	573	PF00069	0.837
MOD_PKA_2	591	597	PF00069	0.675
MOD_PKA_2	662	668	PF00069	0.855
MOD_Plk_1	117	123	PF00069	0.567
MOD_Plk_1	314	320	PF00069	0.661
MOD_Plk_1	618	624	PF00069	0.803
MOD_Plk_1	730	736	PF00069	0.846
MOD_Plk_4	204	210	PF00069	0.643
MOD_Plk_4	225	231	PF00069	0.470
MOD_Plk_4	315	321	PF00069	0.658
MOD_Plk_4	49	55	PF00069	0.530
MOD_Plk_4	539	545	PF00069	0.775
MOD_Plk_4	96	102	PF00069	0.545
MOD_ProDKin_1	286	292	PF00069	0.743
MOD_ProDKin_1	295	301	PF00069	0.694
MOD_ProDKin_1	3	9	PF00069	0.717
MOD_ProDKin_1	354	360	PF00069	0.795
MOD_ProDKin_1	364	370	PF00069	0.769
MOD_ProDKin_1	392	398	PF00069	0.739
MOD_ProDKin_1	563	569	PF00069	0.589
MOD_ProDKin_1	609	615	PF00069	0.792
MOD_ProDKin_1	622	628	PF00069	0.580
MOD_ProDKin_1	712	718	PF00069	0.774
MOD_SUMO_for_1	146	149	PF00179	0.548
MOD_SUMO_rev_2	141	148	PF00179	0.643
MOD_SUMO_rev_2	161	168	PF00179	0.327
MOD_SUMO_rev_2	173	179	PF00179	0.647
MOD_SUMO_rev_2	191	198	PF00179	0.542
TRG_DiLeu_BaEn_1	204	209	PF01217	0.524
TRG_DiLeu_BaEn_1	21	26	PF01217	0.630
TRG_ENDOCYTIC_2	205	208	PF00928	0.440
TRG_ENDOCYTIC_2	351	354	PF00928	0.718
TRG_ENDOCYTIC_2	399	402	PF00928	0.552
TRG_ENDOCYTIC_2	58	61	PF00928	0.509
TRG_ENDOCYTIC_2	79	82	PF00928	0.754
TRG_ER_diArg_1	406	408	PF00400	0.706
TRG_NLS_Bipartite_1	151	173	PF00514	0.580
TRG_NLS_MonoCore_2	589	594	PF00514	0.645
TRG_NLS_MonoExtN_4	166	173	PF00514	0.573
TRG_NLS_MonoExtN_4	589	595	PF00514	0.836
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	338	343	PF00026	0.776
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4R4	Leptomonas seymouri	39%	98%
A0A3Q8ICQ5	Leishmania donovani	85%	99%
A4HCW8	Leishmania braziliensis	59%	99%
A4I0E8	Leishmania infantum	85%	99%
Q4QB64	Leishmania major	84%	100%