DUF632 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AWB0_LEIMU

TriTrypDb:

LmxM.23.0980

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWB0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	156	158	PF00675	0.487
CLV_NRD_NRD_1	175	177	PF00675	0.493
CLV_NRD_NRD_1	199	201	PF00675	0.531
CLV_PCSK_KEX2_1	175	177	PF00082	0.498
CLV_PCSK_KEX2_1	198	200	PF00082	0.574
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.520
CLV_PCSK_SKI1_1	144	148	PF00082	0.509
CLV_PCSK_SKI1_1	151	155	PF00082	0.497
CLV_PCSK_SKI1_1	168	172	PF00082	0.496
CLV_PCSK_SKI1_1	195	199	PF00082	0.556
CLV_PCSK_SKI1_1	30	34	PF00082	0.485
CLV_PCSK_SKI1_1	41	45	PF00082	0.488
DOC_CYCLIN_RxL_1	25	35	PF00134	0.496
DOC_MAPK_gen_1	30	39	PF00069	0.544
DOC_MAPK_MEF2A_6	295	303	PF00069	0.470
DOC_PP2B_LxvP_1	299	302	PF13499	0.460
DOC_USP7_MATH_1	105	109	PF00917	0.481
DOC_USP7_MATH_1	179	183	PF00917	0.382
DOC_USP7_MATH_1	257	261	PF00917	0.602
DOC_USP7_MATH_1	93	97	PF00917	0.658
DOC_USP7_UBL2_3	154	158	PF12436	0.524
DOC_USP7_UBL2_3	191	195	PF12436	0.648
DOC_USP7_UBL2_3	291	295	PF12436	0.668
DOC_WW_Pin1_4	253	258	PF00397	0.595
DOC_WW_Pin1_4	294	299	PF00397	0.663
DOC_WW_Pin1_4	50	55	PF00397	0.496
LIG_14-3-3_CanoR_1	137	141	PF00244	0.504
LIG_14-3-3_CanoR_1	157	161	PF00244	0.393
LIG_14-3-3_CanoR_1	16	26	PF00244	0.588
LIG_Actin_WH2_2	138	156	PF00022	0.503
LIG_BRCT_BRCA1_1	224	228	PF00533	0.585
LIG_FHA_1	137	143	PF00498	0.502
LIG_FHA_1	230	236	PF00498	0.593
LIG_FHA_2	112	118	PF00498	0.600
LIG_FHA_2	131	137	PF00498	0.308
LIG_FHA_2	207	213	PF00498	0.517
LIG_LIR_Gen_1	164	173	PF02991	0.320
LIG_LIR_Gen_1	212	222	PF02991	0.493
LIG_LIR_Gen_1	35	44	PF02991	0.585
LIG_LIR_Gen_1	62	71	PF02991	0.620
LIG_LIR_Nem_3	106	112	PF02991	0.618
LIG_LIR_Nem_3	164	169	PF02991	0.324
LIG_LIR_Nem_3	212	217	PF02991	0.577
LIG_LIR_Nem_3	35	39	PF02991	0.489
LIG_LIR_Nem_3	62	67	PF02991	0.618
LIG_PDZ_Class_2	298	303	PF00595	0.463
LIG_SH2_CRK	64	68	PF00017	0.492
LIG_SH2_GRB2like	218	221	PF00017	0.403
LIG_SH2_GRB2like	64	67	PF00017	0.622
LIG_SH2_PTP2	36	39	PF00017	0.292
LIG_SH2_SRC	218	221	PF00017	0.578
LIG_SH2_STAP1	19	23	PF00017	0.432
LIG_SH2_STAP1	193	197	PF00017	0.557
LIG_SH2_STAP1	218	222	PF00017	0.467
LIG_SH2_STAT5	172	175	PF00017	0.365
LIG_SH2_STAT5	36	39	PF00017	0.292
LIG_SUMO_SIM_anti_2	45	51	PF11976	0.429
LIG_SUMO_SIM_par_1	138	143	PF11976	0.494
LIG_SUMO_SIM_par_1	145	150	PF11976	0.248
LIG_TYR_ITIM	34	39	PF00017	0.592
LIG_TYR_ITSM	60	67	PF00017	0.613
LIG_UBA3_1	282	291	PF00899	0.489
LIG_WRC_WIRS_1	112	117	PF05994	0.528
MOD_CDK_SPK_2	50	55	PF00069	0.307
MOD_CK1_1	182	188	PF00069	0.459
MOD_CK1_1	189	195	PF00069	0.410
MOD_CK1_1	297	303	PF00069	0.731
MOD_CK1_1	76	82	PF00069	0.716
MOD_CK2_1	111	117	PF00069	0.528
MOD_CK2_1	130	136	PF00069	0.333
MOD_CK2_1	171	177	PF00069	0.565
MOD_CK2_1	206	212	PF00069	0.519
MOD_Cter_Amidation	155	158	PF01082	0.594
MOD_GlcNHglycan	278	281	PF01048	0.564
MOD_GlcNHglycan	75	78	PF01048	0.587
MOD_GSK3_1	182	189	PF00069	0.462
MOD_GSK3_1	202	209	PF00069	0.569
MOD_GSK3_1	247	254	PF00069	0.529
MOD_GSK3_1	257	264	PF00069	0.620
MOD_GSK3_1	272	279	PF00069	0.634
MOD_GSK3_1	293	300	PF00069	0.682
MOD_GSK3_1	4	11	PF00069	0.683
MOD_GSK3_1	91	98	PF00069	0.651
MOD_N-GLC_1	4	9	PF02516	0.671
MOD_N-GLC_2	66	68	PF02516	0.544
MOD_NEK2_1	187	192	PF00069	0.641
MOD_NEK2_1	228	233	PF00069	0.516
MOD_NEK2_1	236	241	PF00069	0.527
MOD_NEK2_1	293	298	PF00069	0.571
MOD_NEK2_1	32	37	PF00069	0.511
MOD_NEK2_1	95	100	PF00069	0.495
MOD_NEK2_2	130	135	PF00069	0.294
MOD_NEK2_2	156	161	PF00069	0.524
MOD_NMyristoyl	1	7	PF02799	0.770
MOD_OFUCOSY	259	265	PF10250	0.430
MOD_PIKK_1	222	228	PF00454	0.429
MOD_PK_1	4	10	PF00069	0.505
MOD_PKA_1	199	205	PF00069	0.326
MOD_PKA_2	130	136	PF00069	0.396
MOD_PKA_2	156	162	PF00069	0.535
MOD_PKA_2	164	170	PF00069	0.454
MOD_PKA_2	199	205	PF00069	0.415
MOD_Plk_1	105	111	PF00069	0.617
MOD_Plk_1	4	10	PF00069	0.505
MOD_Plk_2-3	136	142	PF00069	0.505
MOD_Plk_4	202	208	PF00069	0.558
MOD_Plk_4	236	242	PF00069	0.357
MOD_Plk_4	32	38	PF00069	0.577
MOD_ProDKin_1	253	259	PF00069	0.597
MOD_ProDKin_1	294	300	PF00069	0.660
MOD_ProDKin_1	50	56	PF00069	0.502
MOD_SUMO_rev_2	117	124	PF00179	0.591
MOD_SUMO_rev_2	284	293	PF00179	0.485
TRG_ENDOCYTIC_2	19	22	PF00928	0.364
TRG_ENDOCYTIC_2	218	221	PF00928	0.476
TRG_ENDOCYTIC_2	244	247	PF00928	0.493
TRG_ENDOCYTIC_2	36	39	PF00928	0.545
TRG_ENDOCYTIC_2	64	67	PF00928	0.520
TRG_ER_diArg_1	97	100	PF00400	0.633
TRG_NES_CRM1_1	136	150	PF08389	0.553
TRG_NLS_MonoExtN_4	195	202	PF00514	0.334
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C0	Leptomonas seymouri	34%	95%
A0A3S7WXR6	Leishmania donovani	81%	99%
A4HCW7	Leishmania braziliensis	55%	100%
A4I0E7	Leishmania infantum	81%	99%
Q4QB65	Leishmania major	80%	100%