Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWA9_LEIMU

TriTrypDb:

LmxM.23.0970

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWA9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.592
CLV_C14_Caspase3-7	347	351	PF00656	0.521
CLV_NRD_NRD_1	160	162	PF00675	0.488
CLV_NRD_NRD_1	288	290	PF00675	0.471
CLV_NRD_NRD_1	291	293	PF00675	0.489
CLV_NRD_NRD_1	310	312	PF00675	0.590
CLV_NRD_NRD_1	374	376	PF00675	0.563
CLV_NRD_NRD_1	59	61	PF00675	0.382
CLV_PCSK_FUR_1	289	293	PF00082	0.459
CLV_PCSK_KEX2_1	160	162	PF00082	0.488
CLV_PCSK_KEX2_1	290	292	PF00082	0.483
CLV_PCSK_KEX2_1	310	312	PF00082	0.461
CLV_PCSK_KEX2_1	374	376	PF00082	0.563
CLV_PCSK_KEX2_1	383	385	PF00082	0.597
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.458
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.631
CLV_PCSK_SKI1_1	258	262	PF00082	0.432
CLV_PCSK_SKI1_1	278	282	PF00082	0.409
CLV_PCSK_SKI1_1	291	295	PF00082	0.506
CLV_PCSK_SKI1_1	370	374	PF00082	0.481
CLV_PCSK_SKI1_1	46	50	PF00082	0.437
DEG_Nend_Nbox_1	1	3	PF02207	0.564
DEG_SPOP_SBC_1	322	326	PF00917	0.535
DOC_ANK_TNKS_1	203	210	PF00023	0.431
DOC_MAPK_gen_1	254	261	PF00069	0.409
DOC_MAPK_gen_1	289	296	PF00069	0.477
DOC_MAPK_HePTP_8	57	73	PF00069	0.335
DOC_PP2B_LxvP_1	71	74	PF13499	0.465
DOC_USP7_MATH_1	202	206	PF00917	0.621
DOC_USP7_MATH_1	216	220	PF00917	0.387
DOC_USP7_MATH_1	228	232	PF00917	0.370
DOC_USP7_MATH_1	321	325	PF00917	0.671
DOC_USP7_MATH_1	378	382	PF00917	0.575
DOC_USP7_MATH_1	8	12	PF00917	0.558
DOC_WW_Pin1_4	11	16	PF00397	0.624
DOC_WW_Pin1_4	145	150	PF00397	0.632
DOC_WW_Pin1_4	301	306	PF00397	0.575
LIG_14-3-3_CanoR_1	377	385	PF00244	0.592
LIG_14-3-3_CanoR_1	6	16	PF00244	0.546
LIG_DCNL_PONY_1	1	4	PF03556	0.641
LIG_deltaCOP1_diTrp_1	308	315	PF00928	0.598
LIG_eIF4E_1	44	50	PF01652	0.447
LIG_FHA_1	12	18	PF00498	0.625
LIG_FHA_1	45	51	PF00498	0.462
LIG_FHA_2	106	112	PF00498	0.626
LIG_FHA_2	81	87	PF00498	0.440
LIG_LIR_Apic_2	183	188	PF02991	0.483
LIG_LIR_Gen_1	309	318	PF02991	0.576
LIG_LIR_Gen_1	39	50	PF02991	0.478
LIG_LIR_Nem_3	10	16	PF02991	0.520
LIG_LIR_Nem_3	309	315	PF02991	0.600
LIG_LIR_Nem_3	382	388	PF02991	0.585
LIG_LIR_Nem_3	39	45	PF02991	0.485
LIG_LYPXL_SIV_4	41	49	PF13949	0.432
LIG_NRBOX	67	73	PF00104	0.424
LIG_SH2_CRK	13	17	PF00017	0.593
LIG_SH2_CRK	185	189	PF00017	0.482
LIG_SH2_CRK	239	243	PF00017	0.354
LIG_SH2_CRK	38	42	PF00017	0.520
LIG_SH2_NCK_1	185	189	PF00017	0.482
LIG_SH2_NCK_1	38	42	PF00017	0.481
LIG_SH2_PTP2	42	45	PF00017	0.433
LIG_SH2_SRC	42	45	PF00017	0.433
LIG_SH2_SRC	64	67	PF00017	0.406
LIG_SH2_STAP1	31	35	PF00017	0.506
LIG_SH2_STAT5	13	16	PF00017	0.659
LIG_SH2_STAT5	144	147	PF00017	0.584
LIG_SH2_STAT5	42	45	PF00017	0.465
LIG_SH2_STAT5	64	67	PF00017	0.457
LIG_SUMO_SIM_anti_2	257	264	PF11976	0.409
LIG_SUMO_SIM_anti_2	83	89	PF11976	0.422
LIG_TRAF2_1	280	283	PF00917	0.405
LIG_TRAF2_1	359	362	PF00917	0.552
LIG_TYR_ITIM	237	242	PF00017	0.355
LIG_UBA3_1	295	303	PF00899	0.527
LIG_WRC_WIRS_1	220	225	PF05994	0.448
MOD_CK1_1	11	17	PF00069	0.544
MOD_CK1_1	147	153	PF00069	0.603
MOD_CK1_1	172	178	PF00069	0.593
MOD_CK1_1	219	225	PF00069	0.484
MOD_CK1_1	29	35	PF00069	0.523
MOD_CK1_1	75	81	PF00069	0.507
MOD_CK2_1	105	111	PF00069	0.650
MOD_CK2_1	202	208	PF00069	0.542
MOD_CK2_1	249	255	PF00069	0.387
MOD_CK2_1	80	86	PF00069	0.446
MOD_GlcNHglycan	100	103	PF01048	0.752
MOD_GlcNHglycan	224	227	PF01048	0.519
MOD_GlcNHglycan	251	254	PF01048	0.427
MOD_GlcNHglycan	269	272	PF01048	0.483
MOD_GlcNHglycan	31	34	PF01048	0.509
MOD_GlcNHglycan	319	322	PF01048	0.761
MOD_GSK3_1	129	136	PF00069	0.613
MOD_GSK3_1	198	205	PF00069	0.515
MOD_GSK3_1	22	29	PF00069	0.500
MOD_GSK3_1	224	231	PF00069	0.473
MOD_GSK3_1	313	320	PF00069	0.643
MOD_GSK3_1	331	338	PF00069	0.539
MOD_GSK3_1	7	14	PF00069	0.637
MOD_N-GLC_1	169	174	PF02516	0.489
MOD_N-GLC_1	301	306	PF02516	0.651
MOD_N-GLC_1	322	327	PF02516	0.538
MOD_N-GLC_1	80	85	PF02516	0.433
MOD_NEK2_1	2	7	PF00069	0.557
MOD_NEK2_1	22	27	PF00069	0.459
MOD_NEK2_1	261	266	PF00069	0.409
MOD_PIKK_1	75	81	PF00454	0.469
MOD_PK_1	284	290	PF00069	0.429
MOD_PKA_2	172	178	PF00069	0.666
MOD_PKA_2	379	385	PF00069	0.586
MOD_PKA_2	8	14	PF00069	0.535
MOD_Plk_2-3	105	111	PF00069	0.655
MOD_Plk_2-3	129	135	PF00069	0.594
MOD_Plk_4	216	222	PF00069	0.501
MOD_Plk_4	22	28	PF00069	0.532
MOD_Plk_4	368	374	PF00069	0.544
MOD_Plk_4	44	50	PF00069	0.432
MOD_ProDKin_1	11	17	PF00069	0.624
MOD_ProDKin_1	145	151	PF00069	0.635
MOD_ProDKin_1	301	307	PF00069	0.573
TRG_DiLeu_BaEn_1	257	262	PF01217	0.410
TRG_DiLeu_BaEn_2	85	91	PF01217	0.425
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.539
TRG_ENDOCYTIC_2	13	16	PF00928	0.540
TRG_ENDOCYTIC_2	239	242	PF00928	0.352
TRG_ENDOCYTIC_2	385	388	PF00928	0.655
TRG_ENDOCYTIC_2	42	45	PF00928	0.433
TRG_ER_diArg_1	159	161	PF00400	0.498
TRG_ER_diArg_1	288	291	PF00400	0.443
TRG_ER_diArg_1	310	312	PF00400	0.594
TRG_ER_diArg_1	373	375	PF00400	0.473
TRG_NLS_MonoCore_2	288	293	PF00514	0.452
TRG_NLS_MonoExtN_4	289	294	PF00514	0.490
TRG_NLS_MonoExtN_4	58	64	PF00514	0.363
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	292	297	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP9	Leptomonas seymouri	50%	100%
A0A3S5H7C1	Leishmania donovani	85%	99%
A4HCW6	Leishmania braziliensis	74%	99%
A4I0E6	Leishmania infantum	86%	100%
Q4QB66	Leishmania major	88%	100%