Cadherin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWA8_LEIMU

TriTrypDb:

LmxM.23.0960

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AWA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	50	54	PF00656	0.665
CLV_C14_Caspase3-7	650	654	PF00656	0.663
CLV_NRD_NRD_1	244	246	PF00675	0.551
CLV_NRD_NRD_1	350	352	PF00675	0.463
CLV_NRD_NRD_1	37	39	PF00675	0.389
CLV_NRD_NRD_1	44	46	PF00675	0.436
CLV_NRD_NRD_1	445	447	PF00675	0.475
CLV_NRD_NRD_1	521	523	PF00675	0.495
CLV_PCSK_FUR_1	35	39	PF00082	0.443
CLV_PCSK_FUR_1	41	45	PF00082	0.473
CLV_PCSK_KEX2_1	244	246	PF00082	0.528
CLV_PCSK_KEX2_1	35	37	PF00082	0.388
CLV_PCSK_KEX2_1	350	352	PF00082	0.431
CLV_PCSK_KEX2_1	43	45	PF00082	0.425
CLV_PCSK_KEX2_1	445	447	PF00082	0.469
CLV_PCSK_KEX2_1	520	522	PF00082	0.503
CLV_PCSK_KEX2_1	602	604	PF00082	0.555
CLV_PCSK_PC1ET2_1	602	604	PF00082	0.520
CLV_PCSK_SKI1_1	390	394	PF00082	0.458
CLV_PCSK_SKI1_1	446	450	PF00082	0.507
CLV_PCSK_SKI1_1	49	53	PF00082	0.488
CLV_PCSK_SKI1_1	510	514	PF00082	0.492
CLV_PCSK_SKI1_1	547	551	PF00082	0.424
CLV_PCSK_SKI1_1	643	647	PF00082	0.392
DEG_COP1_1	401	410	PF00400	0.713
DEG_SPOP_SBC_1	299	303	PF00917	0.664
DOC_ANK_TNKS_1	319	326	PF00023	0.495
DOC_CKS1_1	110	115	PF01111	0.637
DOC_CKS1_1	217	222	PF01111	0.591
DOC_CKS1_1	306	311	PF01111	0.693
DOC_CKS1_1	407	412	PF01111	0.714
DOC_CYCLIN_RxL_1	38	52	PF00134	0.650
DOC_CYCLIN_yCln2_LP_2	394	400	PF00134	0.638
DOC_MAPK_gen_1	36	48	PF00069	0.641
DOC_MAPK_MEF2A_6	6	14	PF00069	0.364
DOC_MAPK_RevD_3	21	36	PF00069	0.395
DOC_PP1_RVXF_1	444	451	PF00149	0.704
DOC_PP1_RVXF_1	545	551	PF00149	0.588
DOC_PP2B_LxvP_1	211	214	PF13499	0.739
DOC_PP2B_LxvP_1	338	341	PF13499	0.602
DOC_PP2B_PxIxI_1	536	542	PF00149	0.543
DOC_PP4_FxxP_1	110	113	PF00568	0.630
DOC_PP4_FxxP_1	172	175	PF00568	0.551
DOC_PP4_FxxP_1	550	553	PF00568	0.579
DOC_USP7_MATH_1	105	109	PF00917	0.680
DOC_USP7_MATH_1	184	188	PF00917	0.443
DOC_USP7_MATH_1	226	230	PF00917	0.812
DOC_USP7_MATH_1	250	254	PF00917	0.689
DOC_USP7_MATH_1	372	376	PF00917	0.686
DOC_USP7_MATH_1	408	412	PF00917	0.653
DOC_WW_Pin1_4	100	105	PF00397	0.580
DOC_WW_Pin1_4	109	114	PF00397	0.577
DOC_WW_Pin1_4	165	170	PF00397	0.451
DOC_WW_Pin1_4	209	214	PF00397	0.774
DOC_WW_Pin1_4	216	221	PF00397	0.784
DOC_WW_Pin1_4	261	266	PF00397	0.782
DOC_WW_Pin1_4	305	310	PF00397	0.534
DOC_WW_Pin1_4	406	411	PF00397	0.697
DOC_WW_Pin1_4	533	538	PF00397	0.526
DOC_WW_Pin1_4	571	576	PF00397	0.741
DOC_WW_Pin1_4	605	610	PF00397	0.785
DOC_WW_Pin1_4	693	698	PF00397	0.576
LIG_14-3-3_CanoR_1	320	324	PF00244	0.557
LIG_14-3-3_CanoR_1	337	341	PF00244	0.654
LIG_14-3-3_CanoR_1	379	385	PF00244	0.719
LIG_14-3-3_CanoR_1	473	478	PF00244	0.436
LIG_14-3-3_CanoR_1	498	503	PF00244	0.587
LIG_14-3-3_CanoR_1	510	518	PF00244	0.603
LIG_14-3-3_CanoR_1	558	564	PF00244	0.636
LIG_BIR_III_4	281	285	PF00653	0.648
LIG_BIR_III_4	62	66	PF00653	0.705
LIG_BRCT_BRCA1_1	82	86	PF00533	0.488
LIG_CaM_IQ_9	30	46	PF13499	0.433
LIG_Clathr_ClatBox_1	133	137	PF01394	0.594
LIG_Clathr_ClatBox_1	237	241	PF01394	0.582
LIG_Clathr_ClatBox_1	438	442	PF01394	0.606
LIG_eIF4E_1	159	165	PF01652	0.605
LIG_eIF4E_1	627	633	PF01652	0.532
LIG_EVH1_2	289	293	PF00568	0.475
LIG_FHA_1	110	116	PF00498	0.596
LIG_FHA_1	165	171	PF00498	0.585
LIG_FHA_1	217	223	PF00498	0.807
LIG_FHA_1	233	239	PF00498	0.775
LIG_FHA_1	25	31	PF00498	0.454
LIG_FHA_1	258	264	PF00498	0.755
LIG_FHA_1	301	307	PF00498	0.576
LIG_FHA_1	341	347	PF00498	0.552
LIG_FHA_1	430	436	PF00498	0.561
LIG_FHA_1	464	470	PF00498	0.676
LIG_FHA_1	633	639	PF00498	0.610
LIG_FHA_1	67	73	PF00498	0.633
LIG_FHA_1	7	13	PF00498	0.229
LIG_FHA_2	222	228	PF00498	0.801
LIG_FHA_2	299	305	PF00498	0.634
LIG_FHA_2	306	312	PF00498	0.584
LIG_FHA_2	432	438	PF00498	0.626
LIG_FHA_2	560	566	PF00498	0.666
LIG_FHA_2	629	635	PF00498	0.689
LIG_GBD_Chelix_1	22	30	PF00786	0.394
LIG_Integrin_isoDGR_2	556	558	PF01839	0.442
LIG_LIR_Apic_2	108	113	PF02991	0.647
LIG_LIR_Apic_2	171	175	PF02991	0.592
LIG_LIR_Apic_2	329	335	PF02991	0.575
LIG_LIR_Apic_2	401	405	PF02991	0.655
LIG_LIR_Gen_1	148	158	PF02991	0.613
LIG_LIR_Gen_1	434	444	PF02991	0.590
LIG_LIR_LC3C_4	111	116	PF02991	0.613
LIG_LIR_Nem_3	148	153	PF02991	0.670
LIG_LIR_Nem_3	162	166	PF02991	0.550
LIG_LIR_Nem_3	27	32	PF02991	0.454
LIG_LIR_Nem_3	324	330	PF02991	0.577
LIG_LIR_Nem_3	434	439	PF02991	0.579
LIG_LYPXL_SIV_4	125	133	PF13949	0.476
LIG_LYPXL_yS_3	327	330	PF13949	0.610
LIG_Pex14_2	645	649	PF04695	0.624
LIG_Pex14_2	682	686	PF04695	0.598
LIG_Pex14_2	86	90	PF04695	0.627
LIG_PTB_Apo_2	152	159	PF02174	0.735
LIG_PTB_Phospho_1	152	158	PF10480	0.744
LIG_RPA_C_Fungi	239	251	PF08784	0.674
LIG_RPA_C_Fungi	31	43	PF08784	0.522
LIG_SH2_CRK	166	170	PF00017	0.545
LIG_SH2_CRK	332	336	PF00017	0.440
LIG_SH2_CRK	678	682	PF00017	0.619
LIG_SH2_GRB2like	159	162	PF00017	0.439
LIG_SH2_GRB2like	687	690	PF00017	0.659
LIG_SH2_NCK_1	332	336	PF00017	0.592
LIG_SH2_NCK_1	436	440	PF00017	0.535
LIG_SH2_PTP2	627	630	PF00017	0.374
LIG_SH2_SRC	225	228	PF00017	0.717
LIG_SH2_SRC	622	625	PF00017	0.582
LIG_SH2_SRC	627	630	PF00017	0.554
LIG_SH2_STAP1	370	374	PF00017	0.435
LIG_SH2_STAP1	436	440	PF00017	0.531
LIG_SH2_STAT3	178	181	PF00017	0.566
LIG_SH2_STAT3	620	623	PF00017	0.501
LIG_SH2_STAT5	117	120	PF00017	0.492
LIG_SH2_STAT5	126	129	PF00017	0.559
LIG_SH2_STAT5	166	169	PF00017	0.452
LIG_SH2_STAT5	200	203	PF00017	0.511
LIG_SH2_STAT5	332	335	PF00017	0.441
LIG_SH2_STAT5	402	405	PF00017	0.644
LIG_SH2_STAT5	422	425	PF00017	0.457
LIG_SH2_STAT5	47	50	PF00017	0.664
LIG_SH2_STAT5	561	564	PF00017	0.459
LIG_SH2_STAT5	620	623	PF00017	0.546
LIG_SH2_STAT5	627	630	PF00017	0.522
LIG_SH2_STAT5	639	642	PF00017	0.479
LIG_SH2_STAT5	687	690	PF00017	0.659
LIG_SH3_1	402	408	PF00018	0.689
LIG_SH3_3	210	216	PF00018	0.733
LIG_SH3_3	260	266	PF00018	0.754
LIG_SH3_3	284	290	PF00018	0.503
LIG_SH3_3	303	309	PF00018	0.293
LIG_SH3_3	402	408	PF00018	0.546
LIG_SH3_3	570	576	PF00018	0.579
LIG_SH3_3	641	647	PF00018	0.480
LIG_SH3_3	69	75	PF00018	0.659
LIG_Sin3_3	391	398	PF02671	0.514
LIG_SUMO_SIM_par_1	131	137	PF11976	0.490
LIG_SUMO_SIM_par_1	19	25	PF11976	0.469
LIG_SUMO_SIM_par_1	235	241	PF11976	0.478
LIG_SUMO_SIM_par_1	461	467	PF11976	0.575
LIG_TRAF2_1	493	496	PF00917	0.453
LIG_TRAF2_1	94	97	PF00917	0.587
LIG_TYR_ITIM	115	120	PF00017	0.484
LIG_TYR_ITSM	432	439	PF00017	0.535
LIG_WRC_WIRS_1	48	53	PF05994	0.594
MOD_CDK_SPxxK_3	406	413	PF00069	0.628
MOD_CK1_1	103	109	PF00069	0.624
MOD_CK1_1	142	148	PF00069	0.682
MOD_CK1_1	209	215	PF00069	0.727
MOD_CK1_1	272	278	PF00069	0.592
MOD_CK1_1	326	332	PF00069	0.456
MOD_CK1_1	375	381	PF00069	0.657
MOD_CK1_1	386	392	PF00069	0.417
MOD_CK2_1	165	171	PF00069	0.292
MOD_CK2_1	221	227	PF00069	0.778
MOD_CK2_1	250	256	PF00069	0.488
MOD_CK2_1	298	304	PF00069	0.565
MOD_CK2_1	305	311	PF00069	0.500
MOD_CK2_1	431	437	PF00069	0.516
MOD_CK2_1	539	545	PF00069	0.493
MOD_CK2_1	628	634	PF00069	0.602
MOD_Cter_Amidation	600	603	PF01082	0.775
MOD_GlcNHglycan	105	108	PF01048	0.666
MOD_GlcNHglycan	146	150	PF01048	0.508
MOD_GlcNHglycan	208	211	PF01048	0.697
MOD_GlcNHglycan	229	232	PF01048	0.710
MOD_GlcNHglycan	272	275	PF01048	0.766
MOD_GlcNHglycan	277	281	PF01048	0.721
MOD_GlcNHglycan	369	373	PF01048	0.676
MOD_GlcNHglycan	374	377	PF01048	0.662
MOD_GlcNHglycan	381	384	PF01048	0.538
MOD_GlcNHglycan	385	388	PF01048	0.411
MOD_GlcNHglycan	479	482	PF01048	0.641
MOD_GlcNHglycan	487	490	PF01048	0.653
MOD_GlcNHglycan	669	672	PF01048	0.666
MOD_GlcNHglycan	80	83	PF01048	0.617
MOD_GSK3_1	105	112	PF00069	0.564
MOD_GSK3_1	205	212	PF00069	0.645
MOD_GSK3_1	257	264	PF00069	0.740
MOD_GSK3_1	272	279	PF00069	0.724
MOD_GSK3_1	319	326	PF00069	0.455
MOD_GSK3_1	336	343	PF00069	0.512
MOD_GSK3_1	368	375	PF00069	0.683
MOD_GSK3_1	379	386	PF00069	0.545
MOD_GSK3_1	448	455	PF00069	0.509
MOD_GSK3_1	473	480	PF00069	0.556
MOD_GSK3_1	559	566	PF00069	0.457
MOD_GSK3_1	628	635	PF00069	0.487
MOD_GSK3_1	63	70	PF00069	0.717
MOD_GSK3_1	663	670	PF00069	0.714
MOD_N-GLC_1	232	237	PF02516	0.734
MOD_N-GLC_1	417	422	PF02516	0.504
MOD_N-GLC_1	563	568	PF02516	0.578
MOD_N-GLC_1	6	11	PF02516	0.302
MOD_N-GLC_1	688	693	PF02516	0.505
MOD_NEK2_1	164	169	PF00069	0.487
MOD_NEK2_1	257	262	PF00069	0.794
MOD_NEK2_1	269	274	PF00069	0.525
MOD_NEK2_1	330	335	PF00069	0.429
MOD_NEK2_1	336	341	PF00069	0.438
MOD_NEK2_1	414	419	PF00069	0.515
MOD_NEK2_1	423	428	PF00069	0.431
MOD_NEK2_1	632	637	PF00069	0.642
MOD_NEK2_1	78	83	PF00069	0.666
MOD_PIKK_1	345	351	PF00454	0.616
MOD_PIKK_1	429	435	PF00454	0.512
MOD_PIKK_1	452	458	PF00454	0.339
MOD_PIKK_1	632	638	PF00454	0.629
MOD_PK_1	498	504	PF00069	0.581
MOD_PKA_2	139	145	PF00069	0.665
MOD_PKA_2	319	325	PF00069	0.438
MOD_PKA_2	336	342	PF00069	0.616
MOD_PKA_2	378	384	PF00069	0.602
MOD_PKA_2	414	420	PF00069	0.613
MOD_Plk_1	232	238	PF00069	0.733
MOD_Plk_1	310	316	PF00069	0.442
MOD_Plk_1	417	423	PF00069	0.499
MOD_Plk_1	6	12	PF00069	0.300
MOD_Plk_2-3	311	317	PF00069	0.370
MOD_Plk_4	24	30	PF00069	0.422
MOD_Plk_4	326	332	PF00069	0.431
MOD_Plk_4	341	347	PF00069	0.527
MOD_Plk_4	398	404	PF00069	0.552
MOD_Plk_4	417	423	PF00069	0.542
MOD_Plk_4	431	437	PF00069	0.486
MOD_Plk_4	616	622	PF00069	0.473
MOD_Plk_4	628	634	PF00069	0.450
MOD_ProDKin_1	100	106	PF00069	0.483
MOD_ProDKin_1	109	115	PF00069	0.466
MOD_ProDKin_1	165	171	PF00069	0.292
MOD_ProDKin_1	209	215	PF00069	0.745
MOD_ProDKin_1	216	222	PF00069	0.762
MOD_ProDKin_1	261	267	PF00069	0.756
MOD_ProDKin_1	305	311	PF00069	0.421
MOD_ProDKin_1	406	412	PF00069	0.632
MOD_ProDKin_1	533	539	PF00069	0.391
MOD_ProDKin_1	571	577	PF00069	0.692
MOD_ProDKin_1	605	611	PF00069	0.753
MOD_SUMO_rev_2	542	549	PF00179	0.487
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.780
TRG_DiLeu_BaLyEn_6	669	674	PF01217	0.563
TRG_ENDOCYTIC_2	117	120	PF00928	0.535
TRG_ENDOCYTIC_2	327	330	PF00928	0.483
TRG_ENDOCYTIC_2	436	439	PF00928	0.421
TRG_ENDOCYTIC_2	627	630	PF00928	0.374
TRG_ENDOCYTIC_2	678	681	PF00928	0.595
TRG_ENDOCYTIC_2	87	90	PF00928	0.490
TRG_ER_diArg_1	118	121	PF00400	0.544
TRG_ER_diArg_1	35	38	PF00400	0.506
TRG_ER_diArg_1	41	44	PF00400	0.539
TRG_ER_diArg_1	412	415	PF00400	0.557
TRG_ER_diArg_1	520	522	PF00400	0.664
TRG_NLS_MonoExtN_4	445	450	PF00514	0.622
TRG_Pf-PMV_PEXEL_1	521	525	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q7	Leptomonas seymouri	53%	100%
A0A1X0NWT3	Trypanosomatidae	34%	100%
A0A3Q8IM61	Leishmania donovani	90%	100%
A0A3R7NT57	Trypanosoma rangeli	35%	100%
A4HCW5	Leishmania braziliensis	71%	98%
A4I0E5	Leishmania infantum	89%	100%
C9ZV90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4QB67	Leishmania major	87%	100%
V5BEP2	Trypanosoma cruzi	35%	100%