Protein arginine methyltransferase NDUFAF7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative S-adenosyl-L-methionine-dependent methyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AWA4_LEIMU

TriTrypDb:

LmxM.23.0890

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AWA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWA4

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0010257	NADH dehydrogenase complex assembly	6	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0032981	mitochondrial respiratory chain complex I assembly	7	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0008168	methyltransferase activity	4	10
GO:0008170	N-methyltransferase activity	5	10
GO:0008276	protein methyltransferase activity	3	10
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	10
GO:0016273	arginine N-methyltransferase activity	6	10
GO:0016274	protein-arginine N-methyltransferase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10
GO:0035243	protein-arginine omega-N symmetric methyltransferase activity	5	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	434	438	PF00656	0.204
CLV_NRD_NRD_1	200	202	PF00675	0.345
CLV_NRD_NRD_1	383	385	PF00675	0.379
CLV_NRD_NRD_1	427	429	PF00675	0.333
CLV_NRD_NRD_1	7	9	PF00675	0.409
CLV_PCSK_KEX2_1	200	202	PF00082	0.345
CLV_PCSK_KEX2_1	205	207	PF00082	0.345
CLV_PCSK_KEX2_1	383	385	PF00082	0.379
CLV_PCSK_KEX2_1	427	429	PF00082	0.333
CLV_PCSK_KEX2_1	7	9	PF00082	0.409
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.272
CLV_PCSK_PC7_1	201	207	PF00082	0.272
CLV_PCSK_SKI1_1	172	176	PF00082	0.230
CLV_PCSK_SKI1_1	205	209	PF00082	0.230
CLV_PCSK_SKI1_1	373	377	PF00082	0.254
CLV_PCSK_SKI1_1	384	388	PF00082	0.244
CLV_PCSK_SKI1_1	76	80	PF00082	0.341
DEG_APCC_DBOX_1	171	179	PF00400	0.238
DEG_APCC_DBOX_1	372	380	PF00400	0.252
DEG_Nend_UBRbox_3	1	3	PF02207	0.431
DOC_CKS1_1	152	157	PF01111	0.230
DOC_CKS1_1	20	25	PF01111	0.445
DOC_CKS1_1	62	67	PF01111	0.463
DOC_CYCLIN_RxL_1	151	162	PF00134	0.252
DOC_MAPK_gen_1	217	224	PF00069	0.230
DOC_MAPK_gen_1	296	305	PF00069	0.345
DOC_MAPK_MEF2A_6	47	55	PF00069	0.549
DOC_PP1_RVXF_1	215	221	PF00149	0.230
DOC_PP1_RVXF_1	368	375	PF00149	0.230
DOC_PP1_RVXF_1	382	389	PF00149	0.267
DOC_PP4_FxxP_1	351	354	PF00568	0.230
DOC_USP7_MATH_1	13	17	PF00917	0.583
DOC_USP7_MATH_1	26	30	PF00917	0.725
DOC_USP7_MATH_1	280	284	PF00917	0.240
DOC_USP7_UBL2_3	417	421	PF12436	0.358
DOC_USP7_UBL2_3	75	79	PF12436	0.480
DOC_WW_Pin1_4	151	156	PF00397	0.230
DOC_WW_Pin1_4	19	24	PF00397	0.632
DOC_WW_Pin1_4	354	359	PF00397	0.230
DOC_WW_Pin1_4	450	455	PF00397	0.338
DOC_WW_Pin1_4	46	51	PF00397	0.600
DOC_WW_Pin1_4	61	66	PF00397	0.414
LIG_14-3-3_CanoR_1	251	258	PF00244	0.230
LIG_14-3-3_CanoR_1	67	71	PF00244	0.568
LIG_14-3-3_CanoR_1	7	12	PF00244	0.444
LIG_Actin_WH2_2	360	375	PF00022	0.230
LIG_BIR_III_2	243	247	PF00653	0.230
LIG_BRCT_BRCA1_1	225	229	PF00533	0.252
LIG_BRCT_BRCA1_1	452	456	PF00533	0.290
LIG_eIF4E_1	180	186	PF01652	0.230
LIG_EVH1_1	461	465	PF00568	0.452
LIG_FHA_1	152	158	PF00498	0.274
LIG_FHA_1	232	238	PF00498	0.206
LIG_FHA_2	128	134	PF00498	0.307
LIG_FHA_2	258	264	PF00498	0.230
LIG_FHA_2	391	397	PF00498	0.291
LIG_LIR_Apic_2	285	290	PF02991	0.230
LIG_LIR_Gen_1	147	157	PF02991	0.230
LIG_LIR_Gen_1	240	250	PF02991	0.230
LIG_LIR_Gen_1	364	372	PF02991	0.230
LIG_LIR_Gen_1	453	464	PF02991	0.390
LIG_LIR_Nem_3	240	245	PF02991	0.258
LIG_LIR_Nem_3	271	277	PF02991	0.246
LIG_LIR_Nem_3	364	369	PF02991	0.242
LIG_LIR_Nem_3	437	442	PF02991	0.349
LIG_LIR_Nem_3	446	452	PF02991	0.337
LIG_MLH1_MIPbox_1	452	456	PF16413	0.290
LIG_MYND_1	354	358	PF01753	0.230
LIG_NRP_CendR_1	467	470	PF00754	0.643
LIG_PTB_Apo_2	236	243	PF02174	0.230
LIG_SH2_CRK	180	184	PF00017	0.230
LIG_SH2_CRK	426	430	PF00017	0.301
LIG_SH2_GRB2like	180	183	PF00017	0.230
LIG_SH2_SRC	287	290	PF00017	0.230
LIG_SH2_STAT5	241	244	PF00017	0.279
LIG_SH2_STAT5	252	255	PF00017	0.251
LIG_SH2_STAT5	287	290	PF00017	0.230
LIG_SH3_2	462	467	PF14604	0.426
LIG_SH3_3	17	23	PF00018	0.606
LIG_SH3_3	274	280	PF00018	0.288
LIG_SH3_3	30	36	PF00018	0.633
LIG_SH3_3	457	463	PF00018	0.437
LIG_TRFH_1	229	233	PF08558	0.252
LIG_UBA3_1	170	176	PF00899	0.230
LIG_UBA3_1	316	325	PF00899	0.230
LIG_WW_2	462	465	PF00397	0.485
MOD_CDK_SPK_2	151	156	PF00069	0.230
MOD_CDK_SPxK_1	46	52	PF00069	0.602
MOD_CDK_SPxK_1	61	67	PF00069	0.412
MOD_CK1_1	28	34	PF00069	0.511
MOD_CK1_1	60	66	PF00069	0.459
MOD_CK2_1	127	133	PF00069	0.322
MOD_CK2_1	257	263	PF00069	0.234
MOD_CK2_1	354	360	PF00069	0.230
MOD_Cter_Amidation	296	299	PF01082	0.144
MOD_GlcNHglycan	28	31	PF01048	0.734
MOD_GlcNHglycan	280	283	PF01048	0.230
MOD_GlcNHglycan	284	287	PF01048	0.230
MOD_GlcNHglycan	71	74	PF01048	0.568
MOD_GSK3_1	166	173	PF00069	0.345
MOD_GSK3_1	223	230	PF00069	0.291
MOD_GSK3_1	24	31	PF00069	0.736
MOD_GSK3_1	263	270	PF00069	0.297
MOD_GSK3_1	278	285	PF00069	0.167
MOD_GSK3_1	361	368	PF00069	0.230
MOD_GSK3_1	57	64	PF00069	0.456
MOD_N-GLC_1	450	455	PF02516	0.283
MOD_NEK2_1	170	175	PF00069	0.297
MOD_NEK2_1	18	23	PF00069	0.422
MOD_NEK2_1	339	344	PF00069	0.230
MOD_NEK2_1	435	440	PF00069	0.282
MOD_NEK2_1	45	50	PF00069	0.505
MOD_NEK2_2	365	370	PF00069	0.345
MOD_PIKK_1	390	396	PF00454	0.279
MOD_PIKK_1	96	102	PF00454	0.273
MOD_PK_1	7	13	PF00069	0.427
MOD_PKA_1	7	13	PF00069	0.401
MOD_PKA_2	166	172	PF00069	0.230
MOD_PKA_2	250	256	PF00069	0.261
MOD_PKA_2	66	72	PF00069	0.561
MOD_PKA_2	7	13	PF00069	0.446
MOD_Plk_1	361	367	PF00069	0.230
MOD_Plk_4	13	19	PF00069	0.627
MOD_Plk_4	166	172	PF00069	0.230
MOD_Plk_4	231	237	PF00069	0.285
MOD_Plk_4	312	318	PF00069	0.371
MOD_ProDKin_1	151	157	PF00069	0.230
MOD_ProDKin_1	19	25	PF00069	0.632
MOD_ProDKin_1	354	360	PF00069	0.230
MOD_ProDKin_1	450	456	PF00069	0.347
MOD_ProDKin_1	46	52	PF00069	0.602
MOD_ProDKin_1	61	67	PF00069	0.412
MOD_SUMO_for_1	411	414	PF00179	0.370
MOD_SUMO_rev_2	202	207	PF00179	0.252
MOD_SUMO_rev_2	413	419	PF00179	0.372
MOD_SUMO_rev_2	72	81	PF00179	0.377
TRG_DiLeu_BaEn_2	123	129	PF01217	0.398
TRG_DiLeu_BaEn_2	231	237	PF01217	0.252
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.230
TRG_ENDOCYTIC_2	426	429	PF00928	0.334
TRG_ENDOCYTIC_2	439	442	PF00928	0.392
TRG_ENDOCYTIC_2	95	98	PF00928	0.290
TRG_ER_diArg_1	426	428	PF00400	0.345
TRG_ER_FFAT_2	123	133	PF00635	0.379
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.238
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT9	Leptomonas seymouri	88%	95%
A0A1X0NXJ4	Trypanosomatidae	81%	100%
A0A3S7WXU3	Leishmania donovani	97%	100%
A4HCW1	Leishmania braziliensis	96%	100%
A4I0E1	Leishmania infantum	97%	100%
C9ZV33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
Q08BY0	Danio rerio	30%	100%
Q09644	Caenorhabditis elegans	28%	100%
Q2KHV5	Bos taurus	30%	100%
Q4QB74	Leishmania major	97%	100%
Q54S83	Dictyostelium discoideum	35%	97%
Q5BKM6	Xenopus tropicalis	32%	100%
Q5XI79	Rattus norvegicus	32%	100%
Q6GQ37	Xenopus laevis	31%	100%
Q7L592	Homo sapiens	33%	100%
Q9CWG8	Mus musculus	33%	100%
Q9VGR2	Drosophila melanogaster	29%	100%
V5D7M8	Trypanosoma cruzi	81%	100%