Beta-fructosidase-like protein (Invertase-like protein) (Sucrose hydrolase-like protein)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9AWA3_LEIMU

TriTrypDb:

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AWA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	15
GO:0008152	metabolic process	1	15
GO:0044238	primary metabolic process	2	15
GO:0071704	organic substance metabolic process	2	15

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	15
GO:0004564	beta-fructofuranosidase activity	5	13
GO:0016787	hydrolase activity	2	15
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	310	312	PF00675	0.294
CLV_PCSK_KEX2_1	310	312	PF00082	0.294
CLV_PCSK_SKI1_1	193	197	PF00082	0.395
CLV_PCSK_SKI1_1	227	231	PF00082	0.395
CLV_PCSK_SKI1_1	247	251	PF00082	0.166
CLV_PCSK_SKI1_1	310	314	PF00082	0.236
CLV_PCSK_SKI1_1	96	100	PF00082	0.260
DEG_Nend_UBRbox_3	1	3	PF02207	0.404
DOC_MAPK_MEF2A_6	243	250	PF00069	0.329
DOC_MAPK_NFAT4_5	243	251	PF00069	0.254
DOC_PP1_RVXF_1	245	252	PF00149	0.274
DOC_PP2B_LxvP_1	335	338	PF13499	0.304
DOC_PP2B_LxvP_1	361	364	PF13499	0.275
DOC_PP4_FxxP_1	174	177	PF00568	0.304
DOC_USP7_MATH_1	150	154	PF00917	0.395
DOC_WW_Pin1_4	133	138	PF00397	0.240
DOC_WW_Pin1_4	319	324	PF00397	0.395
LIG_deltaCOP1_diTrp_1	279	288	PF00928	0.179
LIG_deltaCOP1_diTrp_1	75	81	PF00928	0.294
LIG_DLG_GKlike_1	339	347	PF00625	0.254
LIG_FHA_1	112	118	PF00498	0.246
LIG_FHA_1	194	200	PF00498	0.394
LIG_FHA_1	205	211	PF00498	0.262
LIG_FHA_1	345	351	PF00498	0.304
LIG_FHA_2	11	17	PF00498	0.431
LIG_FHA_2	204	210	PF00498	0.321
LIG_FHA_2	83	89	PF00498	0.304
LIG_LIR_Gen_1	215	223	PF02991	0.304
LIG_LIR_Gen_1	61	71	PF02991	0.292
LIG_LIR_Nem_3	120	126	PF02991	0.240
LIG_LIR_Nem_3	183	189	PF02991	0.342
LIG_LIR_Nem_3	215	221	PF02991	0.304
LIG_LIR_Nem_3	287	291	PF02991	0.309
LIG_LIR_Nem_3	36	41	PF02991	0.308
LIG_LIR_Nem_3	61	66	PF02991	0.304
LIG_LIR_Nem_3	78	84	PF02991	0.278
LIG_NRBOX	198	204	PF00104	0.395
LIG_PDZ_Class_1	373	378	PF00595	0.281
LIG_Pex14_1	37	41	PF04695	0.428
LIG_SH2_NCK_1	343	347	PF00017	0.274
LIG_SH2_SRC	67	70	PF00017	0.240
LIG_SH2_STAP1	72	76	PF00017	0.260
LIG_SH2_STAT3	298	301	PF00017	0.304
LIG_SH2_STAT5	123	126	PF00017	0.304
LIG_SH2_STAT5	171	174	PF00017	0.368
LIG_SH2_STAT5	271	274	PF00017	0.395
LIG_SH2_STAT5	46	49	PF00017	0.213
LIG_SH3_3	134	140	PF00018	0.260
LIG_SH3_3	161	167	PF00018	0.304
LIG_SH3_3	275	281	PF00018	0.294
LIG_WW_1	168	171	PF00397	0.395
MOD_CDK_SPK_2	133	138	PF00069	0.179
MOD_CK1_1	112	118	PF00069	0.270
MOD_CK1_1	239	245	PF00069	0.179
MOD_CK2_1	10	16	PF00069	0.539
MOD_CK2_1	339	345	PF00069	0.254
MOD_Cter_Amidation	254	257	PF01082	0.274
MOD_GlcNHglycan	111	114	PF01048	0.304
MOD_GlcNHglycan	331	334	PF01048	0.395
MOD_GlcNHglycan	72	75	PF01048	0.449
MOD_GSK3_1	29	36	PF00069	0.353
MOD_GSK3_1	319	326	PF00069	0.304
MOD_GSK3_1	329	336	PF00069	0.304
MOD_N-GLC_1	33	38	PF02516	0.356
MOD_N-GLC_1	373	378	PF02516	0.341
MOD_NEK2_1	111	116	PF00069	0.304
MOD_PKA_1	256	262	PF00069	0.274
MOD_PKA_2	10	16	PF00069	0.427
MOD_Plk_1	33	39	PF00069	0.362
MOD_Plk_1	339	345	PF00069	0.254
MOD_Plk_1	94	100	PF00069	0.200
MOD_Plk_4	112	118	PF00069	0.185
MOD_Plk_4	299	305	PF00069	0.334
MOD_ProDKin_1	133	139	PF00069	0.240
MOD_ProDKin_1	319	325	PF00069	0.395
MOD_SUMO_rev_2	239	249	PF00179	0.242
TRG_DiLeu_BaEn_1	244	249	PF01217	0.254
TRG_DiLeu_BaLyEn_6	308	313	PF01217	0.269
TRG_ENDOCYTIC_2	171	174	PF00928	0.342
TRG_ENDOCYTIC_2	63	66	PF00928	0.323
TRG_ER_diArg_1	263	266	PF00400	0.303
TRG_ER_diArg_1	310	312	PF00400	0.294
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.206

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8F7	Leptomonas seymouri	52%	77%
A0A1X0NFY9	Trypanosomatidae	28%	79%
A0A1X0NYR4	Trypanosomatidae	25%	69%
A0A3Q8IB13	Leishmania donovani	57%	68%
A0A3Q8IFU7	Leishmania donovani	74%	72%
A0A3S5H7I4	Leishmania donovani	49%	77%
A0A3S7WXQ4	Leishmania donovani	90%	74%
A0A3S7WXS2	Leishmania donovani	74%	72%
A1STJ9	Psychromonas ingrahamii (strain 37)	34%	69%
A2R0E0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	26%	70%
A4HCV9	Leishmania braziliensis	55%	100%
A4HCW0	Leishmania braziliensis	81%	100%
A4HG14	Leishmania braziliensis	50%	100%
A4I0D9	Leishmania infantum	57%	68%
A4I0E0	Leishmania infantum	91%	74%
A4I336	Leishmania infantum	49%	77%
A5ABL2	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	28%	73%
A5DHM6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	30%	74%
A5EZZ8	Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)	35%	69%
A8W7I5	Meyerozyma guilliermondii	30%	74%
E1ABX2	Aspergillus ficuum	26%	70%
E8NHF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E8NHF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9ACV4	Leishmania major	50%	100%
E9AZE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
F8DVG5	Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1)	47%	74%
K0E681	Aspergillus rugulosus	30%	74%
O07003	Bacillus subtilis (strain 168)	28%	73%
O33833	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	37%	88%
O42878	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	74%
O74641	Aspergillus niger	29%	73%
O74642	Aspergillus niger	29%	73%
O94220	Aspergillus ficuum	29%	73%
P00724	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	71%
P07819	Bacillus subtilis (strain 168)	42%	79%
P0DJA7	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	47%	74%
P10594	Saccharomyces cerevisiae	27%	71%
P10596	Saccharomyces cerevisiae	28%	71%
P13394	Vibrio alginolyticus	35%	78%
P13522	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	33%	79%
P16553	Escherichia coli	51%	79%
P24133	Schwanniomyces occidentalis	28%	71%
P27217	Klebsiella pneumoniae	39%	81%
P28999	Kluyveromyces marxianus	27%	68%
P37075	Salmonella typhimurium	40%	81%
P40714	Escherichia coli	49%	79%
P40912	Wickerhamomyces anomalus	27%	69%
P43471	Pediococcus pentosaceus	31%	75%
P94469	Geobacillus stearothermophilus	27%	96%
Q04937	Lactococcus lactis subsp. lactis	28%	80%
Q05936	Staphylococcus xylosus	32%	77%
Q43089	Pisum sativum	27%	68%
Q4QB75	Leishmania major	90%	100%
Q4QB76	Leishmania major	58%	100%
Q56660	Vibrio cholerae	35%	69%
Q56UD1	Oryza sativa subsp. japonica	28%	70%
Q6BJW6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	29%	71%
Q76HP6	Aspergillus niger	26%	70%
Q8W4S6	Arabidopsis thaliana	28%	69%
Q96TU3	Aspergillus awamori	26%	70%
Q9KLT6	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	34%	69%
Q9LIB9	Arabidopsis thaliana	27%	66%