Quinone oxidoreductase-like protein (Alcohol dehydrogenase, zinc-containing-like protein)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

quinone oxidoreductase-like protein

Species:

Leishmania mexicana

UniProt:

E9AWA2_LEIMU

TriTrypDb:

LmxM.23.0860

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWA2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	19
GO:0003960	NADPH:quinone reductase activity	5	8
GO:0016491	oxidoreductase activity	2	19
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	9
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	8
GO:0000166	nucleotide binding	3	2
GO:0005488	binding	1	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0050661	NADP binding	4	2
GO:0070402	NADPH binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	49	51	PF00675	0.300
CLV_PCSK_KEX2_1	141	143	PF00082	0.514
CLV_PCSK_KEX2_1	207	209	PF00082	0.263
CLV_PCSK_KEX2_1	49	51	PF00082	0.253
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.521
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.263
CLV_PCSK_SKI1_1	207	211	PF00082	0.362
CLV_PCSK_SKI1_1	3	7	PF00082	0.316
CLV_PCSK_SKI1_1	327	331	PF00082	0.301
DEG_MDM2_SWIB_1	127	134	PF02201	0.300
DEG_ODPH_VHL_1	235	246	PF01847	0.401
DEG_SPOP_SBC_1	171	175	PF00917	0.372
DOC_CDC14_PxL_1	200	208	PF14671	0.278
DOC_CYCLIN_RxL_1	204	214	PF00134	0.392
DOC_MAPK_gen_1	139	148	PF00069	0.427
DOC_MAPK_gen_1	27	34	PF00069	0.392
DOC_MAPK_MEF2A_6	193	202	PF00069	0.564
DOC_MAPK_MEF2A_6	27	36	PF00069	0.320
DOC_USP7_MATH_1	150	154	PF00917	0.359
DOC_USP7_MATH_1	185	189	PF00917	0.447
DOC_USP7_MATH_1	292	296	PF00917	0.462
DOC_USP7_MATH_1	44	48	PF00917	0.366
DOC_USP7_UBL2_3	141	145	PF12436	0.460
DOC_USP7_UBL2_3	23	27	PF12436	0.350
DOC_WW_Pin1_4	191	196	PF00397	0.368
LIG_14-3-3_CanoR_1	3	8	PF00244	0.330
LIG_14-3-3_CanoR_1	43	53	PF00244	0.256
LIG_APCC_ABBA_1	257	262	PF00400	0.256
LIG_BIR_III_4	77	81	PF00653	0.184
LIG_Clathr_ClatBox_1	62	66	PF01394	0.338
LIG_FHA_1	13	19	PF00498	0.442
LIG_FHA_1	28	34	PF00498	0.343
LIG_FHA_1	304	310	PF00498	0.345
LIG_FHA_2	172	178	PF00498	0.387
LIG_FHA_2	192	198	PF00498	0.453
LIG_FHA_2	299	305	PF00498	0.439
LIG_FHA_2	329	335	PF00498	0.425
LIG_LIR_Apic_2	51	56	PF02991	0.256
LIG_LIR_Nem_3	267	271	PF02991	0.299
LIG_Pex14_2	127	131	PF04695	0.298
LIG_RPA_C_Fungi	38	50	PF08784	0.280
LIG_SH2_NCK_1	53	57	PF00017	0.256
LIG_SH2_SRC	53	56	PF00017	0.292
LIG_SH2_STAP1	97	101	PF00017	0.302
LIG_SH2_STAT5	166	169	PF00017	0.342
LIG_SH2_STAT5	227	230	PF00017	0.278
LIG_SH3_3	231	237	PF00018	0.357
LIG_SUMO_SIM_par_1	328	334	PF11976	0.397
LIG_TRAF2_1	175	178	PF00917	0.342
LIG_TRAF2_1	308	311	PF00917	0.338
LIG_WRC_WIRS_1	283	288	PF05994	0.319
MOD_CK2_1	113	119	PF00069	0.350
MOD_CK2_1	14	20	PF00069	0.344
MOD_CK2_1	171	177	PF00069	0.431
MOD_CK2_1	191	197	PF00069	0.246
MOD_CK2_1	328	334	PF00069	0.381
MOD_GlcNHglycan	156	159	PF01048	0.419
MOD_GSK3_1	12	19	PF00069	0.552
MOD_GSK3_1	150	157	PF00069	0.338
MOD_GSK3_1	167	174	PF00069	0.370
MOD_GSK3_1	185	192	PF00069	0.284
MOD_NEK2_1	167	172	PF00069	0.397
MOD_NEK2_1	223	228	PF00069	0.359
MOD_PIKK_1	44	50	PF00454	0.278
MOD_PKA_1	27	33	PF00069	0.394
MOD_Plk_1	211	217	PF00069	0.392
MOD_Plk_1	303	309	PF00069	0.378
MOD_Plk_2-3	14	20	PF00069	0.302
MOD_Plk_4	223	229	PF00069	0.275
MOD_Plk_4	298	304	PF00069	0.342
MOD_ProDKin_1	191	197	PF00069	0.378
MOD_SUMO_rev_2	175	180	PF00179	0.397
TRG_DiLeu_BaEn_1	334	339	PF01217	0.358
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.227

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q4	Leptomonas seymouri	70%	100%
A0A0N1I9E8	Leptomonas seymouri	57%	100%
A0A0N1PB21	Leptomonas seymouri	23%	99%
A0A0N1PDX1	Leptomonas seymouri	60%	97%
A0A0S4INW1	Bodo saltans	45%	78%
A0A0S4IT20	Bodo saltans	24%	99%
A0A0S4IUY2	Bodo saltans	22%	100%
A0A0S4JJT8	Bodo saltans	23%	87%
A0A0S4KHW9	Bodo saltans	25%	100%
A0A1X0NRR2	Trypanosomatidae	27%	70%
A0A1X0NZZ5	Trypanosomatidae	56%	100%
A0A3Q8ICJ5	Leishmania donovani	95%	100%
A0A3S7X2E3	Leishmania donovani	62%	97%
A0A422NF38	Trypanosoma rangeli	52%	100%
A0A451EJQ8	Leishmania donovani	24%	100%
A4H3L9	Leishmania braziliensis	23%	99%
A4HCV8	Leishmania braziliensis	84%	100%
A4HHB3	Leishmania braziliensis	60%	100%
A4HPT6	Leishmania braziliensis	25%	100%
A4I0D8	Leishmania infantum	94%	100%
A4I4G0	Leishmania infantum	62%	97%
A6QQF5	Bos taurus	28%	97%
A7RK30	Nematostella vectensis	26%	93%
B0BNC9	Rattus norvegicus	25%	97%
C9ZLK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9ACK2	Leishmania major	24%	100%
E9ADV9	Leishmania major	62%	100%
E9AG46	Leishmania infantum	24%	100%
E9AJU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ALX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
K4BW79	Solanum lycopersicum	25%	88%
O07615	Bacillus subtilis (strain 168)	26%	100%
O35017	Bacillus subtilis (strain 168)	20%	100%
O35045	Bacillus subtilis (strain 168)	24%	100%
O42909	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	98%
O74822	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
O94564	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	98%
O97764	Bos taurus	27%	100%
P11415	Cavia porcellus	27%	100%
P19333	Tetronarce californica	26%	90%
P28304	Escherichia coli (strain K12)	23%	100%
P34055	Hypocrea atroviridis	25%	100%
P43903	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	26%	100%
P47199	Mus musculus	26%	100%
P63475	Staphylococcus aureus (strain Mu50 / ATCC 700699)	26%	100%
P99173	Staphylococcus aureus (strain N315)	26%	100%
Q08257	Homo sapiens	28%	100%
Q0MVN8	Sus scrofa	27%	100%
Q0VC50	Bos taurus	23%	86%
Q28452	Lama guanicoe	28%	100%
Q3MIE4	Rattus norvegicus	26%	84%
Q3UNZ8	Mus musculus	26%	97%
Q4QB77	Leishmania major	94%	100%
Q4QHF8	Leishmania major	24%	100%
Q4W4Z2	Caenorhabditis elegans	24%	93%
Q53FA7	Homo sapiens	36%	100%
Q54II4	Dictyostelium discoideum	21%	97%
Q59I44	Burkholderia sp.	26%	100%
Q5HE19	Staphylococcus aureus (strain COL)	26%	100%
Q5HM44	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	24%	100%
Q5R4S7	Pongo abelii	27%	100%
Q62465	Mus musculus	27%	84%
Q6AYT0	Rattus norvegicus	27%	100%
Q6G7C8	Staphylococcus aureus (strain MSSA476)	26%	100%
Q6GEP3	Staphylococcus aureus (strain MRSA252)	26%	100%
Q7T3C7	Danio rerio	23%	88%
Q80TB8	Mus musculus	27%	82%
Q8CRJ7	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	23%	100%
Q8H0M1	Spinacia oleracea	27%	100%
Q8JFV8	Danio rerio	25%	70%
Q8NVD1	Staphylococcus aureus (strain MW2)	26%	100%
Q8WWV3	Homo sapiens	25%	86%
Q99536	Homo sapiens	25%	87%
Q9AYU1	Triphysaria versicolor	25%	100%
Q9HCJ6	Homo sapiens	27%	81%
Q9ZUC1	Arabidopsis thaliana	26%	88%
V5B1P3	Trypanosoma cruzi	54%	100%
V5BXF0	Trypanosoma cruzi	25%	100%