Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AWA1_LEIMU

TriTrypDb:

LmxM.23.0850

Length:

776

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWA1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.424
CLV_C14_Caspase3-7	566	570	PF00656	0.443
CLV_NRD_NRD_1	187	189	PF00675	0.407
CLV_NRD_NRD_1	313	315	PF00675	0.690
CLV_NRD_NRD_1	422	424	PF00675	0.409
CLV_NRD_NRD_1	592	594	PF00675	0.622
CLV_NRD_NRD_1	633	635	PF00675	0.583
CLV_PCSK_KEX2_1	187	189	PF00082	0.407
CLV_PCSK_KEX2_1	313	315	PF00082	0.690
CLV_PCSK_KEX2_1	422	424	PF00082	0.428
CLV_PCSK_KEX2_1	44	46	PF00082	0.336
CLV_PCSK_KEX2_1	592	594	PF00082	0.622
CLV_PCSK_KEX2_1	622	624	PF00082	0.606
CLV_PCSK_KEX2_1	633	635	PF00082	0.436
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.336
CLV_PCSK_PC1ET2_1	622	624	PF00082	0.593
CLV_PCSK_SKI1_1	118	122	PF00082	0.486
CLV_PCSK_SKI1_1	179	183	PF00082	0.495
CLV_PCSK_SKI1_1	22	26	PF00082	0.526
CLV_PCSK_SKI1_1	231	235	PF00082	0.408
CLV_PCSK_SKI1_1	573	577	PF00082	0.417
CLV_PCSK_SKI1_1	711	715	PF00082	0.627
CLV_PCSK_SKI1_1	761	765	PF00082	0.702
CLV_PCSK_SKI1_1	87	91	PF00082	0.512
CLV_Separin_Metazoa	762	766	PF03568	0.634
DEG_APCC_DBOX_1	230	238	PF00400	0.403
DEG_APCC_DBOX_1	64	72	PF00400	0.387
DEG_APCC_DBOX_1	760	768	PF00400	0.639
DEG_SCF_FBW7_1	284	289	PF00400	0.612
DEG_SCF_FBW7_1	315	320	PF00400	0.634
DEG_SPOP_SBC_1	302	306	PF00917	0.525
DOC_CKS1_1	112	117	PF01111	0.612
DOC_CYCLIN_RxL_1	176	185	PF00134	0.495
DOC_CYCLIN_RxL_1	19	29	PF00134	0.537
DOC_CYCLIN_RxL_1	228	235	PF00134	0.413
DOC_MAPK_gen_1	735	744	PF00069	0.713
DOC_MAPK_MEF2A_6	405	413	PF00069	0.379
DOC_MAPK_MEF2A_6	476	485	PF00069	0.404
DOC_MAPK_RevD_3	173	188	PF00069	0.388
DOC_MAPK_RevD_3	407	423	PF00069	0.378
DOC_PP2B_PxIxI_1	227	233	PF00149	0.421
DOC_SPAK_OSR1_1	357	361	PF12202	0.417
DOC_USP7_MATH_1	212	216	PF00917	0.397
DOC_USP7_MATH_1	253	257	PF00917	0.569
DOC_USP7_MATH_1	286	290	PF00917	0.715
DOC_USP7_MATH_1	291	295	PF00917	0.620
DOC_USP7_MATH_1	445	449	PF00917	0.508
DOC_USP7_MATH_1	468	472	PF00917	0.423
DOC_USP7_MATH_1	495	499	PF00917	0.534
DOC_USP7_MATH_1	533	537	PF00917	0.586
DOC_USP7_UBL2_3	618	622	PF12436	0.593
DOC_WW_Pin1_4	111	116	PF00397	0.684
DOC_WW_Pin1_4	133	138	PF00397	0.640
DOC_WW_Pin1_4	272	277	PF00397	0.765
DOC_WW_Pin1_4	280	285	PF00397	0.768
DOC_WW_Pin1_4	289	294	PF00397	0.653
DOC_WW_Pin1_4	295	300	PF00397	0.557
DOC_WW_Pin1_4	313	318	PF00397	0.579
DOC_WW_Pin1_4	323	328	PF00397	0.522
DOC_WW_Pin1_4	398	403	PF00397	0.436
DOC_WW_Pin1_4	477	482	PF00397	0.451
DOC_WW_Pin1_4	486	491	PF00397	0.501
DOC_WW_Pin1_4	539	544	PF00397	0.507
DOC_WW_Pin1_4	584	589	PF00397	0.560
DOC_WW_Pin1_4	696	701	PF00397	0.515
LIG_14-3-3_CanoR_1	467	473	PF00244	0.420
LIG_14-3-3_CanoR_1	486	490	PF00244	0.580
LIG_14-3-3_CanoR_1	507	516	PF00244	0.601
LIG_14-3-3_CanoR_1	521	529	PF00244	0.585
LIG_14-3-3_CanoR_1	557	561	PF00244	0.671
LIG_14-3-3_CanoR_1	623	630	PF00244	0.621
LIG_14-3-3_CanoR_1	644	650	PF00244	0.411
LIG_14-3-3_CanoR_1	670	675	PF00244	0.542
LIG_Actin_WH2_1	433	449	PF00022	0.497
LIG_Actin_WH2_2	432	449	PF00022	0.499
LIG_APCC_ABBA_1	614	619	PF00400	0.443
LIG_BRCT_BRCA1_1	355	359	PF00533	0.401
LIG_CaM_IQ_9	37	52	PF13499	0.338
LIG_EH1_1	640	648	PF00400	0.523
LIG_FHA_1	124	130	PF00498	0.577
LIG_FHA_1	170	176	PF00498	0.527
LIG_FHA_1	240	246	PF00498	0.396
LIG_FHA_1	35	41	PF00498	0.450
LIG_FHA_1	404	410	PF00498	0.373
LIG_FHA_1	482	488	PF00498	0.458
LIG_FHA_1	511	517	PF00498	0.719
LIG_FHA_1	553	559	PF00498	0.524
LIG_FHA_1	609	615	PF00498	0.411
LIG_FHA_1	83	89	PF00498	0.618
LIG_FHA_2	169	175	PF00498	0.439
LIG_FHA_2	206	212	PF00498	0.419
LIG_FHA_2	219	225	PF00498	0.447
LIG_FHA_2	51	57	PF00498	0.588
LIG_FHA_2	540	546	PF00498	0.578
LIG_FHA_2	686	692	PF00498	0.464
LIG_GBD_Chelix_1	330	338	PF00786	0.503
LIG_LIR_Apic_2	724	729	PF02991	0.550
LIG_LIR_Gen_1	316	327	PF02991	0.565
LIG_LIR_Gen_1	432	442	PF02991	0.485
LIG_LIR_Gen_1	574	584	PF02991	0.409
LIG_LIR_Nem_3	114	120	PF02991	0.665
LIG_LIR_Nem_3	185	189	PF02991	0.508
LIG_LIR_Nem_3	196	202	PF02991	0.379
LIG_LIR_Nem_3	218	223	PF02991	0.556
LIG_LIR_Nem_3	29	35	PF02991	0.512
LIG_LIR_Nem_3	316	322	PF02991	0.628
LIG_LIR_Nem_3	432	437	PF02991	0.406
LIG_LIR_Nem_3	574	580	PF02991	0.410
LIG_MLH1_MIPbox_1	355	359	PF16413	0.401
LIG_NRBOX	67	73	PF00104	0.563
LIG_NRP_CendR_1	773	776	PF00754	0.700
LIG_Pex14_2	391	395	PF04695	0.446
LIG_SH2_CRK	117	121	PF00017	0.516
LIG_SH2_CRK	200	204	PF00017	0.485
LIG_SH2_CRK	319	323	PF00017	0.603
LIG_SH2_CRK	35	39	PF00017	0.479
LIG_SH2_CRK	4	8	PF00017	0.582
LIG_SH2_CRK	726	730	PF00017	0.568
LIG_SH2_NCK_1	4	8	PF00017	0.582
LIG_SH2_STAP1	200	204	PF00017	0.531
LIG_SH2_STAP1	241	245	PF00017	0.441
LIG_SH2_STAP1	374	378	PF00017	0.500
LIG_SH2_STAT3	148	151	PF00017	0.563
LIG_SH2_STAT5	148	151	PF00017	0.563
LIG_SH2_STAT5	180	183	PF00017	0.381
LIG_SH2_STAT5	220	223	PF00017	0.500
LIG_SH2_STAT5	241	244	PF00017	0.496
LIG_SH2_STAT5	319	322	PF00017	0.728
LIG_SH2_STAT5	35	38	PF00017	0.458
LIG_SH2_STAT5	579	582	PF00017	0.401
LIG_SH3_1	134	140	PF00018	0.751
LIG_SH3_3	106	112	PF00018	0.620
LIG_SH3_3	134	140	PF00018	0.768
LIG_SH3_3	513	519	PF00018	0.600
LIG_SH3_3	76	82	PF00018	0.490
LIG_Sin3_3	525	532	PF02671	0.676
LIG_SUMO_SIM_anti_2	610	616	PF11976	0.412
LIG_SUMO_SIM_par_1	214	221	PF11976	0.522
LIG_TRAF2_1	244	247	PF00917	0.514
LIG_TRAF2_1	772	775	PF00917	0.511
LIG_TYR_ITIM	184	189	PF00017	0.508
LIG_TYR_ITIM	198	203	PF00017	0.329
LIG_UBA3_1	88	92	PF00899	0.407
MOD_CDK_SPK_2	539	544	PF00069	0.507
MOD_CDK_SPxxK_3	111	118	PF00069	0.680
MOD_CDK_SPxxK_3	398	405	PF00069	0.426
MOD_CK1_1	282	288	PF00069	0.674
MOD_CK1_1	289	295	PF00069	0.686
MOD_CK1_1	333	339	PF00069	0.507
MOD_CK1_1	488	494	PF00069	0.599
MOD_CK1_1	49	55	PF00069	0.534
MOD_CK1_1	556	562	PF00069	0.732
MOD_CK2_1	212	218	PF00069	0.401
MOD_CK2_1	323	329	PF00069	0.397
MOD_CK2_1	346	352	PF00069	0.436
MOD_CK2_1	685	691	PF00069	0.465
MOD_Cter_Amidation	590	593	PF01082	0.589
MOD_GlcNHglycan	289	292	PF01048	0.609
MOD_GlcNHglycan	447	450	PF01048	0.506
MOD_GlcNHglycan	498	501	PF01048	0.591
MOD_GlcNHglycan	503	506	PF01048	0.621
MOD_GlcNHglycan	66	71	PF01048	0.457
MOD_GSK3_1	165	172	PF00069	0.593
MOD_GSK3_1	282	289	PF00069	0.681
MOD_GSK3_1	291	298	PF00069	0.625
MOD_GSK3_1	302	309	PF00069	0.696
MOD_GSK3_1	313	320	PF00069	0.690
MOD_GSK3_1	394	401	PF00069	0.557
MOD_GSK3_1	403	410	PF00069	0.419
MOD_GSK3_1	441	448	PF00069	0.492
MOD_GSK3_1	46	53	PF00069	0.532
MOD_GSK3_1	477	484	PF00069	0.530
MOD_GSK3_1	485	492	PF00069	0.575
MOD_GSK3_1	503	510	PF00069	0.657
MOD_GSK3_1	552	559	PF00069	0.716
MOD_N-GLC_1	468	473	PF02516	0.536
MOD_N-GLC_1	481	486	PF02516	0.482
MOD_N-GLC_1	533	538	PF02516	0.569
MOD_N-GLC_1	623	628	PF02516	0.496
MOD_NEK2_1	182	187	PF00069	0.498
MOD_NEK2_1	407	412	PF00069	0.484
MOD_NEK2_1	43	48	PF00069	0.521
MOD_NEK2_1	485	490	PF00069	0.570
MOD_NEK2_1	501	506	PF00069	0.801
MOD_NEK2_1	685	690	PF00069	0.461
MOD_NEK2_2	34	39	PF00069	0.460
MOD_NEK2_2	468	473	PF00069	0.409
MOD_NEK2_2	481	486	PF00069	0.555
MOD_PIKK_1	147	153	PF00454	0.557
MOD_PIKK_1	50	56	PF00454	0.602
MOD_PIKK_1	82	88	PF00454	0.619
MOD_PK_1	3	9	PF00069	0.705
MOD_PKA_2	485	491	PF00069	0.608
MOD_PKA_2	506	512	PF00069	0.626
MOD_PKA_2	520	526	PF00069	0.531
MOD_PKA_2	556	562	PF00069	0.679
MOD_PKB_1	668	676	PF00069	0.545
MOD_Plk_1	165	171	PF00069	0.476
MOD_Plk_1	429	435	PF00069	0.469
MOD_Plk_1	468	474	PF00069	0.506
MOD_Plk_1	481	487	PF00069	0.477
MOD_Plk_1	553	559	PF00069	0.699
MOD_Plk_1	66	72	PF00069	0.491
MOD_Plk_2-3	678	684	PF00069	0.473
MOD_Plk_4	165	171	PF00069	0.514
MOD_Plk_4	212	218	PF00069	0.401
MOD_Plk_4	330	336	PF00069	0.495
MOD_Plk_4	407	413	PF00069	0.521
MOD_Plk_4	670	676	PF00069	0.548
MOD_ProDKin_1	111	117	PF00069	0.680
MOD_ProDKin_1	133	139	PF00069	0.639
MOD_ProDKin_1	272	278	PF00069	0.763
MOD_ProDKin_1	280	286	PF00069	0.765
MOD_ProDKin_1	289	295	PF00069	0.653
MOD_ProDKin_1	313	319	PF00069	0.759
MOD_ProDKin_1	323	329	PF00069	0.417
MOD_ProDKin_1	398	404	PF00069	0.430
MOD_ProDKin_1	477	483	PF00069	0.454
MOD_ProDKin_1	486	492	PF00069	0.499
MOD_ProDKin_1	539	545	PF00069	0.509
MOD_ProDKin_1	584	590	PF00069	0.558
MOD_ProDKin_1	696	702	PF00069	0.523
TRG_DiLeu_BaEn_1	524	529	PF01217	0.681
TRG_DiLeu_BaEn_1	610	615	PF01217	0.410
TRG_DiLeu_BaEn_1	67	72	PF01217	0.554
TRG_DiLeu_BaEn_1	701	706	PF01217	0.548
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.430
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.454
TRG_ENDOCYTIC_2	117	120	PF00928	0.514
TRG_ENDOCYTIC_2	186	189	PF00928	0.498
TRG_ENDOCYTIC_2	200	203	PF00928	0.322
TRG_ENDOCYTIC_2	220	223	PF00928	0.286
TRG_ENDOCYTIC_2	319	322	PF00928	0.613
TRG_ENDOCYTIC_2	35	38	PF00928	0.475
TRG_ENDOCYTIC_2	4	7	PF00928	0.588
TRG_ENDOCYTIC_2	669	672	PF00928	0.413
TRG_ER_diArg_1	186	188	PF00400	0.403
TRG_ER_diArg_1	228	231	PF00400	0.423
TRG_ER_diArg_1	313	315	PF00400	0.623
TRG_ER_diArg_1	422	424	PF00400	0.428
TRG_ER_diArg_1	474	477	PF00400	0.444
TRG_ER_diArg_1	592	594	PF00400	0.622
TRG_NES_CRM1_1	324	337	PF08389	0.287
TRG_NES_CRM1_1	62	78	PF08389	0.569
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	368	373	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	422	426	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	592	597	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	623	627	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	743	747	PF00026	0.737

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6B3	Leptomonas seymouri	57%	88%
A0A3Q8ICJ7	Leishmania donovani	91%	100%
A4HCV7	Leishmania braziliensis	80%	100%
A4I0D7	Leishmania infantum	91%	100%
Q4QB78	Leishmania major	91%	100%