Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AWA0_LEIMU

TriTrypDb:

LmxM.23.0845

Length:

974

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AWA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AWA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.603
CLV_C14_Caspase3-7	740	744	PF00656	0.576
CLV_NRD_NRD_1	221	223	PF00675	0.726
CLV_NRD_NRD_1	263	265	PF00675	0.571
CLV_NRD_NRD_1	417	419	PF00675	0.577
CLV_NRD_NRD_1	548	550	PF00675	0.658
CLV_NRD_NRD_1	610	612	PF00675	0.695
CLV_NRD_NRD_1	631	633	PF00675	0.666
CLV_NRD_NRD_1	658	660	PF00675	0.651
CLV_NRD_NRD_1	764	766	PF00675	0.729
CLV_NRD_NRD_1	811	813	PF00675	0.581
CLV_NRD_NRD_1	848	850	PF00675	0.598
CLV_NRD_NRD_1	875	877	PF00675	0.719
CLV_NRD_NRD_1	881	883	PF00675	0.738
CLV_NRD_NRD_1	946	948	PF00675	0.404
CLV_PCSK_FUR_1	761	765	PF00082	0.583
CLV_PCSK_FUR_1	846	850	PF00082	0.599
CLV_PCSK_KEX2_1	221	223	PF00082	0.726
CLV_PCSK_KEX2_1	417	419	PF00082	0.577
CLV_PCSK_KEX2_1	610	612	PF00082	0.702
CLV_PCSK_KEX2_1	631	633	PF00082	0.659
CLV_PCSK_KEX2_1	658	660	PF00082	0.651
CLV_PCSK_KEX2_1	703	705	PF00082	0.586
CLV_PCSK_KEX2_1	763	765	PF00082	0.721
CLV_PCSK_KEX2_1	811	813	PF00082	0.581
CLV_PCSK_KEX2_1	848	850	PF00082	0.598
CLV_PCSK_KEX2_1	875	877	PF00082	0.719
CLV_PCSK_KEX2_1	881	883	PF00082	0.738
CLV_PCSK_KEX2_1	946	948	PF00082	0.544
CLV_PCSK_PC1ET2_1	703	705	PF00082	0.586
CLV_PCSK_PC7_1	654	660	PF00082	0.645
CLV_PCSK_SKI1_1	208	212	PF00082	0.589
CLV_PCSK_SKI1_1	383	387	PF00082	0.600
CLV_PCSK_SKI1_1	967	971	PF00082	0.506
DEG_APCC_DBOX_1	358	366	PF00400	0.576
DEG_APCC_DBOX_1	382	390	PF00400	0.555
DEG_SPOP_SBC_1	159	163	PF00917	0.580
DOC_ANK_TNKS_1	818	825	PF00023	0.582
DOC_CDC14_PxL_1	899	907	PF14671	0.619
DOC_CKS1_1	189	194	PF01111	0.706
DOC_CKS1_1	248	253	PF01111	0.592
DOC_CKS1_1	55	60	PF01111	0.570
DOC_CKS1_1	905	910	PF01111	0.554
DOC_MAPK_gen_1	270	278	PF00069	0.589
DOC_MAPK_gen_1	549	557	PF00069	0.519
DOC_MAPK_MEF2A_6	270	278	PF00069	0.589
DOC_MAPK_MEF2A_6	550	559	PF00069	0.518
DOC_PP1_RVXF_1	656	663	PF00149	0.647
DOC_PP2B_LxvP_1	901	904	PF13499	0.637
DOC_PP4_FxxP_1	301	304	PF00568	0.705
DOC_PP4_FxxP_1	413	416	PF00568	0.713
DOC_USP7_MATH_1	128	132	PF00917	0.714
DOC_USP7_MATH_1	160	164	PF00917	0.630
DOC_USP7_MATH_1	23	27	PF00917	0.629
DOC_USP7_MATH_1	246	250	PF00917	0.673
DOC_USP7_MATH_1	314	318	PF00917	0.577
DOC_USP7_MATH_1	34	38	PF00917	0.533
DOC_USP7_MATH_1	465	469	PF00917	0.498
DOC_USP7_MATH_1	47	51	PF00917	0.529
DOC_USP7_MATH_1	594	598	PF00917	0.715
DOC_USP7_MATH_1	60	64	PF00917	0.540
DOC_USP7_MATH_1	67	71	PF00917	0.524
DOC_USP7_MATH_1	815	819	PF00917	0.642
DOC_WW_Pin1_4	117	122	PF00397	0.608
DOC_WW_Pin1_4	124	129	PF00397	0.687
DOC_WW_Pin1_4	188	193	PF00397	0.710
DOC_WW_Pin1_4	244	249	PF00397	0.738
DOC_WW_Pin1_4	270	275	PF00397	0.590
DOC_WW_Pin1_4	294	299	PF00397	0.716
DOC_WW_Pin1_4	347	352	PF00397	0.704
DOC_WW_Pin1_4	35	40	PF00397	0.568
DOC_WW_Pin1_4	54	59	PF00397	0.615
DOC_WW_Pin1_4	77	82	PF00397	0.600
DOC_WW_Pin1_4	865	870	PF00397	0.604
DOC_WW_Pin1_4	875	880	PF00397	0.580
DOC_WW_Pin1_4	904	909	PF00397	0.571
LIG_14-3-3_CanoR_1	13	20	PF00244	0.702
LIG_14-3-3_CanoR_1	212	216	PF00244	0.579
LIG_14-3-3_CanoR_1	259	268	PF00244	0.728
LIG_14-3-3_CanoR_1	335	343	PF00244	0.693
LIG_14-3-3_CanoR_1	583	588	PF00244	0.584
LIG_14-3-3_CanoR_1	632	638	PF00244	0.530
LIG_14-3-3_CanoR_1	698	702	PF00244	0.574
LIG_14-3-3_CanoR_1	788	795	PF00244	0.681
LIG_14-3-3_CanoR_1	875	879	PF00244	0.714
LIG_14-3-3_CanoR_1	881	889	PF00244	0.731
LIG_14-3-3_CanoR_1	962	970	PF00244	0.602
LIG_APCC_ABBA_1	400	405	PF00400	0.698
LIG_APCC_ABBAyCdc20_2	399	405	PF00400	0.698
LIG_BRCT_BRCA1_1	614	618	PF00533	0.531
LIG_CSL_BTD_1	194	197	PF09270	0.567
LIG_deltaCOP1_diTrp_1	927	931	PF00928	0.538
LIG_EVH1_1	189	193	PF00568	0.569
LIG_FHA_1	162	168	PF00498	0.581
LIG_FHA_1	375	381	PF00498	0.574
LIG_FHA_1	395	401	PF00498	0.482
LIG_FHA_1	525	531	PF00498	0.722
LIG_FHA_1	643	649	PF00498	0.656
LIG_FHA_1	668	674	PF00498	0.526
LIG_FHA_1	836	842	PF00498	0.572
LIG_FHA_1	905	911	PF00498	0.554
LIG_FHA_2	200	206	PF00498	0.576
LIG_FHA_2	437	443	PF00498	0.638
LIG_FHA_2	479	485	PF00498	0.627
LIG_FHA_2	837	843	PF00498	0.575
LIG_LIR_Apic_2	191	197	PF02991	0.565
LIG_LIR_Apic_2	300	304	PF02991	0.706
LIG_LIR_Apic_2	411	416	PF02991	0.702
LIG_LIR_Gen_1	337	348	PF02991	0.558
LIG_LIR_Gen_1	831	841	PF02991	0.657
LIG_LIR_Nem_3	214	218	PF02991	0.575
LIG_LIR_Nem_3	337	343	PF02991	0.553
LIG_LIR_Nem_3	427	433	PF02991	0.546
LIG_LIR_Nem_3	494	500	PF02991	0.743
LIG_LIR_Nem_3	538	544	PF02991	0.683
LIG_LIR_Nem_3	752	757	PF02991	0.588
LIG_LIR_Nem_3	831	837	PF02991	0.654
LIG_LYPXL_S_1	901	905	PF13949	0.636
LIG_LYPXL_yS_3	902	905	PF13949	0.629
LIG_MYND_1	904	908	PF01753	0.575
LIG_PCNA_yPIPBox_3	572	585	PF02747	0.569
LIG_RPA_C_Fungi	854	866	PF08784	0.603
LIG_SH2_CRK	340	344	PF00017	0.560
LIG_SH2_CRK	497	501	PF00017	0.658
LIG_SH2_CRK	541	545	PF00017	0.674
LIG_SH2_GRB2like	797	800	PF00017	0.565
LIG_SH2_NCK_1	541	545	PF00017	0.674
LIG_SH2_NCK_1	834	838	PF00017	0.567
LIG_SH2_SRC	403	406	PF00017	0.690
LIG_SH2_SRC	541	544	PF00017	0.679
LIG_SH2_SRC	797	800	PF00017	0.579
LIG_SH2_SRC	834	837	PF00017	0.565
LIG_SH2_STAP1	797	801	PF00017	0.576
LIG_SH2_STAT3	94	97	PF00017	0.571
LIG_SH2_STAT5	172	175	PF00017	0.596
LIG_SH2_STAT5	558	561	PF00017	0.787
LIG_SH2_STAT5	94	97	PF00017	0.571
LIG_SH3_1	265	271	PF00018	0.588
LIG_SH3_3	118	124	PF00018	0.744
LIG_SH3_3	187	193	PF00018	0.573
LIG_SH3_3	245	251	PF00018	0.747
LIG_SH3_3	265	271	PF00018	0.612
LIG_SH3_3	33	39	PF00018	0.570
LIG_SH3_3	345	351	PF00018	0.704
LIG_SH3_3	404	410	PF00018	0.550
LIG_SH3_3	52	58	PF00018	0.500
LIG_SH3_3	545	551	PF00018	0.523
LIG_SH3_3	649	655	PF00018	0.660
LIG_SH3_3	756	762	PF00018	0.588
LIG_TRAF2_1	41	44	PF00917	0.575
LIG_TRAF2_1	722	725	PF00917	0.559
LIG_TYR_ITIM	900	905	PF00017	0.638
LIG_UBA3_1	342	349	PF00899	0.565
LIG_WW_3	254	258	PF00397	0.638
LIG_WW_3	267	271	PF00397	0.681
MOD_CDC14_SPxK_1	80	83	PF00782	0.593
MOD_CDC14_SPxK_1	878	881	PF00782	0.613
MOD_CDK_SPxK_1	77	83	PF00069	0.601
MOD_CDK_SPxK_1	875	881	PF00069	0.616
MOD_CDK_SPxxK_3	54	61	PF00069	0.575
MOD_CDK_SPxxK_3	875	882	PF00069	0.617
MOD_CK1_1	150	156	PF00069	0.635
MOD_CK1_1	161	167	PF00069	0.566
MOD_CK1_1	214	220	PF00069	0.614
MOD_CK1_1	247	253	PF00069	0.607
MOD_CK1_1	283	289	PF00069	0.621
MOD_CK1_1	297	303	PF00069	0.659
MOD_CK1_1	316	322	PF00069	0.517
MOD_CK1_1	338	344	PF00069	0.696
MOD_CK1_1	352	358	PF00069	0.565
MOD_CK1_1	366	372	PF00069	0.639
MOD_CK1_1	38	44	PF00069	0.710
MOD_CK1_1	50	56	PF00069	0.583
MOD_CK1_1	535	541	PF00069	0.555
MOD_CK1_1	606	612	PF00069	0.674
MOD_CK1_1	697	703	PF00069	0.693
MOD_CK1_1	790	796	PF00069	0.605
MOD_CK1_1	874	880	PF00069	0.754
MOD_CK2_1	364	370	PF00069	0.600
MOD_CK2_1	372	378	PF00069	0.651
MOD_CK2_1	38	44	PF00069	0.710
MOD_CK2_1	836	842	PF00069	0.572
MOD_CK2_1	921	927	PF00069	0.523
MOD_DYRK1A_RPxSP_1	270	274	PF00069	0.730
MOD_DYRK1A_RPxSP_1	865	869	PF00069	0.606
MOD_GlcNHglycan	128	131	PF01048	0.699
MOD_GlcNHglycan	15	18	PF01048	0.655
MOD_GlcNHglycan	25	28	PF01048	0.538
MOD_GlcNHglycan	261	264	PF01048	0.640
MOD_GlcNHglycan	351	354	PF01048	0.628
MOD_GlcNHglycan	380	383	PF01048	0.601
MOD_GlcNHglycan	410	413	PF01048	0.574
MOD_GlcNHglycan	465	468	PF01048	0.630
MOD_GlcNHglycan	493	496	PF01048	0.696
MOD_GlcNHglycan	544	547	PF01048	0.674
MOD_GlcNHglycan	605	608	PF01048	0.643
MOD_GlcNHglycan	614	617	PF01048	0.533
MOD_GlcNHglycan	638	641	PF01048	0.514
MOD_GlcNHglycan	67	70	PF01048	0.604
MOD_GlcNHglycan	766	769	PF01048	0.764
MOD_GlcNHglycan	776	779	PF01048	0.804
MOD_GlcNHglycan	791	795	PF01048	0.697
MOD_GlcNHglycan	799	802	PF01048	0.651
MOD_GlcNHglycan	861	864	PF01048	0.657
MOD_GlcNHglycan	970	973	PF01048	0.657
MOD_GSK3_1	122	129	PF00069	0.702
MOD_GSK3_1	130	137	PF00069	0.701
MOD_GSK3_1	143	150	PF00069	0.575
MOD_GSK3_1	255	262	PF00069	0.679
MOD_GSK3_1	334	341	PF00069	0.690
MOD_GSK3_1	34	41	PF00069	0.708
MOD_GSK3_1	374	381	PF00069	0.615
MOD_GSK3_1	389	396	PF00069	0.528
MOD_GSK3_1	459	466	PF00069	0.706
MOD_GSK3_1	50	57	PF00069	0.542
MOD_GSK3_1	519	526	PF00069	0.838
MOD_GSK3_1	602	609	PF00069	0.633
MOD_GSK3_1	642	649	PF00069	0.659
MOD_GSK3_1	65	72	PF00069	0.546
MOD_GSK3_1	733	740	PF00069	0.707
MOD_GSK3_1	780	787	PF00069	0.574
MOD_GSK3_1	793	800	PF00069	0.635
MOD_GSK3_1	853	860	PF00069	0.741
MOD_GSK3_1	871	878	PF00069	0.564
MOD_GSK3_1	93	100	PF00069	0.707
MOD_LATS_1	782	788	PF00433	0.573
MOD_LATS_1	857	863	PF00433	0.743
MOD_N-GLC_1	134	139	PF02516	0.599
MOD_NEK2_1	282	287	PF00069	0.675
MOD_NEK2_1	384	389	PF00069	0.651
MOD_NEK2_1	390	395	PF00069	0.655
MOD_NEK2_1	523	528	PF00069	0.747
MOD_NEK2_1	642	647	PF00069	0.684
MOD_NEK2_1	668	673	PF00069	0.523
MOD_NEK2_1	780	785	PF00069	0.708
MOD_NEK2_1	828	833	PF00069	0.567
MOD_NEK2_1	871	876	PF00069	0.615
MOD_NEK2_1	93	98	PF00069	0.571
MOD_NEK2_2	394	399	PF00069	0.545
MOD_NEK2_2	633	638	PF00069	0.599
MOD_OFUCOSY	734	741	PF10250	0.568
MOD_PIKK_1	150	156	PF00454	0.600
MOD_PIKK_1	69	75	PF00454	0.604
MOD_PIKK_1	93	99	PF00454	0.567
MOD_PK_1	272	278	PF00069	0.588
MOD_PKA_1	610	616	PF00069	0.684
MOD_PKA_1	764	770	PF00069	0.596
MOD_PKA_2	112	118	PF00069	0.545
MOD_PKA_2	12	18	PF00069	0.576
MOD_PKA_2	211	217	PF00069	0.579
MOD_PKA_2	334	340	PF00069	0.691
MOD_PKA_2	358	364	PF00069	0.576
MOD_PKA_2	535	541	PF00069	0.695
MOD_PKA_2	60	66	PF00069	0.592
MOD_PKA_2	610	616	PF00069	0.677
MOD_PKA_2	633	639	PF00069	0.523
MOD_PKA_2	646	652	PF00069	0.479
MOD_PKA_2	697	703	PF00069	0.672
MOD_PKA_2	764	770	PF00069	0.617
MOD_PKA_2	787	793	PF00069	0.579
MOD_PKA_2	807	813	PF00069	0.613
MOD_PKA_2	874	880	PF00069	0.754
MOD_PKA_2	961	967	PF00069	0.493
MOD_PKA_2	97	103	PF00069	0.639
MOD_PKB_1	257	265	PF00069	0.739
MOD_PKB_1	270	278	PF00069	0.592
MOD_Plk_1	134	140	PF00069	0.596
MOD_Plk_1	226	232	PF00069	0.729
MOD_Plk_1	726	732	PF00069	0.696
MOD_Plk_1	790	796	PF00069	0.570
MOD_Plk_1	815	821	PF00069	0.867
MOD_Plk_2-3	836	842	PF00069	0.572
MOD_Plk_4	214	220	PF00069	0.579
MOD_Plk_4	297	303	PF00069	0.708
MOD_Plk_4	338	344	PF00069	0.556
MOD_Plk_4	453	459	PF00069	0.546
MOD_ProDKin_1	117	123	PF00069	0.609
MOD_ProDKin_1	124	130	PF00069	0.690
MOD_ProDKin_1	188	194	PF00069	0.707
MOD_ProDKin_1	244	250	PF00069	0.738
MOD_ProDKin_1	270	276	PF00069	0.730
MOD_ProDKin_1	294	300	PF00069	0.715
MOD_ProDKin_1	347	353	PF00069	0.703
MOD_ProDKin_1	35	41	PF00069	0.567
MOD_ProDKin_1	54	60	PF00069	0.616
MOD_ProDKin_1	77	83	PF00069	0.601
MOD_ProDKin_1	865	871	PF00069	0.604
MOD_ProDKin_1	875	881	PF00069	0.581
MOD_ProDKin_1	904	910	PF00069	0.558
TRG_DiLeu_BaEn_1	687	692	PF01217	0.567
TRG_DiLeu_BaEn_1	7	12	PF01217	0.575
TRG_DiLeu_BaEn_1	896	901	PF01217	0.532
TRG_DiLeu_BaEn_4	896	902	PF01217	0.532
TRG_DiLeu_BaLyEn_6	901	906	PF01217	0.622
TRG_ENDOCYTIC_2	340	343	PF00928	0.556
TRG_ENDOCYTIC_2	497	500	PF00928	0.656
TRG_ENDOCYTIC_2	541	544	PF00928	0.679
TRG_ENDOCYTIC_2	834	837	PF00928	0.565
TRG_ENDOCYTIC_2	902	905	PF00928	0.629
TRG_ER_diArg_1	186	189	PF00400	0.719
TRG_ER_diArg_1	256	259	PF00400	0.743
TRG_ER_diArg_1	269	272	PF00400	0.595
TRG_ER_diArg_1	356	359	PF00400	0.578
TRG_ER_diArg_1	399	402	PF00400	0.695
TRG_ER_diArg_1	416	418	PF00400	0.578
TRG_ER_diArg_1	529	532	PF00400	0.725
TRG_ER_diArg_1	631	634	PF00400	0.661
TRG_ER_diArg_1	658	660	PF00400	0.651
TRG_ER_diArg_1	761	764	PF00400	0.699
TRG_ER_diArg_1	846	849	PF00400	0.741
TRG_ER_diArg_1	915	918	PF00400	0.404
TRG_ER_diArg_1	945	947	PF00400	0.381
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	3	7	PF00026	0.708
TRG_Pf-PMV_PEXEL_1	882	887	PF00026	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HCV6	Leishmania braziliensis	57%	100%