Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AW99_LEIMU

TriTrypDb:

LmxM.23.0840

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AW99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	361	363	PF00675	0.665
CLV_NRD_NRD_1	514	516	PF00675	0.617
CLV_PCSK_FUR_1	514	518	PF00082	0.437
CLV_PCSK_KEX2_1	361	363	PF00082	0.663
CLV_PCSK_KEX2_1	514	516	PF00082	0.608
CLV_PCSK_PC1ET2_1	516	518	PF00082	0.532
CLV_PCSK_SKI1_1	362	366	PF00082	0.752
CLV_PCSK_SKI1_1	517	521	PF00082	0.482
CLV_PCSK_SKI1_1	96	100	PF00082	0.620
DEG_Nend_UBRbox_1	1	4	PF02207	0.712
DEG_SIAH_1	242	250	PF03145	0.433
DOC_CDC14_PxL_1	275	283	PF14671	0.423
DOC_CYCLIN_yCln2_LP_2	49	55	PF00134	0.385
DOC_MAPK_FxFP_2	198	201	PF00069	0.383
DOC_MAPK_gen_1	121	130	PF00069	0.307
DOC_MAPK_MEF2A_6	164	173	PF00069	0.378
DOC_MAPK_MEF2A_6	475	482	PF00069	0.345
DOC_PP2B_LxvP_1	19	22	PF13499	0.429
DOC_PP2B_LxvP_1	49	52	PF13499	0.420
DOC_PP4_FxxP_1	198	201	PF00568	0.418
DOC_USP7_MATH_1	212	216	PF00917	0.390
DOC_USP7_MATH_1	221	225	PF00917	0.409
DOC_USP7_MATH_1	259	263	PF00917	0.453
DOC_USP7_MATH_1	441	445	PF00917	0.536
DOC_USP7_MATH_1	461	465	PF00917	0.490
DOC_USP7_MATH_1	97	101	PF00917	0.414
DOC_USP7_MATH_2	302	308	PF00917	0.469
DOC_WW_Pin1_4	219	224	PF00397	0.466
DOC_WW_Pin1_4	245	250	PF00397	0.409
DOC_WW_Pin1_4	402	407	PF00397	0.510
DOC_WW_Pin1_4	453	458	PF00397	0.511
LIG_14-3-3_CanoR_1	132	139	PF00244	0.373
LIG_14-3-3_CanoR_1	14	20	PF00244	0.461
LIG_14-3-3_CanoR_1	361	365	PF00244	0.486
LIG_14-3-3_CanoR_1	367	376	PF00244	0.432
LIG_14-3-3_CanoR_1	517	527	PF00244	0.725
LIG_APCC_ABBA_1	275	280	PF00400	0.326
LIG_BRCT_BRCA1_1	175	179	PF00533	0.458
LIG_BRCT_BRCA1_1	230	234	PF00533	0.337
LIG_CSL_BTD_1	403	406	PF09270	0.444
LIG_deltaCOP1_diTrp_1	334	340	PF00928	0.419
LIG_EH_1	300	304	PF12763	0.638
LIG_FHA_1	149	155	PF00498	0.362
LIG_FHA_1	223	229	PF00498	0.518
LIG_FHA_1	381	387	PF00498	0.357
LIG_FHA_1	419	425	PF00498	0.411
LIG_FHA_1	460	466	PF00498	0.487
LIG_FHA_1	68	74	PF00498	0.293
LIG_FHA_1	85	91	PF00498	0.335
LIG_FHA_2	211	217	PF00498	0.347
LIG_FHA_2	271	277	PF00498	0.429
LIG_LIR_Apic_2	196	201	PF02991	0.422
LIG_LIR_Gen_1	177	188	PF02991	0.477
LIG_LIR_Gen_1	312	319	PF02991	0.511
LIG_LIR_Gen_1	322	333	PF02991	0.395
LIG_LIR_Gen_1	334	341	PF02991	0.375
LIG_LIR_Gen_1	54	63	PF02991	0.393
LIG_LIR_Nem_3	176	182	PF02991	0.491
LIG_LIR_Nem_3	231	237	PF02991	0.392
LIG_LIR_Nem_3	276	281	PF02991	0.455
LIG_LIR_Nem_3	312	318	PF02991	0.600
LIG_LIR_Nem_3	322	328	PF02991	0.402
LIG_LIR_Nem_3	334	339	PF02991	0.366
LIG_LIR_Nem_3	54	59	PF02991	0.379
LIG_LYPXL_S_1	277	281	PF13949	0.521
LIG_LYPXL_yS_3	278	281	PF13949	0.449
LIG_MLH1_MIPbox_1	175	179	PF16413	0.458
LIG_MYND_1	168	172	PF01753	0.515
LIG_Pex14_1	233	237	PF04695	0.399
LIG_PTB_Apo_2	363	370	PF02174	0.427
LIG_SH2_STAP1	467	471	PF00017	0.503
LIG_SH2_STAT3	200	203	PF00017	0.384
LIG_SH2_STAT5	217	220	PF00017	0.362
LIG_SH2_STAT5	325	328	PF00017	0.391
LIG_SH2_STAT5	425	428	PF00017	0.443
LIG_SH3_3	10	16	PF00018	0.657
LIG_SH3_3	166	172	PF00018	0.431
LIG_SH3_3	400	406	PF00018	0.484
LIG_SUMO_SIM_anti_2	151	156	PF11976	0.325
LIG_SUMO_SIM_anti_2	23	28	PF11976	0.413
LIG_SUMO_SIM_anti_2	484	489	PF11976	0.421
LIG_SUMO_SIM_anti_2	491	498	PF11976	0.383
LIG_SUMO_SIM_anti_2	85	94	PF11976	0.307
LIG_SUMO_SIM_par_1	191	196	PF11976	0.374
LIG_SUMO_SIM_par_1	495	500	PF11976	0.510
LIG_SUMO_SIM_par_1	50	57	PF11976	0.288
LIG_SUMO_SIM_par_1	85	94	PF11976	0.299
LIG_TRAF2_1	350	353	PF00917	0.434
LIG_TRAF2_1	405	408	PF00917	0.519
MOD_CK1_1	117	123	PF00069	0.427
MOD_CK1_1	134	140	PF00069	0.307
MOD_CK1_1	250	256	PF00069	0.554
MOD_CK1_1	372	378	PF00069	0.605
MOD_CK1_1	380	386	PF00069	0.512
MOD_CK1_1	456	462	PF00069	0.583
MOD_CK1_1	466	472	PF00069	0.629
MOD_CK1_1	518	524	PF00069	0.641
MOD_CK2_1	120	126	PF00069	0.394
MOD_CK2_1	347	353	PF00069	0.631
MOD_CK2_1	402	408	PF00069	0.629
MOD_GlcNHglycan	116	119	PF01048	0.442
MOD_GlcNHglycan	329	332	PF01048	0.538
MOD_GlcNHglycan	371	374	PF01048	0.494
MOD_GlcNHglycan	418	421	PF01048	0.576
MOD_GlcNHglycan	426	429	PF01048	0.575
MOD_GlcNHglycan	49	52	PF01048	0.398
MOD_GlcNHglycan	517	520	PF01048	0.592
MOD_GlcNHglycan	6	9	PF01048	0.641
MOD_GSK3_1	130	137	PF00069	0.452
MOD_GSK3_1	206	213	PF00069	0.368
MOD_GSK3_1	229	236	PF00069	0.627
MOD_GSK3_1	368	375	PF00069	0.508
MOD_GSK3_1	449	456	PF00069	0.657
MOD_GSK3_1	459	466	PF00069	0.557
MOD_GSK3_1	47	54	PF00069	0.410
MOD_GSK3_1	58	65	PF00069	0.516
MOD_GSK3_1	67	74	PF00069	0.319
MOD_N-GLC_1	228	233	PF02516	0.536
MOD_N-GLC_1	305	310	PF02516	0.558
MOD_N-GLC_1	319	324	PF02516	0.556
MOD_N-GLC_1	377	382	PF02516	0.571
MOD_N-GLC_1	416	421	PF02516	0.524
MOD_NEK2_1	131	136	PF00069	0.386
MOD_NEK2_1	369	374	PF00069	0.515
MOD_NEK2_1	424	429	PF00069	0.571
MOD_NEK2_1	67	72	PF00069	0.327
MOD_OFUCOSY	32	37	PF10250	0.437
MOD_PIKK_1	186	192	PF00454	0.465
MOD_PIKK_1	418	424	PF00454	0.477
MOD_PIKK_1	441	447	PF00454	0.673
MOD_PIKK_1	67	73	PF00454	0.321
MOD_PIKK_1	97	103	PF00454	0.476
MOD_PK_1	377	383	PF00069	0.460
MOD_PKA_1	515	521	PF00069	0.649
MOD_PKA_2	120	126	PF00069	0.527
MOD_PKA_2	131	137	PF00069	0.434
MOD_PKA_2	360	366	PF00069	0.537
MOD_PKA_2	397	403	PF00069	0.534
MOD_Plk_1	228	234	PF00069	0.386
MOD_Plk_1	377	383	PF00069	0.552
MOD_Plk_1	84	90	PF00069	0.327
MOD_Plk_4	15	21	PF00069	0.485
MOD_Plk_4	158	164	PF00069	0.484
MOD_Plk_4	174	180	PF00069	0.506
MOD_Plk_4	229	235	PF00069	0.494
MOD_Plk_4	270	276	PF00069	0.495
MOD_Plk_4	443	449	PF00069	0.596
MOD_Plk_4	481	487	PF00069	0.390
MOD_Plk_4	488	494	PF00069	0.335
MOD_Plk_4	51	57	PF00069	0.462
MOD_ProDKin_1	219	225	PF00069	0.567
MOD_ProDKin_1	245	251	PF00069	0.475
MOD_ProDKin_1	402	408	PF00069	0.623
MOD_ProDKin_1	453	459	PF00069	0.618
MOD_SUMO_for_1	63	66	PF00179	0.367
MOD_SUMO_rev_2	276	284	PF00179	0.371
MOD_SUMO_rev_2	36	45	PF00179	0.379
MOD_SUMO_rev_2	57	65	PF00179	0.352
TRG_DiLeu_LyEn_5	408	413	PF01217	0.536
TRG_ENDOCYTIC_2	113	116	PF00928	0.406
TRG_ENDOCYTIC_2	278	281	PF00928	0.459
TRG_ENDOCYTIC_2	325	328	PF00928	0.530
TRG_ER_diArg_1	514	517	PF00400	0.518
TRG_NLS_MonoExtN_4	514	519	PF00514	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Q7	Leptomonas seymouri	31%	95%
A0A3S5H7C0	Leishmania donovani	78%	100%
A4HCV5	Leishmania braziliensis	52%	99%
A4I0D6	Leishmania infantum	78%	100%
Q4QB79	Leishmania major	76%	100%