SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AW97_LEIMU

TriTrypDb:

LmxM.23.0820

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AW97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW97

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.496
CLV_C14_Caspase3-7	439	443	PF00656	0.474
CLV_PCSK_SKI1_1	323	327	PF00082	0.375
CLV_PCSK_SKI1_1	329	333	PF00082	0.320
CLV_PCSK_SKI1_1	480	484	PF00082	0.332
CLV_PCSK_SKI1_1	88	92	PF00082	0.461
DEG_Nend_UBRbox_2	1	3	PF02207	0.448
DEG_SPOP_SBC_1	222	226	PF00917	0.507
DOC_CKS1_1	119	124	PF01111	0.394
DOC_CKS1_1	294	299	PF01111	0.444
DOC_CYCLIN_RxL_1	320	328	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.416
DOC_MAPK_gen_1	453	463	PF00069	0.457
DOC_MAPK_MEF2A_6	181	189	PF00069	0.221
DOC_PP1_RVXF_1	235	242	PF00149	0.316
DOC_PP4_FxxP_1	167	170	PF00568	0.329
DOC_PP4_FxxP_1	45	48	PF00568	0.381
DOC_USP7_MATH_1	107	111	PF00917	0.261
DOC_USP7_MATH_1	112	116	PF00917	0.267
DOC_USP7_MATH_1	147	151	PF00917	0.680
DOC_USP7_MATH_1	210	214	PF00917	0.719
DOC_USP7_MATH_1	222	226	PF00917	0.586
DOC_USP7_MATH_1	272	276	PF00917	0.570
DOC_USP7_MATH_1	4	8	PF00917	0.423
DOC_USP7_MATH_2	403	409	PF00917	0.614
DOC_WW_Pin1_4	110	115	PF00397	0.496
DOC_WW_Pin1_4	118	123	PF00397	0.562
DOC_WW_Pin1_4	141	146	PF00397	0.694
DOC_WW_Pin1_4	166	171	PF00397	0.336
DOC_WW_Pin1_4	293	298	PF00397	0.437
DOC_WW_Pin1_4	300	305	PF00397	0.452
LIG_14-3-3_CanoR_1	245	249	PF00244	0.404
LIG_14-3-3_CanoR_1	329	336	PF00244	0.427
LIG_14-3-3_CanoR_1	347	353	PF00244	0.402
LIG_Actin_WH2_2	434	452	PF00022	0.478
LIG_APCC_ABBA_1	100	105	PF00400	0.349
LIG_BRCT_BRCA1_1	119	123	PF00533	0.404
LIG_BRCT_BRCA1_1	408	412	PF00533	0.399
LIG_EVH1_2	41	45	PF00568	0.337
LIG_FHA_1	209	215	PF00498	0.607
LIG_FHA_1	241	247	PF00498	0.397
LIG_FHA_1	254	260	PF00498	0.347
LIG_FHA_1	281	287	PF00498	0.541
LIG_FHA_1	290	296	PF00498	0.476
LIG_FHA_1	330	336	PF00498	0.373
LIG_FHA_1	377	383	PF00498	0.446
LIG_FHA_1	442	448	PF00498	0.477
LIG_FHA_1	450	456	PF00498	0.477
LIG_FHA_1	91	97	PF00498	0.426
LIG_FHA_2	224	230	PF00498	0.534
LIG_FHA_2	349	355	PF00498	0.595
LIG_FHA_2	81	87	PF00498	0.558
LIG_Integrin_RGD_1	277	279	PF01839	0.411
LIG_LIR_Apic_2	110	114	PF02991	0.367
LIG_LIR_Apic_2	165	170	PF02991	0.326
LIG_LIR_Apic_2	398	402	PF02991	0.542
LIG_LIR_Apic_2	44	48	PF02991	0.368
LIG_LIR_Gen_1	285	295	PF02991	0.398
LIG_LIR_Gen_1	296	305	PF02991	0.334
LIG_LIR_Gen_1	409	419	PF02991	0.493
LIG_LIR_Gen_1	97	108	PF02991	0.400
LIG_LIR_Nem_3	285	291	PF02991	0.393
LIG_LIR_Nem_3	296	301	PF02991	0.312
LIG_LIR_Nem_3	309	313	PF02991	0.430
LIG_LIR_Nem_3	409	415	PF02991	0.493
LIG_LIR_Nem_3	464	468	PF02991	0.509
LIG_LIR_Nem_3	69	74	PF02991	0.449
LIG_LIR_Nem_3	97	103	PF02991	0.407
LIG_NRBOX	321	327	PF00104	0.511
LIG_NRBOX	420	426	PF00104	0.535
LIG_PCNA_PIPBox_1	479	488	PF02747	0.449
LIG_PCNA_yPIPBox_3	475	486	PF02747	0.436
LIG_PDZ_Class_3	505	510	PF00595	0.416
LIG_PTB_Apo_2	481	488	PF02174	0.502
LIG_SH2_CRK	422	426	PF00017	0.535
LIG_SH2_PTP2	399	402	PF00017	0.491
LIG_SH2_PTP2	465	468	PF00017	0.376
LIG_SH2_STAT3	264	267	PF00017	0.417
LIG_SH2_STAT5	166	169	PF00017	0.391
LIG_SH2_STAT5	248	251	PF00017	0.298
LIG_SH2_STAT5	264	267	PF00017	0.347
LIG_SH2_STAT5	399	402	PF00017	0.574
LIG_SH2_STAT5	465	468	PF00017	0.361
LIG_SH2_STAT5	485	488	PF00017	0.388
LIG_SH3_3	106	112	PF00018	0.323
LIG_SH3_3	35	41	PF00018	0.379
LIG_SH3_3	358	364	PF00018	0.485
LIG_SH3_3	397	403	PF00018	0.498
LIG_SUMO_SIM_par_1	115	121	PF11976	0.417
LIG_SUMO_SIM_par_1	459	464	PF11976	0.493
LIG_TRFH_1	399	403	PF08558	0.507
LIG_TYR_ITIM	463	468	PF00017	0.503
MOD_CDK_SPxxK_3	293	300	PF00069	0.282
MOD_CK1_1	110	116	PF00069	0.405
MOD_CK1_1	213	219	PF00069	0.744
MOD_CK1_1	220	226	PF00069	0.698
MOD_CK1_1	228	234	PF00069	0.373
MOD_CK1_1	28	34	PF00069	0.412
MOD_CK1_1	282	288	PF00069	0.556
MOD_CK1_1	314	320	PF00069	0.496
MOD_CK1_1	378	384	PF00069	0.468
MOD_CK1_1	423	429	PF00069	0.522
MOD_CK2_1	223	229	PF00069	0.565
MOD_CK2_1	29	35	PF00069	0.517
MOD_CK2_1	348	354	PF00069	0.479
MOD_CK2_1	471	477	PF00069	0.480
MOD_CK2_1	80	86	PF00069	0.520
MOD_GlcNHglycan	145	148	PF01048	0.704
MOD_GlcNHglycan	149	152	PF01048	0.646
MOD_GlcNHglycan	215	218	PF01048	0.755
MOD_GlcNHglycan	274	277	PF01048	0.690
MOD_GlcNHglycan	32	35	PF01048	0.501
MOD_GlcNHglycan	408	411	PF01048	0.261
MOD_GlcNHglycan	438	441	PF01048	0.179
MOD_GlcNHglycan	83	86	PF01048	0.490
MOD_GSK3_1	143	150	PF00069	0.624
MOD_GSK3_1	162	169	PF00069	0.353
MOD_GSK3_1	206	213	PF00069	0.754
MOD_GSK3_1	216	223	PF00069	0.633
MOD_GSK3_1	224	231	PF00069	0.387
MOD_GSK3_1	240	247	PF00069	0.382
MOD_GSK3_1	25	32	PF00069	0.416
MOD_GSK3_1	289	296	PF00069	0.445
MOD_GSK3_1	466	473	PF00069	0.384
MOD_GSK3_1	497	504	PF00069	0.592
MOD_N-GLC_1	428	433	PF02516	0.231
MOD_NEK2_1	117	122	PF00069	0.453
MOD_NEK2_1	128	133	PF00069	0.428
MOD_NEK2_1	221	226	PF00069	0.535
MOD_NEK2_1	36	41	PF00069	0.381
MOD_NEK2_1	428	433	PF00069	0.473
MOD_NEK2_1	43	48	PF00069	0.344
MOD_NEK2_1	449	454	PF00069	0.485
MOD_NEK2_1	461	466	PF00069	0.405
MOD_NEK2_2	485	490	PF00069	0.380
MOD_OFUCOSY	427	432	PF10250	0.278
MOD_PIKK_1	155	161	PF00454	0.371
MOD_PIKK_1	208	214	PF00454	0.582
MOD_PIKK_1	289	295	PF00454	0.500
MOD_PIKK_1	329	335	PF00454	0.318
MOD_PKA_2	190	196	PF00069	0.447
MOD_PKA_2	244	250	PF00069	0.413
MOD_PKA_2	346	352	PF00069	0.467
MOD_Plk_1	228	234	PF00069	0.444
MOD_Plk_1	25	31	PF00069	0.419
MOD_Plk_1	428	434	PF00069	0.522
MOD_Plk_4	112	118	PF00069	0.458
MOD_Plk_4	162	168	PF00069	0.364
MOD_Plk_4	185	191	PF00069	0.451
MOD_Plk_4	244	250	PF00069	0.421
MOD_Plk_4	314	320	PF00069	0.407
MOD_Plk_4	362	368	PF00069	0.414
MOD_Plk_4	420	426	PF00069	0.482
MOD_Plk_4	66	72	PF00069	0.515
MOD_ProDKin_1	110	116	PF00069	0.493
MOD_ProDKin_1	118	124	PF00069	0.552
MOD_ProDKin_1	141	147	PF00069	0.695
MOD_ProDKin_1	166	172	PF00069	0.334
MOD_ProDKin_1	293	299	PF00069	0.447
MOD_ProDKin_1	300	306	PF00069	0.465
MOD_SUMO_rev_2	84	90	PF00179	0.428
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.417
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.362
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.400
TRG_ENDOCYTIC_2	288	291	PF00928	0.384
TRG_ENDOCYTIC_2	422	425	PF00928	0.541
TRG_ENDOCYTIC_2	465	468	PF00928	0.425
TRG_NES_CRM1_1	66	79	PF08389	0.478
TRG_Pf-PMV_PEXEL_1	323	328	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	383	388	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL96	Leptomonas seymouri	56%	100%
A0A0S4IN59	Bodo saltans	31%	100%
A0A1X0NWW3	Trypanosomatidae	38%	100%
A0A3Q8IBR8	Leishmania donovani	89%	100%
A0A422N8X4	Trypanosoma rangeli	39%	100%
A4HCV2	Leishmania braziliensis	75%	99%
A4I0D3	Leishmania infantum	89%	100%
C9ZV37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4QB81	Leishmania major	87%	100%
V5BBM7	Trypanosoma cruzi	38%	100%