Actin interacting protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin interacting protein-like protein

Species:

Leishmania mexicana

UniProt:

E9AW96_LEIMU

TriTrypDb:

LmxM.23.0810

Length:

519

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9AW96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW96

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0008762	UDP-N-acetylmuramate dehydrogenase activity	5	1
GO:0016491	oxidoreductase activity	2	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	1
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	280	284	PF00656	0.333
CLV_C14_Caspase3-7	447	451	PF00656	0.378
CLV_NRD_NRD_1	211	213	PF00675	0.438
CLV_NRD_NRD_1	42	44	PF00675	0.530
CLV_PCSK_KEX2_1	42	44	PF00082	0.531
CLV_PCSK_KEX2_1	478	480	PF00082	0.441
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.531
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.457
CLV_PCSK_SKI1_1	18	22	PF00082	0.490
CLV_PCSK_SKI1_1	221	225	PF00082	0.382

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q0	Leptomonas seymouri	78%	100%
A0A0N1PE88	Leptomonas seymouri	25%	100%
A0A0S4IT80	Bodo saltans	51%	100%
A0A0S4JD99	Bodo saltans	26%	100%
A0A1X0NXE7	Trypanosomatidae	66%	100%
A0A1X0P026	Trypanosomatidae	25%	100%
A0A3Q8IDH3	Leishmania donovani	25%	100%
A0A3Q8IDH5	Leishmania donovani	23%	100%
A0A3Q8IEJ5	Leishmania donovani	94%	100%
A0A422N8Z9	Trypanosoma rangeli	65%	100%

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