Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW95_LEIMU

TriTrypDb:

LmxM.23.0800

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AW95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW95

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.393
CLV_NRD_NRD_1	215	217	PF00675	0.538
CLV_NRD_NRD_1	56	58	PF00675	0.440
CLV_NRD_NRD_1	61	63	PF00675	0.443
CLV_PCSK_KEX2_1	105	107	PF00082	0.392
CLV_PCSK_KEX2_1	184	186	PF00082	0.566
CLV_PCSK_KEX2_1	56	58	PF00082	0.437
CLV_PCSK_KEX2_1	83	85	PF00082	0.517
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.583
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.517
CLV_PCSK_SKI1_1	196	200	PF00082	0.619
CLV_PCSK_SKI1_1	57	61	PF00082	0.414
DEG_Nend_UBRbox_2	1	3	PF02207	0.632
DOC_PP2B_LxvP_1	115	118	PF13499	0.351
DOC_PP4_FxxP_1	199	202	PF00568	0.455
DOC_USP7_MATH_1	10	14	PF00917	0.628
DOC_USP7_MATH_1	16	20	PF00917	0.611
DOC_USP7_UBL2_3	60	64	PF12436	0.722
DOC_WW_Pin1_4	151	156	PF00397	0.428
LIG_14-3-3_CanoR_1	110	118	PF00244	0.429
LIG_14-3-3_CanoR_1	176	183	PF00244	0.463
LIG_14-3-3_CanoR_1	193	202	PF00244	0.433
LIG_Clathr_ClatBox_1	209	213	PF01394	0.508
LIG_FHA_1	110	116	PF00498	0.383
LIG_FHA_1	165	171	PF00498	0.487
LIG_FHA_1	202	208	PF00498	0.385
LIG_LIR_Apic_2	197	202	PF02991	0.450
LIG_LIR_Gen_1	112	121	PF02991	0.336
LIG_LIR_Nem_3	112	117	PF02991	0.336
LIG_NRBOX	143	149	PF00104	0.449
LIG_Pex14_1	183	187	PF04695	0.387
LIG_SH2_STAP1	111	115	PF00017	0.429
LIG_SH2_STAP1	160	164	PF00017	0.458
LIG_SH2_STAP1	187	191	PF00017	0.422
LIG_SH2_STAT5	108	111	PF00017	0.656
LIG_UBA3_1	209	217	PF00899	0.438
MOD_CDK_SPK_2	151	156	PF00069	0.428
MOD_CDK_SPxxK_3	151	158	PF00069	0.451
MOD_CK1_1	154	160	PF00069	0.437
MOD_CK1_1	33	39	PF00069	0.696
MOD_CK1_1	44	50	PF00069	0.695
MOD_CK2_1	194	200	PF00069	0.496
MOD_CK2_1	72	78	PF00069	0.705
MOD_GlcNHglycan	12	15	PF01048	0.432
MOD_GlcNHglycan	16	19	PF01048	0.430
MOD_GlcNHglycan	196	199	PF01048	0.626
MOD_GlcNHglycan	222	225	PF01048	0.659
MOD_GlcNHglycan	28	31	PF01048	0.479
MOD_GlcNHglycan	4	7	PF01048	0.494
MOD_GlcNHglycan	43	46	PF01048	0.390
MOD_GSK3_1	10	17	PF00069	0.717
MOD_GSK3_1	109	116	PF00069	0.548
MOD_GSK3_1	150	157	PF00069	0.426
MOD_GSK3_1	216	223	PF00069	0.510
MOD_GSK3_1	26	33	PF00069	0.725
MOD_GSK3_1	44	51	PF00069	0.722
MOD_NEK2_1	1	6	PF00069	0.755
MOD_NEK2_1	124	129	PF00069	0.493
MOD_NEK2_1	192	197	PF00069	0.419
MOD_NEK2_1	72	77	PF00069	0.633
MOD_PKA_1	216	222	PF00069	0.340
MOD_PKA_2	109	115	PF00069	0.516
MOD_PKA_2	192	198	PF00069	0.426
MOD_PKA_2	200	206	PF00069	0.443
MOD_PKA_2	215	221	PF00069	0.452
MOD_PKA_2	24	30	PF00069	0.789
MOD_PKA_2	31	37	PF00069	0.718
MOD_PKA_2	72	78	PF00069	0.648
MOD_Plk_2-3	74	80	PF00069	0.660
MOD_Plk_4	124	130	PF00069	0.604
MOD_ProDKin_1	151	157	PF00069	0.425
MOD_SUMO_rev_2	211	219	PF00179	0.335
TRG_ENDOCYTIC_2	111	114	PF00928	0.389
TRG_ER_diArg_1	104	106	PF00400	0.601
TRG_ER_diArg_1	175	178	PF00400	0.478
TRG_ER_diArg_1	55	57	PF00400	0.670
TRG_NLS_MonoExtC_3	61	66	PF00514	0.681
TRG_NLS_MonoExtN_4	60	66	PF00514	0.684
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P744	Leptomonas seymouri	64%	96%
A0A1X0NYB1	Trypanosomatidae	52%	100%
A4HCV0	Leishmania braziliensis	78%	100%
C9ZV39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	98%
Q4QB83	Leishmania major	89%	100%