SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AW94_LEIMU

TriTrypDb:

LmxM.23.0790

Length:

872

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AW94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW94

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	2
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	2
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.523
CLV_C14_Caspase3-7	232	236	PF00656	0.412
CLV_C14_Caspase3-7	286	290	PF00656	0.472
CLV_C14_Caspase3-7	430	434	PF00656	0.712
CLV_C14_Caspase3-7	480	484	PF00656	0.534
CLV_C14_Caspase3-7	508	512	PF00656	0.519
CLV_C14_Caspase3-7	642	646	PF00656	0.569
CLV_NRD_NRD_1	22	24	PF00675	0.482
CLV_NRD_NRD_1	220	222	PF00675	0.598
CLV_NRD_NRD_1	232	234	PF00675	0.521
CLV_NRD_NRD_1	259	261	PF00675	0.565
CLV_NRD_NRD_1	265	267	PF00675	0.584
CLV_NRD_NRD_1	275	277	PF00675	0.707
CLV_NRD_NRD_1	517	519	PF00675	0.592
CLV_NRD_NRD_1	751	753	PF00675	0.392
CLV_PCSK_FUR_1	263	267	PF00082	0.552
CLV_PCSK_KEX2_1	22	24	PF00082	0.482
CLV_PCSK_KEX2_1	258	260	PF00082	0.567
CLV_PCSK_KEX2_1	263	265	PF00082	0.580
CLV_PCSK_KEX2_1	275	277	PF00082	0.688
CLV_PCSK_KEX2_1	517	519	PF00082	0.592
CLV_PCSK_KEX2_1	616	618	PF00082	0.261
CLV_PCSK_KEX2_1	750	752	PF00082	0.377
CLV_PCSK_PC1ET2_1	616	618	PF00082	0.324
CLV_PCSK_PC7_1	259	265	PF00082	0.554
CLV_PCSK_PC7_1	612	618	PF00082	0.242
CLV_PCSK_SKI1_1	221	225	PF00082	0.589
CLV_PCSK_SKI1_1	616	620	PF00082	0.248
CLV_PCSK_SKI1_1	630	634	PF00082	0.302
CLV_PCSK_SKI1_1	752	756	PF00082	0.375
DEG_APCC_DBOX_1	160	168	PF00400	0.627
DEG_Nend_UBRbox_2	1	3	PF02207	0.497
DEG_ODPH_VHL_1	651	664	PF01847	0.364
DEG_SCF_FBW7_1	837	844	PF00400	0.574
DEG_SPOP_SBC_1	349	353	PF00917	0.554
DEG_SPOP_SBC_1	374	378	PF00917	0.552
DOC_CKS1_1	838	843	PF01111	0.426
DOC_CYCLIN_RxL_1	241	254	PF00134	0.541
DOC_CYCLIN_RxL_1	749	757	PF00134	0.375
DOC_MAPK_gen_1	233	240	PF00069	0.562
DOC_MAPK_gen_1	263	273	PF00069	0.575
DOC_PP1_RVXF_1	379	386	PF00149	0.520
DOC_PP2B_LxvP_1	821	824	PF13499	0.566
DOC_PP4_FxxP_1	452	455	PF00568	0.479
DOC_PP4_FxxP_1	802	805	PF00568	0.642
DOC_USP7_MATH_1	101	105	PF00917	0.746
DOC_USP7_MATH_1	106	110	PF00917	0.752
DOC_USP7_MATH_1	189	193	PF00917	0.433
DOC_USP7_MATH_1	226	230	PF00917	0.552
DOC_USP7_MATH_1	298	302	PF00917	0.396
DOC_USP7_MATH_1	350	354	PF00917	0.497
DOC_USP7_MATH_1	427	431	PF00917	0.610
DOC_USP7_MATH_1	481	485	PF00917	0.557
DOC_USP7_MATH_1	536	540	PF00917	0.715
DOC_USP7_MATH_1	62	66	PF00917	0.591
DOC_USP7_MATH_1	697	701	PF00917	0.429
DOC_USP7_MATH_1	785	789	PF00917	0.519
DOC_USP7_MATH_1	810	814	PF00917	0.615
DOC_USP7_MATH_1	824	828	PF00917	0.566
DOC_USP7_MATH_1	832	836	PF00917	0.671
DOC_USP7_MATH_2	488	494	PF00917	0.465
DOC_USP7_UBL2_3	224	228	PF12436	0.561
DOC_USP7_UBL2_3	74	78	PF12436	0.536
DOC_WW_Pin1_4	138	143	PF00397	0.513
DOC_WW_Pin1_4	23	28	PF00397	0.462
DOC_WW_Pin1_4	284	289	PF00397	0.532
DOC_WW_Pin1_4	475	480	PF00397	0.642
DOC_WW_Pin1_4	539	544	PF00397	0.668
DOC_WW_Pin1_4	580	585	PF00397	0.512
DOC_WW_Pin1_4	795	800	PF00397	0.575
DOC_WW_Pin1_4	837	842	PF00397	0.504
LIG_14-3-3_CanoR_1	136	142	PF00244	0.570
LIG_14-3-3_CanoR_1	284	288	PF00244	0.592
LIG_14-3-3_CanoR_1	375	380	PF00244	0.574
LIG_14-3-3_CanoR_1	406	416	PF00244	0.475
LIG_14-3-3_CanoR_1	604	608	PF00244	0.456
LIG_14-3-3_CanoR_1	630	636	PF00244	0.582
LIG_14-3-3_CanoR_1	784	788	PF00244	0.644
LIG_14-3-3_CanoR_1	851	856	PF00244	0.460
LIG_Actin_WH2_2	237	254	PF00022	0.392
LIG_APCC_ABBA_1	693	698	PF00400	0.442
LIG_BIR_III_2	511	515	PF00653	0.557
LIG_BRCT_BRCA1_1	145	149	PF00533	0.410
LIG_BRCT_BRCA1_1	386	390	PF00533	0.409
LIG_FHA_1	114	120	PF00498	0.570
LIG_FHA_1	252	258	PF00498	0.388
LIG_FHA_1	344	350	PF00498	0.550
LIG_FHA_1	502	508	PF00498	0.659
LIG_FHA_1	656	662	PF00498	0.483
LIG_FHA_2	188	194	PF00498	0.462
LIG_FHA_2	230	236	PF00498	0.410
LIG_FHA_2	408	414	PF00498	0.675
LIG_FHA_2	445	451	PF00498	0.682
LIG_FHA_2	478	484	PF00498	0.539
LIG_FHA_2	738	744	PF00498	0.661
LIG_FHA_2	842	848	PF00498	0.530
LIG_LIR_Apic_2	449	455	PF02991	0.633
LIG_LIR_Gen_1	141	152	PF02991	0.561
LIG_LIR_Gen_1	384	393	PF02991	0.372
LIG_LIR_Gen_1	560	566	PF02991	0.419
LIG_LIR_Gen_1	583	592	PF02991	0.552
LIG_LIR_Gen_1	666	676	PF02991	0.430
LIG_LIR_Gen_1	736	745	PF02991	0.518
LIG_LIR_Nem_3	141	147	PF02991	0.523
LIG_LIR_Nem_3	335	340	PF02991	0.437
LIG_LIR_Nem_3	384	388	PF02991	0.382
LIG_LIR_Nem_3	560	564	PF02991	0.419
LIG_LIR_Nem_3	583	589	PF02991	0.554
LIG_LIR_Nem_3	605	610	PF02991	0.446
LIG_LIR_Nem_3	666	672	PF02991	0.430
LIG_LIR_Nem_3	680	684	PF02991	0.457
LIG_LIR_Nem_3	736	742	PF02991	0.429
LIG_LIR_Nem_3	757	761	PF02991	0.367
LIG_LYPXL_S_1	336	340	PF13949	0.369
LIG_LYPXL_yS_3	337	340	PF13949	0.377
LIG_NRBOX	621	627	PF00104	0.474
LIG_PTB_Apo_2	39	46	PF02174	0.451
LIG_PTB_Phospho_1	39	45	PF10480	0.344
LIG_SH2_CRK	561	565	PF00017	0.412
LIG_SH2_GRB2like	701	704	PF00017	0.429
LIG_SH2_NCK_1	739	743	PF00017	0.471
LIG_SH2_STAP1	115	119	PF00017	0.571
LIG_SH2_STAP1	586	590	PF00017	0.525
LIG_SH2_STAP1	724	728	PF00017	0.474
LIG_SH2_STAT3	684	687	PF00017	0.474
LIG_SH2_STAT5	115	118	PF00017	0.712
LIG_SH2_STAT5	138	141	PF00017	0.487
LIG_SH2_STAT5	311	314	PF00017	0.255
LIG_SH2_STAT5	345	348	PF00017	0.556
LIG_SH2_STAT5	45	48	PF00017	0.442
LIG_SH2_STAT5	51	54	PF00017	0.429
LIG_SH2_STAT5	561	564	PF00017	0.651
LIG_SH2_STAT5	668	671	PF00017	0.524
LIG_SH2_STAT5	701	704	PF00017	0.429
LIG_SH2_STAT5	739	742	PF00017	0.394
LIG_SH2_STAT5	817	820	PF00017	0.408
LIG_SH3_1	817	823	PF00018	0.430
LIG_SH3_3	37	43	PF00018	0.457
LIG_SH3_3	482	488	PF00018	0.697
LIG_SH3_3	520	526	PF00018	0.736
LIG_SH3_3	647	653	PF00018	0.364
LIG_SH3_3	728	734	PF00018	0.498
LIG_SH3_3	784	790	PF00018	0.695
LIG_SH3_3	817	823	PF00018	0.453
LIG_SUMO_SIM_anti_2	506	511	PF11976	0.515
LIG_SUMO_SIM_anti_2	593	600	PF11976	0.432
LIG_SUMO_SIM_par_1	504	511	PF11976	0.549
LIG_TRAF2_1	11	14	PF00917	0.600
LIG_TRAF2_1	653	656	PF00917	0.364
LIG_TRAF2_1	730	733	PF00917	0.474
LIG_TRAF2_1	844	847	PF00917	0.617
LIG_TYR_ITIM	737	742	PF00017	0.371
MOD_CDK_SPK_2	580	585	PF00069	0.508
MOD_CK1_1	113	119	PF00069	0.751
MOD_CK1_1	130	136	PF00069	0.642
MOD_CK1_1	227	233	PF00069	0.636
MOD_CK1_1	283	289	PF00069	0.726
MOD_CK1_1	3	9	PF00069	0.457
MOD_CK1_1	352	358	PF00069	0.601
MOD_CK1_1	459	465	PF00069	0.712
MOD_CK1_1	477	483	PF00069	0.706
MOD_CK1_1	539	545	PF00069	0.724
MOD_CK1_1	54	60	PF00069	0.670
MOD_CK1_1	560	566	PF00069	0.691
MOD_CK1_1	597	603	PF00069	0.268
MOD_CK1_1	65	71	PF00069	0.597
MOD_CK1_1	79	85	PF00069	0.641
MOD_CK1_1	827	833	PF00069	0.502
MOD_CK1_1	839	845	PF00069	0.652
MOD_CK2_1	160	166	PF00069	0.596
MOD_CK2_1	23	29	PF00069	0.328
MOD_CK2_1	373	379	PF00069	0.530
MOD_CK2_1	444	450	PF00069	0.696
MOD_CK2_1	490	496	PF00069	0.560
MOD_CK2_1	527	533	PF00069	0.755
MOD_CK2_1	7	13	PF00069	0.577
MOD_CK2_1	737	743	PF00069	0.419
MOD_CK2_1	841	847	PF00069	0.548
MOD_DYRK1A_RPxSP_1	284	288	PF00069	0.472
MOD_DYRK1A_RPxSP_1	580	584	PF00069	0.401
MOD_GlcNHglycan	103	106	PF01048	0.707
MOD_GlcNHglycan	108	111	PF01048	0.711
MOD_GlcNHglycan	212	215	PF01048	0.644
MOD_GlcNHglycan	300	303	PF01048	0.442
MOD_GlcNHglycan	325	329	PF01048	0.438
MOD_GlcNHglycan	354	357	PF01048	0.624
MOD_GlcNHglycan	359	362	PF01048	0.652
MOD_GlcNHglycan	390	393	PF01048	0.537
MOD_GlcNHglycan	435	438	PF01048	0.646
MOD_GlcNHglycan	458	461	PF01048	0.642
MOD_GlcNHglycan	47	50	PF01048	0.419
MOD_GlcNHglycan	530	533	PF01048	0.731
MOD_GlcNHglycan	637	640	PF01048	0.184
MOD_GlcNHglycan	64	67	PF01048	0.691
MOD_GlcNHglycan	70	73	PF01048	0.727
MOD_GlcNHglycan	746	749	PF01048	0.542
MOD_GlcNHglycan	767	770	PF01048	0.477
MOD_GlcNHglycan	787	790	PF01048	0.683
MOD_GlcNHglycan	791	794	PF01048	0.594
MOD_GlcNHglycan	834	837	PF01048	0.585
MOD_GSK3_1	106	113	PF00069	0.786
MOD_GSK3_1	127	134	PF00069	0.595
MOD_GSK3_1	136	143	PF00069	0.489
MOD_GSK3_1	279	286	PF00069	0.700
MOD_GSK3_1	3	10	PF00069	0.522
MOD_GSK3_1	348	355	PF00069	0.600
MOD_GSK3_1	384	391	PF00069	0.471
MOD_GSK3_1	435	442	PF00069	0.733
MOD_GSK3_1	477	484	PF00069	0.668
MOD_GSK3_1	50	57	PF00069	0.524
MOD_GSK3_1	61	68	PF00069	0.668
MOD_GSK3_1	631	638	PF00069	0.433
MOD_GSK3_1	72	79	PF00069	0.639
MOD_GSK3_1	733	740	PF00069	0.442
MOD_GSK3_1	785	792	PF00069	0.657
MOD_GSK3_1	826	833	PF00069	0.650
MOD_GSK3_1	837	844	PF00069	0.555
MOD_GSK3_1	847	854	PF00069	0.420
MOD_N-GLC_1	594	599	PF02516	0.264
MOD_N-GLC_1	702	707	PF02516	0.264
MOD_N-GLC_2	44	46	PF02516	0.453
MOD_N-GLC_2	709	711	PF02516	0.264
MOD_NEK2_1	131	136	PF00069	0.672
MOD_NEK2_1	251	256	PF00069	0.460
MOD_NEK2_1	332	337	PF00069	0.524
MOD_NEK2_1	388	393	PF00069	0.514
MOD_NEK2_1	474	479	PF00069	0.742
MOD_NEK2_1	50	55	PF00069	0.579
MOD_NEK2_1	557	562	PF00069	0.525
MOD_NEK2_1	7	12	PF00069	0.599
MOD_NEK2_1	702	707	PF00069	0.294
MOD_NEK2_1	754	759	PF00069	0.376
MOD_NEK2_1	825	830	PF00069	0.715
MOD_NEK2_2	435	440	PF00069	0.482
MOD_NEK2_2	810	815	PF00069	0.439
MOD_PIKK_1	169	175	PF00454	0.437
MOD_PIKK_1	440	446	PF00454	0.793
MOD_PIKK_1	683	689	PF00454	0.326
MOD_PKA_1	224	230	PF00069	0.642
MOD_PKA_2	160	166	PF00069	0.596
MOD_PKA_2	187	193	PF00069	0.613
MOD_PKA_2	283	289	PF00069	0.566
MOD_PKA_2	374	380	PF00069	0.481
MOD_PKA_2	550	556	PF00069	0.725
MOD_PKA_2	603	609	PF00069	0.298
MOD_PKA_2	765	771	PF00069	0.475
MOD_PKA_2	783	789	PF00069	0.610
MOD_Plk_1	127	133	PF00069	0.471
MOD_Plk_1	594	600	PF00069	0.280
MOD_Plk_1	697	703	PF00069	0.264
MOD_Plk_1	810	816	PF00069	0.613
MOD_Plk_2-3	490	496	PF00069	0.461
MOD_Plk_4	251	257	PF00069	0.385
MOD_Plk_4	384	390	PF00069	0.375
MOD_Plk_4	469	475	PF00069	0.785
MOD_Plk_4	481	487	PF00069	0.681
MOD_Plk_4	594	600	PF00069	0.288
MOD_Plk_4	697	703	PF00069	0.269
MOD_ProDKin_1	138	144	PF00069	0.505
MOD_ProDKin_1	23	29	PF00069	0.459
MOD_ProDKin_1	284	290	PF00069	0.533
MOD_ProDKin_1	475	481	PF00069	0.638
MOD_ProDKin_1	539	545	PF00069	0.668
MOD_ProDKin_1	580	586	PF00069	0.510
MOD_ProDKin_1	795	801	PF00069	0.571
MOD_ProDKin_1	837	843	PF00069	0.496
TRG_DiLeu_BaEn_1	384	389	PF01217	0.332
TRG_DiLeu_BaEn_1	803	808	PF01217	0.596
TRG_DiLeu_BaEn_3	176	182	PF01217	0.393
TRG_DiLeu_BaLyEn_6	802	807	PF01217	0.605
TRG_ENDOCYTIC_2	337	340	PF00928	0.359
TRG_ENDOCYTIC_2	344	347	PF00928	0.402
TRG_ENDOCYTIC_2	561	564	PF00928	0.651
TRG_ENDOCYTIC_2	586	589	PF00928	0.547
TRG_ENDOCYTIC_2	611	614	PF00928	0.264
TRG_ENDOCYTIC_2	739	742	PF00928	0.394
TRG_ENDOCYTIC_2	758	761	PF00928	0.357
TRG_ER_diArg_1	240	243	PF00400	0.708
TRG_ER_diArg_1	257	260	PF00400	0.628
TRG_ER_diArg_1	263	266	PF00400	0.631
TRG_ER_diArg_1	274	276	PF00400	0.694
TRG_ER_diArg_1	516	518	PF00400	0.744
TRG_ER_diArg_1	579	582	PF00400	0.550
TRG_ER_diArg_1	750	752	PF00400	0.377
TRG_ER_diArg_1	857	860	PF00400	0.498
TRG_NLS_MonoExtC_3	220	225	PF00514	0.578
TRG_NLS_MonoExtC_3	76	81	PF00514	0.531
TRG_NLS_MonoExtN_4	74	81	PF00514	0.565
TRG_Pf-PMV_PEXEL_1	381	386	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	517	522	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEZ6	Leptomonas seymouri	49%	100%
A0A1X0NYH3	Trypanosomatidae	33%	100%
A0A3R7KV16	Trypanosoma rangeli	30%	100%
A0A3S7WXM7	Leishmania donovani	85%	100%
A4I0D0	Leishmania infantum	85%	100%
C9ZV40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4QB84	Leishmania major	82%	98%
V5ARQ1	Trypanosoma cruzi	30%	100%