DUF676 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative serine esterase (DUF676), putative

Species:

Leishmania mexicana

UniProt:

E9AW93_LEIMU

TriTrypDb:

LmxM.23.0780

Length:

926

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW93

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0051536	iron-sulfur cluster binding	3	1
GO:0051537	2 iron, 2 sulfur cluster binding	4	1
GO:0051540	metal cluster binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.647
CLV_C14_Caspase3-7	36	40	PF00656	0.688
CLV_C14_Caspase3-7	541	545	PF00656	0.485
CLV_NRD_NRD_1	250	252	PF00675	0.512
CLV_NRD_NRD_1	300	302	PF00675	0.395
CLV_NRD_NRD_1	324	326	PF00675	0.445
CLV_NRD_NRD_1	457	459	PF00675	0.463
CLV_NRD_NRD_1	473	475	PF00675	0.229
CLV_NRD_NRD_1	597	599	PF00675	0.502
CLV_NRD_NRD_1	729	731	PF00675	0.657
CLV_NRD_NRD_1	769	771	PF00675	0.641
CLV_NRD_NRD_1	792	794	PF00675	0.532
CLV_NRD_NRD_1	878	880	PF00675	0.545
CLV_PCSK_FUR_1	790	794	PF00082	0.535
CLV_PCSK_KEX2_1	250	252	PF00082	0.512
CLV_PCSK_KEX2_1	300	302	PF00082	0.449
CLV_PCSK_KEX2_1	324	326	PF00082	0.445
CLV_PCSK_KEX2_1	457	459	PF00082	0.450
CLV_PCSK_KEX2_1	472	474	PF00082	0.239
CLV_PCSK_KEX2_1	728	730	PF00082	0.664
CLV_PCSK_KEX2_1	741	743	PF00082	0.528
CLV_PCSK_KEX2_1	769	771	PF00082	0.641
CLV_PCSK_KEX2_1	792	794	PF00082	0.532
CLV_PCSK_KEX2_1	840	842	PF00082	0.483
CLV_PCSK_KEX2_1	878	880	PF00082	0.545
CLV_PCSK_PC1ET2_1	741	743	PF00082	0.583
CLV_PCSK_PC1ET2_1	840	842	PF00082	0.483
CLV_PCSK_PC7_1	453	459	PF00082	0.437
CLV_PCSK_SKI1_1	193	197	PF00082	0.684
CLV_PCSK_SKI1_1	300	304	PF00082	0.384
CLV_PCSK_SKI1_1	324	328	PF00082	0.497
CLV_PCSK_SKI1_1	368	372	PF00082	0.453
CLV_PCSK_SKI1_1	457	461	PF00082	0.461
CLV_PCSK_SKI1_1	473	477	PF00082	0.229
CLV_PCSK_SKI1_1	482	486	PF00082	0.335
CLV_PCSK_SKI1_1	528	532	PF00082	0.620
DEG_APCC_DBOX_1	188	196	PF00400	0.603
DEG_APCC_DBOX_1	299	307	PF00400	0.425
DEG_APCC_DBOX_1	367	375	PF00400	0.335
DEG_APCC_DBOX_1	395	403	PF00400	0.335
DEG_COP1_1	857	866	PF00400	0.480
DEG_SCF_TRCP1_1	703	709	PF00400	0.528
DEG_SPOP_SBC_1	626	630	PF00917	0.759
DEG_SPOP_SBC_1	808	812	PF00917	0.577
DOC_CKS1_1	412	417	PF01111	0.335
DOC_CYCLIN_RxL_1	189	201	PF00134	0.507
DOC_CYCLIN_RxL_1	453	462	PF00134	0.493
DOC_CYCLIN_RxL_1	471	480	PF00134	0.208
DOC_CYCLIN_yCln2_LP_2	423	429	PF00134	0.335
DOC_CYCLIN_yCln2_LP_2	720	726	PF00134	0.668
DOC_MAPK_DCC_7	26	35	PF00069	0.402
DOC_MAPK_gen_1	396	404	PF00069	0.335
DOC_MAPK_gen_1	598	605	PF00069	0.511
DOC_MAPK_gen_1	728	735	PF00069	0.676
DOC_MAPK_MEF2A_6	26	35	PF00069	0.402
DOC_MAPK_MEF2A_6	368	375	PF00069	0.335
DOC_MAPK_MEF2A_6	398	406	PF00069	0.335
DOC_MAPK_MEF2A_6	458	467	PF00069	0.335
DOC_MAPK_MEF2A_6	598	607	PF00069	0.513
DOC_MAPK_MEF2A_6	683	691	PF00069	0.523
DOC_MAPK_NFAT4_5	368	376	PF00069	0.335
DOC_PP1_RVXF_1	471	478	PF00149	0.335
DOC_PP2B_LxvP_1	733	736	PF13499	0.675
DOC_PP2B_LxvP_1	806	809	PF13499	0.633
DOC_PP4_FxxP_1	120	123	PF00568	0.498
DOC_USP7_MATH_1	164	168	PF00917	0.552
DOC_USP7_MATH_1	38	42	PF00917	0.676
DOC_USP7_MATH_1	626	630	PF00917	0.774
DOC_USP7_MATH_1	751	755	PF00917	0.673
DOC_USP7_MATH_1	831	835	PF00917	0.644
DOC_WW_Pin1_4	12	17	PF00397	0.646
DOC_WW_Pin1_4	127	132	PF00397	0.707
DOC_WW_Pin1_4	160	165	PF00397	0.581
DOC_WW_Pin1_4	279	284	PF00397	0.418
DOC_WW_Pin1_4	411	416	PF00397	0.351
DOC_WW_Pin1_4	42	47	PF00397	0.593
DOC_WW_Pin1_4	634	639	PF00397	0.756
DOC_WW_Pin1_4	645	650	PF00397	0.671
DOC_WW_Pin1_4	734	739	PF00397	0.631
DOC_WW_Pin1_4	809	814	PF00397	0.727
DOC_WW_Pin1_4	847	852	PF00397	0.584
DOC_WW_Pin1_4	908	913	PF00397	0.500
LIG_14-3-3_CanoR_1	212	218	PF00244	0.509
LIG_14-3-3_CanoR_1	342	350	PF00244	0.455
LIG_14-3-3_CanoR_1	382	389	PF00244	0.447
LIG_14-3-3_CanoR_1	401	407	PF00244	0.504
LIG_14-3-3_CanoR_1	565	570	PF00244	0.549
LIG_14-3-3_CanoR_1	590	595	PF00244	0.539
LIG_14-3-3_CanoR_1	658	664	PF00244	0.676
LIG_14-3-3_CanoR_1	722	727	PF00244	0.579
LIG_14-3-3_CanoR_1	770	780	PF00244	0.632
LIG_14-3-3_CanoR_1	785	794	PF00244	0.603
LIG_14-3-3_CanoR_1	841	845	PF00244	0.620
LIG_14-3-3_CanoR_1	878	884	PF00244	0.616
LIG_Actin_WH2_2	179	195	PF00022	0.514
LIG_APCC_ABBA_1	674	679	PF00400	0.607
LIG_BRCT_BRCA1_1	491	495	PF00533	0.444
LIG_BRCT_BRCA1_1	660	664	PF00533	0.671
LIG_BRCT_BRCA1_1	720	724	PF00533	0.640
LIG_Clathr_ClatBox_1	373	377	PF01394	0.319
LIG_CSL_BTD_1	423	426	PF09270	0.335
LIG_deltaCOP1_diTrp_1	421	429	PF00928	0.335
LIG_deltaCOP1_diTrp_1	803	807	PF00928	0.541
LIG_EVH1_2	123	127	PF00568	0.481
LIG_FHA_1	132	138	PF00498	0.538
LIG_FHA_1	488	494	PF00498	0.335
LIG_FHA_1	501	507	PF00498	0.554
LIG_FHA_1	617	623	PF00498	0.709
LIG_FHA_1	671	677	PF00498	0.635
LIG_FHA_1	679	685	PF00498	0.762
LIG_FHA_1	776	782	PF00498	0.680
LIG_FHA_1	810	816	PF00498	0.666
LIG_FHA_1	840	846	PF00498	0.612
LIG_FHA_1	87	93	PF00498	0.503
LIG_FHA_2	13	19	PF00498	0.551
LIG_FHA_2	168	174	PF00498	0.515
LIG_FHA_2	440	446	PF00498	0.335
LIG_FHA_2	478	484	PF00498	0.345
LIG_FHA_2	568	574	PF00498	0.472
LIG_FHA_2	818	824	PF00498	0.601
LIG_FHA_2	857	863	PF00498	0.704
LIG_GBD_Chelix_1	873	881	PF00786	0.455
LIG_Integrin_isoDGR_2	269	271	PF01839	0.495
LIG_LIR_Apic_2	119	123	PF02991	0.499
LIG_LIR_Gen_1	369	376	PF02991	0.335
LIG_LIR_Gen_1	405	413	PF02991	0.344
LIG_LIR_Gen_1	442	451	PF02991	0.335
LIG_LIR_Gen_1	492	501	PF02991	0.515
LIG_LIR_Gen_1	52	58	PF02991	0.413
LIG_LIR_Gen_1	534	543	PF02991	0.609
LIG_LIR_Gen_1	661	670	PF02991	0.503
LIG_LIR_Gen_1	69	78	PF02991	0.320
LIG_LIR_Gen_1	721	731	PF02991	0.553
LIG_LIR_Nem_3	361	365	PF02991	0.335
LIG_LIR_Nem_3	369	375	PF02991	0.335
LIG_LIR_Nem_3	405	409	PF02991	0.344
LIG_LIR_Nem_3	421	427	PF02991	0.302
LIG_LIR_Nem_3	442	446	PF02991	0.335
LIG_LIR_Nem_3	492	498	PF02991	0.553
LIG_LIR_Nem_3	503	508	PF02991	0.495
LIG_LIR_Nem_3	52	57	PF02991	0.418
LIG_LIR_Nem_3	661	667	PF02991	0.497
LIG_LIR_Nem_3	69	73	PF02991	0.320
LIG_LIR_Nem_3	721	727	PF02991	0.634
LIG_NRBOX	370	376	PF00104	0.453
LIG_PDZ_Class_2	921	926	PF00595	0.570
LIG_Pex14_1	424	428	PF04695	0.353
LIG_PTB_Apo_2	901	908	PF02174	0.485
LIG_REV1ctd_RIR_1	905	911	PF16727	0.443
LIG_SH2_CRK	128	132	PF00017	0.675
LIG_SH2_CRK	54	58	PF00017	0.380
LIG_SH2_STAP1	331	335	PF00017	0.444
LIG_SH2_STAP1	443	447	PF00017	0.335
LIG_SH2_STAT3	258	261	PF00017	0.549
LIG_SH2_STAT5	288	291	PF00017	0.522
LIG_SH2_STAT5	372	375	PF00017	0.335
LIG_SH2_STAT5	428	431	PF00017	0.335
LIG_SH2_STAT5	569	572	PF00017	0.458
LIG_SH3_3	120	126	PF00018	0.498
LIG_SH3_3	158	164	PF00018	0.578
LIG_SH3_3	166	172	PF00018	0.663
LIG_SH3_3	409	415	PF00018	0.453
LIG_SH3_3	47	53	PF00018	0.576
LIG_SH3_3	523	529	PF00018	0.550
LIG_SH3_3	589	595	PF00018	0.548
LIG_SH3_3	684	690	PF00018	0.759
LIG_SUMO_SIM_anti_2	82	87	PF11976	0.502
LIG_SUMO_SIM_anti_2	920	926	PF11976	0.331
LIG_SUMO_SIM_par_1	31	36	PF11976	0.436
LIG_SUMO_SIM_par_1	372	377	PF11976	0.405
LIG_SUMO_SIM_par_1	527	534	PF11976	0.509
LIG_SUMO_SIM_par_1	603	609	PF11976	0.596
LIG_SUMO_SIM_par_1	84	89	PF11976	0.423
LIG_TRAF2_1	534	537	PF00917	0.638
LIG_TRAF2_1	918	921	PF00917	0.507
LIG_UBA3_1	1	7	PF00899	0.563
LIG_ULM_U2AF65_1	324	329	PF00076	0.502
LIG_WRC_WIRS_1	532	537	PF05994	0.514
LIG_WRC_WIRS_1	75	80	PF05994	0.379
LIG_WW_1	642	645	PF00397	0.539
LIG_WW_2	123	126	PF00397	0.479
MOD_CDK_SPK_2	127	132	PF00069	0.498
MOD_CDK_SPK_2	809	814	PF00069	0.670
MOD_CDK_SPxxK_3	42	49	PF00069	0.553
MOD_CDK_SPxxK_3	734	741	PF00069	0.648
MOD_CK1_1	11	17	PF00069	0.551
MOD_CK1_1	139	145	PF00069	0.496
MOD_CK1_1	152	158	PF00069	0.594
MOD_CK1_1	163	169	PF00069	0.629
MOD_CK1_1	174	180	PF00069	0.685
MOD_CK1_1	282	288	PF00069	0.456
MOD_CK1_1	45	51	PF00069	0.457
MOD_CK1_1	549	555	PF00069	0.756
MOD_CK1_1	593	599	PF00069	0.651
MOD_CK1_1	612	618	PF00069	0.679
MOD_CK1_1	629	635	PF00069	0.615
MOD_CK1_1	637	643	PF00069	0.749
MOD_CK1_1	706	712	PF00069	0.704
MOD_CK1_1	718	724	PF00069	0.613
MOD_CK1_1	764	770	PF00069	0.628
MOD_CK1_1	771	777	PF00069	0.612
MOD_CK1_1	821	827	PF00069	0.572
MOD_CK1_1	839	845	PF00069	0.687
MOD_CK1_1	847	853	PF00069	0.590
MOD_CK2_1	167	173	PF00069	0.513
MOD_CK2_1	439	445	PF00069	0.337
MOD_CK2_1	531	537	PF00069	0.527
MOD_CK2_1	603	609	PF00069	0.636
MOD_CK2_1	743	749	PF00069	0.573
MOD_CK2_1	81	87	PF00069	0.498
MOD_CK2_1	817	823	PF00069	0.581
MOD_GlcNHglycan	119	123	PF01048	0.734
MOD_GlcNHglycan	142	145	PF01048	0.736
MOD_GlcNHglycan	151	154	PF01048	0.556
MOD_GlcNHglycan	227	230	PF01048	0.728
MOD_GlcNHglycan	274	277	PF01048	0.568
MOD_GlcNHglycan	343	346	PF01048	0.398
MOD_GlcNHglycan	35	38	PF01048	0.638
MOD_GlcNHglycan	39	43	PF01048	0.691
MOD_GlcNHglycan	560	563	PF01048	0.615
MOD_GlcNHglycan	575	578	PF01048	0.445
MOD_GlcNHglycan	581	584	PF01048	0.701
MOD_GlcNHglycan	595	598	PF01048	0.610
MOD_GlcNHglycan	629	632	PF01048	0.611
MOD_GlcNHglycan	65	68	PF01048	0.442
MOD_GlcNHglycan	703	706	PF01048	0.658
MOD_GlcNHglycan	708	711	PF01048	0.694
MOD_GlcNHglycan	820	823	PF01048	0.648
MOD_GlcNHglycan	846	849	PF01048	0.742
MOD_GlcNHglycan	856	859	PF01048	0.571
MOD_GlcNHglycan	98	102	PF01048	0.577
MOD_GSK3_1	127	134	PF00069	0.613
MOD_GSK3_1	135	142	PF00069	0.665
MOD_GSK3_1	160	167	PF00069	0.642
MOD_GSK3_1	171	178	PF00069	0.708
MOD_GSK3_1	288	295	PF00069	0.502
MOD_GSK3_1	33	40	PF00069	0.724
MOD_GSK3_1	331	338	PF00069	0.507
MOD_GSK3_1	546	553	PF00069	0.744
MOD_GSK3_1	612	619	PF00069	0.661
MOD_GSK3_1	625	632	PF00069	0.648
MOD_GSK3_1	634	641	PF00069	0.824
MOD_GSK3_1	650	657	PF00069	0.598
MOD_GSK3_1	666	673	PF00069	0.552
MOD_GSK3_1	701	708	PF00069	0.591
MOD_GSK3_1	711	718	PF00069	0.645
MOD_GSK3_1	761	768	PF00069	0.646
MOD_GSK3_1	771	778	PF00069	0.654
MOD_GSK3_1	8	15	PF00069	0.612
MOD_GSK3_1	817	824	PF00069	0.619
MOD_GSK3_1	836	843	PF00069	0.658
MOD_N-GLC_1	549	554	PF02516	0.514
MOD_N-GLC_1	772	777	PF02516	0.688
MOD_NEK2_1	10	15	PF00069	0.619
MOD_NEK2_1	197	202	PF00069	0.535
MOD_NEK2_1	20	25	PF00069	0.473
MOD_NEK2_1	272	277	PF00069	0.458
MOD_NEK2_1	33	38	PF00069	0.545
MOD_NEK2_1	358	363	PF00069	0.335
MOD_NEK2_1	477	482	PF00069	0.345
MOD_NEK2_1	558	563	PF00069	0.535
MOD_NEK2_1	618	623	PF00069	0.640
MOD_NEK2_1	659	664	PF00069	0.699
MOD_NEK2_1	743	748	PF00069	0.544
MOD_NEK2_1	844	849	PF00069	0.579
MOD_NEK2_1	854	859	PF00069	0.564
MOD_NEK2_1	86	91	PF00069	0.436
MOD_NEK2_2	678	683	PF00069	0.591
MOD_PIKK_1	292	298	PF00454	0.580
MOD_PIKK_1	643	649	PF00454	0.778
MOD_PIKK_1	703	709	PF00454	0.713
MOD_PK_1	910	916	PF00069	0.600
MOD_PKA_1	729	735	PF00069	0.626
MOD_PKA_1	840	846	PF00069	0.482
MOD_PKA_1	879	885	PF00069	0.317
MOD_PKA_2	131	137	PF00069	0.695
MOD_PKA_2	341	347	PF00069	0.454
MOD_PKA_2	381	387	PF00069	0.510
MOD_PKA_2	729	735	PF00069	0.657
MOD_PKA_2	768	774	PF00069	0.641
MOD_PKA_2	840	846	PF00069	0.657
MOD_PKB_1	565	573	PF00069	0.550
MOD_PKB_1	770	778	PF00069	0.689
MOD_Plk_1	197	203	PF00069	0.530
MOD_Plk_1	549	555	PF00069	0.514
MOD_Plk_1	678	684	PF00069	0.639
MOD_Plk_1	772	778	PF00069	0.687
MOD_Plk_1	81	87	PF00069	0.509
MOD_Plk_2-3	609	615	PF00069	0.613
MOD_Plk_4	157	163	PF00069	0.703
MOD_Plk_4	309	315	PF00069	0.548
MOD_Plk_4	489	495	PF00069	0.447
MOD_Plk_4	584	590	PF00069	0.491
MOD_Plk_4	603	609	PF00069	0.755
MOD_Plk_4	659	665	PF00069	0.667
MOD_Plk_4	715	721	PF00069	0.664
MOD_Plk_4	729	735	PF00069	0.502
MOD_Plk_4	74	80	PF00069	0.467
MOD_Plk_4	776	782	PF00069	0.628
MOD_Plk_4	81	87	PF00069	0.504
MOD_Plk_4	840	846	PF00069	0.592
MOD_Plk_4	910	916	PF00069	0.600
MOD_ProDKin_1	12	18	PF00069	0.643
MOD_ProDKin_1	127	133	PF00069	0.706
MOD_ProDKin_1	160	166	PF00069	0.582
MOD_ProDKin_1	279	285	PF00069	0.424
MOD_ProDKin_1	411	417	PF00069	0.351
MOD_ProDKin_1	42	48	PF00069	0.588
MOD_ProDKin_1	634	640	PF00069	0.755
MOD_ProDKin_1	645	651	PF00069	0.667
MOD_ProDKin_1	734	740	PF00069	0.629
MOD_ProDKin_1	809	815	PF00069	0.730
MOD_ProDKin_1	847	853	PF00069	0.586
MOD_ProDKin_1	908	914	PF00069	0.490
TRG_DiLeu_BaEn_1	369	374	PF01217	0.335
TRG_DiLeu_BaEn_3	920	926	PF01217	0.454
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.389
TRG_DiLeu_BaLyEn_6	455	460	PF01217	0.335
TRG_DiLeu_BaLyEn_6	735	740	PF01217	0.645
TRG_ENDOCYTIC_2	372	375	PF00928	0.335
TRG_ENDOCYTIC_2	443	446	PF00928	0.335
TRG_ENDOCYTIC_2	54	57	PF00928	0.388
TRG_ER_diArg_1	114	117	PF00400	0.505
TRG_ER_diArg_1	300	302	PF00400	0.449
TRG_ER_diArg_1	395	398	PF00400	0.335
TRG_ER_diArg_1	457	459	PF00400	0.435
TRG_ER_diArg_1	471	474	PF00400	0.249
TRG_ER_diArg_1	727	730	PF00400	0.661
TRG_ER_diArg_1	769	772	PF00400	0.698
TRG_ER_diArg_1	790	793	PF00400	0.537
TRG_ER_diArg_1	877	879	PF00400	0.472
TRG_ER_diArg_1	883	886	PF00400	0.382
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Q8	Leptomonas seymouri	47%	98%
A0A3Q8IFT8	Leishmania donovani	83%	99%
A4HCU8	Leishmania braziliensis	67%	99%
A4I0C9	Leishmania infantum	83%	99%
Q4QB85	Leishmania major	82%	100%