Putative mitochondrial RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9AW91_LEIMU

TriTrypDb:

LmxM.23.0760

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AW91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW91

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003697	single-stranded DNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.333
CLV_NRD_NRD_1	104	106	PF00675	0.532
CLV_NRD_NRD_1	182	184	PF00675	0.530
CLV_NRD_NRD_1	212	214	PF00675	0.551
CLV_NRD_NRD_1	279	281	PF00675	0.571
CLV_NRD_NRD_1	3	5	PF00675	0.605
CLV_NRD_NRD_1	310	312	PF00675	0.474
CLV_PCSK_KEX2_1	182	184	PF00082	0.621
CLV_PCSK_KEX2_1	212	214	PF00082	0.560
CLV_PCSK_KEX2_1	3	5	PF00082	0.605
CLV_PCSK_KEX2_1	309	311	PF00082	0.428
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.400
CLV_PCSK_SKI1_1	13	17	PF00082	0.510
DEG_APCC_DBOX_1	3	11	PF00400	0.665
DEG_APCC_KENBOX_2	137	141	PF00400	0.615
DEG_Nend_Nbox_1	1	3	PF02207	0.642
DOC_MAPK_gen_1	309	315	PF00069	0.368
DOC_PP1_RVXF_1	109	115	PF00149	0.513
DOC_PP2B_LxvP_1	88	91	PF13499	0.336
DOC_USP7_MATH_1	147	151	PF00917	0.487
DOC_USP7_MATH_1	273	277	PF00917	0.683
DOC_USP7_MATH_1	97	101	PF00917	0.503
DOC_USP7_UBL2_3	155	159	PF12436	0.544
DOC_USP7_UBL2_3	305	309	PF12436	0.328
DOC_WW_Pin1_4	43	48	PF00397	0.349
DOC_WW_Pin1_4	86	91	PF00397	0.313
LIG_14-3-3_CanoR_1	122	126	PF00244	0.603
LIG_14-3-3_CanoR_1	3	8	PF00244	0.670
LIG_BRCT_BRCA1_1	200	204	PF00533	0.664
LIG_Clathr_ClatBox_1	327	331	PF01394	0.427
LIG_Clathr_ClatBox_1	81	85	PF01394	0.368
LIG_DLG_GKlike_1	3	10	PF00625	0.665
LIG_FHA_1	14	20	PF00498	0.593
LIG_FHA_1	24	30	PF00498	0.578
LIG_FHA_1	264	270	PF00498	0.564
LIG_FHA_1	69	75	PF00498	0.342
LIG_FHA_2	232	238	PF00498	0.575
LIG_FHA_2	291	297	PF00498	0.474
LIG_LIR_Apic_2	298	303	PF02991	0.375
LIG_LIR_Gen_1	190	199	PF02991	0.449
LIG_LIR_Nem_3	190	195	PF02991	0.460
LIG_LIR_Nem_3	216	220	PF02991	0.474
LIG_NRBOX	6	12	PF00104	0.468
LIG_Pex14_2	282	286	PF04695	0.628
LIG_REV1ctd_RIR_1	215	221	PF16727	0.452
LIG_SH2_STAT5	209	212	PF00017	0.470
LIG_SH3_3	259	265	PF00018	0.545
LIG_SUMO_SIM_par_1	25	31	PF11976	0.355
LIG_TRFH_1	218	222	PF08558	0.532
LIG_WRC_WIRS_1	264	269	PF05994	0.533
MOD_CK1_1	100	106	PF00069	0.523
MOD_CK1_1	124	130	PF00069	0.604
MOD_CK1_1	164	170	PF00069	0.596
MOD_CK1_1	178	184	PF00069	0.509
MOD_CK1_1	276	282	PF00069	0.678
MOD_CK1_1	316	322	PF00069	0.502
MOD_CK2_1	164	170	PF00069	0.607
MOD_CK2_1	86	92	PF00069	0.313
MOD_GlcNHglycan	166	169	PF01048	0.538
MOD_GlcNHglycan	177	180	PF01048	0.496
MOD_GlcNHglycan	205	208	PF01048	0.487
MOD_GlcNHglycan	269	272	PF01048	0.527
MOD_GlcNHglycan	319	322	PF01048	0.408
MOD_GlcNHglycan	7	10	PF01048	0.721
MOD_GSK3_1	147	154	PF00069	0.465
MOD_GSK3_1	160	167	PF00069	0.415
MOD_GSK3_1	19	26	PF00069	0.704
MOD_GSK3_1	263	270	PF00069	0.594
MOD_GSK3_1	313	320	PF00069	0.482
MOD_GSK3_1	97	104	PF00069	0.494
MOD_NEK2_1	153	158	PF00069	0.536
MOD_NEK2_1	160	165	PF00069	0.401
MOD_NEK2_1	208	213	PF00069	0.433
MOD_NEK2_1	5	10	PF00069	0.584
MOD_PIKK_1	153	159	PF00454	0.560
MOD_PIKK_1	161	167	PF00454	0.397
MOD_PIKK_1	28	34	PF00454	0.348
MOD_PIKK_1	68	74	PF00454	0.349
MOD_PKA_1	3	9	PF00069	0.663
MOD_PKA_2	121	127	PF00069	0.635
MOD_PKA_2	147	153	PF00069	0.460
MOD_PKA_2	3	9	PF00069	0.663
MOD_Plk_4	147	153	PF00069	0.460
MOD_Plk_4	263	269	PF00069	0.526
MOD_ProDKin_1	43	49	PF00069	0.349
MOD_ProDKin_1	86	92	PF00069	0.313
MOD_SUMO_for_1	62	65	PF00179	0.474
TRG_DiLeu_BaEn_1	190	195	PF01217	0.489
TRG_ENDOCYTIC_2	325	328	PF00928	0.491
TRG_ER_diArg_1	182	184	PF00400	0.621
TRG_ER_diArg_1	2	4	PF00400	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8F7	Leptomonas seymouri	82%	100%
A0A0S4IYJ9	Bodo saltans	45%	100%
A0A1X0NXK3	Trypanosomatidae	71%	100%
A0A3Q8IB02	Leishmania donovani	97%	100%
A0A3R7MG63	Trypanosoma rangeli	70%	100%
A4HCU6	Leishmania braziliensis	93%	100%
A4I0C7	Leishmania infantum	97%	100%
C9ZV43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
Q4QB87	Leishmania major	97%	100%
V5BBM3	Trypanosoma cruzi	72%	93%