G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania mexicana

UniProt:

E9AW89_LEIMU

TriTrypDb:

LmxM.23.0740

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW89

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0005488	binding	1	10
GO:0005525	GTP binding	5	10
GO:0017076	purine nucleotide binding	4	10
GO:0019001	guanyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032561	guanyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.653
CLV_C14_Caspase3-7	356	360	PF00656	0.350
CLV_C14_Caspase3-7	81	85	PF00656	0.432
CLV_NRD_NRD_1	14	16	PF00675	0.465
CLV_NRD_NRD_1	266	268	PF00675	0.597
CLV_NRD_NRD_1	64	66	PF00675	0.417
CLV_NRD_NRD_1	67	69	PF00675	0.452
CLV_PCSK_KEX2_1	139	141	PF00082	0.760
CLV_PCSK_KEX2_1	14	16	PF00082	0.368
CLV_PCSK_KEX2_1	265	267	PF00082	0.576
CLV_PCSK_KEX2_1	322	324	PF00082	0.325
CLV_PCSK_KEX2_1	64	66	PF00082	0.407
CLV_PCSK_KEX2_1	71	73	PF00082	0.467
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.775
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.320
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.501
CLV_PCSK_PC7_1	261	267	PF00082	0.346
CLV_PCSK_SKI1_1	110	114	PF00082	0.481
CLV_PCSK_SKI1_1	142	146	PF00082	0.601
CLV_PCSK_SKI1_1	217	221	PF00082	0.204
CLV_PCSK_SKI1_1	270	274	PF00082	0.537
CLV_PCSK_SKI1_1	319	323	PF00082	0.328
CLV_PCSK_SKI1_1	51	55	PF00082	0.372
CLV_PCSK_SKI1_1	68	72	PF00082	0.442
DEG_APCC_DBOX_1	50	58	PF00400	0.368
DEG_Nend_Nbox_1	1	3	PF02207	0.454
DEG_SCF_FBW7_1	127	134	PF00400	0.563
DEG_SPOP_SBC_1	35	39	PF00917	0.611
DOC_CKS1_1	195	200	PF01111	0.468
DOC_CKS1_1	232	237	PF01111	0.419
DOC_CYCLIN_yClb1_LxF_4	206	212	PF00134	0.427
DOC_MAPK_DCC_7	167	176	PF00069	0.517
DOC_MAPK_MEF2A_6	167	176	PF00069	0.413
DOC_PP1_RVXF_1	70	77	PF00149	0.425
DOC_USP7_UBL2_3	145	149	PF12436	0.603
DOC_WW_Pin1_4	127	132	PF00397	0.708
DOC_WW_Pin1_4	152	157	PF00397	0.545
DOC_WW_Pin1_4	194	199	PF00397	0.524
DOC_WW_Pin1_4	231	236	PF00397	0.431
DOC_WW_Pin1_4	275	280	PF00397	0.566
DOC_WW_Pin1_4	415	420	PF00397	0.485
LIG_14-3-3_CanoR_1	110	115	PF00244	0.528
LIG_14-3-3_CanoR_1	179	187	PF00244	0.431
LIG_14-3-3_CanoR_1	267	275	PF00244	0.614
LIG_14-3-3_CanoR_1	379	387	PF00244	0.379
LIG_14-3-3_CanoR_1	72	77	PF00244	0.485
LIG_Actin_WH2_2	188	205	PF00022	0.468
LIG_BIR_III_2	359	363	PF00653	0.387
LIG_BRCT_BRCA1_1	207	211	PF00533	0.480
LIG_Clathr_ClatBox_1	218	222	PF01394	0.499
LIG_eIF4E_1	338	344	PF01652	0.409
LIG_eIF4E_1	372	378	PF01652	0.400
LIG_FHA_1	204	210	PF00498	0.466
LIG_FHA_1	232	238	PF00498	0.391
LIG_FHA_1	308	314	PF00498	0.547
LIG_FHA_1	387	393	PF00498	0.341
LIG_FHA_1	84	90	PF00498	0.453
LIG_FHA_2	354	360	PF00498	0.320
LIG_FHA_2	79	85	PF00498	0.412
LIG_GBD_Chelix_1	187	195	PF00786	0.324
LIG_LIR_Apic_2	345	350	PF02991	0.482
LIG_LIR_Gen_1	337	347	PF02991	0.354
LIG_LIR_Gen_1	418	425	PF02991	0.435
LIG_LIR_Nem_3	197	202	PF02991	0.533
LIG_LIR_Nem_3	208	214	PF02991	0.466
LIG_LIR_Nem_3	337	343	PF02991	0.278
LIG_LIR_Nem_3	418	424	PF02991	0.470
LIG_LIR_Nem_3	56	61	PF02991	0.376
LIG_PCNA_yPIPBox_3	184	196	PF02747	0.431
LIG_PDZ_Class_1	420	425	PF00595	0.481
LIG_SH2_CRK	229	233	PF00017	0.308
LIG_SH2_CRK	347	351	PF00017	0.365
LIG_SH2_NCK_1	212	216	PF00017	0.421
LIG_SH2_SRC	229	232	PF00017	0.268
LIG_SH2_STAT5	249	252	PF00017	0.337
LIG_SH2_STAT5	340	343	PF00017	0.292
LIG_SH2_STAT5	372	375	PF00017	0.524
LIG_SH2_STAT5	380	383	PF00017	0.374
LIG_SH2_STAT5	58	61	PF00017	0.521
LIG_SH3_3	218	224	PF00018	0.429
LIG_WRC_WIRS_1	404	409	PF05994	0.490
MOD_CDC14_SPxK_1	160	163	PF00782	0.544
MOD_CDK_SPxK_1	157	163	PF00069	0.551
MOD_CDK_SPxxK_3	152	159	PF00069	0.492
MOD_CDK_SPxxK_3	275	282	PF00069	0.519
MOD_CK1_1	182	188	PF00069	0.256
MOD_CK1_1	36	42	PF00069	0.596
MOD_CK2_1	36	42	PF00069	0.596
MOD_CMANNOS	76	79	PF00535	0.397
MOD_Cter_Amidation	137	140	PF01082	0.732
MOD_Cter_Amidation	62	65	PF01082	0.403
MOD_GlcNHglycan	126	130	PF01048	0.561
MOD_GlcNHglycan	136	139	PF01048	0.703
MOD_GlcNHglycan	181	184	PF01048	0.264
MOD_GlcNHglycan	270	273	PF01048	0.643
MOD_GlcNHglycan	282	285	PF01048	0.730
MOD_GlcNHglycan	328	331	PF01048	0.411
MOD_GSK3_1	127	134	PF00069	0.673
MOD_GSK3_1	178	185	PF00069	0.256
MOD_GSK3_1	29	36	PF00069	0.570
MOD_GSK3_1	403	410	PF00069	0.515
MOD_GSK3_1	415	422	PF00069	0.462
MOD_LATS_1	201	207	PF00433	0.322
MOD_LATS_1	268	274	PF00433	0.505
MOD_LATS_1	305	311	PF00433	0.701
MOD_N-GLC_1	122	127	PF02516	0.692
MOD_N-GLC_1	90	95	PF02516	0.544
MOD_NEK2_1	202	207	PF00069	0.316
MOD_NEK2_1	326	331	PF00069	0.373
MOD_NEK2_1	387	392	PF00069	0.315
MOD_NEK2_1	403	408	PF00069	0.348
MOD_NEK2_1	90	95	PF00069	0.530
MOD_PIKK_1	372	378	PF00454	0.478
MOD_PKA_2	178	184	PF00069	0.270
MOD_PKA_2	202	208	PF00069	0.322
MOD_PKA_2	29	35	PF00069	0.527
MOD_PKA_2	367	373	PF00069	0.455
MOD_PKA_2	378	384	PF00069	0.326
MOD_PKA_2	6	12	PF00069	0.506
MOD_Plk_1	419	425	PF00069	0.435
MOD_Plk_4	183	189	PF00069	0.256
MOD_ProDKin_1	127	133	PF00069	0.713
MOD_ProDKin_1	152	158	PF00069	0.547
MOD_ProDKin_1	194	200	PF00069	0.400
MOD_ProDKin_1	231	237	PF00069	0.434
MOD_ProDKin_1	275	281	PF00069	0.565
MOD_ProDKin_1	415	421	PF00069	0.474
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.599
TRG_ENDOCYTIC_2	199	202	PF00928	0.290
TRG_ENDOCYTIC_2	229	232	PF00928	0.364
TRG_ENDOCYTIC_2	340	343	PF00928	0.386
TRG_ENDOCYTIC_2	58	61	PF00928	0.376
TRG_ER_diArg_1	13	15	PF00400	0.380
TRG_ER_diArg_1	265	267	PF00400	0.462
TRG_ER_diArg_1	44	47	PF00400	0.410
TRG_ER_diArg_1	64	66	PF00400	0.284
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I045	Leptomonas seymouri	63%	72%
A0A0S4IVC3	Bodo saltans	49%	94%
A0A1X0NWZ9	Trypanosomatidae	56%	89%
A0A422MX57	Trypanosoma rangeli	55%	90%
A4HCU4	Leishmania braziliensis	83%	100%
C9ZV46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	89%
Q4QB89	Leishmania major	92%	100%
V5ARP5	Trypanosoma cruzi	55%	89%