Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9AW88_LEIMU

TriTrypDb:

LmxM.23.0730

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AW88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW88

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.657
CLV_C14_Caspase3-7	320	324	PF00656	0.637
CLV_NRD_NRD_1	128	130	PF00675	0.423
CLV_NRD_NRD_1	234	236	PF00675	0.711
CLV_NRD_NRD_1	242	244	PF00675	0.611
CLV_NRD_NRD_1	248	250	PF00675	0.560
CLV_NRD_NRD_1	254	256	PF00675	0.577
CLV_PCSK_FUR_1	232	236	PF00082	0.693
CLV_PCSK_FUR_1	240	244	PF00082	0.614
CLV_PCSK_KEX2_1	128	130	PF00082	0.423
CLV_PCSK_KEX2_1	234	236	PF00082	0.697
CLV_PCSK_KEX2_1	242	244	PF00082	0.704
CLV_PCSK_KEX2_1	248	250	PF00082	0.590
CLV_PCSK_KEX2_1	254	256	PF00082	0.543
DEG_SCF_FBW7_1	362	368	PF00400	0.650
DEG_SCF_FBW7_2	113	118	PF00400	0.610
DEG_SPOP_SBC_1	99	103	PF00917	0.499
DOC_CKS1_1	362	367	PF01111	0.588
DOC_CYCLIN_yCln2_LP_2	274	280	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	436	442	PF00134	0.474
DOC_MAPK_FxFP_2	440	443	PF00069	0.654
DOC_PP2B_LxvP_1	225	228	PF13499	0.676
DOC_PP2B_LxvP_1	274	277	PF13499	0.530
DOC_PP2B_LxvP_1	392	395	PF13499	0.588
DOC_PP4_FxxP_1	303	306	PF00568	0.591
DOC_PP4_FxxP_1	440	443	PF00568	0.654
DOC_USP7_MATH_1	26	30	PF00917	0.648
DOC_USP7_MATH_1	286	290	PF00917	0.626
DOC_USP7_MATH_1	306	310	PF00917	0.450
DOC_USP7_MATH_1	342	346	PF00917	0.719
DOC_USP7_MATH_1	365	369	PF00917	0.681
DOC_USP7_MATH_1	380	384	PF00917	0.532
DOC_USP7_MATH_1	395	399	PF00917	0.557
DOC_USP7_MATH_1	46	50	PF00917	0.613
DOC_USP7_MATH_1	516	520	PF00917	0.691
DOC_USP7_MATH_1	532	536	PF00917	0.628
DOC_USP7_MATH_1	95	99	PF00917	0.584
DOC_WW_Pin1_4	1	6	PF00397	0.736
DOC_WW_Pin1_4	111	116	PF00397	0.615
DOC_WW_Pin1_4	207	212	PF00397	0.505
DOC_WW_Pin1_4	328	333	PF00397	0.667
DOC_WW_Pin1_4	337	342	PF00397	0.594
DOC_WW_Pin1_4	354	359	PF00397	0.753
DOC_WW_Pin1_4	361	366	PF00397	0.643
DOC_WW_Pin1_4	383	388	PF00397	0.594
DOC_WW_Pin1_4	390	395	PF00397	0.593
DOC_WW_Pin1_4	435	440	PF00397	0.579
DOC_WW_Pin1_4	512	517	PF00397	0.647
LIG_14-3-3_CanoR_1	11	20	PF00244	0.551
LIG_14-3-3_CanoR_1	400	408	PF00244	0.508
LIG_14-3-3_CanoR_1	97	107	PF00244	0.657
LIG_BIR_II_1	1	5	PF00653	0.685
LIG_BIR_III_4	425	429	PF00653	0.689
LIG_BRCT_BRCA1_1	141	145	PF00533	0.475
LIG_BRCT_BRCA1_1	18	22	PF00533	0.628
LIG_BRCT_BRCA1_1	332	336	PF00533	0.616
LIG_BRCT_BRCA1_1	6	10	PF00533	0.613
LIG_EVH1_1	359	363	PF00568	0.502
LIG_FHA_1	1	7	PF00498	0.627
LIG_FHA_1	312	318	PF00498	0.626
LIG_FHA_1	45	51	PF00498	0.662
LIG_FHA_1	460	466	PF00498	0.633
LIG_FHA_2	470	476	PF00498	0.639
LIG_LIR_Apic_2	438	443	PF02991	0.649
LIG_LIR_Apic_2	473	479	PF02991	0.624
LIG_LIR_Gen_1	52	61	PF02991	0.612
LIG_LIR_Nem_3	142	148	PF02991	0.475
LIG_LIR_Nem_3	298	303	PF02991	0.524
LIG_LIR_Nem_3	333	339	PF02991	0.705
LIG_LIR_Nem_3	483	489	PF02991	0.563
LIG_LIR_Nem_3	493	499	PF02991	0.576
LIG_LIR_Nem_3	52	56	PF02991	0.724
LIG_LIR_Nem_3	575	580	PF02991	0.593
LIG_MYND_1	556	560	PF01753	0.635
LIG_Pex14_2	18	22	PF04695	0.683
LIG_Pex14_2	440	444	PF04695	0.654
LIG_SH2_SRC	561	564	PF00017	0.665
LIG_SH2_STAT5	132	135	PF00017	0.475
LIG_SH2_STAT5	300	303	PF00017	0.660
LIG_SH2_STAT5	540	543	PF00017	0.587
LIG_SH2_STAT5	561	564	PF00017	0.786
LIG_SH3_1	66	72	PF00018	0.517
LIG_SH3_2	116	121	PF14604	0.600
LIG_SH3_3	110	116	PF00018	0.631
LIG_SH3_3	274	280	PF00018	0.667
LIG_SH3_3	357	363	PF00018	0.560
LIG_SH3_3	446	452	PF00018	0.705
LIG_SH3_3	484	490	PF00018	0.545
LIG_SH3_3	510	516	PF00018	0.572
LIG_SH3_3	553	559	PF00018	0.563
LIG_SH3_3	560	566	PF00018	0.600
LIG_SH3_3	66	72	PF00018	0.592
LIG_WRC_WIRS_1	50	55	PF05994	0.612
LIG_WW_1	137	140	PF00397	0.475
MOD_CK1_1	179	185	PF00069	0.500
MOD_CK1_1	207	213	PF00069	0.511
MOD_CK1_1	21	27	PF00069	0.618
MOD_CK1_1	241	247	PF00069	0.701
MOD_CK1_1	33	39	PF00069	0.651
MOD_CK1_1	331	337	PF00069	0.663
MOD_CK1_1	343	349	PF00069	0.587
MOD_CK1_1	383	389	PF00069	0.621
MOD_CK1_1	398	404	PF00069	0.665
MOD_CK1_1	4	10	PF00069	0.626
MOD_CK1_1	407	413	PF00069	0.651
MOD_CK1_1	49	55	PF00069	0.629
MOD_CK1_1	98	104	PF00069	0.562
MOD_CK2_1	11	17	PF00069	0.631
MOD_CK2_1	26	32	PF00069	0.564
MOD_CK2_1	469	475	PF00069	0.639
MOD_Cter_Amidation	252	255	PF01082	0.701
MOD_GlcNHglycan	133	136	PF01048	0.291
MOD_GlcNHglycan	180	184	PF01048	0.302
MOD_GlcNHglycan	243	246	PF01048	0.666
MOD_GlcNHglycan	26	29	PF01048	0.638
MOD_GlcNHglycan	288	291	PF01048	0.642
MOD_GlcNHglycan	308	311	PF01048	0.554
MOD_GlcNHglycan	319	322	PF01048	0.688
MOD_GlcNHglycan	32	35	PF01048	0.649
MOD_GlcNHglycan	367	370	PF01048	0.641
MOD_GlcNHglycan	382	385	PF01048	0.581
MOD_GlcNHglycan	409	412	PF01048	0.678
MOD_GlcNHglycan	509	512	PF01048	0.713
MOD_GlcNHglycan	563	566	PF01048	0.613
MOD_GlcNHglycan	577	580	PF01048	0.518
MOD_GlcNHglycan	93	96	PF01048	0.653
MOD_GlcNHglycan	97	100	PF01048	0.674
MOD_GSK3_1	12	19	PF00069	0.772
MOD_GSK3_1	24	31	PF00069	0.585
MOD_GSK3_1	244	251	PF00069	0.765
MOD_GSK3_1	311	318	PF00069	0.630
MOD_GSK3_1	327	334	PF00069	0.585
MOD_GSK3_1	361	368	PF00069	0.630
MOD_GSK3_1	386	393	PF00069	0.612
MOD_GSK3_1	395	402	PF00069	0.655
MOD_GSK3_1	403	410	PF00069	0.734
MOD_GSK3_1	412	419	PF00069	0.700
MOD_GSK3_1	45	52	PF00069	0.709
MOD_GSK3_1	466	473	PF00069	0.546
MOD_GSK3_1	498	505	PF00069	0.612
MOD_GSK3_1	512	519	PF00069	0.676
MOD_GSK3_1	532	539	PF00069	0.611
MOD_GSK3_1	81	88	PF00069	0.570
MOD_GSK3_1	91	98	PF00069	0.615
MOD_GSK3_1	99	106	PF00069	0.674
MOD_N-GLC_1	11	16	PF02516	0.747
MOD_N-GLC_1	190	195	PF02516	0.275
MOD_N-GLC_1	221	226	PF02516	0.620
MOD_N-GLC_1	238	243	PF02516	0.727
MOD_N-GLC_1	258	263	PF02516	0.628
MOD_N-GLC_1	328	333	PF02516	0.663
MOD_N-GLC_1	532	537	PF02516	0.600
MOD_N-GLC_1	567	572	PF02516	0.632
MOD_NEK2_1	18	23	PF00069	0.651
MOD_NEK2_1	190	195	PF00069	0.475
MOD_NEK2_1	204	209	PF00069	0.481
MOD_NEK2_1	317	322	PF00069	0.656
MOD_NEK2_1	39	44	PF00069	0.623
MOD_NEK2_1	45	50	PF00069	0.562
MOD_NEK2_1	458	463	PF00069	0.626
MOD_NEK2_2	395	400	PF00069	0.674
MOD_PIKK_1	248	254	PF00454	0.651
MOD_PIKK_1	26	32	PF00454	0.650
MOD_PIKK_1	295	301	PF00454	0.669
MOD_PIKK_1	33	39	PF00454	0.591
MOD_PIKK_1	430	436	PF00454	0.739
MOD_PIKK_1	64	70	PF00454	0.698
MOD_PIKK_1	81	87	PF00454	0.492
MOD_PKA_1	248	254	PF00069	0.703
MOD_PKA_2	241	247	PF00069	0.676
MOD_PKA_2	248	254	PF00069	0.601
MOD_PKA_2	399	405	PF00069	0.503
MOD_Plk_1	16	22	PF00069	0.680
MOD_Plk_1	221	227	PF00069	0.600
MOD_Plk_4	103	109	PF00069	0.506
MOD_Plk_4	190	196	PF00069	0.475
MOD_Plk_4	46	52	PF00069	0.607
MOD_Plk_4	536	542	PF00069	0.504
MOD_ProDKin_1	1	7	PF00069	0.736
MOD_ProDKin_1	111	117	PF00069	0.616
MOD_ProDKin_1	207	213	PF00069	0.511
MOD_ProDKin_1	328	334	PF00069	0.668
MOD_ProDKin_1	337	343	PF00069	0.594
MOD_ProDKin_1	354	360	PF00069	0.752
MOD_ProDKin_1	361	367	PF00069	0.649
MOD_ProDKin_1	383	389	PF00069	0.594
MOD_ProDKin_1	390	396	PF00069	0.594
MOD_ProDKin_1	435	441	PF00069	0.580
MOD_ProDKin_1	512	518	PF00069	0.642
TRG_ENDOCYTIC_2	300	303	PF00928	0.584
TRG_ENDOCYTIC_2	488	491	PF00928	0.590
TRG_ENDOCYTIC_2	496	499	PF00928	0.621
TRG_ENDOCYTIC_2	540	543	PF00928	0.549
TRG_ER_diArg_1	127	129	PF00400	0.444
TRG_ER_diArg_1	240	243	PF00400	0.696
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P747	Leptomonas seymouri	40%	99%
A0A3Q8ICI4	Leishmania donovani	89%	100%
A4HCU3	Leishmania braziliensis	73%	100%
A4I0C4	Leishmania infantum	90%	100%
Q4QB90	Leishmania major	90%	100%