RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9AW87_LEIMU

TriTrypDb:

LmxM.23.0720

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW87

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	451	455	PF00656	0.769
CLV_C14_Caspase3-7	75	79	PF00656	0.702
CLV_NRD_NRD_1	285	287	PF00675	0.474
CLV_PCSK_KEX2_1	285	287	PF00082	0.530
CLV_PCSK_SKI1_1	190	194	PF00082	0.600
CLV_PCSK_SKI1_1	204	208	PF00082	0.534
DEG_SCF_FBW7_1	89	95	PF00400	0.708
DEG_SPOP_SBC_1	466	470	PF00917	0.810
DEG_SPOP_SBC_1	572	576	PF00917	0.465
DOC_CKS1_1	108	113	PF01111	0.804
DOC_CKS1_1	132	137	PF01111	0.682
DOC_CKS1_1	309	314	PF01111	0.682
DOC_CKS1_1	360	365	PF01111	0.648
DOC_CKS1_1	89	94	PF01111	0.709
DOC_MAPK_gen_1	250	259	PF00069	0.546
DOC_PP2B_LxvP_1	484	487	PF13499	0.800
DOC_PP4_FxxP_1	108	111	PF00568	0.612
DOC_PP4_FxxP_1	360	363	PF00568	0.645
DOC_PP4_FxxP_1	582	585	PF00568	0.672
DOC_PP4_MxPP_1	510	513	PF00568	0.706
DOC_USP7_MATH_1	133	137	PF00917	0.677
DOC_USP7_MATH_1	144	148	PF00917	0.697
DOC_USP7_MATH_1	245	249	PF00917	0.563
DOC_USP7_MATH_1	34	38	PF00917	0.738
DOC_USP7_MATH_1	390	394	PF00917	0.705
DOC_USP7_MATH_1	407	411	PF00917	0.695
DOC_USP7_MATH_1	467	471	PF00917	0.708
DOC_USP7_MATH_1	498	502	PF00917	0.757
DOC_USP7_MATH_1	547	551	PF00917	0.689
DOC_USP7_MATH_1	572	576	PF00917	0.651
DOC_USP7_MATH_2	531	537	PF00917	0.711
DOC_WW_Pin1_4	107	112	PF00397	0.804
DOC_WW_Pin1_4	131	136	PF00397	0.679
DOC_WW_Pin1_4	308	313	PF00397	0.699
DOC_WW_Pin1_4	334	339	PF00397	0.754
DOC_WW_Pin1_4	359	364	PF00397	0.644
DOC_WW_Pin1_4	398	403	PF00397	0.688
DOC_WW_Pin1_4	454	459	PF00397	0.759
DOC_WW_Pin1_4	581	586	PF00397	0.674
DOC_WW_Pin1_4	88	93	PF00397	0.781
LIG_14-3-3_CanoR_1	104	109	PF00244	0.726
LIG_14-3-3_CanoR_1	518	523	PF00244	0.675
LIG_APCC_ABBA_1	256	261	PF00400	0.546
LIG_BRCT_BRCA1_1	576	580	PF00533	0.768
LIG_BRCT_BRCA1_1	59	63	PF00533	0.646
LIG_Clathr_ClatBox_1	567	571	PF01394	0.596
LIG_FHA_1	279	285	PF00498	0.619
LIG_FHA_1	309	315	PF00498	0.551
LIG_FHA_1	399	405	PF00498	0.716
LIG_FHA_1	66	72	PF00498	0.752
LIG_HCF-1_HBM_1	127	130	PF13415	0.492
LIG_LIR_Apic_2	107	111	PF02991	0.611
LIG_LIR_Apic_2	127	133	PF02991	0.681
LIG_LIR_Apic_2	359	363	PF02991	0.641
LIG_LIR_Gen_1	91	101	PF02991	0.499
LIG_LIR_Nem_3	127	132	PF02991	0.625
LIG_LIR_Nem_3	330	336	PF02991	0.674
LIG_LIR_Nem_3	577	583	PF02991	0.672
LIG_LIR_Nem_3	60	65	PF02991	0.747
LIG_LIR_Nem_3	91	97	PF02991	0.497
LIG_MLH1_MIPbox_1	59	63	PF16413	0.748
LIG_Pex14_2	61	65	PF04695	0.748
LIG_PTAP_UEV_1	134	139	PF05743	0.679
LIG_SH2_CRK	130	134	PF00017	0.683
LIG_SH2_GRB2like	85	88	PF00017	0.787
LIG_SH2_STAP1	85	89	PF00017	0.787
LIG_SH2_STAT5	566	569	PF00017	0.693
LIG_SH2_STAT5	581	584	PF00017	0.667
LIG_SH2_STAT5	62	65	PF00017	0.748
LIG_SH3_2	135	140	PF14604	0.682
LIG_SH3_2	513	518	PF14604	0.720
LIG_SH3_3	132	138	PF00018	0.678
LIG_SH3_3	164	170	PF00018	0.808
LIG_SH3_3	22	28	PF00018	0.544
LIG_SH3_3	292	298	PF00018	0.637
LIG_SH3_3	307	313	PF00018	0.698
LIG_SH3_3	322	328	PF00018	0.727
LIG_SH3_3	335	341	PF00018	0.655
LIG_SH3_3	363	369	PF00018	0.713
LIG_SH3_3	43	49	PF00018	0.682
LIG_SH3_3	436	442	PF00018	0.786
LIG_SH3_3	503	509	PF00018	0.720
LIG_SH3_3	510	516	PF00018	0.712
LIG_SH3_3	86	92	PF00018	0.674
LIG_SUMO_SIM_anti_2	191	197	PF11976	0.683
LIG_WRC_WIRS_1	62	67	PF05994	0.749
MOD_CK1_1	100	106	PF00069	0.760
MOD_CK1_1	107	113	PF00069	0.732
MOD_CK1_1	147	153	PF00069	0.751
MOD_CK1_1	17	23	PF00069	0.722
MOD_CK1_1	172	178	PF00069	0.529
MOD_CK1_1	264	270	PF00069	0.546
MOD_CK1_1	37	43	PF00069	0.770
MOD_CK1_1	377	383	PF00069	0.723
MOD_CK1_1	391	397	PF00069	0.671
MOD_CK1_1	400	406	PF00069	0.644
MOD_CK1_1	408	414	PF00069	0.688
MOD_CK1_1	443	449	PF00069	0.826
MOD_CK1_1	465	471	PF00069	0.819
MOD_CK1_1	554	560	PF00069	0.726
MOD_CK2_1	343	349	PF00069	0.515
MOD_GlcNHglycan	116	119	PF01048	0.717
MOD_GlcNHglycan	135	138	PF01048	0.668
MOD_GlcNHglycan	146	149	PF01048	0.697
MOD_GlcNHglycan	16	19	PF01048	0.714
MOD_GlcNHglycan	214	217	PF01048	0.346
MOD_GlcNHglycan	22	25	PF01048	0.756
MOD_GlcNHglycan	223	226	PF01048	0.346
MOD_GlcNHglycan	263	266	PF01048	0.346
MOD_GlcNHglycan	288	292	PF01048	0.597
MOD_GlcNHglycan	306	309	PF01048	0.675
MOD_GlcNHglycan	353	356	PF01048	0.759
MOD_GlcNHglycan	390	393	PF01048	0.680
MOD_GlcNHglycan	431	434	PF01048	0.796
MOD_GlcNHglycan	469	472	PF01048	0.781
MOD_GlcNHglycan	475	478	PF01048	0.685
MOD_GlcNHglycan	536	539	PF01048	0.742
MOD_GlcNHglycan	545	548	PF01048	0.607
MOD_GlcNHglycan	549	552	PF01048	0.594
MOD_GlcNHglycan	553	556	PF01048	0.537
MOD_GlcNHglycan	94	97	PF01048	0.711
MOD_GlcNHglycan	99	102	PF01048	0.660
MOD_GSK3_1	100	107	PF00069	0.661
MOD_GSK3_1	110	117	PF00069	0.516
MOD_GSK3_1	143	150	PF00069	0.702
MOD_GSK3_1	172	179	PF00069	0.628
MOD_GSK3_1	264	271	PF00069	0.546
MOD_GSK3_1	304	311	PF00069	0.698
MOD_GSK3_1	339	346	PF00069	0.675
MOD_GSK3_1	34	41	PF00069	0.765
MOD_GSK3_1	374	381	PF00069	0.671
MOD_GSK3_1	388	395	PF00069	0.757
MOD_GSK3_1	396	403	PF00069	0.663
MOD_GSK3_1	407	414	PF00069	0.688
MOD_GSK3_1	445	452	PF00069	0.745
MOD_GSK3_1	457	464	PF00069	0.718
MOD_GSK3_1	543	550	PF00069	0.776
MOD_GSK3_1	57	64	PF00069	0.666
MOD_GSK3_1	81	88	PF00069	0.728
MOD_N-GLC_1	150	155	PF02516	0.700
MOD_N-GLC_1	302	307	PF02516	0.699
MOD_N-GLC_1	388	393	PF02516	0.775
MOD_N-GLC_1	408	413	PF02516	0.461
MOD_N-GLC_1	572	577	PF02516	0.694
MOD_N-GLC_1	79	84	PF02516	0.785
MOD_N-GLC_1	97	102	PF02516	0.668
MOD_N-GLC_2	266	268	PF02516	0.346
MOD_NEK2_1	38	43	PF00069	0.717
MOD_NEK2_1	396	401	PF00069	0.698
MOD_NEK2_1	412	417	PF00069	0.684
MOD_NEK2_1	445	450	PF00069	0.842
MOD_NEK2_1	475	480	PF00069	0.785
MOD_NEK2_1	61	66	PF00069	0.749
MOD_NEK2_1	81	86	PF00069	0.456
MOD_NEK2_2	57	62	PF00069	0.751
MOD_PIKK_1	172	178	PF00454	0.607
MOD_PIKK_1	297	303	PF00454	0.693
MOD_PIKK_1	475	481	PF00454	0.687
MOD_PK_1	518	524	PF00069	0.718
MOD_PKA_2	162	168	PF00069	0.812
MOD_PKA_2	221	227	PF00069	0.546
MOD_PKB_1	302	310	PF00069	0.698
MOD_Plk_1	408	414	PF00069	0.712
MOD_Plk_4	369	375	PF00069	0.735
MOD_Plk_4	400	406	PF00069	0.715
MOD_Plk_4	408	414	PF00069	0.688
MOD_Plk_4	440	446	PF00069	0.735
MOD_Plk_4	48	54	PF00069	0.734
MOD_Plk_4	57	63	PF00069	0.585
MOD_ProDKin_1	107	113	PF00069	0.803
MOD_ProDKin_1	131	137	PF00069	0.680
MOD_ProDKin_1	308	314	PF00069	0.702
MOD_ProDKin_1	334	340	PF00069	0.746
MOD_ProDKin_1	359	365	PF00069	0.644
MOD_ProDKin_1	398	404	PF00069	0.690
MOD_ProDKin_1	454	460	PF00069	0.758
MOD_ProDKin_1	88	94	PF00069	0.786
TRG_ENDOCYTIC_2	529	532	PF00928	0.681
TRG_ENDOCYTIC_2	62	65	PF00928	0.748
TRG_ER_diArg_1	284	286	PF00400	0.525
TRG_ER_FFAT_2	103	114	PF00635	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEZ5	Leptomonas seymouri	48%	89%
A0A3S7WXP3	Leishmania donovani	91%	100%
A4HCU2	Leishmania braziliensis	77%	100%
A4I0C3	Leishmania infantum	91%	100%
Q4QB91	Leishmania major	93%	100%