Cytochrome C oxidase copper chaperone (COX17)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW85_LEIMU

TriTrypDb:

LmxM.23.0700

Length:

113

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005758	mitochondrial intermembrane space	6	9
GO:0031970	organelle envelope lumen	5	9
GO:0031974	membrane-enclosed lumen	2	9
GO:0043233	organelle lumen	3	9
GO:0070013	intracellular organelle lumen	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AW85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW85

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0005507	copper ion binding	6	9
GO:0016530	metallochaperone activity	2	9
GO:0016531	copper chaperone activity	3	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0140104	molecular carrier activity	1	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	74	76	PF00675	0.492
CLV_PCSK_SKI1_1	76	80	PF00082	0.514
DOC_USP7_UBL2_3	7	11	PF12436	0.592
LIG_deltaCOP1_diTrp_1	36	43	PF00928	0.284
LIG_deltaCOP1_diTrp_1	4	9	PF00928	0.538
LIG_LIR_Gen_1	56	67	PF02991	0.284
LIG_LIR_Nem_3	4	9	PF02991	0.518
LIG_LIR_Nem_3	56	62	PF02991	0.281
LIG_LIR_Nem_3	88	94	PF02991	0.510
LIG_Pex14_1	39	43	PF04695	0.284
LIG_Rb_LxCxE_1	27	42	PF01857	0.338
LIG_SH2_STAT5	91	94	PF00017	0.504
LIG_SH2_STAT5	98	101	PF00017	0.503
LIG_SH3_3	18	24	PF00018	0.566
LIG_SH3_3	27	33	PF00018	0.641
MOD_OFUCOSY	44	51	PF10250	0.525
MOD_Plk_4	87	93	PF00069	0.524
MOD_SUMO_rev_2	50	55	PF00179	0.291
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P745	Leptomonas seymouri	91%	100%
A0A0S4IV12	Bodo saltans	77%	72%
A0A1X0NX85	Trypanosomatidae	83%	99%
A0A3S7WXM8	Leishmania donovani	97%	100%
A4I0C1	Leishmania infantum	97%	100%
C9ZV16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	99%
Q9U0W0	Leishmania major	98%	100%