3-ketoacyl-CoA thiolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-ketoacyl-CoA thiolase-like protein

Species:

Leishmania mexicana

UniProt:

E9AW84_LEIMU

TriTrypDb:

LmxM.23.0690

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW84

PDB structure(s): 3zbg_A , 3zbg_B , 3zbk_A , 3zbk_B , 3zbl_A , 3zbl_B , 3zbn_A , 3zbn_B , 3zbn_C , 3zbn_D , 5lnq_A , 5lnq_B , 5lnq_C , 5lnq_D , 5lot_A , 5lot_B , 5lot_C , 5lot_D

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003988	acetyl-CoA C-acyltransferase activity	6	7
GO:0016408	C-acyltransferase activity	5	7
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	174	176	PF00675	0.471
CLV_NRD_NRD_1	225	227	PF00675	0.384
CLV_PCSK_KEX2_1	188	190	PF00082	0.410
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.403
CLV_PCSK_SKI1_1	188	192	PF00082	0.365
CLV_PCSK_SKI1_1	403	407	PF00082	0.371
DEG_Nend_Nbox_1	1	3	PF02207	0.632
DOC_CDC14_PxL_1	414	422	PF14671	0.451
DOC_CYCLIN_RxL_1	222	231	PF00134	0.386
DOC_MAPK_FxFP_2	180	183	PF00069	0.365
DOC_MAPK_gen_1	43	49	PF00069	0.517
DOC_MAPK_JIP1_4	328	334	PF00069	0.384
DOC_PP1_RVXF_1	224	231	PF00149	0.432
DOC_PP4_FxxP_1	180	183	PF00568	0.365
DOC_PP4_FxxP_1	386	389	PF00568	0.365
DOC_USP7_MATH_1	122	126	PF00917	0.365
DOC_USP7_MATH_1	283	287	PF00917	0.518
DOC_USP7_MATH_1	96	100	PF00917	0.384
DOC_WW_Pin1_4	20	25	PF00397	0.388
DOC_WW_Pin1_4	279	284	PF00397	0.543
LIG_14-3-3_CanoR_1	226	231	PF00244	0.385
LIG_14-3-3_CanoR_1	254	261	PF00244	0.384
LIG_14-3-3_CanoR_1	3	7	PF00244	0.625
LIG_Actin_WH2_2	124	140	PF00022	0.477
LIG_BRCT_BRCA1_1	12	16	PF00533	0.514
LIG_BRCT_BRCA1_1	29	33	PF00533	0.450
LIG_EH1_1	340	348	PF00400	0.365
LIG_FHA_1	10	16	PF00498	0.367
LIG_FHA_1	132	138	PF00498	0.384
LIG_FHA_1	155	161	PF00498	0.475
LIG_FHA_1	202	208	PF00498	0.357
LIG_FHA_1	21	27	PF00498	0.381
LIG_FHA_1	223	229	PF00498	0.383
LIG_FHA_2	198	204	PF00498	0.365
LIG_FHA_2	246	252	PF00498	0.526
LIG_FHA_2	340	346	PF00498	0.438
LIG_FHA_2	367	373	PF00498	0.365
LIG_FHA_2	46	52	PF00498	0.366
LIG_LIR_Apic_2	178	183	PF02991	0.365
LIG_LIR_Apic_2	299	305	PF02991	0.554
LIG_LIR_Apic_2	385	389	PF02991	0.419
LIG_LIR_Gen_1	251	257	PF02991	0.510
LIG_LIR_Nem_3	179	185	PF02991	0.365
LIG_LIR_Nem_3	247	252	PF02991	0.365
LIG_PCNA_PIPBox_1	75	84	PF02747	0.463
LIG_PCNA_yPIPBox_3	69	82	PF02747	0.463
LIG_Pex14_2	182	186	PF04695	0.365
LIG_PTB_Apo_2	243	250	PF02174	0.419
LIG_PTB_Phospho_1	243	249	PF10480	0.365
LIG_RPA_C_Fungi	310	322	PF08784	0.384
LIG_SH2_GRB2like	212	215	PF00017	0.365
LIG_SH2_NCK_1	302	306	PF00017	0.473
LIG_SH2_SRC	212	215	PF00017	0.365
LIG_SH2_SRC	302	305	PF00017	0.446
LIG_SH2_STAT3	171	174	PF00017	0.365
LIG_SH2_STAT5	164	167	PF00017	0.365
LIG_SH2_STAT5	192	195	PF00017	0.477
LIG_SH2_STAT5	252	255	PF00017	0.477
LIG_SUMO_SIM_par_1	285	293	PF11976	0.471
LIG_TRAF2_1	271	274	PF00917	0.384
LIG_TRAF2_1	48	51	PF00917	0.384
LIG_TYR_ITIM	347	352	PF00017	0.365
LIG_WRC_WIRS_1	383	388	PF05994	0.419
MOD_CK1_1	259	265	PF00069	0.362
MOD_CK1_1	4	10	PF00069	0.708
MOD_CK2_1	245	251	PF00069	0.510
MOD_CK2_1	339	345	PF00069	0.365
MOD_CK2_1	366	372	PF00069	0.408
MOD_CK2_1	45	51	PF00069	0.366
MOD_Cter_Amidation	41	44	PF01082	0.365
MOD_GlcNHglycan	124	127	PF01048	0.365
MOD_GlcNHglycan	131	134	PF01048	0.365
MOD_GlcNHglycan	140	143	PF01048	0.405
MOD_GlcNHglycan	434	437	PF01048	0.455
MOD_GSK3_1	197	204	PF00069	0.368
MOD_GSK3_1	222	229	PF00069	0.408
MOD_GSK3_1	279	286	PF00069	0.501
MOD_GSK3_1	53	60	PF00069	0.462
MOD_LATS_1	224	230	PF00433	0.438
MOD_N-GLC_1	245	250	PF02516	0.425
MOD_N-GLC_1	283	288	PF02516	0.505
MOD_N-GLC_1	45	50	PF02516	0.365
MOD_N-GLC_1	62	67	PF02516	0.218
MOD_NEK2_1	1	6	PF00069	0.642
MOD_NEK2_1	201	206	PF00069	0.357
MOD_NEK2_1	311	316	PF00069	0.400
MOD_NEK2_1	420	425	PF00069	0.408
MOD_NEK2_1	53	58	PF00069	0.392
MOD_NEK2_1	85	90	PF00069	0.361
MOD_NEK2_1	9	14	PF00069	0.530
MOD_PIKK_1	256	262	PF00454	0.365
MOD_PIKK_1	85	91	PF00454	0.358
MOD_PKA_1	226	232	PF00069	0.394
MOD_PKA_2	2	8	PF00069	0.651
MOD_PKA_2	253	259	PF00069	0.384
MOD_Plk_1	178	184	PF00069	0.365
MOD_Plk_1	245	251	PF00069	0.377
MOD_Plk_1	256	262	PF00069	0.337
MOD_Plk_1	283	289	PF00069	0.518
MOD_Plk_1	367	373	PF00069	0.438
MOD_Plk_1	429	435	PF00069	0.405
MOD_Plk_1	45	51	PF00069	0.365
MOD_Plk_1	62	68	PF00069	0.371
MOD_Plk_2-3	339	345	PF00069	0.365
MOD_ProDKin_1	20	26	PF00069	0.389
MOD_ProDKin_1	279	285	PF00069	0.538
MOD_SUMO_rev_2	285	294	PF00179	0.428
MOD_SUMO_rev_2	30	39	PF00179	0.466
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.319
TRG_ENDOCYTIC_2	252	255	PF00928	0.408
TRG_ENDOCYTIC_2	349	352	PF00928	0.365
TRG_ENDOCYTIC_2	402	405	PF00928	0.365
TRG_NLS_Bipartite_1	175	192	PF00514	0.446
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	226	231	PF00026	0.386
TRG_PTS2	1	22	PF00400	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFA5	Leptomonas seymouri	81%	100%
A0A0S4IUN8	Bodo saltans	64%	100%
A0A1X0NX18	Trypanosomatidae	75%	100%
A0A3R7K9N6	Trypanosoma rangeli	72%	100%
A0A3S7WXL6	Leishmania donovani	97%	100%
A0KK76	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	25%	100%
A1ADI9	Escherichia coli O1:K1 / APEC	22%	100%
A1RI91	Shewanella sp. (strain W3-18-1)	24%	100%
A4HCU5	Leishmania braziliensis	90%	100%
A4I0C0	Leishmania infantum	97%	100%
A4SMT9	Aeromonas salmonicida (strain A449)	25%	100%
A4WCW7	Enterobacter sp. (strain 638)	21%	100%
A6TC20	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	21%	100%
A7ZPF9	Escherichia coli O139:H28 (strain E24377A / ETEC)	21%	100%
A8A2L1	Escherichia coli O9:H4 (strain HS)	22%	100%
A8ADP1	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	22%	100%
A8FTR6	Shewanella sediminis (strain HAW-EB3)	23%	100%
A8GH87	Serratia proteamaculans (strain 568)	22%	100%
A8H5T2	Shewanella pealeana (strain ATCC 700345 / ANG-SQ1)	24%	100%
A9MJ36	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	23%	100%
A9N452	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	23%	100%
B0TL22	Shewanella halifaxensis (strain HAW-EB4)	24%	100%
B0YA65	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	23%	100%
B1IXA4	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	21%	100%
B1KKT1	Shewanella woodyi (strain ATCC 51908 / MS32)	23%	100%
B1LME8	Escherichia coli (strain SMS-3-5 / SECEC)	22%	100%
B1X9L5	Escherichia coli (strain K12 / DH10B)	21%	100%
B2TWV5	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	21%	100%
B4RTU9	Alteromonas mediterranea (strain DSM 17117 / CIP 110805 / LMG 28347 / Deep ecotype)	25%	100%
B4SZR1	Salmonella newport (strain SL254)	23%	100%
B4TCA9	Salmonella heidelberg (strain SL476)	23%	100%
B4TQC3	Salmonella schwarzengrund (strain CVM19633)	23%	100%
B5BBA0	Salmonella paratyphi A (strain AKU_12601)	23%	100%
B5EZS0	Salmonella agona (strain SL483)	23%	100%
B5FPN2	Salmonella dublin (strain CT_02021853)	23%	100%
B5R3S0	Salmonella enteritidis PT4 (strain P125109)	23%	100%
B5XVW1	Klebsiella pneumoniae (strain 342)	22%	100%
B5YXY5	Escherichia coli O157:H7 (strain EC4115 / EHEC)	22%	100%
B6I6Q5	Escherichia coli (strain SE11)	21%	100%
B7LBJ6	Escherichia coli (strain 55989 / EAEC)	21%	100%
B7LLC9	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	22%	100%
B7M6M3	Escherichia coli O8 (strain IAI1)	21%	100%
B7MGV8	Escherichia coli O45:K1 (strain S88 / ExPEC)	22%	100%
B7MY17	Escherichia coli O81 (strain ED1a)	22%	100%
B7N5V3	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	22%	100%
B7NP25	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	21%	100%
B7UFZ9	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	22%	100%
B8CPY7	Shewanella piezotolerans (strain WP3 / JCM 13877)	24%	100%
C0PZX5	Salmonella paratyphi C (strain RKS4594)	23%	100%
C4ZVN3	Escherichia coli (strain K12 / MC4100 / BW2952)	21%	100%
C6DAL8	Pectobacterium carotovorum subsp. carotovorum (strain PC1)	24%	100%
G5EDP2	Caenorhabditis elegans	25%	100%
I6XHJ3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	23%	100%
O26884	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	32%	100%
O46629	Bos taurus	23%	93%
O62742	Oryctolagus cuniculus	27%	81%
P07857	Bos taurus	25%	81%
P11915	Rattus norvegicus	27%	81%
P14611	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	25%	100%
P22307	Homo sapiens	27%	81%
P27796	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P32020	Mus musculus	27%	81%
P34255	Caenorhabditis elegans	22%	98%
P55084	Homo sapiens	23%	93%
P76503	Escherichia coli (strain K12)	21%	100%
Q07598	Gallus gallus	28%	81%
Q07ZP7	Shewanella frigidimarina (strain NCIMB 400)	22%	100%
Q0T2E5	Shigella flexneri serotype 5b (strain 8401)	21%	100%
Q0TFA5	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	22%	100%
Q12P12	Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)	23%	100%
Q1R971	Escherichia coli (strain UTI89 / UPEC)	22%	100%
Q31YB6	Shigella boydii serotype 4 (strain Sb227)	21%	100%
Q32DJ3	Shigella dysenteriae serotype 1 (strain Sd197)	22%	100%
Q3YZM1	Shigella sonnei (strain Ss046)	21%	100%
Q4WCL5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	23%	100%
Q51956	Pseudomonas putida	24%	100%
Q57LW5	Salmonella choleraesuis (strain SC-B67)	23%	100%
Q58944	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	31%	100%
Q5PCX7	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	23%	100%
Q5R1W7	Pan troglodytes	23%	93%
Q6D2L6	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)	23%	100%
Q83K95	Shigella flexneri	20%	100%
Q8FFG3	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	22%	100%
Q8S4Y1	Arabidopsis thaliana	25%	100%
Q8VPF1	Pseudomonas knackmussii (strain DSM 6978 / LMG 23759 / B13)	26%	100%
Q8XCN9	Escherichia coli O157:H7	22%	100%
Q8Z4Y9	Salmonella typhi	23%	100%
Q8ZNA6	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	23%	100%
Q9U0V9	Leishmania major	97%	100%
V5ARP0	Trypanosoma cruzi	73%	100%