Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania mexicana

UniProt:

E9AW82_LEIMU

TriTrypDb:

LmxM.23.0670

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW82

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	22
GO:0005488	binding	1	22
GO:0036094	small molecule binding	2	22
GO:0097159	organic cyclic compound binding	2	22
GO:1901265	nucleoside phosphate binding	3	22
GO:1901363	heterocyclic compound binding	2	22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	334	336	PF00675	0.447
CLV_PCSK_KEX2_1	138	140	PF00082	0.344
CLV_PCSK_KEX2_1	334	336	PF00082	0.415
CLV_PCSK_KEX2_1	47	49	PF00082	0.208
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.359
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.177
CLV_PCSK_SKI1_1	138	142	PF00082	0.432
CLV_PCSK_SKI1_1	155	159	PF00082	0.508
CLV_PCSK_SKI1_1	195	199	PF00082	0.316
CLV_PCSK_SKI1_1	212	216	PF00082	0.408
CLV_PCSK_SKI1_1	334	338	PF00082	0.496
CLV_Separin_Metazoa	112	116	PF03568	0.214
DEG_APCC_DBOX_1	194	202	PF00400	0.327
DOC_MAPK_gen_1	47	55	PF00069	0.355
DOC_PP4_FxxP_1	203	206	PF00568	0.374
DOC_USP7_MATH_1	238	242	PF00917	0.500
DOC_USP7_MATH_1	347	351	PF00917	0.469
DOC_USP7_MATH_1	62	66	PF00917	0.455
DOC_USP7_UBL2_3	215	219	PF12436	0.312
DOC_USP7_UBL2_3	302	306	PF12436	0.321
DOC_WW_Pin1_4	306	311	PF00397	0.590
LIG_14-3-3_CanoR_1	344	350	PF00244	0.374
LIG_14-3-3_CanoR_1	41	46	PF00244	0.185
LIG_BIR_II_1	1	5	PF00653	0.545
LIG_Clathr_ClatBox_1	126	130	PF01394	0.295
LIG_FHA_1	208	214	PF00498	0.373
LIG_FHA_1	251	257	PF00498	0.388
LIG_FHA_1	260	266	PF00498	0.393
LIG_FHA_1	351	357	PF00498	0.355
LIG_FHA_2	107	113	PF00498	0.389
LIG_FHA_2	174	180	PF00498	0.400
LIG_FHA_2	255	261	PF00498	0.449
LIG_LIR_Apic_2	202	206	PF02991	0.428
LIG_LIR_Gen_1	241	250	PF02991	0.352
LIG_LIR_Gen_1	65	73	PF02991	0.295
LIG_LIR_Gen_1	76	86	PF02991	0.300
LIG_LIR_Nem_3	188	194	PF02991	0.316
LIG_LIR_Nem_3	241	246	PF02991	0.312
LIG_LIR_Nem_3	277	283	PF02991	0.387
LIG_LIR_Nem_3	315	321	PF02991	0.370
LIG_LIR_Nem_3	343	349	PF02991	0.419
LIG_LIR_Nem_3	65	69	PF02991	0.295
LIG_LIR_Nem_3	76	82	PF02991	0.284
LIG_MYND_1	178	182	PF01753	0.414
LIG_PCNA_yPIPBox_3	352	361	PF02747	0.317
LIG_PDZ_Class_1	369	374	PF00595	0.408
LIG_Pex14_2	242	246	PF04695	0.373
LIG_SH2_PTP2	79	82	PF00017	0.277
LIG_SH2_SRC	326	329	PF00017	0.326
LIG_SH2_STAP1	196	200	PF00017	0.343
LIG_SH2_STAP1	66	70	PF00017	0.253
LIG_SH2_STAT5	192	195	PF00017	0.291
LIG_SH2_STAT5	79	82	PF00017	0.277
LIG_SUMO_SIM_anti_2	74	79	PF11976	0.327
LIG_TRAF2_1	338	341	PF00917	0.479
LIG_TRAF2_1	65	68	PF00917	0.421
LIG_TYR_ITIM	77	82	PF00017	0.285
LIG_TYR_ITSM	276	283	PF00017	0.565
LIG_WRC_WIRS_1	222	227	PF05994	0.322
LIG_WRC_WIRS_1	239	244	PF05994	0.327
MOD_CK1_1	312	318	PF00069	0.392
MOD_CK1_1	350	356	PF00069	0.412
MOD_CK2_1	106	112	PF00069	0.366
MOD_CK2_1	113	119	PF00069	0.355
MOD_CK2_1	161	167	PF00069	0.229
MOD_CK2_1	173	179	PF00069	0.290
MOD_CK2_1	254	260	PF00069	0.442
MOD_CK2_1	62	68	PF00069	0.292
MOD_CMANNOS	18	21	PF00535	0.370
MOD_Cter_Amidation	136	139	PF01082	0.306
MOD_GlcNHglycan	1	4	PF01048	0.600
MOD_GlcNHglycan	163	166	PF01048	0.295
MOD_GlcNHglycan	362	365	PF01048	0.439
MOD_GlcNHglycan	70	73	PF01048	0.217
MOD_GSK3_1	238	245	PF00069	0.397
MOD_GSK3_1	250	257	PF00069	0.362
MOD_N-GLC_1	159	164	PF02516	0.426
MOD_N-GLC_1	284	289	PF02516	0.534
MOD_N-GLC_2	290	292	PF02516	0.411
MOD_NEK2_1	1	6	PF00069	0.501
MOD_NEK2_1	113	118	PF00069	0.397
MOD_NEK2_1	129	134	PF00069	0.335
MOD_NEK2_1	250	255	PF00069	0.443
MOD_NEK2_1	29	34	PF00069	0.362
MOD_NEK2_1	360	365	PF00069	0.372
MOD_NEK2_2	238	243	PF00069	0.406
MOD_PIKK_1	309	315	PF00454	0.487
MOD_PIKK_1	350	356	PF00454	0.325
MOD_Plk_1	159	165	PF00069	0.255
MOD_Plk_1	250	256	PF00069	0.387
MOD_Plk_1	340	346	PF00069	0.318
MOD_Plk_4	129	135	PF00069	0.302
MOD_Plk_4	218	224	PF00069	0.213
MOD_Plk_4	238	244	PF00069	0.327
MOD_Plk_4	41	47	PF00069	0.230
MOD_ProDKin_1	306	312	PF00069	0.581
MOD_SUMO_for_1	336	339	PF00179	0.297
TRG_ENDOCYTIC_2	280	283	PF00928	0.477
TRG_ENDOCYTIC_2	66	69	PF00928	0.293
TRG_ENDOCYTIC_2	79	82	PF00928	0.271
TRG_ER_diArg_1	334	336	PF00400	0.433
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	323	328	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P740	Leptomonas seymouri	33%	81%
A0A0N1I5Z7	Leptomonas seymouri	40%	100%
A0A0N1I7E8	Leptomonas seymouri	58%	100%
A0A0S4IRH3	Bodo saltans	39%	100%
A0A1X0NWZ0	Trypanosomatidae	24%	77%
A0A1X0NX10	Trypanosomatidae	50%	100%
A0A1X0NX22	Trypanosomatidae	39%	81%
A0A1X0NXP4	Trypanosomatidae	42%	100%
A0A3Q8IM07	Leishmania donovani	40%	100%
A0A3S7WXP2	Leishmania donovani	33%	80%
A0A3S7WXT7	Leishmania donovani	90%	100%
A4HCS3	Leishmania braziliensis	32%	100%
A4I097	Leishmania infantum	33%	80%
A4I0B8	Leishmania infantum	91%	100%
B3TMR8	Actinomadura kijaniata	25%	100%
D4GP30	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	25%	100%
E9AH12	Leishmania infantum	40%	87%
E9AW61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AW62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	99%
P49305	Rhizobium meliloti	26%	100%
Q4QBB6	Leishmania major	41%	100%
Q4QBB7	Leishmania major	32%	100%
Q6DKE0	Xenopus laevis	26%	100%
Q9RR32	Streptomyces antibioticus	26%	100%
Q9SZ83	Arabidopsis thaliana	29%	100%
Q9U0V7	Leishmania major	92%	100%
Q9ZA33	Streptomyces violaceoruber	24%	100%
V5BB31	Trypanosoma cruzi	29%	86%
V5BH08	Trypanosoma cruzi	38%	93%