Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AW81_LEIMU

TriTrypDb:

LmxM.23.0660

Length:

886

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW81

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.625
CLV_C14_Caspase3-7	692	696	PF00656	0.508
CLV_C14_Caspase3-7	75	79	PF00656	0.577
CLV_C14_Caspase3-7	833	837	PF00656	0.507
CLV_C14_Caspase3-7	853	857	PF00656	0.662
CLV_NRD_NRD_1	140	142	PF00675	0.590
CLV_NRD_NRD_1	374	376	PF00675	0.761
CLV_NRD_NRD_1	385	387	PF00675	0.433
CLV_NRD_NRD_1	392	394	PF00675	0.593
CLV_NRD_NRD_1	578	580	PF00675	0.584
CLV_NRD_NRD_1	754	756	PF00675	0.610
CLV_NRD_NRD_1	830	832	PF00675	0.637
CLV_PCSK_FUR_1	752	756	PF00082	0.579
CLV_PCSK_FUR_1	828	832	PF00082	0.636
CLV_PCSK_KEX2_1	363	365	PF00082	0.625
CLV_PCSK_KEX2_1	374	376	PF00082	0.526
CLV_PCSK_KEX2_1	392	394	PF00082	0.661
CLV_PCSK_KEX2_1	578	580	PF00082	0.584
CLV_PCSK_KEX2_1	754	756	PF00082	0.610
CLV_PCSK_KEX2_1	830	832	PF00082	0.637
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.625
CLV_PCSK_SKI1_1	321	325	PF00082	0.487
CLV_PCSK_SKI1_1	363	367	PF00082	0.559
CLV_PCSK_SKI1_1	392	396	PF00082	0.623
CLV_PCSK_SKI1_1	410	414	PF00082	0.535
CLV_PCSK_SKI1_1	660	664	PF00082	0.583
CLV_PCSK_SKI1_1	739	743	PF00082	0.672
DEG_APCC_DBOX_1	320	328	PF00400	0.479
DEG_Nend_UBRbox_3	1	3	PF02207	0.488
DEG_SCF_FBW7_1	475	482	PF00400	0.681
DEG_SPOP_SBC_1	209	213	PF00917	0.647
DEG_SPOP_SBC_1	694	698	PF00917	0.575
DEG_SPOP_SBC_1	784	788	PF00917	0.521
DOC_AGCK_PIF_2	437	442	PF00069	0.541
DOC_ANK_TNKS_1	179	186	PF00023	0.613
DOC_CYCLIN_yClb5_NLxxxL_5	442	451	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	669	675	PF00134	0.566
DOC_MAPK_DCC_7	579	589	PF00069	0.583
DOC_MAPK_gen_1	752	761	PF00069	0.627
DOC_MAPK_JIP1_4	619	625	PF00069	0.500
DOC_MAPK_MEF2A_6	174	181	PF00069	0.658
DOC_MAPK_MEF2A_6	619	627	PF00069	0.489
DOC_PP1_RVXF_1	152	159	PF00149	0.613
DOC_PP2B_LxvP_1	487	490	PF13499	0.647
DOC_PP2B_LxvP_1	729	732	PF13499	0.503
DOC_PP4_FxxP_1	59	62	PF00568	0.489
DOC_USP7_MATH_1	134	138	PF00917	0.486
DOC_USP7_MATH_1	164	168	PF00917	0.566
DOC_USP7_MATH_1	221	225	PF00917	0.536
DOC_USP7_MATH_1	291	295	PF00917	0.583
DOC_USP7_MATH_1	514	518	PF00917	0.602
DOC_USP7_MATH_1	542	546	PF00917	0.621
DOC_USP7_MATH_1	618	622	PF00917	0.565
DOC_USP7_MATH_1	680	684	PF00917	0.601
DOC_USP7_MATH_1	693	697	PF00917	0.509
DOC_USP7_MATH_1	703	707	PF00917	0.787
DOC_USP7_MATH_1	708	712	PF00917	0.614
DOC_USP7_MATH_1	732	736	PF00917	0.643
DOC_USP7_MATH_1	843	847	PF00917	0.589
DOC_USP7_MATH_1	882	886	PF00917	0.554
DOC_USP7_UBL2_3	359	363	PF12436	0.620
DOC_USP7_UBL2_3	397	401	PF12436	0.628
DOC_WW_Pin1_4	264	269	PF00397	0.555
DOC_WW_Pin1_4	285	290	PF00397	0.659
DOC_WW_Pin1_4	404	409	PF00397	0.656
DOC_WW_Pin1_4	475	480	PF00397	0.677
DOC_WW_Pin1_4	531	536	PF00397	0.602
DOC_WW_Pin1_4	577	582	PF00397	0.478
DOC_WW_Pin1_4	671	676	PF00397	0.720
DOC_WW_Pin1_4	678	683	PF00397	0.635
DOC_WW_Pin1_4	706	711	PF00397	0.668
DOC_WW_Pin1_4	785	790	PF00397	0.628
DOC_WW_Pin1_4	80	85	PF00397	0.627
LIG_14-3-3_CanoR_1	108	112	PF00244	0.583
LIG_14-3-3_CanoR_1	16	24	PF00244	0.597
LIG_14-3-3_CanoR_1	261	270	PF00244	0.592
LIG_14-3-3_CanoR_1	279	289	PF00244	0.513
LIG_14-3-3_CanoR_1	31	40	PF00244	0.567
LIG_14-3-3_CanoR_1	374	382	PF00244	0.543
LIG_14-3-3_CanoR_1	386	390	PF00244	0.442
LIG_14-3-3_CanoR_1	466	475	PF00244	0.576
LIG_14-3-3_CanoR_1	614	623	PF00244	0.534
LIG_14-3-3_CanoR_1	828	838	PF00244	0.635
LIG_Actin_WH2_2	436	454	PF00022	0.655
LIG_BIR_III_4	453	457	PF00653	0.688
LIG_BRCT_BRCA1_1	415	419	PF00533	0.509
LIG_FHA_1	204	210	PF00498	0.691
LIG_FHA_1	240	246	PF00498	0.446
LIG_FHA_1	27	33	PF00498	0.556
LIG_FHA_1	482	488	PF00498	0.590
LIG_FHA_1	491	497	PF00498	0.571
LIG_FHA_1	716	722	PF00498	0.552
LIG_FHA_1	740	746	PF00498	0.720
LIG_FHA_1	795	801	PF00498	0.681
LIG_FHA_1	81	87	PF00498	0.572
LIG_FHA_2	565	571	PF00498	0.537
LIG_FHA_2	598	604	PF00498	0.597
LIG_FHA_2	638	644	PF00498	0.623
LIG_FHA_2	686	692	PF00498	0.525
LIG_Integrin_RGD_1	644	646	PF01839	0.513
LIG_LIR_Apic_2	565	569	PF02991	0.531
LIG_LIR_Apic_2	57	62	PF02991	0.488
LIG_LIR_Gen_1	235	245	PF02991	0.548
LIG_LIR_Gen_1	416	427	PF02991	0.776
LIG_LIR_Gen_1	438	447	PF02991	0.628
LIG_LIR_Gen_1	551	561	PF02991	0.513
LIG_LIR_Gen_1	621	630	PF02991	0.522
LIG_LIR_Gen_1	772	780	PF02991	0.633
LIG_LIR_Nem_3	235	240	PF02991	0.549
LIG_LIR_Nem_3	416	422	PF02991	0.780
LIG_LIR_Nem_3	432	437	PF02991	0.578
LIG_LIR_Nem_3	48	53	PF02991	0.615
LIG_LIR_Nem_3	551	557	PF02991	0.515
LIG_LIR_Nem_3	592	597	PF02991	0.609
LIG_LIR_Nem_3	621	625	PF02991	0.533
LIG_LIR_Nem_3	772	776	PF02991	0.647
LIG_LIR_Nem_3	797	801	PF02991	0.667
LIG_NRBOX	323	329	PF00104	0.546
LIG_PALB2_WD40_1	235	243	PF16756	0.570
LIG_Pex14_1	237	241	PF04695	0.570
LIG_Pex14_2	96	100	PF04695	0.512
LIG_PTAP_UEV_1	501	506	PF05743	0.592
LIG_PTB_Apo_2	799	806	PF02174	0.611
LIG_PTB_Phospho_1	799	805	PF10480	0.613
LIG_SH2_CRK	159	163	PF00017	0.572
LIG_SH2_GRB2like	805	808	PF00017	0.653
LIG_SH2_SRC	40	43	PF00017	0.489
LIG_SH2_STAT5	307	310	PF00017	0.618
LIG_SH2_STAT5	622	625	PF00017	0.513
LIG_SH3_3	178	184	PF00018	0.640
LIG_SH3_3	499	505	PF00018	0.608
LIG_SH3_3	662	668	PF00018	0.599
LIG_SH3_4	359	366	PF00018	0.618
LIG_SUMO_SIM_anti_2	301	307	PF11976	0.527
LIG_SUMO_SIM_anti_2	555	561	PF11976	0.574
LIG_SUMO_SIM_par_1	241	247	PF11976	0.503
LIG_SUMO_SIM_par_1	526	531	PF11976	0.531
LIG_UBA3_1	324	332	PF00899	0.657
MOD_CDC14_SPxK_1	407	410	PF00782	0.614
MOD_CDK_SPK_2	785	790	PF00069	0.642
MOD_CDK_SPK_2	80	85	PF00069	0.627
MOD_CDK_SPxK_1	404	410	PF00069	0.620
MOD_CK1_1	130	136	PF00069	0.520
MOD_CK1_1	200	206	PF00069	0.634
MOD_CK1_1	213	219	PF00069	0.749
MOD_CK1_1	249	255	PF00069	0.637
MOD_CK1_1	263	269	PF00069	0.531
MOD_CK1_1	277	283	PF00069	0.612
MOD_CK1_1	284	290	PF00069	0.654
MOD_CK1_1	295	301	PF00069	0.610
MOD_CK1_1	34	40	PF00069	0.625
MOD_CK1_1	341	347	PF00069	0.472
MOD_CK1_1	378	384	PF00069	0.436
MOD_CK1_1	403	409	PF00069	0.631
MOD_CK1_1	417	423	PF00069	0.800
MOD_CK1_1	473	479	PF00069	0.636
MOD_CK1_1	534	540	PF00069	0.726
MOD_CK1_1	580	586	PF00069	0.466
MOD_CK1_1	698	704	PF00069	0.648
MOD_CK1_1	706	712	PF00069	0.614
MOD_CK1_1	715	721	PF00069	0.541
MOD_CK1_1	746	752	PF00069	0.687
MOD_CK1_1	788	794	PF00069	0.646
MOD_CK1_1	846	852	PF00069	0.642
MOD_CK2_1	134	140	PF00069	0.483
MOD_CK2_1	597	603	PF00069	0.594
MOD_Cter_Amidation	828	831	PF01082	0.636
MOD_GlcNHglycan	12	15	PF01048	0.552
MOD_GlcNHglycan	129	132	PF01048	0.541
MOD_GlcNHglycan	143	146	PF01048	0.519
MOD_GlcNHglycan	166	169	PF01048	0.590
MOD_GlcNHglycan	203	206	PF01048	0.631
MOD_GlcNHglycan	221	224	PF01048	0.649
MOD_GlcNHglycan	276	279	PF01048	0.699
MOD_GlcNHglycan	294	297	PF01048	0.524
MOD_GlcNHglycan	310	314	PF01048	0.477
MOD_GlcNHglycan	340	343	PF01048	0.552
MOD_GlcNHglycan	36	39	PF01048	0.638
MOD_GlcNHglycan	402	405	PF01048	0.592
MOD_GlcNHglycan	416	419	PF01048	0.585
MOD_GlcNHglycan	42	45	PF01048	0.565
MOD_GlcNHglycan	502	505	PF01048	0.692
MOD_GlcNHglycan	539	542	PF01048	0.589
MOD_GlcNHglycan	56	59	PF01048	0.589
MOD_GlcNHglycan	6	9	PF01048	0.610
MOD_GlcNHglycan	616	619	PF01048	0.624
MOD_GlcNHglycan	682	685	PF01048	0.616
MOD_GlcNHglycan	705	708	PF01048	0.650
MOD_GlcNHglycan	722	725	PF01048	0.622
MOD_GlcNHglycan	74	77	PF01048	0.719
MOD_GlcNHglycan	744	748	PF01048	0.648
MOD_GlcNHglycan	762	765	PF01048	0.540
MOD_GlcNHglycan	790	793	PF01048	0.605
MOD_GlcNHglycan	817	820	PF01048	0.561
MOD_GlcNHglycan	845	848	PF01048	0.613
MOD_GlcNHglycan	858	861	PF01048	0.498
MOD_GlcNHglycan	879	882	PF01048	0.538
MOD_GSK3_1	130	137	PF00069	0.470
MOD_GSK3_1	16	23	PF00069	0.643
MOD_GSK3_1	197	204	PF00069	0.808
MOD_GSK3_1	209	216	PF00069	0.724
MOD_GSK3_1	26	33	PF00069	0.767
MOD_GSK3_1	260	267	PF00069	0.614
MOD_GSK3_1	268	275	PF00069	0.731
MOD_GSK3_1	277	284	PF00069	0.582
MOD_GSK3_1	291	298	PF00069	0.531
MOD_GSK3_1	400	407	PF00069	0.622
MOD_GSK3_1	413	420	PF00069	0.581
MOD_GSK3_1	467	474	PF00069	0.633
MOD_GSK3_1	475	482	PF00069	0.585
MOD_GSK3_1	496	503	PF00069	0.543
MOD_GSK3_1	531	538	PF00069	0.484
MOD_GSK3_1	614	621	PF00069	0.572
MOD_GSK3_1	671	678	PF00069	0.614
MOD_GSK3_1	680	687	PF00069	0.648
MOD_GSK3_1	689	696	PF00069	0.682
MOD_GSK3_1	698	705	PF00069	0.684
MOD_GSK3_1	708	715	PF00069	0.563
MOD_GSK3_1	739	746	PF00069	0.629
MOD_GSK3_1	780	787	PF00069	0.519
MOD_GSK3_1	873	880	PF00069	0.524
MOD_N-GLC_1	164	169	PF02516	0.608
MOD_N-GLC_1	780	785	PF02516	0.687
MOD_NEK2_1	107	112	PF00069	0.532
MOD_NEK2_1	127	132	PF00069	0.455
MOD_NEK2_1	233	238	PF00069	0.469
MOD_NEK2_1	385	390	PF00069	0.625
MOD_NEK2_1	413	418	PF00069	0.509
MOD_NEK2_1	442	447	PF00069	0.587
MOD_NEK2_1	564	569	PF00069	0.523
MOD_NEK2_1	623	628	PF00069	0.565
MOD_NEK2_1	650	655	PF00069	0.629
MOD_NEK2_1	780	785	PF00069	0.619
MOD_NEK2_1	800	805	PF00069	0.612
MOD_NEK2_2	435	440	PF00069	0.637
MOD_NEK2_2	483	488	PF00069	0.529
MOD_PIKK_1	31	37	PF00454	0.624
MOD_PIKK_1	380	386	PF00454	0.556
MOD_PIKK_1	739	745	PF00454	0.607
MOD_PIKK_1	775	781	PF00454	0.662
MOD_PKA_1	141	147	PF00069	0.585
MOD_PKA_1	201	207	PF00069	0.625
MOD_PKA_1	392	398	PF00069	0.665
MOD_PKA_2	107	113	PF00069	0.586
MOD_PKA_2	24	30	PF00069	0.628
MOD_PKA_2	260	266	PF00069	0.499
MOD_PKA_2	385	391	PF00069	0.597
MOD_PKA_2	392	398	PF00069	0.565
MOD_PKA_2	618	624	PF00069	0.500
MOD_PKA_2	829	835	PF00069	0.648
MOD_Plk_1	164	170	PF00069	0.485
MOD_Plk_1	378	384	PF00069	0.436
MOD_Plk_1	470	476	PF00069	0.629
MOD_Plk_1	694	700	PF00069	0.510
MOD_Plk_1	757	763	PF00069	0.618
MOD_Plk_4	107	113	PF00069	0.465
MOD_Plk_4	210	216	PF00069	0.658
MOD_Plk_4	295	301	PF00069	0.637
MOD_Plk_4	514	520	PF00069	0.674
MOD_Plk_4	618	624	PF00069	0.556
MOD_Plk_4	695	701	PF00069	0.638
MOD_Plk_4	873	879	PF00069	0.549
MOD_Plk_4	91	97	PF00069	0.654
MOD_ProDKin_1	264	270	PF00069	0.554
MOD_ProDKin_1	285	291	PF00069	0.659
MOD_ProDKin_1	404	410	PF00069	0.656
MOD_ProDKin_1	475	481	PF00069	0.678
MOD_ProDKin_1	531	537	PF00069	0.600
MOD_ProDKin_1	577	583	PF00069	0.478
MOD_ProDKin_1	671	677	PF00069	0.720
MOD_ProDKin_1	678	684	PF00069	0.636
MOD_ProDKin_1	706	712	PF00069	0.671
MOD_ProDKin_1	785	791	PF00069	0.627
MOD_ProDKin_1	80	86	PF00069	0.624
MOD_SUMO_for_1	494	497	PF00179	0.662
MOD_SUMO_rev_2	116	121	PF00179	0.628
MOD_SUMO_rev_2	137	144	PF00179	0.539
MOD_SUMO_rev_2	198	203	PF00179	0.621
TRG_DiLeu_BaEn_1	304	309	PF01217	0.589
TRG_DiLeu_BaLyEn_6	665	670	PF01217	0.604
TRG_ENDOCYTIC_2	434	437	PF00928	0.479
TRG_ENDOCYTIC_2	594	597	PF00928	0.556
TRG_ENDOCYTIC_2	622	625	PF00928	0.513
TRG_ER_diArg_1	391	393	PF00400	0.660
TRG_ER_diArg_1	577	579	PF00400	0.563
TRG_ER_diArg_1	827	830	PF00400	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I942	Leptomonas seymouri	38%	97%
A0A3S7WXM2	Leishmania donovani	86%	100%
A4HCT7	Leishmania braziliensis	67%	99%
A4I0B7	Leishmania infantum	86%	100%
Q9U0V6	Leishmania major	84%	100%