Putative spliceosomal U5 snRNP-specific protein (Putative dim-like protein)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

spliceosomal U5 snRNP-specific protein, putative

Species:

Leishmania mexicana

UniProt:

E9AW80_LEIMU

TriTrypDb:

LmxM.23.0650

Length:

217

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0030532	small nuclear ribonucleoprotein complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	10
GO:0097525	spliceosomal snRNP complex	4	10
GO:0097526	spliceosomal tri-snRNP complex	5	10
GO:0120114	Sm-like protein family complex	2	10
GO:0140513	nuclear protein-containing complex	2	10
GO:1990904	ribonucleoprotein complex	2	10
GO:0005681	spliceosomal complex	3	1
GO:0005682	U5 snRNP	5	4

Expansion

Sequence features

E9AW80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW80

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	10
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	10
GO:0000398	mRNA splicing, via spliceosome	8	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006397	mRNA processing	7	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0008380	RNA splicing	7	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0016071	mRNA metabolic process	6	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.683
CLV_MEL_PAP_1	26	32	PF00089	0.379
CLV_NRD_NRD_1	122	124	PF00675	0.342
CLV_NRD_NRD_1	207	209	PF00675	0.610
CLV_NRD_NRD_1	72	74	PF00675	0.741
CLV_NRD_NRD_1	75	77	PF00675	0.728
CLV_PCSK_FUR_1	73	77	PF00082	0.699
CLV_PCSK_KEX2_1	48	50	PF00082	0.648
CLV_PCSK_KEX2_1	74	76	PF00082	0.736
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.648
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.736
CLV_PCSK_SKI1_1	134	138	PF00082	0.444
CLV_PCSK_SKI1_1	201	205	PF00082	0.310
CLV_PCSK_SKI1_1	24	28	PF00082	0.365
CLV_PCSK_SKI1_1	45	49	PF00082	0.632
DEG_ODPH_VHL_1	118	130	PF01847	0.401
DEG_SPOP_SBC_1	52	56	PF00917	0.587
DOC_MAPK_gen_1	121	130	PF00069	0.444
DOC_MAPK_gen_1	159	167	PF00069	0.441
DOC_MAPK_gen_1	208	215	PF00069	0.581
DOC_MAPK_MEF2A_6	159	167	PF00069	0.364
DOC_PP1_RVXF_1	172	178	PF00149	0.339
DOC_USP7_MATH_1	87	91	PF00917	0.629
LIG_14-3-3_CanoR_1	123	129	PF00244	0.194
LIG_14-3-3_CanoR_1	201	210	PF00244	0.441
LIG_14-3-3_CanoR_1	29	34	PF00244	0.408
LIG_14-3-3_CanoR_1	49	59	PF00244	0.710
LIG_AP2alpha_2	150	152	PF02296	0.444
LIG_FHA_1	131	137	PF00498	0.330
LIG_FHA_1	210	216	PF00498	0.492
LIG_FHA_1	91	97	PF00498	0.594
LIG_FHA_2	202	208	PF00498	0.304
LIG_LIR_Gen_1	137	145	PF02991	0.351
LIG_LIR_Gen_1	150	158	PF02991	0.278
LIG_LIR_Gen_1	181	192	PF02991	0.441
LIG_LIR_Gen_1	207	215	PF02991	0.583
LIG_LIR_Nem_3	137	142	PF02991	0.444
LIG_LIR_Nem_3	181	187	PF02991	0.441
LIG_LIR_Nem_3	207	213	PF02991	0.580
LIG_NRP_CendR_1	216	217	PF00754	0.571
LIG_Pex14_2	152	156	PF04695	0.346
LIG_REV1ctd_RIR_1	154	163	PF16727	0.322
LIG_SH2_CRK	184	188	PF00017	0.441
LIG_SH2_NCK_1	33	37	PF00017	0.592
LIG_SH2_STAP1	33	37	PF00017	0.578
LIG_SH2_STAP1	43	47	PF00017	0.637
LIG_SH2_STAT3	43	46	PF00017	0.615
LIG_SH2_STAT5	105	108	PF00017	0.491
LIG_SH2_STAT5	125	128	PF00017	0.328
LIG_SH2_STAT5	129	132	PF00017	0.321
LIG_SH2_STAT5	33	36	PF00017	0.580
LIG_SUMO_SIM_anti_2	23	29	PF11976	0.390
LIG_SUMO_SIM_par_1	2	9	PF11976	0.550
LIG_UBA3_1	114	121	PF00899	0.403
MOD_CK1_1	202	208	PF00069	0.402
MOD_CK1_1	31	37	PF00069	0.567
MOD_CK1_1	62	68	PF00069	0.744
MOD_CK1_1	90	96	PF00069	0.598
MOD_GlcNHglycan	20	23	PF01048	0.551
MOD_GlcNHglycan	34	37	PF01048	0.608
MOD_GlcNHglycan	55	58	PF01048	0.726
MOD_GlcNHglycan	67	70	PF01048	0.747
MOD_GlcNHglycan	8	11	PF01048	0.445
MOD_GlcNHglycan	89	92	PF01048	0.570
MOD_GlcNHglycan	97	100	PF01048	0.434
MOD_GSK3_1	130	137	PF00069	0.401
MOD_GSK3_1	28	35	PF00069	0.437
MOD_GSK3_1	48	55	PF00069	0.678
MOD_GSK3_1	59	66	PF00069	0.729
MOD_NEK2_1	63	68	PF00069	0.554
MOD_PKA_1	208	214	PF00069	0.479
MOD_PKA_1	48	54	PF00069	0.657
MOD_PKA_2	28	34	PF00069	0.387
MOD_PKA_2	48	54	PF00069	0.720
MOD_Plk_1	134	140	PF00069	0.444
MOD_Plk_4	124	130	PF00069	0.401
MOD_SUMO_rev_2	202	211	PF00179	0.351
TRG_ENDOCYTIC_2	125	128	PF00928	0.344
TRG_ENDOCYTIC_2	184	187	PF00928	0.441
TRG_ER_diArg_1	106	109	PF00400	0.544
TRG_ER_diArg_1	158	161	PF00400	0.444
TRG_ER_diArg_1	215	217	PF00400	0.541
TRG_ER_diArg_1	73	76	PF00400	0.705
TRG_ER_FFAT_2	31	39	PF00635	0.616
TRG_NLS_MonoCore_2	72	77	PF00514	0.699
TRG_NLS_MonoExtC_3	72	78	PF00514	0.734

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILU9	Leptomonas seymouri	71%	100%
A0A1X0NWY8	Trypanosomatidae	49%	100%
A0A3R7KYL3	Trypanosoma rangeli	46%	100%
A0A3S7WXR3	Leishmania donovani	93%	100%
A4HCT6	Leishmania braziliensis	85%	100%
A4I0B6	Leishmania infantum	93%	100%
C9ZV19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q9U0V5	Leishmania major	91%	100%