Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW79_LEIMU

TriTrypDb:

LmxM.23.0640

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 2, no: 0
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AW79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW79

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0019899	enzyme binding	3	3
GO:0031267	small GTPase binding	5	3
GO:0051020	GTPase binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	34	38	PF00656	0.444
CLV_C14_Caspase3-7	515	519	PF00656	0.313
CLV_C14_Caspase3-7	586	590	PF00656	0.610
CLV_NRD_NRD_1	10	12	PF00675	0.578
CLV_NRD_NRD_1	105	107	PF00675	0.617
CLV_NRD_NRD_1	178	180	PF00675	0.585
CLV_NRD_NRD_1	192	194	PF00675	0.582
CLV_NRD_NRD_1	220	222	PF00675	0.594
CLV_NRD_NRD_1	229	231	PF00675	0.551
CLV_NRD_NRD_1	239	241	PF00675	0.518
CLV_NRD_NRD_1	248	250	PF00675	0.555
CLV_NRD_NRD_1	88	90	PF00675	0.545
CLV_NRD_NRD_1	96	98	PF00675	0.665
CLV_PCSK_FUR_1	245	249	PF00082	0.615
CLV_PCSK_FUR_1	86	90	PF00082	0.528
CLV_PCSK_KEX2_1	104	106	PF00082	0.624
CLV_PCSK_KEX2_1	177	179	PF00082	0.586
CLV_PCSK_KEX2_1	191	193	PF00082	0.583
CLV_PCSK_KEX2_1	219	221	PF00082	0.597
CLV_PCSK_KEX2_1	229	231	PF00082	0.549
CLV_PCSK_KEX2_1	239	241	PF00082	0.517
CLV_PCSK_KEX2_1	247	249	PF00082	0.556
CLV_PCSK_KEX2_1	424	426	PF00082	0.567
CLV_PCSK_KEX2_1	88	90	PF00082	0.639
CLV_PCSK_KEX2_1	9	11	PF00082	0.581
CLV_PCSK_KEX2_1	96	98	PF00082	0.665
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.624
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.559
CLV_PCSK_SKI1_1	11	15	PF00082	0.656
CLV_PCSK_SKI1_1	293	297	PF00082	0.630
CLV_PCSK_SKI1_1	571	575	PF00082	0.367
DEG_APCC_DBOX_1	9	17	PF00400	0.443
DEG_APCC_DBOX_1	96	104	PF00400	0.321
DEG_Nend_UBRbox_1	1	4	PF02207	0.527
DOC_CYCLIN_RxL_1	373	383	PF00134	0.304
DOC_MAPK_gen_1	361	370	PF00069	0.313
DOC_MAPK_gen_1	424	430	PF00069	0.304
DOC_MAPK_gen_1	435	441	PF00069	0.323
DOC_MAPK_gen_1	9	18	PF00069	0.442
DOC_MAPK_MEF2A_6	477	484	PF00069	0.305
DOC_MAPK_MEF2A_6	9	18	PF00069	0.372
DOC_USP7_MATH_1	500	504	PF00917	0.312
DOC_USP7_MATH_1	531	535	PF00917	0.413
DOC_USP7_MATH_1	577	581	PF00917	0.638
DOC_USP7_MATH_1	583	587	PF00917	0.628
DOC_USP7_UBL2_3	570	574	PF12436	0.563
DOC_WW_Pin1_4	391	396	PF00397	0.333
LIG_14-3-3_CanoR_1	369	379	PF00244	0.303
LIG_14-3-3_CanoR_1	568	576	PF00244	0.614
LIG_14-3-3_CanoR_1	9	14	PF00244	0.494
LIG_BIR_III_4	41	45	PF00653	0.426
LIG_FHA_1	375	381	PF00498	0.291
LIG_FHA_1	392	398	PF00498	0.476
LIG_FHA_1	399	405	PF00498	0.277
LIG_FHA_1	454	460	PF00498	0.487
LIG_FHA_2	337	343	PF00498	0.275
LIG_FHA_2	55	61	PF00498	0.468
LIG_LIR_Gen_1	412	421	PF02991	0.330
LIG_LIR_Gen_1	512	521	PF02991	0.342
LIG_LIR_Nem_3	383	388	PF02991	0.283
LIG_LIR_Nem_3	392	396	PF02991	0.319
LIG_LIR_Nem_3	412	418	PF02991	0.323
LIG_LIR_Nem_3	481	486	PF02991	0.329
LIG_LIR_Nem_3	512	516	PF02991	0.334
LIG_LIR_Nem_3	533	539	PF02991	0.309
LIG_Pex14_1	479	483	PF04695	0.305
LIG_SH2_CRK	393	397	PF00017	0.338
LIG_SH2_CRK	443	447	PF00017	0.268
LIG_SH2_CRK	472	476	PF00017	0.325
LIG_SH2_CRK	536	540	PF00017	0.321
LIG_SH2_NCK_1	443	447	PF00017	0.235
LIG_SH2_NCK_1	576	580	PF00017	0.591
LIG_SH2_SRC	388	391	PF00017	0.270
LIG_SH2_SRC	472	475	PF00017	0.273
LIG_SH2_STAP1	258	262	PF00017	0.385
LIG_SH2_STAP1	400	404	PF00017	0.275
LIG_SH2_STAP1	415	419	PF00017	0.331
LIG_SH2_STAP1	472	476	PF00017	0.305
LIG_SH2_STAT3	324	327	PF00017	0.289
LIG_SH2_STAT5	274	277	PF00017	0.408
LIG_SH2_STAT5	366	369	PF00017	0.338
LIG_SH2_STAT5	379	382	PF00017	0.239
LIG_SH2_STAT5	388	391	PF00017	0.296
LIG_SH2_STAT5	393	396	PF00017	0.319
LIG_SH2_STAT5	400	403	PF00017	0.401
LIG_SH2_STAT5	407	410	PF00017	0.305
LIG_SH2_STAT5	474	477	PF00017	0.532
LIG_SH2_STAT5	487	490	PF00017	0.349
LIG_SH2_STAT5	543	546	PF00017	0.268
LIG_SH3_3	298	304	PF00018	0.360
LIG_SH3_3	423	429	PF00018	0.304
LIG_SH3_3	458	464	PF00018	0.305
LIG_SUMO_SIM_anti_2	546	552	PF11976	0.450
LIG_SUMO_SIM_par_1	455	460	PF11976	0.235
LIG_TRAF2_1	32	35	PF00917	0.458
LIG_TRAF2_1	57	60	PF00917	0.429
LIG_TYR_ITIM	441	446	PF00017	0.235
LIG_TYR_ITIM	470	475	PF00017	0.235
LIG_UBA3_1	430	436	PF00899	0.289
LIG_WRC_WIRS_1	26	31	PF05994	0.401
MOD_CK1_1	584	590	PF00069	0.723
MOD_CK2_1	336	342	PF00069	0.269
MOD_CK2_1	353	359	PF00069	0.353
MOD_CK2_1	49	55	PF00069	0.463
MOD_Cter_Amidation	422	425	PF01082	0.562
MOD_Cter_Amidation	568	571	PF01082	0.406
MOD_GlcNHglycan	258	261	PF01048	0.629
MOD_GlcNHglycan	293	296	PF01048	0.506
MOD_GlcNHglycan	382	385	PF01048	0.449
MOD_GlcNHglycan	421	424	PF01048	0.717
MOD_GlcNHglycan	581	584	PF01048	0.447
MOD_GlcNHglycan	593	596	PF01048	0.414
MOD_GSK3_1	332	339	PF00069	0.335
MOD_GSK3_1	370	377	PF00069	0.387
MOD_GSK3_1	396	403	PF00069	0.407
MOD_GSK3_1	453	460	PF00069	0.235
MOD_GSK3_1	496	503	PF00069	0.345
MOD_GSK3_1	5	12	PF00069	0.470
MOD_GSK3_1	51	58	PF00069	0.545
MOD_GSK3_1	512	519	PF00069	0.272
MOD_GSK3_1	577	584	PF00069	0.650
MOD_NEK2_1	368	373	PF00069	0.390
MOD_NEK2_1	378	383	PF00069	0.443
MOD_NEK2_1	389	394	PF00069	0.368
MOD_NEK2_1	544	549	PF00069	0.462
MOD_NEK2_2	531	536	PF00069	0.317
MOD_PIKK_1	341	347	PF00454	0.323
MOD_PK_1	249	255	PF00069	0.433
MOD_PKA_1	591	597	PF00069	0.611
MOD_PKA_1	9	15	PF00069	0.448
MOD_PKA_2	368	374	PF00069	0.265
MOD_PKA_2	9	15	PF00069	0.448
MOD_Plk_1	352	358	PF00069	0.307
MOD_Plk_1	36	42	PF00069	0.410
MOD_Plk_1	511	517	PF00069	0.289
MOD_Plk_1	531	537	PF00069	0.310
MOD_Plk_2-3	353	359	PF00069	0.304
MOD_Plk_2-3	512	518	PF00069	0.292
MOD_Plk_2-3	55	61	PF00069	0.428
MOD_Plk_4	25	31	PF00069	0.430
MOD_Plk_4	374	380	PF00069	0.470
MOD_Plk_4	457	463	PF00069	0.332
MOD_Plk_4	516	522	PF00069	0.342
MOD_Plk_4	531	537	PF00069	0.358
MOD_ProDKin_1	391	397	PF00069	0.334
MOD_SUMO_rev_2	584	593	PF00179	0.609
TRG_DiLeu_BaEn_4	108	114	PF01217	0.340
TRG_DiLeu_BaEn_4	78	84	PF01217	0.344
TRG_ENDOCYTIC_2	393	396	PF00928	0.337
TRG_ENDOCYTIC_2	415	418	PF00928	0.336
TRG_ENDOCYTIC_2	443	446	PF00928	0.235
TRG_ENDOCYTIC_2	472	475	PF00928	0.444
TRG_ENDOCYTIC_2	536	539	PF00928	0.372
TRG_ER_diArg_1	103	106	PF00400	0.437
TRG_ER_diArg_1	177	179	PF00400	0.374
TRG_ER_diArg_1	191	193	PF00400	0.379
TRG_ER_diArg_1	219	221	PF00400	0.380
TRG_ER_diArg_1	229	232	PF00400	0.368
TRG_ER_diArg_1	248	250	PF00400	0.355
TRG_ER_diArg_1	86	89	PF00400	0.328
TRG_ER_diArg_1	9	11	PF00400	0.453
TRG_ER_diLys_1	605	608	PF00400	0.640
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.701
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H6H3	Leishmania braziliensis	62%	100%