LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AW74_LEIMU
TriTrypDb:
LmxM.23.0590
Length:
409

Annotations

LeishMANIAdb annotations

Unique kinetoplastid membrane protein. Protein duplicated in Leishmanniids as well as in T. rangeli.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

E9AW74
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW74

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 270 274 PF00656 0.819
CLV_NRD_NRD_1 132 134 PF00675 0.496
CLV_NRD_NRD_1 383 385 PF00675 0.494
CLV_NRD_NRD_1 79 81 PF00675 0.406
CLV_NRD_NRD_1 90 92 PF00675 0.365
CLV_PCSK_KEX2_1 122 124 PF00082 0.464
CLV_PCSK_KEX2_1 132 134 PF00082 0.489
CLV_PCSK_KEX2_1 383 385 PF00082 0.494
CLV_PCSK_KEX2_1 79 81 PF00082 0.407
CLV_PCSK_KEX2_1 89 91 PF00082 0.372
CLV_PCSK_PC1ET2_1 122 124 PF00082 0.470
CLV_PCSK_PC7_1 379 385 PF00082 0.518
CLV_PCSK_SKI1_1 152 156 PF00082 0.386
CLV_PCSK_SKI1_1 188 192 PF00082 0.477
CLV_PCSK_SKI1_1 98 102 PF00082 0.450
DEG_APCC_DBOX_1 55 63 PF00400 0.314
DOC_CKS1_1 292 297 PF01111 0.731
DOC_MAPK_gen_1 79 85 PF00069 0.632
DOC_PP2B_LxvP_1 10 13 PF13499 0.388
DOC_PP2B_LxvP_1 74 77 PF13499 0.312
DOC_USP7_MATH_1 213 217 PF00917 0.781
DOC_USP7_MATH_1 246 250 PF00917 0.648
DOC_USP7_MATH_1 349 353 PF00917 0.756
DOC_USP7_MATH_1 396 400 PF00917 0.650
DOC_WW_Pin1_4 211 216 PF00397 0.771
DOC_WW_Pin1_4 262 267 PF00397 0.714
DOC_WW_Pin1_4 291 296 PF00397 0.764
LIG_14-3-3_CanoR_1 170 178 PF00244 0.742
LIG_14-3-3_CanoR_1 182 187 PF00244 0.663
LIG_14-3-3_CanoR_1 255 263 PF00244 0.610
LIG_14-3-3_CanoR_1 290 295 PF00244 0.731
LIG_14-3-3_CanoR_1 298 304 PF00244 0.692
LIG_14-3-3_CanoR_1 357 361 PF00244 0.790
LIG_14-3-3_CanoR_1 6 11 PF00244 0.400
LIG_Actin_WH2_2 14 32 PF00022 0.312
LIG_BIR_II_1 1 5 PF00653 0.545
LIG_BRCT_BRCA1_1 257 261 PF00533 0.740
LIG_EH1_1 22 30 PF00400 0.302
LIG_FHA_1 236 242 PF00498 0.604
LIG_FHA_1 292 298 PF00498 0.698
LIG_FHA_1 33 39 PF00498 0.342
LIG_FHA_2 268 274 PF00498 0.732
LIG_FHA_2 307 313 PF00498 0.708
LIG_FHA_2 94 100 PF00498 0.651
LIG_GBD_Chelix_1 17 25 PF00786 0.312
LIG_GBD_Chelix_1 66 74 PF00786 0.340
LIG_Integrin_RGD_1 340 342 PF01839 0.519
LIG_LIR_Apic_2 289 295 PF02991 0.675
LIG_LIR_Gen_1 258 268 PF02991 0.607
LIG_LIR_Gen_1 35 41 PF02991 0.337
LIG_LIR_Nem_3 258 264 PF02991 0.612
LIG_LIR_Nem_3 35 39 PF02991 0.340
LIG_Pex14_1 69 73 PF04695 0.312
LIG_SH2_CRK 292 296 PF00017 0.729
LIG_SH2_NCK_1 153 157 PF00017 0.587
LIG_SH2_NCK_1 292 296 PF00017 0.781
LIG_SH2_STAP1 153 157 PF00017 0.587
LIG_SH2_STAT5 292 295 PF00017 0.811
LIG_SH2_STAT5 61 64 PF00017 0.312
LIG_SH3_3 260 266 PF00018 0.703
LIG_WRC_WIRS_1 183 188 PF05994 0.485
MOD_CDK_SPxxK_3 291 298 PF00069 0.673
MOD_CK1_1 198 204 PF00069 0.640
MOD_CK1_1 2 8 PF00069 0.439
MOD_CK1_1 217 223 PF00069 0.548
MOD_CK1_1 235 241 PF00069 0.766
MOD_CK1_1 257 263 PF00069 0.560
MOD_CK1_1 359 365 PF00069 0.674
MOD_CK1_1 369 375 PF00069 0.589
MOD_CK2_1 279 285 PF00069 0.638
MOD_CK2_1 306 312 PF00069 0.641
MOD_CK2_1 93 99 PF00069 0.522
MOD_Cter_Amidation 130 133 PF01082 0.526
MOD_Cter_Amidation 381 384 PF01082 0.581
MOD_GlcNHglycan 105 110 PF01048 0.570
MOD_GlcNHglycan 129 132 PF01048 0.771
MOD_GlcNHglycan 138 142 PF01048 0.551
MOD_GlcNHglycan 171 174 PF01048 0.718
MOD_GlcNHglycan 204 207 PF01048 0.640
MOD_GlcNHglycan 216 219 PF01048 0.621
MOD_GlcNHglycan 242 245 PF01048 0.628
MOD_GlcNHglycan 248 251 PF01048 0.550
MOD_GlcNHglycan 299 302 PF01048 0.790
MOD_GlcNHglycan 314 317 PF01048 0.564
MOD_GlcNHglycan 345 348 PF01048 0.660
MOD_GlcNHglycan 369 372 PF01048 0.655
MOD_GlcNHglycan 380 383 PF01048 0.651
MOD_GlcNHglycan 398 401 PF01048 0.614
MOD_GSK3_1 123 130 PF00069 0.613
MOD_GSK3_1 148 155 PF00069 0.538
MOD_GSK3_1 198 205 PF00069 0.677
MOD_GSK3_1 2 9 PF00069 0.556
MOD_GSK3_1 207 214 PF00069 0.644
MOD_GSK3_1 217 224 PF00069 0.559
MOD_GSK3_1 240 247 PF00069 0.715
MOD_GSK3_1 262 269 PF00069 0.772
MOD_GSK3_1 286 293 PF00069 0.691
MOD_GSK3_1 308 315 PF00069 0.511
MOD_GSK3_1 345 352 PF00069 0.794
MOD_GSK3_1 356 363 PF00069 0.643
MOD_GSK3_1 365 372 PF00069 0.517
MOD_GSK3_1 46 53 PF00069 0.406
MOD_N-GLC_1 32 37 PF02516 0.406
MOD_N-GLC_2 52 54 PF02516 0.464
MOD_NEK2_1 169 174 PF00069 0.633
MOD_NEK2_1 23 28 PF00069 0.348
MOD_NEK2_1 360 365 PF00069 0.605
MOD_NEK2_1 62 67 PF00069 0.436
MOD_NEK2_1 85 90 PF00069 0.537
MOD_PK_1 255 261 PF00069 0.632
MOD_PKA_2 118 124 PF00069 0.560
MOD_PKA_2 148 154 PF00069 0.592
MOD_PKA_2 169 175 PF00069 0.647
MOD_PKA_2 181 187 PF00069 0.573
MOD_PKA_2 202 208 PF00069 0.751
MOD_PKA_2 235 241 PF00069 0.592
MOD_PKA_2 254 260 PF00069 0.514
MOD_PKA_2 297 303 PF00069 0.647
MOD_PKA_2 305 311 PF00069 0.653
MOD_PKA_2 356 362 PF00069 0.774
MOD_PKA_2 378 384 PF00069 0.686
MOD_Plk_1 137 143 PF00069 0.563
MOD_Plk_1 198 204 PF00069 0.637
MOD_Plk_1 32 38 PF00069 0.408
MOD_Plk_2-3 279 285 PF00069 0.587
MOD_Plk_4 223 229 PF00069 0.637
MOD_Plk_4 356 362 PF00069 0.625
MOD_ProDKin_1 211 217 PF00069 0.726
MOD_ProDKin_1 262 268 PF00069 0.644
MOD_ProDKin_1 291 297 PF00069 0.719
MOD_SUMO_rev_2 46 51 PF00179 0.406
TRG_ER_diArg_1 233 236 PF00400 0.611
TRG_ER_diArg_1 383 385 PF00400 0.609
TRG_ER_diArg_1 79 81 PF00400 0.495
TRG_ER_diArg_1 89 91 PF00400 0.445
TRG_ER_diLys_1 405 409 PF00400 0.644
TRG_NES_CRM1_1 276 287 PF08389 0.665
TRG_Pf-PMV_PEXEL_1 188 192 PF00026 0.596
TRG_Pf-PMV_PEXEL_1 79 84 PF00026 0.490

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZ47 Leptomonas seymouri 34% 96%
A0A3Q8IEI6 Leishmania donovani 86% 100%
A4H6H5 Leishmania braziliensis 65% 100%
A4I0B0 Leishmania infantum 87% 100%
Q9NF81 Leishmania major 84% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS