Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin-C

Species:

Leishmania mexicana

UniProt:

E9AW71_LEIMU

TriTrypDb:

LmxM.23.0560

Length:

656

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	15
GO:0099080	supramolecular complex	2	15
GO:0099081	supramolecular polymer	3	15
GO:0099512	supramolecular fiber	4	15
GO:0099513	polymeric cytoskeletal fiber	5	15
GO:0110165	cellular anatomical entity	1	15
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

E9AW71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW71

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	15
GO:0007018	microtubule-based movement	3	15
GO:0009987	cellular process	1	15
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0000902	cell morphogenesis	3	1
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0009653	anatomical structure morphogenesis	2	1
GO:0016043	cellular component organization	3	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0030865	cortical cytoskeleton organization	6	1
GO:0031122	cytoplasmic microtubule organization	4	1
GO:0032502	developmental process	1	1
GO:0043622	cortical microtubule organization	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003774	cytoskeletal motor activity	1	15
GO:0003777	microtubule motor activity	2	15
GO:0005488	binding	1	15
GO:0005515	protein binding	2	15
GO:0005524	ATP binding	5	15
GO:0008017	microtubule binding	5	15
GO:0008092	cytoskeletal protein binding	3	15
GO:0015631	tubulin binding	4	15
GO:0017076	purine nucleotide binding	4	15
GO:0030554	adenyl nucleotide binding	5	15
GO:0032553	ribonucleotide binding	3	15
GO:0032555	purine ribonucleotide binding	4	15
GO:0032559	adenyl ribonucleotide binding	5	15
GO:0035639	purine ribonucleoside triphosphate binding	4	15
GO:0036094	small molecule binding	2	15
GO:0043167	ion binding	2	15
GO:0043168	anion binding	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:0097367	carbohydrate derivative binding	2	15
GO:0140657	ATP-dependent activity	1	15
GO:1901265	nucleoside phosphate binding	3	15
GO:1901363	heterocyclic compound binding	2	15
GO:0003824	catalytic activity	1	6
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	6
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	602	606	PF00656	0.466
CLV_MEL_PAP_1	117	123	PF00089	0.327
CLV_NRD_NRD_1	296	298	PF00675	0.312
CLV_NRD_NRD_1	501	503	PF00675	0.566
CLV_NRD_NRD_1	544	546	PF00675	0.642
CLV_NRD_NRD_1	550	552	PF00675	0.645
CLV_NRD_NRD_1	571	573	PF00675	0.562
CLV_NRD_NRD_1	6	8	PF00675	0.474
CLV_NRD_NRD_1	612	614	PF00675	0.610
CLV_NRD_NRD_1	635	637	PF00675	0.449
CLV_PCSK_FUR_1	626	630	PF00082	0.601
CLV_PCSK_FUR_1	633	637	PF00082	0.590
CLV_PCSK_KEX2_1	296	298	PF00082	0.312
CLV_PCSK_KEX2_1	543	545	PF00082	0.653
CLV_PCSK_KEX2_1	550	552	PF00082	0.577
CLV_PCSK_KEX2_1	571	573	PF00082	0.566
CLV_PCSK_KEX2_1	586	588	PF00082	0.423
CLV_PCSK_KEX2_1	6	8	PF00082	0.469
CLV_PCSK_KEX2_1	612	614	PF00082	0.581
CLV_PCSK_KEX2_1	628	630	PF00082	0.383
CLV_PCSK_KEX2_1	635	637	PF00082	0.486
CLV_PCSK_PC1ET2_1	586	588	PF00082	0.650
CLV_PCSK_PC1ET2_1	612	614	PF00082	0.623
CLV_PCSK_PC1ET2_1	628	630	PF00082	0.421
CLV_PCSK_PC7_1	540	546	PF00082	0.646
CLV_PCSK_SKI1_1	16	20	PF00082	0.477
CLV_PCSK_SKI1_1	163	167	PF00082	0.303
CLV_PCSK_SKI1_1	252	256	PF00082	0.391
CLV_PCSK_SKI1_1	436	440	PF00082	0.525
CLV_PCSK_SKI1_1	450	454	PF00082	0.451
CLV_PCSK_SKI1_1	456	460	PF00082	0.373
CLV_PCSK_SKI1_1	467	471	PF00082	0.444
CLV_PCSK_SKI1_1	513	517	PF00082	0.672
CLV_Separin_Metazoa	562	566	PF03568	0.652
CLV_Separin_Metazoa	638	642	PF03568	0.411
DEG_APCC_DBOX_1	263	271	PF00400	0.298
DEG_APCC_DBOX_1	410	418	PF00400	0.649
DEG_Nend_UBRbox_2	1	3	PF02207	0.581
DOC_MAPK_gen_1	143	152	PF00069	0.332
DOC_MAPK_gen_1	376	383	PF00069	0.412
DOC_MAPK_gen_1	454	461	PF00069	0.536
DOC_MAPK_gen_1	586	593	PF00069	0.435
DOC_MAPK_MEF2A_6	120	129	PF00069	0.340
DOC_MAPK_MEF2A_6	145	154	PF00069	0.310
DOC_MAPK_MEF2A_6	325	332	PF00069	0.311
DOC_MAPK_RevD_3	620	636	PF00069	0.360
DOC_USP7_MATH_1	105	109	PF00917	0.371
DOC_USP7_MATH_1	119	123	PF00917	0.323
DOC_USP7_MATH_1	577	581	PF00917	0.503
DOC_USP7_UBL2_3	440	444	PF12436	0.512
DOC_USP7_UBL2_3	513	517	PF12436	0.575
DOC_USP7_UBL2_3	652	656	PF12436	0.543
DOC_WW_Pin1_4	355	360	PF00397	0.300
LIG_14-3-3_CanoR_1	219	226	PF00244	0.301
LIG_14-3-3_CanoR_1	350	354	PF00244	0.331
LIG_14-3-3_CanoR_1	378	384	PF00244	0.417
LIG_14-3-3_CanoR_1	418	422	PF00244	0.629
LIG_14-3-3_CanoR_1	46	52	PF00244	0.527
LIG_14-3-3_CanoR_1	6	10	PF00244	0.496
LIG_Actin_WH2_2	155	173	PF00022	0.311
LIG_APCC_ABBA_1	155	160	PF00400	0.287
LIG_BRCT_BRCA1_1	189	193	PF00533	0.327
LIG_CaM_IQ_9	495	510	PF13499	0.459
LIG_deltaCOP1_diTrp_1	24	32	PF00928	0.416
LIG_FHA_1	13	19	PF00498	0.440
LIG_FHA_1	288	294	PF00498	0.357
LIG_FHA_1	336	342	PF00498	0.300
LIG_FHA_1	349	355	PF00498	0.300
LIG_FHA_1	42	48	PF00498	0.557
LIG_FHA_1	433	439	PF00498	0.584
LIG_FHA_2	196	202	PF00498	0.352
LIG_FHA_2	208	214	PF00498	0.240
LIG_FHA_2	48	54	PF00498	0.508
LIG_FHA_2	59	65	PF00498	0.335
LIG_FHA_2	600	606	PF00498	0.455
LIG_LIR_Apic_2	187	192	PF02991	0.327
LIG_LIR_Apic_2	37	42	PF02991	0.396
LIG_LIR_Gen_1	124	133	PF02991	0.311
LIG_LIR_Gen_1	151	162	PF02991	0.288
LIG_LIR_Gen_1	497	505	PF02991	0.725
LIG_LIR_Gen_1	634	645	PF02991	0.503
LIG_LIR_Gen_1	64	74	PF02991	0.325
LIG_LIR_Gen_1	96	105	PF02991	0.298
LIG_LIR_Nem_3	124	129	PF02991	0.311
LIG_LIR_Nem_3	151	157	PF02991	0.300
LIG_LIR_Nem_3	497	501	PF02991	0.737
LIG_LIR_Nem_3	634	640	PF02991	0.503
LIG_LIR_Nem_3	64	69	PF02991	0.319
LIG_NRBOX	336	342	PF00104	0.312
LIG_PCNA_yPIPBox_3	55	69	PF02747	0.333
LIG_PTB_Apo_2	120	127	PF02174	0.311
LIG_Rb_pABgroove_1	97	105	PF01858	0.449
LIG_SH2_CRK	189	193	PF00017	0.327
LIG_SH2_CRK	253	257	PF00017	0.327
LIG_SH2_CRK	66	70	PF00017	0.371
LIG_SH2_NCK_1	253	257	PF00017	0.346
LIG_SH2_NCK_1	66	70	PF00017	0.298
LIG_SH2_STAP1	364	368	PF00017	0.383
LIG_SH2_STAP1	533	537	PF00017	0.624
LIG_SH2_STAT3	59	62	PF00017	0.346
LIG_SH2_STAT5	281	284	PF00017	0.314
LIG_SH2_STAT5	97	100	PF00017	0.325
LIG_SH3_1	325	331	PF00018	0.311
LIG_SH3_2	328	333	PF14604	0.311
LIG_SH3_3	325	331	PF00018	0.311
LIG_SUMO_SIM_par_1	13	21	PF11976	0.413
LIG_TRAF2_1	423	426	PF00917	0.541
LIG_UBA3_1	125	130	PF00899	0.317
LIG_UBA3_1	599	607	PF00899	0.653
LIG_WRC_WIRS_1	48	53	PF05994	0.529
LIG_WW_3	140	144	PF00397	0.308
MOD_CDK_SPxxK_3	355	362	PF00069	0.311
MOD_CK1_1	14	20	PF00069	0.409
MOD_CK1_1	230	236	PF00069	0.332
MOD_CK1_1	335	341	PF00069	0.300
MOD_CK1_1	37	43	PF00069	0.406
MOD_CK1_1	93	99	PF00069	0.305
MOD_CK2_1	150	156	PF00069	0.311
MOD_CK2_1	195	201	PF00069	0.468
MOD_CK2_1	207	213	PF00069	0.437
MOD_CK2_1	420	426	PF00069	0.550
MOD_CK2_1	5	11	PF00069	0.434
MOD_CK2_1	532	538	PF00069	0.514
MOD_GlcNHglycan	189	192	PF01048	0.327
MOD_GlcNHglycan	284	287	PF01048	0.311
MOD_GlcNHglycan	92	95	PF01048	0.325
MOD_GSK3_1	10	17	PF00069	0.397
MOD_GSK3_1	203	210	PF00069	0.389
MOD_GSK3_1	213	220	PF00069	0.313
MOD_GSK3_1	335	342	PF00069	0.340
MOD_GSK3_1	349	356	PF00069	0.333
MOD_GSK3_1	367	374	PF00069	0.311
MOD_GSK3_1	37	44	PF00069	0.451
MOD_GSK3_1	413	420	PF00069	0.558
MOD_GSK3_1	438	445	PF00069	0.516
MOD_GSK3_1	47	54	PF00069	0.455
MOD_GSK3_1	599	606	PF00069	0.435
MOD_GSK3_1	80	87	PF00069	0.319
MOD_N-GLC_1	105	110	PF02516	0.389
MOD_N-GLC_1	203	208	PF02516	0.242
MOD_N-GLC_1	227	232	PF02516	0.311
MOD_N-GLC_1	288	293	PF02516	0.300
MOD_N-GLC_1	300	305	PF02516	0.370
MOD_N-GLC_1	489	494	PF02516	0.636
MOD_N-GLC_2	82	84	PF02516	0.287
MOD_NEK2_1	12	17	PF00069	0.567
MOD_NEK2_1	170	175	PF00069	0.315
MOD_NEK2_1	237	242	PF00069	0.311
MOD_NEK2_1	332	337	PF00069	0.324
MOD_NEK2_1	34	39	PF00069	0.384
MOD_NEK2_1	341	346	PF00069	0.328
MOD_NEK2_1	353	358	PF00069	0.318
MOD_NEK2_1	371	376	PF00069	0.316
MOD_NEK2_1	417	422	PF00069	0.545
MOD_NEK2_1	438	443	PF00069	0.593
MOD_NEK2_1	51	56	PF00069	0.518
MOD_NEK2_1	599	604	PF00069	0.415
MOD_PIKK_1	203	209	PF00454	0.466
MOD_PIKK_1	213	219	PF00454	0.436
MOD_PIKK_1	257	263	PF00454	0.450
MOD_PIKK_1	58	64	PF00454	0.309
MOD_PKA_2	119	125	PF00069	0.299
MOD_PKA_2	170	176	PF00069	0.371
MOD_PKA_2	213	219	PF00069	0.301
MOD_PKA_2	332	338	PF00069	0.300
MOD_PKA_2	349	355	PF00069	0.405
MOD_PKA_2	417	423	PF00069	0.599
MOD_PKA_2	432	438	PF00069	0.563
MOD_PKA_2	5	11	PF00069	0.461
MOD_Plk_1	150	156	PF00069	0.327
MOD_Plk_1	288	294	PF00069	0.300
MOD_Plk_1	323	329	PF00069	0.210
MOD_Plk_1	34	40	PF00069	0.398
MOD_Plk_2-3	5	11	PF00069	0.461
MOD_Plk_2-3	520	526	PF00069	0.695
MOD_Plk_4	14	20	PF00069	0.408
MOD_Plk_4	150	156	PF00069	0.325
MOD_Plk_4	207	213	PF00069	0.418
MOD_Plk_4	237	243	PF00069	0.369
MOD_Plk_4	288	294	PF00069	0.353
MOD_Plk_4	332	338	PF00069	0.313
MOD_Plk_4	34	40	PF00069	0.398
MOD_Plk_4	349	355	PF00069	0.294
MOD_Plk_4	379	385	PF00069	0.423
MOD_Plk_4	95	101	PF00069	0.291
MOD_ProDKin_1	355	361	PF00069	0.300
MOD_SUMO_for_1	516	519	PF00179	0.641
MOD_SUMO_rev_2	131	139	PF00179	0.337
MOD_SUMO_rev_2	432	441	PF00179	0.636
MOD_SUMO_rev_2	519	528	PF00179	0.643
TRG_ENDOCYTIC_2	637	640	PF00928	0.499
TRG_ENDOCYTIC_2	66	69	PF00928	0.287
TRG_ENDOCYTIC_2	97	100	PF00928	0.298
TRG_ER_diArg_1	295	297	PF00400	0.311
TRG_ER_diArg_1	542	545	PF00400	0.655
TRG_ER_diArg_1	550	553	PF00400	0.642
TRG_ER_diArg_1	632	635	PF00400	0.522
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.311
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDD6	Leptomonas seymouri	78%	86%
A0A0S4IP49	Bodo saltans	28%	81%
A0A0S4IR67	Bodo saltans	63%	84%
A0A0S4J2K1	Bodo saltans	31%	69%
A0A0S4JRN9	Bodo saltans	32%	100%
A0A0S4KL43	Bodo saltans	28%	100%
A0A1X0NQ03	Trypanosomatidae	27%	79%
A0A1X0NWZ8	Trypanosomatidae	63%	88%
A0A3Q8IAZ2	Leishmania donovani	95%	100%
A0A3Q8IEL2	Leishmania donovani	31%	100%
A0A3R7KHX7	Trypanosoma rangeli	30%	89%
A0A3S7X9Y1	Leishmania donovani	27%	100%
A0A422NEQ8	Trypanosoma rangeli	61%	87%
A0A422NMD1	Trypanosoma rangeli	23%	100%
A4HAQ7	Leishmania braziliensis	32%	100%
A4HCT2	Leishmania braziliensis	82%	100%
A4HND6	Leishmania braziliensis	28%	100%
A4HSA6	Leishmania infantum	30%	100%
A4I0A6	Leishmania infantum	95%	100%
A4I4V3	Leishmania infantum	30%	100%
A4IC09	Leishmania infantum	27%	100%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	87%
D0A8T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AEA1	Leishmania major	30%	100%
E9AFU7	Leishmania major	27%	100%
E9B6Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
O35066	Mus musculus	26%	82%
P28743	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	93%
Q4KLL9	Rattus norvegicus	31%	79%
Q6PFD6	Mus musculus	31%	79%
Q8LNZ2	Arabidopsis thaliana	30%	70%
Q9NF78	Leishmania major	94%	100%
V5B8M1	Trypanosoma cruzi	33%	100%
V5D733	Trypanosoma cruzi	62%	87%